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1. 发明授权

US5755715A Tissue heating and ablation systems and methods using time-variable set point temperature curves for monitoring and control 失效
标题翻译：组织加热和消融系统和方法使用时变设定点温度曲线进行监测和控制
公开(公告)号：US5755715A
公开(公告)日：1998-05-26
申请号：US656756
申请日：1996-06-03
申请人： Roger A. Stern , Dorin Panescu , David K. Swanson
发明人： Roger A. Stern , Dorin Panescu , David K. Swanson
IPC分类号： A61B17/00 , A61B18/00 , A61B18/10 , A61B18/12 , A61B18/14 , A61B19/00 , A61B17/39
CPC分类号： A61B18/00 , A61B18/1206 , A61B18/1492 , A61B18/14 , A61B2017/00017 , A61B2017/00084 , A61B2017/00101 , A61B2017/00292 , A61B2017/003 , A61B2017/00482 , A61B2018/00083 , A61B2018/00095 , A61B2018/00101 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00815 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00892 , A61B2018/00916 , A61B2018/00988 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2090/0803 , A61B2562/08 , A61M2205/273 , A61M2205/6018 , A61M2205/6027 , A61M2205/70 , A61M2230/50
摘要： Systems and methods employ an energy emitting electrode to heat tissue. The systems and methods follow a prescribed temperature set curve, in which a setpoint temperature changes over time, to control the application of energy to the electrode.
摘要翻译：系统和方法采用能量发射电极来加热组织。系统和方法遵循规定的温度设定曲线，其中设定点温度随时间而变化，以控制向电极施加能量。

2. 发明授权

US5702386A Non-linear control systems and methods for heating and ablating body tissue 失效
标题翻译：用于加热和消融身体组织的非线性控制系统和方法
公开(公告)号：US5702386A
公开(公告)日：1997-12-30
申请号：US670985
申请日：1996-06-28
申请人： Roger A. Stern , Dorin Panescu , David K. Swanson
发明人： Roger A. Stern , Dorin Panescu , David K. Swanson
IPC分类号： A61B17/00 , A61B18/00 , A61B18/10 , A61B18/12 , A61B18/14 , A61B19/00 , A61B17/36
CPC分类号： A61B18/00 , A61B18/1206 , A61B18/1492 , A61B18/14 , A61B2017/00017 , A61B2017/00084 , A61B2017/00101 , A61B2017/00292 , A61B2017/003 , A61B2017/00482 , A61B2018/00083 , A61B2018/00095 , A61B2018/00101 , A61B2018/00178 , A61B2018/00351 , A61B2018/00357 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00684 , A61B2018/0069 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00815 , A61B2018/00827 , A61B2018/00869 , A61B2018/00875 , A61B2018/00892 , A61B2018/00916 , A61B2018/00988 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2090/0803 , A61B2562/08 , A61M2205/273 , A61M2205/6018 , A61M2205/6027 , A61M2205/70 , A61M2230/50
摘要： Systems and methods employ an energy emitting electrode to heat tissue. The systems and methods control the application of energy to the electrode using adjustments that take into account, in a non-linear fashion, changes in monitored operating conditions.
摘要翻译：系统和方法采用能量发射电极来加热组织。这些系统和方法通过使用非线性方式考虑监视的操作条件的变化的调整来控制对电极的能量的应用。

3. 发明授权

US5906614A Tissue heating and ablation systems and methods using predicted temperature for monitoring and control 失效
标题翻译：组织加热和消融系统和使用预测温度进行监测和控制的方法
公开(公告)号：US5906614A
公开(公告)日：1999-05-25
申请号：US801484
申请日：1997-02-18
申请人： Roger A. Stern , Dorin Panescu
发明人： Roger A. Stern , Dorin Panescu
IPC分类号： A61B17/00 , A61B18/12 , A61B18/14 , A61B18/20 , A61B17/39
CPC分类号： A61B18/1492 , A61B18/12 , A61B18/1206 , A61B18/20 , A61B2017/00092 , A61B2017/00154 , A61B2018/00083 , A61B2018/00095 , A61B2018/00636 , A61B2018/0066 , A61B2018/0069 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00803 , A61B2018/00821 , A61B2018/00886 , A61B2018/124 , A61B2018/128 , A61B2018/1467 , A61B2562/08 , A61M2205/6018
摘要： Systems and methods employ an energy emitting electrode to heat tissue. The systems and methods derive a temperature prediction for a future time period. The systems and methods control the application of energy to the energy emitting electrode based, at least in part, upon the temperature prediction.
摘要翻译：系统和方法采用能量发射电极来加热组织。系统和方法为未来时间段提供温度预测。系统和方法至少部分地基于温度预测来控制对能量发射电极的能量应用。

4. 发明授权

US09039699B2 Methods and systems for treatment of tissue in a body lumen 有权
标题翻译：用于治疗体腔内组织的方法和系统
公开(公告)号：US09039699B2
公开(公告)日：2015-05-26
申请号：US13181484
申请日：2011-07-12
申请人： Jerome Jackson , Roger A. Stern
发明人： Jerome Jackson , Roger A. Stern
IPC分类号： A61B18/14 , A61B5/107 , A61B5/03 , A61B5/00 , A61N1/06 , A61B18/00 , A61B19/00 , A61N1/08
CPC分类号： A61B18/1492 , A61B5/037 , A61B5/053 , A61B5/0538 , A61B5/1076 , A61B5/4233 , A61B5/6885 , A61B18/1485 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00488 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467 , A61B2090/061 , A61B2090/064 , A61N1/06 , A61N1/08 , A61N1/403
摘要： A system for measuring physiologic characteristics or treating tissue in a body lumen. The system may be used for treating abnormal mucosa in the esophagus. The system comprises an energy delivery device, such as an ablation device including an electrode support and an electrode pattern on the support. The ablation device may expand in size from a pre-deployed state to a deployed state. The system may include a sizing device having an inflatable balloon on a distal end of a catheter that is inflated with an expansion medium to expand the balloon to engage the wall of the esophagus so that the internal cross-section can be calculated or measured. The sizing device may also a controller for delivering an expansion medium and measuring the amount and pressure of the expansion medium inside the catheter. Methods of treating or diagnosing tissue are also disclosed.
摘要翻译：用于测量生理特征或处理体腔中的组织的系统。该系统可用于治疗食管异常粘膜。该系统包括能量输送装置，例如包括电极支撑件的消融装置和载体上的电极图案。消融装置可以从预部署状态扩展到部署状态。该系统可以包括具有在导管的远端上的可膨胀气囊的施胶装置，该膨胀气囊用膨胀介质膨胀以膨胀气囊以接合食道的壁，使得可以计算或测量内部横截面。定型装置还可以是用于输送膨胀介质并测量导管内部的膨胀介质的量和压力的控制器。还公开了治疗或诊断组织的方法。

5. 发明授权

US08888769B2 Control system and process for application of energy to airway walls and other mediums 有权
标题翻译：控制系统和能量应用于气道壁和其他介质的过程
公开(公告)号：US08888769B2
公开(公告)日：2014-11-18
申请号：US12944238
申请日：2010-11-11
申请人： Michael Biggs , Roger A. Stern , Christopher J. Danek
发明人： Michael Biggs , Roger A. Stern , Christopher J. Danek
IPC分类号： A61B18/10 , A61N1/06 , A61N1/40 , A61B18/00
CPC分类号： A61N1/06 , A61B18/14 , A61B2018/00541 , A61N1/40
摘要： The present invention includes a system for delivering energy to an airway wall of a lung comprising an energy delivering apparatus and a PID controller having one or more variable gain factors which are rest after energy deliver has begun. The energy delivering apparatus may include a flexible elongated member and a distal expandable basket having at least one electrode for transferring energy to the airway wall and at least one temperature sensor for measuring temperature. The PID controller determines a new power set point base on an error between a preset temperature and the measured temperature. The algorithm can be Pi+1=Pi+G(αei+βei−1+γei−2) where α, β and γ are preset values and α is from 1 to 2; β is from −1 to −2; and γ is from −0.5 to 0.5. In another variation, the controller is configured to shut down if various measured parameters are exceeded such as, for example, energy, impedance, temperature, temperature differences, activation time and combinations thereof. Methods for treating a target medium using a PID algorithm are also provided.
摘要翻译：本发明包括一种用于向肺气道壁输送能量的系统，包括能量输送装置和具有一个或多个可变增益因子的PID控制器，所述可变增益因子在能量传递开始之后休息。能量输送装置可以包括柔性细长构件和远端可膨胀篮，其具有用于将能量传递到气道壁的至少一个电极和用于测量温度的至少一个温度传感器。 PID控制器根据预设温度和测量温度之间的误差确定新的功率设定点。该算法可以是Pi + 1 = Pi + G（αei+＆bgr; ei-1 +γei-2）其中α，＆bgr; γ为预设值，α为1〜2; ＆bgr 从-1到-2; γ为-0.5〜0.5。在另一变型中，控制器被配置为如果超过各种测量参数，例如能量，阻抗，温度，温差，激活时间及其组合，则关闭。还提供了使用PID算法处理目标介质的方法。

6. 发明申请

US20120004656A1 METHODS AND SYSTEMS FOR TREATMENT OF TISSUE IN A BODY LUMEN 有权
标题翻译：用于治疗身体组织的组织的方法和系统
公开(公告)号：US20120004656A1
公开(公告)日：2012-01-05
申请号：US13181484
申请日：2011-07-12
申请人： Jerome Jackson , Roger A. Stern
发明人： Jerome Jackson , Roger A. Stern
IPC分类号： A61B18/18
CPC分类号： A61B18/1492 , A61B5/037 , A61B5/053 , A61B5/0538 , A61B5/1076 , A61B5/4233 , A61B5/6885 , A61B18/1485 , A61B2018/0016 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00488 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467 , A61B2090/061 , A61B2090/064 , A61N1/06 , A61N1/08 , A61N1/403
摘要： A system for measuring physiologic characteristics or treating tissue in a body lumen. The system may be used for treating abnormal mucosa in the esophagus. The system comprises an energy delivery device, such as an ablation device including an electrode support and an electrode pattern on the support. The ablation device may expand in size from a pre-deployed state to a deployed state. The system may include a sizing device having an inflatable balloon on a distal end of a catheter that is inflated with an expansion medium to expand the balloon to engage the wall of the esophagus so that the internal cross-section can be calculated or measured. The sizing device may also a controller for delivering an expansion medium and measuring the amount and pressure of the expansion medium inside the catheter. Methods of treating or diagnosing tissue are also disclosed.
摘要翻译：用于测量生理特征或处理体腔中的组织的系统。该系统可用于治疗食管异常粘膜。该系统包括能量输送装置，例如包括电极支撑件的消融装置和载体上的电极图案。消融装置可以从预部署状态扩展到部署状态。该系统可以包括具有在导管的远端上的可膨胀气囊的施胶装置，该膨胀气囊用膨胀介质膨胀以膨胀气囊以接合食道的壁，使得可以计算或测量内部横截面。定型装置还可以是用于输送膨胀介质并测量导管内部的膨胀介质的量和压力的控制器。还公开了治疗或诊断组织的方法。

7. 发明申请

US20100234840A1 METHODS AND SYSTEMS FOR DETERMINING PHYSIOLOGIC CHARACTERISTICS FOR TREATMENT OF THE ESOPHAGUS 有权
标题翻译：用于确定治疗ESOPHAGUS的生理特征的方法和系统
公开(公告)号：US20100234840A1
公开(公告)日：2010-09-16
申请号：US12787324
申请日：2010-05-25
申请人： Jerome Jackson , Roger A. Stern , David S. Utley
发明人： Jerome Jackson , Roger A. Stern , David S. Utley
IPC分类号： A61B18/18
CPC分类号： A61M25/10184 , A61B5/053 , A61B5/0538 , A61B5/1076 , A61B5/4233 , A61B5/6885 , A61B17/1114 , A61B18/1206 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00026 , A61B2017/00084 , A61B2017/00296 , A61B2017/00482 , A61B2017/00818 , A61B2018/0016 , A61B2018/00178 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00488 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00642 , A61B2018/00738 , A61B2018/00791 , A61B2018/00797 , A61B2018/00875 , A61B2018/00898 , A61B2018/126 , A61B2018/1467 , A61B2018/1807 , A61B2090/061 , A61B2090/064 , A61M25/10181 , A61N1/06 , A61N5/062 , A61N2005/0609
摘要： A method and apparatus for treating abnormal mucosa in the esophagus is disclosed, such that the depth of the treated tissue is controlled. The depth of ablation is controlled by monitoring the tissue impedance and/or the tissue temperature. A desired ablation depth is also achieved by controlling the energy density or power density, and the amount of time required for energy delivery. A method and apparatus is disclosed for measuring an inner diameter of a body lumen, where a balloon is inflated inside the body lumen at a fixed pressure.
摘要翻译：公开了一种用于治疗食管异常粘膜的方法和装置，使得治疗组织的深度受到控制。通过监测组织阻抗和/或组织温度来控制消融深度。也可以通过控制能量密度或功率密度以及能量输送所需的时间量来实现期望的消融深度。公开了一种用于测量体腔的内径的方法和装置，其中气囊以固定的压力在体腔内充气。

8. 发明授权

US07229436B2 Method and kit for treatment of tissue 有权
标题翻译：用于治疗组织的方法和试剂盒
公开(公告)号：US07229436B2
公开(公告)日：2007-06-12
申请号：US10400187
申请日：2003-03-25
申请人： Roger A. Stern , Mitchell Levinson , Bryan Weber
发明人： Roger A. Stern , Mitchell Levinson , Bryan Weber
IPC分类号： A61B18/18
CPC分类号： A61B18/00 , A45D44/22 , A61B18/12 , A61B18/1206 , A61B18/14 , A61B18/1402 , A61B18/148 , A61B90/02 , A61B2017/003 , A61B2018/00011 , A61B2018/00023 , A61B2018/00452 , A61B2018/0047 , A61B2018/00488 , A61B2018/0066 , A61B2018/00702 , A61B2018/00714 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/1495 , A61B2090/064 , A61F7/007 , A61F2007/0021 , A61H7/001 , A61H9/005 , A61H9/0071 , A61H2201/10 , A61M2205/3606 , A61N1/0468 , A61N1/0472 , A61N1/06 , A61N1/28 , A61N1/30 , A61N1/32 , A61N1/403 , A61N2005/0645
摘要： These and other objects of the present invention are achieved in a method for creating a desired tissue effect. An RF electrode is provided that includes a conductive portion. The RF electrode is coupled to a fluid delivery member that delivers a cooling fluidic medium to a back surface of the RF electrode. A dielectric is positioned on a skin surface. The RF electrode is coupled with the dielectric. RF energy is delivered from the RF electrode and the dielectric to the skin surface.
摘要翻译：本发明的这些和其它目的在用于产生期望的组织效应的方法中实现。提供了包括导电部分的RF电极。 RF电极耦合到流体输送构件，其将冷却流体介质输送到RF电极的后表面。电介质位于皮肤表面上。 RF电极与电介质耦合。 RF能量从RF电极和电介质输送到皮肤表面。

9. 发明授权

US07022121B2 Handpiece for treatment of tissue 有权
公开(公告)号：US07022121B2
公开(公告)日：2006-04-04
申请号：US10072475
申请日：2002-02-06
申请人： Roger A. Stern , Mitchell Levinson , Bryan Weber
发明人： Roger A. Stern , Mitchell Levinson , Bryan Weber
IPC分类号： A61B18/18
CPC分类号： A61B18/14 , A61B18/1402 , A61B18/148 , A61B2018/00011 , A61B2018/00023 , A61B2018/00452 , A61B2018/00702 , A61B2018/00779 , A61B2018/00791 , A61B2018/00875 , A61B2018/1495 , A61B2090/064 , A61B2090/065 , A61N1/403
摘要： A handpiece has a handpiece assembly and includes a handpiece housing. An insert is detachably coupled to the handpiece housing. The insert includes an RF electrode with a conductive portion and a dielectric.

10. 发明授权

US06551310B1 System and method of treating abnormal tissue in the human esophagus 有权
标题翻译：治疗人类食管异常组织的系统和方法
公开(公告)号：US06551310B1
公开(公告)日：2003-04-22
申请号：US09714344
申请日：2000-11-16
申请人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
发明人： Robert A. Ganz , Brian D. Zelickson , Roger A. Stern
IPC分类号： A61B1818
CPC分类号： A61B18/18 , A61B18/1485 , A61B18/1492 , A61B2018/00214 , A61B2018/0022 , A61B2018/00482 , A61B2018/00553 , A61B2018/00577 , A61B2018/00738 , A61B2018/00797 , A61B2018/126 , A61B2018/1467
摘要： An ablation catheter system and method of use is provided to endoscopically access portions of the human esophagus experiencing undesired growth of columnar epithelium. The ablation catheter system and method includes controlled depth of ablation features and use of either radio frequency spectrum, non-ionizing ultraviolet radiation, warm fluid or microwave radiation, which may also be accompanied by improved sensitizer agents.
摘要翻译：提供了一种消融导管系统和使用方法，用于内窥镜检查经历柱状上皮不期望生长的人食管部分。消融导管系统和方法包括受控的消融深度特征以及无线电频谱，非电离紫外线辐射，暖流体或微波辐射的使用，还可伴随改进的敏化剂。

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