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1. 发明申请

US20060009432A1 Use of neurosteroids to treat neuropathic pain 审中-公开
标题翻译：使用神经甾体治疗神经性疼痛
公开(公告)号：US20060009432A1
公开(公告)日：2006-01-12
申请号：US11177977
申请日：2005-07-08
申请人： Roger Whiting , Lakshmi Sangameswaran
发明人： Roger Whiting , Lakshmi Sangameswaran
IPC分类号： A61K31/57
CPC分类号： A61K31/57
摘要： Ganaxolone (3α-hydroxy-3β-methyl-5β-pregnan-20-one) and 3α-hydroxy-3β-methyl-5β-pregnan-20-one and their physiologically cleavable esters are useful for treating neuropathic pain. Compositions comprising a pharmaceutically acceptable excipient and an appropriate compound, along with methods for preparing the compositions are disclosed. Also disclosed are articles of manufacture wherein the composition is combine with labeling instructions for treating neuropathic pain.
摘要翻译： Ganaxolone（3α-羟基-3β-甲基-5β-孕烷-20-酮）和3α-羟基-3β-甲基-5β-孕烷-20-酮及其生理学上可裂解的酯可用于治疗神经性疼痛。公开了包含药学上可接受的赋形剂和合适的化合物的组合物以及制备组合物的方法。还公开了制品，其中组合物与用于治疗神经性疼痛的标签说明书组合。

2. 发明申请

US20050186627A1 Cloned peripheral nerve, tetrodotoxin-resistant sodium channel alpha-subunit 审中-公开
标题翻译：克隆的周围神经，河豚毒素耐药钠通道α-亚基
公开(公告)号：US20050186627A1
公开(公告)日：2005-08-25
申请号：US11105894
申请日：2005-04-14
申请人： Ronald Herman , Stephen Delgado , Linda Fish , Lakshmi Sangameswaran , Douglas Rabert
发明人： Ronald Herman , Stephen Delgado , Linda Fish , Lakshmi Sangameswaran , Douglas Rabert
IPC分类号： C07K14/705 , C12N15/12 , C12Q1/68 , A61K48/00 , C07H21/04
CPC分类号： C07K14/705
摘要： The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
摘要翻译：本发明涉及存在于患有河豚毒素的周围神经组织中的电压门控钠通道。本发明的一个方面是纯化和分离的编码该钠通道的DNA。本发明的另一方面是由该DNA表达的重组蛋白，包含DNA序列的表达载体和用这些表达载体转化的宿主细胞。本发明的另一方面是使用该电压门控的河豚毒素钠通道作为化合物治疗周围神经系统疾病的治疗靶标。

3. 发明授权

US06335172B1 Cloned tetrodotoxin-sensitive sodium channel &agr;-subunit and a splice variant thereof 失效
标题翻译：克隆的河豚毒素敏感性钠通道α-亚基及其剪接变体
公开(公告)号：US06335172B1
公开(公告)日：2002-01-01
申请号：US09425043
申请日：1999-10-21
申请人： Stephen Gregory Delgado , Paul Shartzer Dietrich , Linda Marie Fish , Ronald Charles Herman , Lakshmi Sangameswaran
发明人： Stephen Gregory Delgado , Paul Shartzer Dietrich , Linda Marie Fish , Ronald Charles Herman , Lakshmi Sangameswaran
IPC分类号： C07K14705
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.
摘要翻译：分离编码电压门控，TTX敏感性钠通道的DNA。还公开了这些DNA序列的重组表达的多肽产物，包含DNA序列的表达载体和用这些表达载体转化的宿主细胞。本发明的其它方面是其序列基于从这些DNA序列推导的氨基酸序列，对这些蛋白质和肽特异性的抗体，检测和定量这些蛋白质的程序以及与其相关的核酸的肽。本发明的另一方面是使用这种电压门控毒性敏感的钠通道作为化合物的治疗靶标。

4. 发明授权

US6030810A Cloned tetrodotoxin-sensitive sodium channel .alpha.-subunit and a splice variant thereof 失效
标题翻译：克隆的河豚毒素敏感性钠通道α-亚基及其剪接变体
公开(公告)号：US6030810A
公开(公告)日：2000-02-29
申请号：US24020
申请日：1998-02-16
申请人： Stephen Gregory Delgado , Paul Shartzer Dietrich , Linda Marie Fish , Ronald Charles Herman , Lakshmi Sangameswaran
发明人： Stephen Gregory Delgado , Paul Shartzer Dietrich , Linda Marie Fish , Ronald Charles Herman , Lakshmi Sangameswaran
IPC分类号： A61K38/00 , C07K14/705 , C12N1/21 , C12N15/12
CPC分类号： C07K14/705 , A61K38/00
摘要： DNA encoding for a voltage-gated, TTX-sensitive sodium channel is isolated. Also disclosed are polypeptide products of recombinant expression of these DNA sequences, expression vectors comprising the DNA sequences, and host cells transformed with these expression vectors. Other aspects of this invention are peptides whose sequences are based on the amino acid sequences deduced from these DNA sequences, antibodies specific for such proteins and peptides, procedures for detection and quantitation of such proteins, and nucleic acids related thereto. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-sensitive sodium channel as a therapeutic target for compounds.
摘要翻译：分离编码电压门控，TTX敏感性钠通道的DNA。还公开了这些DNA序列的重组表达的多肽产物，包含DNA序列的表达载体和用这些表达载体转化的宿主细胞。本发明的其它方面是其序列基于从这些DNA序列推导的氨基酸序列，对这些蛋白质和肽特异的抗体，用于检测和定量这些蛋白质的程序以及与其相关的核酸的肽。本发明的另一方面是使用这种电压门控毒性敏感的钠通道作为化合物的治疗靶标。

5. 发明授权

US07122325B2 Method of modulating tetrotodoxin-resistant sodium channel 有权
标题翻译：调节四佐丹毒素钠通道的方法
公开(公告)号：US07122325B2
公开(公告)日：2006-10-17
申请号：US10209776
申请日：2002-08-01
申请人： Ronald Herman , Stephen Gregory Delgado , Linda Marie Fish , Lakshmi Sangameswaran , Douglas Kenneth Rabert
发明人： Ronald Herman , Stephen Gregory Delgado , Linda Marie Fish , Lakshmi Sangameswaran , Douglas Kenneth Rabert
IPC分类号： G01N33/53
CPC分类号： C07K14/705
摘要： The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
摘要翻译：本发明涉及存在于患有河豚毒素的周围神经组织中的电压门控钠通道。本发明的一个方面是纯化和分离的编码该钠通道的DNA。本发明的另一方面是由该DNA表达的重组蛋白，包含DNA序列的表达载体和用这些表达载体转化的宿主细胞。本发明的另一方面是使用该电压门控的河豚毒素钠通道作为化合物治疗周围神经系统疾病的治疗靶标。

6. 发明授权

US06184349B2 Cloned peripheral nerve, tetrodotoxin-resistant sodium channel &agr;-subunit 失效
标题翻译：克隆的周围神经，河豚毒素耐药钠通道α-亚基
公开(公告)号：US06184349B2
公开(公告)日：2001-02-06
申请号：US08843417
申请日：1997-04-15
申请人： Ronald Herman , Stephen Gregory Delgado , Linda Marie Fish , Lakshmi Sangameswaran , Douglas Kenneth Rabert
发明人： Ronald Herman , Stephen Gregory Delgado , Linda Marie Fish , Lakshmi Sangameswaran , Douglas Kenneth Rabert
IPC分类号： C07K14435
CPC分类号： C07K14/705
摘要： The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
摘要翻译：本发明涉及存在于患有河豚毒素的周围神经组织中的电压门控钠通道。本发明的一个方面是纯化和分离的编码该钠通道的DNA。本发明的另一方面是由该DNA表达的重组蛋白，包含DNA序列的表达载体和用这些表达载体转化的宿主细胞。本发明的另一方面是使用该电压门控的河豚毒素钠通道作为化合物治疗周围神经系统疾病的治疗靶标。

7. 发明授权

US08158682B2 Instillation administration of capsaicinoids for the treatment of pain 有权
标题翻译：用于治疗疼痛的辣椒素的滴注
公开(公告)号：US08158682B2
公开(公告)日：2012-04-17
申请号：US12559071
申请日：2009-09-14
申请人： Lakshmi Sangameswaran , Susan Kramer
发明人： Lakshmi Sangameswaran , Susan Kramer
IPC分类号： A61K31/166
CPC分类号： A61K31/165 , A61K31/167 , Y10S514/818
摘要： This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.
摘要翻译：本发明涉及治疗或减轻患者疼痛的方法。具体而言，本发明提供了一种减轻开放伤口或手术切口部位附近的疼痛的方法，包括将包含辣椒素的药物组合物滴入伤口或切口中，使药物组合物停留预定时间段，以及抽吸伤口或切口以去除药物组合物。本发明还提供了一种减轻接近接近的疼痛的方法，包括将包含辣椒素的药物组合物关节内注射到关节中，使药物组合物停留预定时间段，并吸出关节以除去药物组合物。在本发明的某些实施方案中，辣椒素类是辣椒素。

8. 发明申请

US20100234470A1 Instillation Administration of Capsaicinoids for the Treatment of Pain 有权
标题翻译：辣椒素治疗疼痛的药物治疗
公开(公告)号：US20100234470A1
公开(公告)日：2010-09-16
申请号：US12559071
申请日：2009-09-14
申请人： Lakshmi Sangameswaran , Susan Kramer
发明人： Lakshmi Sangameswaran , Susan Kramer
IPC分类号： A61K31/167 , A61K31/165 , A61P19/02
CPC分类号： A61K31/165 , A61K31/167 , Y10S514/818
摘要： This present invention relates to methods for treating or attenuating pain in a patient. Specifically, the invention provides a method for attenuating pain in proximity to the site of an open wound or surgical incision comprising instilling a pharmaceutical composition comprising a capsaicinoid into the wound or incision, allowing the pharmaceutical composition to dwell for a predetermined period of time, and aspirating the wound or incision to remove the pharmaceutical composition. The invention also provides a method for attenuating pain in proximity to a joint comprising intra-articularly injecting a pharmaceutical composition comprising a capsaicinoid into the joint, allowing the pharmaceutical composition to dwell for predetermined period of time, and aspirating the joint to remove the pharmaceutical composition. In certain embodiments of the invention, the capsaicinoid is capsaicin.
摘要翻译：本发明涉及治疗或减轻患者疼痛的方法。具体而言，本发明提供了一种减轻开放伤口或手术切口部位附近的疼痛的方法，包括将包含辣椒素的药物组合物滴入伤口或切口中，使药物组合物停留预定时间段，以及抽吸伤口或切口以去除药物组合物。本发明还提供了一种减轻接近接近的疼痛的方法，包括将包含辣椒素的药物组合物关节内注射到关节中，使药物组合物停留预定时间段，并吸出关节以除去药物组合物。在本发明的某些实施方案中，辣椒素类是辣椒素。

9. 发明授权

US06479259B1 Human peripheral nerve, tetrodotoxin-resistant sodium channel &agr;-subunit polypeptide 有权
标题翻译：人类周围神经，河豚毒素耐药钠通道α-亚基多肽
公开(公告)号：US06479259B1
公开(公告)日：2002-11-12
申请号：US09527013
申请日：2000-03-16
申请人： Ronald Herman , Stephen Gregory Delgado , Linda Marie Fish , Lakshmi Sangameswaran , Douglas Kenneth Rabert
发明人： Ronald Herman , Stephen Gregory Delgado , Linda Marie Fish , Lakshmi Sangameswaran , Douglas Kenneth Rabert
IPC分类号： C12N1512
CPC分类号： C07K14/705
摘要： The present invention relates to a voltage-gated sodium channel present in peripheral nerve tissue that is tetrodotoxin-resistant. One aspect of the present invention is purified and isolated DNA encoding this sodium channel. Another aspect of the present invention is the recombinant protein expressed by this DNA, expression vectors comprising the DNA sequence, and host cells transformed with these expression vectors. Another aspect of this invention is the use of this voltage-gated, tetrodotoxin-resistant sodium channel as a therapeutic target for compounds to treat disorders of the peripheral nervous system.
摘要翻译：本发明涉及存在于患有河豚毒素的周围神经组织中的电压门控钠通道。本发明的一个方面是纯化和分离的编码该钠通道的DNA。本发明的另一方面是由该DNA表达的重组蛋白，包含DNA序列的表达载体和用这些表达载体转化的宿主细胞。本发明的另一方面是使用该电压门控的河豚毒素钠通道作为化合物治疗周围神经系统疾病的治疗靶标。

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