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1. 发明申请

US20060194795A1 Platelet ADP receptor inhibitors 有权
公开(公告)号：US20060194795A1
公开(公告)日：2006-08-31
申请号：US11293026
申请日：2005-12-01
申请人： Robert Scarborough , Wolin Huang , Charles Marlowe , Kim Kane-Maguire
发明人： Robert Scarborough , Wolin Huang , Charles Marlowe , Kim Kane-Maguire
IPC分类号： A61K31/5513 , A61K31/4745 , A61K31/4704
CPC分类号： C07D487/04 , C07D209/48 , C07D239/22 , C07D239/48 , C07D239/50 , C07D239/96 , C07D333/34 , C07D333/62 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D521/00
摘要： Novel compounds of formulae (I) to (VIII), which more particularly include sulfonylurea derivatives, sulfonylthiourea derivatives, sulfonylguanidine derivatives, sulfonylcyanoguanidine derivatives, thioacylsulfonamide derivatives, and acylsulfonamide derivatives which are effective platelet ADP receptor inhibitors. These derivatives may be used in various pharmaceutical compositions, and are particularly effective for the prevention and/or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also relates to a method for preventing or treating thrombosis in a mammal comprising the step of administering a therapeutically effective amount of a compound of formulae (I) to (VIII), or a pharmaceutically acceptable salt thereof.

2. 发明授权

US06887880B2 Adenine based inhibitors of adenylyl cyclase, pharmaceutical compositions, and method of use thereof 失效
标题翻译：腺嘌呤环腺苷酸腺嘌呤抑制剂，药物组合物及其使用方法
公开(公告)号：US06887880B2
公开(公告)日：2005-05-03
申请号：US09989348
申请日：2001-11-20
申请人： Daniel Levy , Charles Marlowe , Kim Kane-Maguire , Robert M. Scarborough
发明人： Daniel Levy , Charles Marlowe , Kim Kane-Maguire , Robert M. Scarborough
IPC分类号： C07D473/34 , A61K31/52 , A61P9/04
CPC分类号： C07D473/34
摘要： The present invention relates to derivatives and analogues of adenine of the formula: wherein L, A, Y and Z are those defined herein. Compounds of the present invention are useful in inhibiting adenylyl cyclase activity. The present invention also relates to a method of preventing and inhibiting a patient's fibroproliferative vasculopathy following vascular injury or a vascular surgical operation which includes administering to the patient, an effective amount of a compound according to the invention subsequent to a vascular injury, or subsequent to a vascular surgical operation, for one to two weeks after the injury or surgical operation, effective to treat or prevent a patient's fibroproliferative vasculopathy such as chronic allograft rejection or vascular restenosis following vascular trauma. The present invention also relates to a method for measuring the inhibition of adenylyl cyclase activity and a method for treating congestive heart failure.
摘要翻译：本发明涉及下式的腺嘌呤的衍生物和类似物：其中L，A，Y和Z是本文定义的那些。本发明的化合物可用于抑制腺苷酸环化酶活性。本发明还涉及在血管损伤或血管外科手术之后预防和抑制患者的纤维增生性血管病变的方法，其包括向患者施用有效量的血管损伤后的本发明化合物或随后的在损伤或外科手术后一至两周进行血管外科手术，有效治疗或预防患者的纤维增生性血管病变，如血管创伤后的慢性同种异体移植排斥或血管再狭窄。本发明还涉及测定腺苷酸环化酶活性抑制的方法和治疗充血性心力衰竭的方法。

3. 发明授权

US06534535B1 Inhibitors of factor Xa 失效
标题翻译：因子Xa的抑制剂
公开(公告)号：US06534535B1
公开(公告)日：2003-03-18
申请号：US09636804
申请日：2000-08-10
申请人： Bing-Yan Zhu , Robert M. Scarborough , Lane Clizbe , Brandon Doughan , Zhaozhong Jon Jia , Kim Kane-Maguire , Charles Marlowe , Yonghong Song , Ting Su , Willy Teng , Penglie Zhang
发明人： Bing-Yan Zhu , Robert M. Scarborough , Lane Clizbe , Brandon Doughan , Zhaozhong Jon Jia , Kim Kane-Maguire , Charles Marlowe , Yonghong Song , Ting Su , Willy Teng , Penglie Zhang
IPC分类号： A61K3140
CPC分类号： C07D215/227 , C07D209/08 , C07D209/34 , C07D209/38 , C07D215/08 , C07D231/56 , C07D235/06 , C07D235/26 , C07D241/38 , C07D241/44 , C07D243/24 , C07D265/36 , C07D401/06 , C07D401/10 , C07D401/14 , C07D403/06 , C07D403/12 , C07D403/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds of formula (I) below: are useful in vitro or in vivo for preventing or treating coagulation disorders.
摘要翻译：公开了与哺乳动物因子Xa具有活性的新型化合物，其盐和与其相关的组合物。以下式（I）的化合物：在体外或体内可用于预防或治疗凝血障碍。

4. 发明授权

US06638980B1 Inhibitors of factor Xa 失效
公开(公告)号：US06638980B1
公开(公告)日：2003-10-28
申请号：US09576633
申请日：2000-05-24
申请人： Ting Su , Bing-Yan Zhu , Kim Kane-Maguire , Robert M. Scarborough , Penglie Zhang
发明人： Ting Su , Bing-Yan Zhu , Kim Kane-Maguire , Robert M. Scarborough , Penglie Zhang
IPC分类号： A61K31165
CPC分类号： C07D213/40 , C07C311/16 , C07C311/46 , C07D217/22 , C07D295/192 , C07D295/26 , C07D307/52 , C07D401/12
摘要： Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

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