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1. 发明授权

US08644934B2 Cardiac stimulation using leadless electrode assemblies 有权
标题翻译：使用无铅电极组件的心脏刺激
公开(公告)号：US08644934B2
公开(公告)日：2014-02-04
申请号：US11854844
申请日：2007-09-13
申请人： Roger N. Hastings , Daniel M. Lafontaine , Michael J. Pikus , Martin R. Willard
发明人： Roger N. Hastings , Daniel M. Lafontaine , Michael J. Pikus , Martin R. Willard
IPC分类号： A61N1/362
CPC分类号： A61N1/059 , A61N1/365 , A61N1/372 , A61N1/37205 , A61N1/37288 , A61N1/375 , A61N1/3756
摘要： An implantable cardiac tissue excitation system includes an implantable pacing controller unit with a pulse generation circuit. The system also includes a lead with a lead body extending between a proximal lead end attachable to the pacing controller unit and a distal lead end configured to be implanted within a heart. A lead conductor extends within the lead body. The system also includes a transmitter assembly located near the distal lead end that is electrically connected to the pulse generation circuit through the lead conductor to wirelessly transmit pacing control information and pacing energy. The system also includes a leadless electrode assembly configured to be implanted within the heart that includes a receiver to receive the wireless transmission, a charge storage unit to store the charge energy, and an electrical stimulation circuit to deliver an electrical stimulus to cardiac tissue using the pacing control information and the charge energy.
摘要翻译：可植入心脏组织激励系统包括具有脉冲发生电路的可植入起搏控制器单元。该系统还包括引线，引线体在可附接到起搏控制器单元的近端引导端与被配置为植入心脏内的远端引线端之间延伸。引线导体在引线体内延伸。该系统还包括位于远端引导端附近的发射器组件，其通过引线导体电连接到脉冲发生电路，以无线地发送起搏控制信息和起搏能量。该系统还包括被配置成植入心脏内的无引线电极组件，其包括用于接收无线传输的接收器，用于存储充电能量的电荷存储单元，以及电刺激电路，以使用起搏控制信息和充电能量。

2. 发明申请

US20090018599A1 Cardiac Stimulation Using Leadless Electrode Assemblies 有权
标题翻译：心脏刺激使用无铅电极组件
公开(公告)号：US20090018599A1
公开(公告)日：2009-01-15
申请号：US11854844
申请日：2007-09-13
申请人： Roger N. Hastings , Daniel M. Lafontaine , Michael J. Pikus , Martin R. Willard
发明人： Roger N. Hastings , Daniel M. Lafontaine , Michael J. Pikus , Martin R. Willard
IPC分类号： A61N1/362 , A61N2/02 , A61N7/00
CPC分类号： A61N1/059 , A61N1/365 , A61N1/372 , A61N1/37205 , A61N1/37288 , A61N1/375 , A61N1/3756
摘要： An implantable cardiac tissue excitation system includes an implantable pacing controller unit with a pulse generation circuit. The system also includes a lead with a lead body extending between a proximal lead end attachable to the pacing controller unit and a distal lead end configured to be implanted within a heart. A lead conductor extends within the lead body. The system also includes a transmitter assembly located near the distal lead end that is electrically connected to the pulse generation circuit through the lead conductor to wirelessly transmit pacing control information and pacing energy. The system also includes a leadless electrode assembly configured to be implanted within the heart that includes a receiver to receive the wireless transmission, a charge storage unit to store the charge energy, and an electrical stimulation circuit to deliver an electrical stimulus to cardiac tissue using the pacing control information and the charge energy.
摘要翻译：可植入心脏组织激励系统包括具有脉冲发生电路的可植入起搏控制器单元。该系统还包括引线，引线体在可附接到起搏控制器单元的近端引导端与被配置为植入心脏内的远端引线端之间延伸。引线导体在引线体内延伸。该系统还包括位于远端引导端附近的发射器组件，其通过引线导体电连接到脉冲发生电路，以无线地发送起搏控制信息和起搏能量。该系统还包括被配置成植入心脏内的无引线电极组件，其包括用于接收无线传输的接收器，用于存储充电能量的电荷存储单元，以及电刺激电路，以使用起搏控制信息和充电能量。

3. 发明申请

US20090234407A1 MULTI-SITE ATRIAL ELECTROSTIMULATION 有权
标题翻译：多场ATRIAL电化学
公开(公告)号：US20090234407A1
公开(公告)日：2009-09-17
申请号：US12365428
申请日：2009-02-04
申请人： Roger Hastings , Daniel M. Lafontaine , John A. Becker , Michael J. Pikus , Kevin D. Edmunds , Martin R. Willard
发明人： Roger Hastings , Daniel M. Lafontaine , John A. Becker , Michael J. Pikus , Kevin D. Edmunds , Martin R. Willard
IPC分类号： A61N1/362
CPC分类号： A61N1/3787 , A61N1/0565 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/3624 , A61N1/3684 , A61N1/37205 , A61N1/37223 , A61N1/37229 , A61N1/3756
摘要： An apparatus and method can receive wireless energy using a wireless electrostimulation electrode assembly. In certain examples, at least some of the received wireless energy can be delivered as an electrostimulation to a heart. In certain examples, the wireless electrostimulation electrode can be mechanically supported at least partially using a ring formed by an annulus of a mitral valve of the heart. In certain examples, the wireless electrostimulation electrode assembly can be configured to be intravascularly delivered to an implant location within a chamber of the heart at the annulus of the mitral valve of the heart, and can fit entirely within the heart.
摘要翻译：一种装置和方法可以使用无线电刺激电极组件接收无线能量。在某些示例中，所接收的无线能量中的至少一些可以作为电刺激递送到心脏。在某些示例中，无线电刺激电极可以至少部分地使用由心脏的二尖瓣的环形成的环机械地支撑。在某些实例中，无线电刺激电极组件可被配置为在心脏的二尖瓣的环处血管内递送到心脏腔室内的植入位置，并且可以完全配合在心脏内。

4. 发明授权

US08204605B2 Multi-site atrial electrostimulation 有权
标题翻译：多部位心房电刺激
公开(公告)号：US08204605B2
公开(公告)日：2012-06-19
申请号：US12365428
申请日：2009-02-04
申请人： Roger Hastings , Daniel M. Lafontaine , John A. Becker , Michael J. Pikus , Kevin D. Edmunds , Martin R. Willard
发明人： Roger Hastings , Daniel M. Lafontaine , John A. Becker , Michael J. Pikus , Kevin D. Edmunds , Martin R. Willard
IPC分类号： A61N1/05
CPC分类号： A61N1/3787 , A61N1/0565 , A61N1/057 , A61N1/0573 , A61N1/3622 , A61N1/3624 , A61N1/3684 , A61N1/37205 , A61N1/37223 , A61N1/37229 , A61N1/3756
摘要： An apparatus and method can receive wireless energy using a wireless electrostimulation electrode assembly. In certain examples, at least some of the received wireless energy can be delivered as an electrostimulation to a heart. In certain examples, the wireless electrostimulation electrode can be mechanically supported at least partially using a ring formed by an annulus of a mitral valve of the heart. In certain examples, the wireless electrostimulation electrode assembly can be configured to be intravascularly delivered to an implant location within a chamber of the heart at the annulus of the mitral valve of the heart, and can fit entirely within the heart.
摘要翻译：一种装置和方法可以使用无线电刺激电极组件接收无线能量。在某些示例中，所接收的无线能量中的至少一些可以作为电刺激递送到心脏。在某些示例中，无线电刺激电极可以至少部分地使用由心脏的二尖瓣的环形成的环机械地支撑。在某些实例中，无线电刺激电极组件可被配置为在心脏的二尖瓣的环处血管内递送到心脏腔室内的植入位置，并且可以完全配合在心脏内。

5. 发明授权

US07670364B2 Stent delivery system having stent securement apparatus 失效
标题翻译：支架输送系统具有支架固定装置
公开(公告)号：US07670364B2
公开(公告)日：2010-03-02
申请号：US10737497
申请日：2003-12-16
申请人： Andrew J. Dusbabek , Louis G. Ellis , Christopher R. Larson , Terry V. Brown , Charles L. Euteneuer , Steven P. Mertens , Richard C. Mattison , David J. Blaeser , Linda R. Lorentzen Cornelius , Martin R. Willard , Fernando Di Caprio , Stanley A. Nordin
发明人： Andrew J. Dusbabek , Louis G. Ellis , Christopher R. Larson , Terry V. Brown , Charles L. Euteneuer , Steven P. Mertens , Richard C. Mattison , David J. Blaeser , Linda R. Lorentzen Cornelius , Martin R. Willard , Fernando Di Caprio , Stanley A. Nordin
IPC分类号： A61F2/06 , A61F11/00
CPC分类号： A61F2/958 , A61F2002/9522 , A61F2002/9583 , A61F2002/9586 , A61M25/1011 , A61M25/10184 , A61M25/10186 , A61M25/104 , A61M2025/1013 , A61M2025/1063 , A61M2025/1079 , A61M2025/1081 , A61M2025/1093
摘要： A system/assembly for delivery and deployment of an inflation expandable stent within a vessel, comprising a catheter having proximal and distal ends; a stent, inflation expandable from a delivery diameter to a deployment diameter, such that the delivery diameter is reduced from the deployment diameter for conforming the stent to the catheter, such that the stent, in its delivery diameter, is coaxially mounted on the catheter near the catheter distal end; an expandable inflation means coaxially mounted on the catheter axially within the stent, for expansion of the stent from the delivery diameter to the deployment diameter upon application of fluid deployment pressure to the inflation means; and a securement component coaxially mounted on the catheter, axially within the expandable inflation means, the securement component designed and adapted to provide a securement pressure to the stent in the delivery diameter to maintain the stent in position on the catheter during delivery to the deployment site.
摘要翻译：一种用于在容器内递送和展开膨胀扩张支架的系统/组件，包括具有近端和远端的导管; 支架，膨胀从输送直径扩展到展开直径，使得输送直径从展开直径减小，以使支架与导管吻合，使得支架在其输送直径中同轴地安装在导管附近导管远端; 可扩张的膨胀装置同轴地安装在支架内轴向的导管上，用于在向通气装置施加流体展开压力时将支架从输送直径扩展到展开直径; 以及固定组件，其轴向地同轴地安装在导管上，在可膨胀的充气装置内，固定部件设计和适于在输送直径中向支架提供固定压力，以在输送到展开部位期间将支架维持在导管上的适当位置。

6. 发明申请

US20080021505A1 Electrical stimulation of body tissue using interconnected electrode assemblies 有权
标题翻译：使用互连的电极组件对身体组织进行电刺激
公开(公告)号：US20080021505A1
公开(公告)日：2008-01-24
申请号：US11490576
申请日：2006-07-21
申请人： Roger Hastings , Martin R. Willard , Kevin D. Edmunds
发明人： Roger Hastings , Martin R. Willard , Kevin D. Edmunds
IPC分类号： A61N1/00
CPC分类号： A61N1/375 , A61N1/0573 , A61N1/0587 , A61N1/3622 , A61N1/3787
摘要： Some embodiments of a cardiac stimulation system may include a plurality of electrode assemblies that are interconnected by one or more wires while at least one of the electrode assemblies (e.g., a control electrode) wirelessly receives energy through inductive coupling with a power communication unit external to the heart (e.g., a device implanted along one or more ribs). These embodiments may provide an arrangement for efficient inductive coupling from the power communication unit to the control electrode. Also, in some circumstances, the cardiac stimulation system may eliminate the need for wired leads that extend to a location outside the heart, thereby reducing the likelihood of infection that passes along the wire and into the heart.
摘要翻译：心脏刺激系统的一些实施例可以包括通过一个或多个线互连的多个电极组件，而电极组件（例如，控制电极）中的至少一个通过与外部的电力通信单元的电感耦合无线地接收能量心脏（例如，沿一个或多个肋植入的装置）。这些实施例可以提供用于从电力通信单元到控制电极的有效电感耦合的布置。此外，在某些情况下，心脏刺激系统可以消除对延伸到心脏外部的位置的有线引线的需要，从而减少沿导线进入心脏的感染的可能性。

7. 发明授权

US6036682A Catheter having a plurality of integral radiopaque bands 失效
标题翻译：导管具有多个整体的不透射线带
公开(公告)号：US6036682A
公开(公告)日：2000-03-14
申请号：US982538
申请日：1997-12-02
申请人： Michael R. Lange , Martin R. Willard
发明人： Michael R. Lange , Martin R. Willard
IPC分类号： A61M25/01 , A61M25/098 , A61M25/00 , A61M5/00
CPC分类号： A61M25/0108
摘要： A tubular member for manufacture of medical devices insertable into body lumens. The tubular member includes an inner tubular member, and outer tubular member, and a lumen through the inner tubular member. The outer tubular member has a plurality of radiopaque segments formed of radiopaque material incorporated into the tube polymeric material. One tubular member has highly radiopaque segments separated by less radiopaque segments at intervals greater than the radiopaque segment length, such that the radiopaque segments serve as marker bands. Another tubular member has long radiopaque segments separated by less radiopaque segments at intervals less than the radiopaque segment length, such that the less radiopaque segments serve as marker bands. Marker bands can be located at either regular intervals to aid in measuring internal dimensions or at significant structural locations to aid in catheter positioning.
摘要翻译：用于制造可插入体腔内的医疗装置的管状构件。管状构件包括内部管状构件和外部管状构件，以及通过内部管状构件的内腔。外部管状构件具有多个由不透射线材料形成的不透射线部分，该不透射线材料结合到管状聚合物材料中。一个管状构件具有高度不透射线的段，其间隔较大的不透射线段长度的较小的不透射线段，使得不透射线段用作标记带。另一个管状构件具有长的不透射线段，其间隔小于不透射线段长度的间隔较小的不透射线段，使得较小的不透射线段用作标记带。标记带可以以规则的间隔定位，以帮助测量内部尺寸或在重要的结构位置以帮助导管定位。

8. 发明授权

US06663660B2 Stent delivery system having stent securement apparatus 失效
标题翻译：支架输送系统具有支架固定装置
公开(公告)号：US06663660B2
公开(公告)日：2003-12-16
申请号：US09794648
申请日：2001-02-27
申请人： Andrew J. Dusbabek , Louis G. Ellis , Christopher R. Larson , Terry V. Brown , Charles L. Euteneuer , Steven P. Mertens , Richard C. Mattison , David J. Blaeser , Linda R. Lorentzen Cornelius , Martin R. Willard , Fernando Di Caprio , Stanley A. Nordin
发明人： Andrew J. Dusbabek , Louis G. Ellis , Christopher R. Larson , Terry V. Brown , Charles L. Euteneuer , Steven P. Mertens , Richard C. Mattison , David J. Blaeser , Linda R. Lorentzen Cornelius , Martin R. Willard , Fernando Di Caprio , Stanley A. Nordin
IPC分类号： A61M2902
CPC分类号： A61F2/958 , A61F2002/9522 , A61F2002/9583 , A61F2002/9586 , A61M25/1011 , A61M25/10184 , A61M25/10186 , A61M25/104 , A61M2025/1013 , A61M2025/1063 , A61M2025/1079 , A61M2025/1081 , A61M2025/1093
摘要： A system/assembly for delivery and deployment of an inflation expandable stent within a vessel, comprising a catheter having proximal and distal ends; a stent, inflation expandable from a delivery diameter to a deployment diameter, such that the delivery diameter is reduced from the deployment diameter for conforming the stent to the catheter, such that the stent, in its delivery diameter, is coaxially mounted on the catheter near the catheter distal end; an expandable inflation means coaxially mounted on the catheter axially within the stent, for expansion of the stent from the delivery diameter to the deployment diameter upon application of fluid deployment pressure to the inflation means; and a securement component coaxially mounted on the catheter, axially within the expandable inflation means, the securement component designed and adapted to provide a securement pressure to the stent in the delivery diameter to maintain the stent in position on the catheter during delivery to the deployment site.
摘要翻译：一种用于在容器内递送和展开膨胀扩张支架的系统/组件，包括具有近端和远端的导管; 支架，膨胀从输送直径扩展到展开直径，使得输送直径从展开直径减小，以使支架与导管吻合，使得支架在其输送直径中同轴地安装在导管附近导管远端; 可扩张的膨胀装置同轴地安装在支架内轴向的导管上，用于在向通气装置施加流体展开压力时将支架从输送直径扩展到展开直径; 以及固定组件，其轴向地同轴地安装在导管上，在可膨胀的充气装置内，固定部件设计和适于在输送直径中向支架提供固定压力，以在输送到展开部位期间将支架维持在导管上的适当位置。

9. 发明授权

US09089350B2 Renal denervation catheter with RF electrode and integral contrast dye injection arrangement 有权
标题翻译：肾动脉去神经导管与RF电极和整体造影剂注射排列
公开(公告)号：US09089350B2
公开(公告)日：2015-07-28
申请号：US13292694
申请日：2011-11-09
申请人： Martin R. Willard
发明人： Martin R. Willard
IPC分类号： A61B6/00 , A61B18/18 , A61B18/14 , A61B17/00 , A61B18/00 , A61B19/00 , A61M25/00 , A61M25/01
CPC分类号： A61B18/18 , A61B18/1492 , A61B2017/003 , A61B2018/00011 , A61B2018/00166 , A61B2018/0022 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00571 , A61B2018/00577 , A61B2090/3966 , A61M25/0041 , A61M25/005 , A61M25/0147 , A61M2025/0046
摘要： A catheter includes a flexible braided shaft having a length sufficient to access a target vessel of the body, such as a renal artery. An electrode at the catheter's distal tip is configured to ablate extravascular target tissue, such as perivascular renal nerve tissue. An electrical conductor coupled to the electrode extends along a first lumen of the shaft. A second lumen of the shaft terminates at a port arrangement on an outer surface of the shaft near the electrode. The second lumen transports a contrast media from the catheter's proximal end and through the port arrangement. The catheter may include a steering arrangement and a lubricious coating on an outer surface of the shaft, allowing a clinician to navigate the catheter through vasculature and into the target vessel without use of a separate delivery sheath or guiding catheter.
摘要翻译：导管包括柔性编织轴，其具有足以进入身体的目标血管（例如肾动脉）的长度。在导管的远端处的电极被配置为消融血管外靶标组织，例如血管周围肾神经组织。耦合到电极的电导体沿着轴的第一内腔延伸。轴的第二内腔终止于靠近电极的轴的外表面上的端口布置。第二管腔从导管的近端输送造影剂并通过端口装置。导管可以包括转轴装置和在轴的外表面上的润滑涂层，允许临床医生通过脉管系统导管导管并进入靶容器，而不使用单独的输送护套或引导导管。

10. 发明授权

US08709062B2 Stent delivery system having stent securement apparatus 失效
标题翻译：支架输送系统具有支架固定装置
公开(公告)号：US08709062B2
公开(公告)日：2014-04-29
申请号：US13619231
申请日：2012-09-14
申请人： Andrew J. Dusbabek , Louis G. Ellis , Christopher R. Larson , Terry V. Brown , Charles L. Euteneuer , Steven P. Mertens , Richard C. Mattison , David J. Blaeser , Linda R. Lorentzen Cornelius , Martin R. Willard , Fernando DiCaprio , Stanley A. Nordin
发明人： Andrew J. Dusbabek , Louis G. Ellis , Christopher R. Larson , Terry V. Brown , Charles L. Euteneuer , Steven P. Mertens , Richard C. Mattison , David J. Blaeser , Linda R. Lorentzen Cornelius , Martin R. Willard , Fernando DiCaprio , Stanley A. Nordin
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2002/9522 , A61F2002/9583 , A61F2002/9586 , A61M25/1011 , A61M25/10184 , A61M25/10186 , A61M25/104 , A61M2025/1013 , A61M2025/1063 , A61M2025/1079 , A61M2025/1081 , A61M2025/1093
摘要： Medical devices and methods for making and using medical devices are disclosed. An example medical device may include an elongate shaft including a first tubular member and a second tubular member. A balloon may be coupled to the shaft. A first member may be coupled to the first tubular member and positioned within the balloon. A second member may be coupled to the first tubular member and positioned within the balloon. A medical implant may be coupled to the shaft and positioned adjacent to the balloon.
摘要翻译：公开了用于制造和使用医疗装置的医疗装置和方法。示例性医疗装置可以包括细长轴，其包括第一管状构件和第二管状构件。气球可以联接到轴。第一构件可以联接到第一管状构件并且定位在气囊内。第二构件可以联接到第一管状构件并且定位在气囊内。医疗植入物可以联接到轴并且邻近气囊定位。

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