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    • 5. 发明申请
    • HORMONAL COMPOSITION CONSISTING OF AN OESTROGEN COMPOUND AND OF A PROGESTATIONAL COMPOUND
    • 雌激素化合物和孕激素组合物的组成
    • WO1998015279A1
    • 1998-04-16
    • PCT/FR1997001792
    • 1997-10-08
    • LABORATOIRE THERAMEXLANQUETIN, MichelPARIS, JacquesTHOMAS, Jean-Louis
    • LABORATOIRE THERAMEX
    • A61K31/57
    • A61K45/06A61K31/56A61K31/565A61K31/57Y10S424/811Y10S514/841Y10S514/843A61K2300/00
    • The invention concerns the field of chemical therapy and more particularly the field of pharmaceutical hormonal technique. More precisely it concerns novel pharmaceutical hormonal compositions characterised in that they are formed by an oestroprogestational combination consisting of an oestrogen compound and a progestational compound, associated or mixed with one or several non-toxic, inert and pharmaceutically acceptable excipients, for oral administration. The invention also concerns the use of the oestroprogestational mixture in which the oestrogenic constituent and the progestational constituent are administered in combination. The combined association can be prescribed continuously or intermittently, for producing a composition for treating oestrogenic deficiencies, preventing osteoporosis and cardiovascular diseases in the menopausal woman, or still for blocking ovulation in a woman during the period of ovarian activity. The invention also concerns a method for preparing these novel pharmaceutical oestroprogestational compositions.
    • 本发明涉及化学治疗领域,更具体地涉及药物激素技术领域。 更确切地说,它涉及新型药物激素组合物,其特征在于它们由与雌激素化合物和促孕化合物组成的产卵组合形成,其与一种或多种无毒,惰性和药学上可接受的赋形剂相关或混合,用于口服给药。 本发明还涉及其中雌激素成分和促孕成分组合施用的产卵药混合物的用途。 可以连续或间歇地规定组合关联,用于生产用于治疗雌激素缺乏症,预防绝经妇女的骨质疏松症和心血管疾病的组合物,或仍然在卵巢活动期间阻止女性排卵。 本发明还涉及制备这些新型药物产卵药组合物的方法。