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1. 发明申请

US20110039760A1 MULTIMERIC FORMS OF ANTIMICROBIAL PEPTIDES 有权
标题翻译：抗微生物肽的多形式
公开(公告)号：US20110039760A1
公开(公告)日：2011-02-17
申请号：US12988994
申请日：2009-04-21
申请人： Roger W. Beuerman , Shouping Liu , Jing Li , Lei Zhou , Chandra Shekhar Verma , Donald Tan
发明人： Roger W. Beuerman , Shouping Liu , Jing Li , Lei Zhou , Chandra Shekhar Verma , Donald Tan
IPC分类号： A61K38/17 , C07K14/435 , C07K1/06 , A61P31/00 , C07K7/08 , A01N63/02 , A01P1/00
CPC分类号： C07K14/4723 , A61K38/00 , C07K2319/00
摘要： The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3.
摘要翻译：本发明涉及多聚体形式的抗微生物肽，例如防御素肽。防御素肽的多聚体形式具有抗微生物活性，并且可以配制成抗微生物组合物，药物组合物，滴眼剂组合物，用于涂覆医疗装置的隐形眼镜溶液组合物等。本发明还涉及这些多聚体形式的肽的用途，例如，用于抑制和/或减少微生物生长的多聚体形式的防御素肽通常包括在宿主中。本发明还涉及制备衍生自防御素例如hBD3的肽的多聚体的方法。

2. 发明授权

US08809262B2 Multimeric forms of antimicrobial peptides 有权
标题翻译：多聚体形式的抗微生物肽
公开(公告)号：US08809262B2
公开(公告)日：2014-08-19
申请号：US12988994
申请日：2009-04-21
申请人： Roger W. Beuerman , Shouping Liu , Jing Li , Lei Zhou , Chandra Shekhar Verma , Donald Tan
发明人： Roger W. Beuerman , Shouping Liu , Jing Li , Lei Zhou , Chandra Shekhar Verma , Donald Tan
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/4723 , A61K38/00 , C07K2319/00
摘要： The invention relates to multimeric forms of antimicrobial peptides, for example, defensin peptides. The multimeric forms of defensin peptides possesses antimicrobial activity and may be formulated into antimicrobial compositions, pharmaceutical compositions, eyedrop composition, contact lens solution compositions for coating medical devices and the like. The invention also relates to the use of these multimeric forms of peptides, e.g. multimeric forms of defensin peptides for inhibiting and/or reducing the growth of microorganisms in general, including in a host. The invention further relates to a method of preparing multimers of peptides derived from defensins, for example hBD3.
摘要翻译：本发明涉及多聚体形式的抗微生物肽，例如防御素肽。防御素肽的多聚体形式具有抗微生物活性，并且可以配制成抗微生物组合物，药物组合物，滴眼剂组合物，用于涂覆医疗装置的隐形眼镜溶液组合物等。本发明还涉及这些多聚体形式的肽的用途，例如，用于抑制和/或减少微生物生长的多聚体形式的防御素肽通常包括在宿主中。本发明还涉及制备衍生自防御素例如hBD3的肽的多聚体的方法。

3. 发明授权

US08691945B2 Antimicrobial peptides 有权
标题翻译：抗菌肽
公开(公告)号：US08691945B2
公开(公告)日：2014-04-08
申请号：US12298702
申请日：2007-04-27
申请人： Roger Beuerman , Lei Zhou , Shouping Liu , Jing Li , Anita Suresh , Chandra Shekhar Verma , Donald Tan
发明人： Roger Beuerman , Lei Zhou , Shouping Liu , Jing Li , Anita Suresh , Chandra Shekhar Verma , Donald Tan
IPC分类号： C07K14/00 , C07K14/46 , C07K14/47 , A61K38/00 , A61K39/00 , A61K38/04 , A61K38/17
CPC分类号： A61K38/1729 , A61K38/00 , C07K14/4723 , Y02A50/473
摘要： There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.
摘要翻译：提供至少一种分离的抗微生物肽，其中肽是hBD3的线性类似物或其片段。特别地，提供hBD3的线性类似物，其中与野生型hBD3相比，肽对至少一种细胞的细胞毒性降低。

4. 发明申请

US20100048469A1 ANTIMICROBIAL PEPTIDES 有权
标题翻译：抗菌肽
公开(公告)号：US20100048469A1
公开(公告)日：2010-02-25
申请号：US12298702
申请日：2007-04-27
申请人： Roger Beuerman , Lei Zhou , Shouping Liu , Jing Li , Anita Suresh , Chandra Shekhar Verma , Donald Tan
发明人： Roger Beuerman , Lei Zhou , Shouping Liu , Jing Li , Anita Suresh , Chandra Shekhar Verma , Donald Tan
IPC分类号： A61K38/16 , C07K14/00 , C07K7/08 , C07K7/06 , C07H21/00 , C12N15/63 , C12N5/00 , C12N1/00 , A61K38/10 , A61K38/08 , A61P31/00 , C12Q1/02
CPC分类号： A61K38/1729 , A61K38/00 , C07K14/4723 , Y02A50/473
摘要： There is provided at least one isolated antimicrobial peptide, wherein the peptide is a linear analog of hBD3 or a fragment thereof. In particular, there is provided a linear analog of hBD3 wherein the peptide has a reduced cytotoxicity to at least one cell compared to the wild type hBD3.
摘要翻译：提供至少一种分离的抗微生物肽，其中肽是hBD3的线性类似物或其片段。特别地，提供hBD3的线性类似物，其中与野生型hBD3相比，肽对至少一种细胞的细胞毒性降低。

5. 发明申请

US20090258828A1 INVESTIGATION OF MUCOSA DRYNESS CONDITIONS 有权
标题翻译：调查干旱条件
公开(公告)号：US20090258828A1
公开(公告)日：2009-10-15
申请号：US12298829
申请日：2007-04-26
申请人： Roger Beuerman , Lei Zhou , Shouping Liu , He Yang , Donald Tan
发明人： Roger Beuerman , Lei Zhou , Shouping Liu , He Yang , Donald Tan
IPC分类号： A61K38/00 , C12Q1/00 , A61K38/43 , C40B40/10
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
摘要： The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.
摘要翻译：本发明涉及医疗条件的诊断和/或治疗。本发明涉及诊断受试者中干燥粘膜状况的新方法。病情可能是干眼症。本发明还提供了一种监测干性粘膜病症治疗功效，干性粘膜病症治疗方法和/或用于干性粘膜病症的诊断试剂盒的方法。

6. 发明授权

US08080428B2 Investigation of mucosa dryness conditions 有权
标题翻译：调查粘膜干燥条件
公开(公告)号：US08080428B2
公开(公告)日：2011-12-20
申请号：US12298829
申请日：2007-04-26
申请人： Roger Beuerman , Lei Zhou , Shouping Liu , He Yang , Donald Tan
发明人： Roger Beuerman , Lei Zhou , Shouping Liu , He Yang , Donald Tan
IPC分类号： A61K49/00 , A61K49/14 , G01N24/00 , C12Q1/00 , G01N33/53 , C07K2/00 , C07K14/435
CPC分类号： G01N33/6893 , C12Q1/527 , G01N33/6848 , G01N2800/16 , G01N2800/52 , Y10S424/811 , Y10T436/24
摘要： The present invention relates to diagnosis and/or treatment of medical conditions. The present invention relates to new method of diagnosing dry mucosa condition in a subject. The condition may be dry eye. The present invention also provides a method to monitor the efficacy of a treatment of a dry mucosa condition, a method of treating a dry mucosa condition and/or a diagnostic kit for a dry mucosa condition.
摘要翻译：本发明涉及医疗条件的诊断和/或治疗。本发明涉及诊断受试者中干燥粘膜状况的新方法。病情可能是干眼症。本发明还提供了一种监测干性粘膜病症治疗功效，干性粘膜病症治疗方法和/或用于干性粘膜病症的诊断试剂盒的方法。

7. 发明申请

US20120226286A1 System and method for preparing a lenticular or corneal implant 审中-公开
标题翻译：制备透镜或角膜植入物的系统和方法
公开(公告)号：US20120226286A1
公开(公告)日：2012-09-06
申请号：US13374292
申请日：2011-12-20
申请人： Philip Douglas Weston , Donald Tan , Jod Mehta
发明人： Philip Douglas Weston , Donald Tan , Jod Mehta
IPC分类号： A61F9/00
CPC分类号： A61F2/0095 , A61F2/148
摘要： A system for use in preparing a lenticular or corneal implant includes a cartridge having a generally tubular portion, comprised of a sidewall defining a longitudinal bore of curvilinear cross section and having open forward and rearward ends. The system also includes a preparation base with an upper portion having a recess and cartridge-receiving structure for removably engaging the cartridge in position with the open, rearward end of the longitudinal bore thereof proximate one side of the recess, allowing for facile removal of the cartridge from the base. An insert member has structure for removably engaging it in the recess, and has one portion defining a platform for receiving the implant and another, adjacent portion defining funnel structure having a wider end facing the platform and a narrower end facing the open rearward end of the cartridge.
摘要翻译：用于制备透镜或角膜植入物的系统包括具有大致管状部分的药筒，该药筒由限定曲线横截面的纵向孔的侧壁组成并具有敞开的前后端。该系统还包括具有上部的准备基部，该上部具有凹部和药筒接收结构，用于可拆卸地将药筒接合在其位置上，其纵向孔的开放的后端靠近凹部的一侧，允许容易地移除墨盒从底座。插入构件具有用于将其可移除地接合在凹部中的结构，并且具有限定用于接收植入物的平台的一个部分和限定漏斗结构的另一个相邻部分，其具有面向平台的较宽端部和面向平台的敞开的后端的较窄端部墨盒。

8. 发明申请

US20100211051A1 System and method for descemet's stripping automated endothelial keratoplasty (DSAEK) surgery 审中-公开
标题翻译：腰椎剥离自动内皮角膜移植术（DSAEK）手术的系统和方法
公开(公告)号：US20100211051A1
公开(公告)日：2010-08-19
申请号：US12657943
申请日：2010-01-28
申请人： Philip Douglas Weston , Donald Tan , Jod Mehta
发明人： Philip Douglas Weston , Donald Tan , Jod Mehta
IPC分类号： A61F9/007
CPC分类号： A61F2/148 , A61F9/0017 , A61F2009/00872
摘要： The system for donor cornea implantation includes a preparation base having a well for receiving a posterior lamellar donor corneal lenticule, a cartridge disengageably mounted on the base adjacent the well, and a handle for disengageable attachment to a posterior end portion of the cartridge. In drawing the donor lenticule from the well into and through a bore or chamber of the cartridge, from the posterior end, the lenticule is caused to assume a double coil configuration. After attachment of the handle, removal of the assembly from the preparation base, and insertion of blade and adjacent body portions of the cartridge through an incision in the cornea, the coiled donor lenticule is pulled from the cartridge bore through its forward end, to uncoil automatically within the anterior chamber of the recipient's eye.
摘要翻译：用于供体角膜植入的系统包括具有用于接收后片状供体角膜微透镜的孔的准备基底，可分离地安装在邻近所述孔的基部上的药筒和用于可脱离地连接到药筒的后端部分的手柄。在将供体微透镜从井中抽出并穿过筒的孔或室时，从后端将微透镜呈现为双线圈构型。在安装手柄之后，将组件从准备基座上取出，以及通过角膜中的切口插入刀片和刀片的相邻主体部分，将盘绕的捐赠者微透镜通过其前端从药筒孔中拉出，以解开自动在接受者眼睛的前房内。

9. 外观设计

USD633203S1 Ophthalmic surgical device for endothelial keratoplasty 有权
标题翻译：用于内皮角膜移植术的眼科手术装置
公开(公告)号：USD633203S1
公开(公告)日：2011-02-22
申请号：US29348716
申请日：2010-01-28
申请人： Philip Douglas Weston , Donald Tan , Jod Mehta
设计人： Philip Douglas Weston , Donald Tan , Jod Mehta

10. 发明授权

US07611895B2 Method for growth of human conjunctival tissue equivalents for research, clinical ocular surface transplantation and tissue engineering 失效
标题翻译：用于研究，临床眼表面移植和组织工程的人结膜组织等效生长方法
公开(公告)号：US07611895B2
公开(公告)日：2009-11-03
申请号：US11398557
申请日：2006-04-06
申请人： Donald Tan , Leonard Ang , Roger Beuerman
发明人： Donald Tan , Leonard Ang , Roger Beuerman
IPC分类号： C12N5/06 , C12N5/08
CPC分类号： C12N5/0623 , A61K35/12 , C12N5/0068 , C12N5/0621 , C12N2500/14 , C12N2500/84 , C12N2500/90 , C12N2501/01 , C12N2501/11 , C12N2501/33 , C12N2501/39 , C12N2533/92 , Y02A50/471
摘要： The invention relates to materials and methods for producing equivalents of tissues of the ocular surface, especially conjunctival tissue equivalents. The method of the invention involves biopsy of an appropriate tissue, primary culture in a certain medium, proliferative culture in a second medium, and differentiative culture in a third medium. The tissue equivalents are typically grown upon a substrate, typically amniotic membrane, which provides ease of handling as one advantage.
摘要翻译：本发明涉及用于产生眼表面组织等同物的材料和方法，特别是结膜组织等同物。本发明的方法涉及适当组织的活组织检查，某种培养基中的原代培养，第二培养基中的增殖培养和第三培养基中的差异培养。组织等价物通常在基底上生长，通常是羊膜，其提供易于处理作为一个优点。

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