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    • 6. 发明授权
    • Integrated LC-ESI on a chip
    • 集成LC-ESI芯片
    • US07976779B2
    • 2011-07-12
    • US11177505
    • 2005-07-11
    • Yu-Chong TaiJun XieJason ShihTerry LeeYunan Miao
    • Yu-Chong TaiJun XieJason ShihTerry LeeYunan Miao
    • B01L3/00G01N30/02F04F99/00C02F11/00C02F1/469
    • G01N30/34G01N30/16G01N30/6095G01N30/7266
    • A microfluidic system with on-chip pumping which can be used for liquid chromatography and also electrospray ionization mass spectrometry and which provides improved efficiency, better integration with sensors, improved portability, reduced power consumption, and reduced cost. The system can include (A) a main chip comprising: a substrate having a front face and a back face; a chromatography column on the front face of said substrate, wherein said column has an inlet and an outlet; an electrospray ionization (ESI) nozzle on the front face of said substrate, wherein said nozzle has an inlet and an outlet, and wherein the inlet of the nozzle is microfluidically coupled to the outlet of the column; one or more pump systems on the front face of said substrate comprising a pump chamber, one or more electrodes, and an outlet microfluidically coupled to the inlet of said column; and (B) a reservoir chip comprising a front surface and a back surface, wherein the reservoir chip has one or more cavities in the back surface which when disposed next to the front surface of the main chip extends the volume of the pump chamber of one of the pump system. Microfabrication can be used to prepare the chips, which can be assembled with a cover and inserted into a testing jig for electronic control and mass spectral analysis. Peptide separations are demonstrated which compete with present commercial systems.
    • 具有片上泵浦的微流体系统,其可用于液相色谱和电喷雾离子化质谱,并且其提供更高的效率,更好地与传感器的集成,改进的便携性,降低的功率消耗和降低的成本。 该系统可以包括(A)主芯片,其包括:具有正面和背面的基板; 所述基板前表面上的色谱柱,其中所述色谱柱具有入口和出口; 在所述基板的前表面上的电喷雾离子化(ESI)喷嘴,其中所述喷嘴具有入口和出口,并且其中所述喷嘴的入口微流体耦合到所述塔的出口; 所述衬底的前表面上的一个或多个泵系统包括泵室,一个或多个电极和微流体耦合到所述塔的入口的出口; 和(B)包括前表面和后表面的储存器芯片,其中所述储存器芯片在所述后表面中具有一个或多个空腔,当所述储存器芯片靠近所述主芯片的前表面设置时,所述泵室的体积将一个 的泵系统。 可以使用微加工来制备芯片,其可以与盖组装并插入用于电子控制和质谱分析的测试夹具中。 展示了与现有商业系统竞争的肽分离。
    • 7. 发明授权
    • Semaphoring system between system firmware and hardware manipulation subsystem
    • 系统固件与硬件操纵子系统之间的信号系统
    • US07305508B2
    • 2007-12-04
    • US10692038
    • 2003-10-22
    • Shiraz Ali QureshiDong WeiTerry Lee
    • Shiraz Ali QureshiDong WeiTerry Lee
    • G06F12/00G06F12/14
    • G06F9/52
    • In one embodiment of the invention, a method of semaphoring between a system firmware and ACPI subsystem, includes: prior to entering a critical section by a first entity, checking a turn flag to determine if a second entity has a turn to access a critical section; if the second entity has the turn, then checking an In flag of the second entity to determine if the second entity is in the critical section; if the second entity is in the critical section, then waiting for the second entity to exit the critical section; and entering the critical section by the first entity. The method may further include: if the second entity is not in the critical section, then entering the critical section by the first entity.
    • 在本发明的一个实施例中,一种在系统固件和ACPI子系统之间进行信号的方法包括:在由第一实体进入关键部分之前,检查转弯标志以确定第二实体是否具有接近临界部分的转弯 ; 如果第二实体具有转弯,则检查第二实体的In标志以确定第二实体是否在临界区; 如果第二个实体处于临界区,那么等待第二个实体退出临界区; 并由第一实体进入关键部分。 该方法还可以包括:如果第二实体不在临界区,则由第一实体进入临界区。
    • 10. 发明申请
    • Posted write buffers and method of posting write requests in memory modules
    • 发布的写入缓冲区和在内存模块中发布写入请求的方法
    • US20060212655A1
    • 2006-09-21
    • US11433201
    • 2006-05-11
    • Joseph JeddelohTerry Lee
    • Joseph JeddelohTerry Lee
    • G06F12/00
    • G11C7/1006G11C7/1051G11C7/1069G11C7/1078G11C7/1096G11C11/4093G11C11/4096
    • A memory module includes a memory hub coupled to several memory devices. The memory hub includes a posted write buffer that stores write requests so that subsequently issued read requests can first be coupled to the memory devices. The write request addresses are also posted in the buffer and compared to subsequent read request addresses. In the event of a positive comparison indicating that a read request is directed to an address to which an earlier write request was directed, the read data are provided from the buffer. When the memory devices are not busy servicing read request, the write requests can be transferred from the posted write buffer to the memory devices. The write requests may also be accumulated in the posted write buffer until either a predetermined number of write requests have been accumulated or the write requests have been posted for a predetermined duration.
    • 存储器模块包括耦合到多个存储器件的存储器集线器。 存储器集线器包括存储写入请求的已发布的写入缓冲器,以便随后发出的读取请求可以首先耦合到存储器件。 写请求地址也被发布在缓冲区中,并与随后的读请求地址进行比较。 在正面比较的情况下,指示读请求被引导到较早写请求所针对的地址,从缓冲器提供读数据。 当存储器件不忙于读取请求时,写入请求可以从发布的写入缓冲区传送到存储器件。 写入请求也可以被累积在发布的写入缓冲器中,直到预定数量的写入请求已经被累积或写入请求已经被发布了预定的持续时间。