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1. 发明授权

US5573520A Flexible tubular device for use in medical applications 失效
标题翻译：用于医疗应用的柔性管状装置
公开(公告)号：US5573520A
公开(公告)日：1996-11-12
申请号：US329691
申请日：1994-10-26
申请人： Robert S. Schwartz , David R. Holmes , Frederick S. Halverson , James V. Donadio, III , David Berry
发明人： Robert S. Schwartz , David R. Holmes , Frederick S. Halverson , James V. Donadio, III , David Berry
IPC分类号： A61M25/00 , A61M25/06 , B29C41/20 , B29C47/02 , C23F1/02
CPC分类号： A61M25/0013 , A61M25/0043 , B29C41/20 , B29C47/0023 , B29C47/023 , C23F1/02 , A61M2025/09066 , A61M2025/091 , A61M25/0051 , A61M25/0053 , A61M25/0054 , A61M25/0662 , A61M25/09 , B29C47/0026 , B29L2023/001 , B29L2031/7542
摘要： An apparatus for use as a catheter, a guidewire, a catheter sheath for use with catheter introducers or a drug infusion catheter/guidewire. The apparatus includes a flexible tubular member with an encasing covering the tubular member that creates a fluid-tight seal around the periphery of the tubular member. The tubular member is self-supporting and includes a plurality of apertures therein in a predetermined configuration to increase the flexibility of the tubular member.
摘要翻译：用作导管的装置，导丝，用于导管导引器或药物输注导管/导丝的导管护套。该装置包括柔性管状构件，其具有覆盖管状构件的封装，其围绕管状构件的周边产生流体密封的密封。管状构件是自支撑的并且在预定构造中包括多个孔，以增加管状构件的柔性。

2. 发明授权

US5437288A Flexible catheter guidewire 失效
标题翻译：柔性导管导丝
公开(公告)号：US5437288A
公开(公告)日：1995-08-01
申请号：US940523
申请日：1992-09-04
申请人： Robert S. Schwartz , David Berry , Frederick S. Halverson , James V. Donadio, III
发明人： Robert S. Schwartz , David Berry , Frederick S. Halverson , James V. Donadio, III
IPC分类号： A61B5/00 , A61M25/09
CPC分类号： A61M25/09 , A61M2025/09075 , A61M2025/09133
摘要： An apparatus for use as a catheter guidewire and a method for making a catheter guidewire. The apparatus comprises an elongate non-coiled wire having a proximal portion, a distal tip and a flexible portion located between the proximal portion and the distal tip having axially spaced grooves cut therein. The method for making the guidewire includes burnishing one end of a wire to create a rounded distal tip and cutting a predetermined pattern of axially spaced grooves in a length of wire adjacent to the distal tip to create a flexible portion.
摘要翻译：用作导管导丝的装置和制造导管导丝的方法。该装置包括细长的非卷绕的线，其具有近端部分，远端部和位于近端部分和远端部之间的柔性部分，其中在其中切割有轴向间隔开的沟槽。用于制造导丝的方法包括抛光线的一端以产生圆形的远侧末端，并且切割与远侧末端相邻的线的长度方向上的轴向间隔开的凹槽的预定图案以形成柔性部分。

3. 发明授权

US5741429A Flexible tubular device for use in medical applications 失效
标题翻译：用于医疗应用的柔性管状装置
公开(公告)号：US5741429A
公开(公告)日：1998-04-21
申请号：US455331
申请日：1995-05-31
申请人： James V. Donadio, III , David R. Holmes , Robert S. Schwartz , David Berry
发明人： James V. Donadio, III , David R. Holmes , Robert S. Schwartz , David Berry
IPC分类号： A61M25/00 , A61M25/06 , A61M25/16 , B29C41/20 , C23F1/02 , B44C1/22
CPC分类号： C23F1/02 , A61M25/0043 , A61M25/0054 , B29C41/20 , A61M2025/09066 , A61M2025/091 , A61M2025/09191 , A61M25/0662 , A61M25/09 , B29L2023/001 , B29L2031/7542
摘要： Manufacturing processes for apparatus, including slotted hypotube, for use as a catheter, a guidewire, a catheter sheath for use with catheter introducers or a drug infusion catheter/guidewire are disclosed. The manufacturing process includes creating a pattern of slots or apertures in a flexible metallic tubular member, by processes including but not limited to, electrostatic discharge machining (EDM), chemical milling, ablation and laser cutting. These slots or apertures may be cut completely or partially through the wall of the flexible metallic tubular member. These manufacturing processes may include the additional step of encasing the flexible metallic member such that a fluid tight seal is formed around the periphery of the tubular member.
摘要翻译：公开了用于装置的制造过程，包括用作导管的开槽海波管，导丝，用于导管导引器的导管护套或药物输注导管/导丝。制造过程包括通过包括但不限于静电放电加工（EDM），化学铣削，消融和激光切割的方法在柔性金属管状构件中形成槽或孔的图案。这些槽或孔可以完全或部分地穿过柔性金属管状构件的壁进行切割。这些制造方法可以包括包围柔性金属构件的附加步骤，使得围绕管状构件的周边形成流体密封。

4. 发明授权

US06258117B1 Multi-section stent 有权
标题翻译：多段支架
公开(公告)号：US06258117B1
公开(公告)日：2001-07-10
申请号：US09292558
申请日：1999-04-15
申请人： Allen R. Camrud , Robert S. Schwartz , David R. Holmes, Jr. , Timothy D. Argo , David Berry
发明人： Allen R. Camrud , Robert S. Schwartz , David R. Holmes, Jr. , Timothy D. Argo , David Berry
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/826 , A61F2002/828 , A61F2210/0004 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61F2250/0071 , A61F2250/0098
摘要： A multi-section stent includes a connecting structure that allows the stent sections to move and flex relative to one another. For deployment and positioning, the connecting structure connects the multiple stent sections and holds the stent sections substantially stationary relative to one another. Following deployment, the connecting structure allows the multiple stent sections to move relative to one another. Movable stent sections enable flexure of the stent upon deployment within a body lumen. This flexing structure allows better conformance of the stent to the shape of the body lumen, and exerts less overall pressure against the lumen wall, reducing the potential for trauma. Upon deployment, the multiple stent sections may be completely detached from one another. Alternatively, the stent sections may remain partially connected in a manner that allows substantial independent movement. The connecting structure can be manufactured to separate upon deployment, for example, by breaking or degrading within the body lumen in which the stent is positioned.
摘要翻译：多部分支架包括允许支架部分相对于彼此移动和弯曲的连接结构。为了部署和定位，连接结构连接多个支架部分并且将支架部分相对于彼此基本上保持固定。在部署之后，连接结构允许多个支架部分相对于彼此移动。可移动支架部分能够在展开在体腔内时使支架挠曲。该弯曲结构允许支架更好地符合体腔的形状，并且对腔壁施加较小的整体压力，降低创伤的可能性。在部署时，多个支架部分可以彼此完全分离。或者，支架部分可以以允许基本独立运动的方式保持部分连接。连接结构可以被制造成在展开时分离，例如通过在支架所在的体腔内破碎或降解。

5. 发明授权

US06913762B2 Stent having non-woven framework containing cells 有权
标题翻译：支架具有无纺布框架，含有细胞
公开(公告)号：US06913762B2
公开(公告)日：2005-07-05
申请号：US09843295
申请日：2001-04-25
申请人： Noel Caplice , David Berry , Robert S. Schwartz , David R. Holmes, Jr. , Robert D. Simari
发明人： Noel Caplice , David Berry , Robert S. Schwartz , David R. Holmes, Jr. , Robert D. Simari
IPC分类号： A61F2/00 , A61F2/90 , A61L31/14 , C12N5/06 , C12N5/08 , C12N11/08 , C12N11/14
CPC分类号： A61F2/90 , A61F2250/0067 , A61L31/14 , B33Y70/00 , B33Y80/00
摘要： Implantable medical devices that include a non-woven framework are described, as well as methods of using such devices to deliver therapeutic compounds to a patient.
摘要翻译：描述了包括无纺织框架的植入式医疗装置，以及使用这种装置将治疗化合物递送至患者的方法。

6. 发明授权

US06638258B2 Automatic manifold for vascular catheter 失效
公开(公告)号：US06638258B2
公开(公告)日：2003-10-28
申请号：US10003665
申请日：2001-10-23
申请人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
发明人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
IPC分类号： A61M500
CPC分类号： A61M39/24 , A61M2039/2473 , A61M2039/2486 , A61M2039/2493 , Y10T137/87571 , Y10T137/87652 , Y10T137/87684 , Y10T137/88054
摘要： An automatic manifold for a catheter assembly. Valve means automatically open and close flow between a liquid supply port for connection to injection means and a liquid delivery port for communication with the catheter assembly. A pressure sensor is integrated into the manifold. The manifold also includes a quick-disconnect coupling mechanism for a liquid supply port.

7. 发明授权

US6117102A Apparatus for flushing a vascular catheter 失效
标题翻译：用于冲洗血管导管的装置
公开(公告)号：US6117102A
公开(公告)日：2000-09-12
申请号：US159007
申请日：1998-09-23
申请人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
发明人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
IPC分类号： A61M39/22 , A61M1/00
CPC分类号： A61M39/225
摘要： An apparatus for flushing a vascular catheter. Inlet and outlet passages extending from inlet and outlet ports, respectively, are selectably in communication with one another via a manually operable member cooperating with a sealing member and biased toward a closed position. Mechanisms for continuously and periodically flushing the catheter are incorporated.
摘要翻译：一种用于冲洗血管导管的装置。从入口和出口分别延伸的入口和出口通道可选地通过与密封构件配合并被朝向关闭位置偏压的可手动操作的构件彼此连通。引入连续定期冲洗导管的机制。

8. 发明授权

US5895376A Hemostasis valve, system and assembly 失效
标题翻译：止血阀，系统和装配
公开(公告)号：US5895376A
公开(公告)日：1999-04-20
申请号：US735521
申请日：1996-10-23
申请人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
发明人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
IPC分类号： A61M25/00 , A61M39/00 , A61M39/06 , A61M5/00
CPC分类号： A61M39/0613 , A61M2039/062 , A61M2039/0673 , A61M39/228
摘要： A hemostasis valve including a collapsible membrane in a portion of a through-lumen. Fluid pressure in a chamber surrounding the collapsible membrane assists in sealing the collapsible membrane around an operating device inserted through the hemostasis valve. Different mechanisms for mechanically deforming the collapsible membrane to assist in sealing are disclosed. Also, a system for continuously flushing a vascular catheter connected to a hemostasis valve at a rate of 0.10 to 10.0 cubic centimeters per minute, and a hemostasis valve assembly including an expandable reservoir which stores liquid volume under pressure.
摘要翻译：止血阀，其包括在通管的一部分中的可折叠膜。围绕可折叠膜的腔室中的流体压力有助于将可收缩膜密封在插入通过止血阀的操作装置周围。公开了用于机械地使可折叠膜变形以辅助密封的不同机构。另外，一种用于以0.10至10.0立方厘米每分钟的速率连续冲洗连接到止血阀的血管导管的系统，以及包括在压力下储存液体体积的可膨胀储存器的止血阀组件。

9. 发明授权

US06371942B1 Automatic manifold for vascular catheter 失效
公开(公告)号：US06371942B1
公开(公告)日：2002-04-16
申请号：US09159008
申请日：1998-09-23
申请人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
发明人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
IPC分类号： A61M500
CPC分类号： A61M39/24 , A61M2039/2473 , A61M2039/2486 , A61M2039/2493 , Y10T137/87571 , Y10T137/87652 , Y10T137/87684 , Y10T137/88054
摘要： An automatic manifold for a catheter assembly. Valve means automatically open and close flow between a liquid supply port for connection to injection means and a liquid delivery port for communication with the catheter assembly. A pressure sensor is integrated into the manifold. The manifold also includes a quick-disconnect coupling mechanism for a liquid supply port.

10. 发明授权

US06293958B1 Catheter having flow diffusing tip 失效
标题翻译：导管具有流动扩散尖端
公开(公告)号：US06293958B1
公开(公告)日：2001-09-25
申请号：US09123807
申请日：1998-07-27
申请人： David Berry , David R. Holmes , Robert S. Schwartz , Robert A. VanTassel
发明人： David Berry , David R. Holmes , Robert S. Schwartz , Robert A. VanTassel
IPC分类号： A61M2900
CPC分类号： A61M25/0075 , A61M2025/0076
摘要： An intravascular catheter having a flow diffusing distal tip includes a plurality of cuts formed through the tubular wall thereof so as to define a plurality of generally U-shaped flaps, the flaps being disposed in at least one and preferably two axially displaced bands. When contrast fluid or the like is injected under pressure into the proximal end of the catheter, the flow of the liquid exits the openings in which the plurality of flaps are hinged, causing the flaps to vibrate and effectively eliminate any tendency for the contrast media to be expelled as a jet from the open distal end of the catheter. Having an open distal end allows the catheter to be passed over a guidewire.
摘要翻译：具有流动扩散远侧末端的血管内导管包括通过其管状壁形成的多个切口，以便限定多个大致U形的翼片，翼片设置在至少一个且优选两个轴向移位的带中。当在压力下将对比液或类似物注入导管的近端时，液体的流动离开多个翼片铰接的开口，导致襟翼振动并有效地消除造影剂对作为射流从导管的开放远端排出。具有开放的远端允许导管穿过导丝。

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