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1. 发明申请

US20110178539A1 LEFT ATRIAL APPENDAGE OCCLUSION DEVICES 审中-公开
标题翻译：左侧ATRIAL APPENDAGE OCCLUSION设备
公开(公告)号：US20110178539A1
公开(公告)日：2011-07-21
申请号：US13003707
申请日：2009-07-08
申请人： David R. Holmes, Jr. , David R. Holmes, III , Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Susan B. Johnson , Rebecca B. Fountain
发明人： David R. Holmes, Jr. , David R. Holmes, III , Paul A. Friedman , Charles J. Bruce , Samuel J. Asirvatham , Susan B. Johnson , Rebecca B. Fountain
IPC分类号： A61F2/00
CPC分类号： A61B17/0057 , A61B17/12013 , A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12159 , A61B17/12172 , A61B2017/00575 , A61B2017/0061 , A61B2017/00659 , A61B2017/00663 , A61M29/02
摘要： This document provides methods and materials related to minimally invasive techniques for reducing the volume of and/or occluding left atrial appendages.
摘要翻译：本文档提供了与减少左心耳和/或闭塞左心耳的微创技术相关的方法和材料。

2. 发明申请

US20100121188A1 REDUCING CONTRAST AGENT-INDUCED TOXICITY 审中-公开
标题翻译：减少对比剂引起的毒性
公开(公告)号：US20100121188A1
公开(公告)日：2010-05-13
申请号：US12445062
申请日：2007-10-10
申请人： Gurpreet S. Sandhu , David R. Holmes, III , David R. Holmes, JR. , Nicole P. Sandhu , Robert D. Simari
发明人： Gurpreet S. Sandhu , David R. Holmes, III , David R. Holmes, JR. , Nicole P. Sandhu , Robert D. Simari
IPC分类号： A61B6/10 , A61M25/00 , A61M25/10
CPC分类号： A61K49/18 , A61B17/22031 , A61B2017/00876 , A61B2017/22035 , A61F2/01 , A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0065 , A61F2230/0067 , A61F2230/0069 , A61F2230/0071 , A61F2230/0076
摘要： This document provides methods and materials that can be used to reduce or prevent contrast agent-induced toxicity. For example, devices for capturing contrast agents from blood are provided.
摘要翻译：本文档提供了可用于减少或预防造影剂诱导的毒性的方法和材料。例如，提供用于从血液捕获造影剂的装置。

3. 发明授权

US08544474B2 Systems and methods for magnetic-assisted therapeutic agent delivery 有权
标题翻译：用于磁辅助治疗剂递送的系统和方法
公开(公告)号：US08544474B2
公开(公告)日：2013-10-01
申请号：US12809197
申请日：2008-12-19
申请人： Gurpreet S. Sandhu , David R. Holmes, Jr. , Robert D. Simari , Nicole P. Sandhu , David R. Holmes, III
发明人： Gurpreet S. Sandhu , David R. Holmes, Jr. , Robert D. Simari , Nicole P. Sandhu , David R. Holmes, III
IPC分类号： A61B19/00
CPC分类号： A61M37/00 , A61K9/5094 , A61N2/002 , A61N2/06
摘要： Systems and methods that provide magnetically-enhanced delivery of therapeutic agents to selected tissue are disclosed. The systems and methods involve the use of carrier devices and release devices and two different magnetic fields to move magnetic particles into selected tissue. Movement of the magnetic particles (and any associated therapeutic agent) into the tissue may be assisted by both magnetic attractive forces as well as magnetic repulsive forces.
摘要翻译：公开了向选定组织提供治疗剂磁力增强递送的系统和方法。系统和方法涉及使用载体装置和释放装置以及两个不同的磁场以将磁性颗粒移动到选定的组织中。磁性颗粒（和任何相关联的治疗剂）进入组织的移动可以通过磁性吸引力以及磁性排斥力来辅助。

4. 发明申请

US20110257460A1 CAPTURING AND DELIVERING MOLECULES IN A MAMMAL 审中-公开
标题翻译：捕获和传播分子在一个妈妈
公开(公告)号：US20110257460A1
公开(公告)日：2011-10-20
申请号：US13129298
申请日：2009-11-13
申请人： David R. Holmes , Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , David R. Holmes, III , Jonathan Harburn
发明人： David R. Holmes , Gurpreet S. Sandhu , Robert D. Simari , Nicole P. Sandhu , David R. Holmes, III , Jonathan Harburn
IPC分类号： A61M37/00 , A61P35/00 , A61K38/02
CPC分类号： G01N33/6896 , B01J20/26 , B01J20/268 , G01N33/54326 , G01N33/6854 , G01N33/84 , G01N33/948 , G01N33/9486 , G01N2333/475 , G01N2333/948 , G01N2430/00 , G01N2800/2821
摘要： This document relates to molecularly imprinted polymers for use in mammals. For example, methods and materials for capturing a molecule in the body of a mammal using a molecularly imprinted polymer are provided. In some cases methods for delivering a molecule using a molecularly imprinted polymer into the body of a mammal are provided. The methods provided can be used to target any molecule in the body of a mammal.
摘要翻译：本文件涉及用于哺乳动物的分子印迹聚合物。例如，提供了使用分子印迹聚合物捕获哺乳动物体内分子的方法和材料。在一些情况下，提供了使用分子印迹聚合物递送到哺乳动物体内的分子的方法。所提供的方法可用于靶向哺乳动物体内的任何分子。

5. 发明申请

US20120220890A1 DETECTING AND TREATING NERVOUS SYSTEM DISORDERS 审中-公开
标题翻译：检测和治疗神经系统疾病
公开(公告)号：US20120220890A1
公开(公告)日：2012-08-30
申请号：US13468337
申请日：2012-05-10
申请人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
发明人： Samuel J. Asirvatham , Paul A. Friedman , Charles J. Bruce , David R. Holmes, JR.
IPC分类号： A61B5/0476 , A61M5/168 , A61N1/36
CPC分类号： A61B5/0478 , A61B5/4064 , A61B5/6851 , A61B5/6852 , A61B5/6853 , A61B18/082 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B2018/00214 , A61B2018/00446 , A61B2018/00577 , A61B2018/1467 , A61N1/0529
摘要： Some embodiments of a mapping device may be capable of passing through cerebral veins and other cerebrovascular spaces to provide electrophysiological mapping of the brain. These embodiments of the device may also be capable of providing, simultaneously or separately, ablation energy or other treatments to targeted brain tissue. In such circumstances, a user may be enabled to analyze an electrophysiological map of a patient's brain and, at the same time or within a short time period before or after the mapping process, may be enabled to apply ablation energy for treatment of a central nervous system disorder. Such treatment may be accomplished without the use of invasive surgery in which the brain is accessed through an opening in the patient's cranium.
摘要翻译：映射设备的一些实施例可以能够通过脑静脉和其他脑血管空间以提供大脑的电生理映射。该装置的这些实施例还可能能够同时或分开地向目标脑组织提供消融能量或其他治疗。在这种情况下，可以使用户能够分析患者大脑的电生理图，并且可以在绘制过程之前或之后的同一时间或在短时间内分析可以使用消融能量来治疗中枢神经系统紊乱这种治疗可以在不使用侵入性手术的情况下完成，其中脑通过患者颅骨中的开口进入。

6. 发明申请

US20100285510A1 MARKER FOR INFLAMMATORY CONDITIONS 有权
标题翻译：危害条件标志
公开(公告)号：US20100285510A1
公开(公告)日：2010-11-11
申请号：US12785893
申请日：2010-05-24
申请人： Cheryl A. Conover , Antonio Bayes-Genis , David R. Holmes , Robert S. Schwartz
发明人： Cheryl A. Conover , Antonio Bayes-Genis , David R. Holmes , Robert S. Schwartz
IPC分类号： G01N33/53
CPC分类号： G01N33/5091 , C07K14/4715 , G01N33/564 , G01N33/689 , G01N33/6893 , G01N2800/324 , G01N2800/368
摘要： Use of pregnancy-associated plasma protein-A as a marker for inflammatory conditions, and in particular, for acute coronary syndromes is described.
摘要翻译：描述了使用怀孕相关血浆蛋白-A作为炎性病症的标志物，特别是用于急性冠状动脉综合征。

7. 发明授权

US07252654B2 Apparatus with weeping tip and method of use 有权
标题翻译：具有啜饮尖端和使用方法的设备
公开(公告)号：US07252654B2
公开(公告)日：2007-08-07
申请号：US11218700
申请日：2005-09-02
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M5/32 , A61M25/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

8. 发明授权

US07235096B1 Implantable device for promoting repair of a body lumen 失效
标题翻译：用于促进体腔修复的植入式装置
公开(公告)号：US07235096B1
公开(公告)日：2007-06-26
申请号：US09382275
申请日：1999-08-25
申请人： Robert A. Van Tassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. Van Tassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/028 , A61B5/6862 , A61B5/6876 , A61F2/0077 , A61F2/91 , A61L31/14
摘要： An implantable stent having surface features adapted to promote an organized growth pattern of infiltrating cells when implanted in a tubular organ is provided. The surface features comprise depressions, pores, projections, pleats, channels or grooves in the stent body and are designed to increase turbulence or stagnation in the flow of a liquid, such as blood through the stent, and/or to promote the growth of infiltrating cells in an organized pattern. Alternatively, the invention stent can be populated with living cells prior to implant and can be heatable from an external source of energy, thereby inducing production of therapeutic bioactive agents from ingrowing cells. The invention also provides an implantable heatable stent for transcutaneously monitoring the flow of fluid through a lumen into which the stent is implanted by measuring the rate at which the heated stent cools in response to blood flow when the source of heat is removed.
摘要翻译：提供了一种植入式支架，其具有适于在植入管状器官时促进浸润细胞的有组织生长模式的表面特征。表面特征包括支架主体中的凹陷，孔，突起，褶皱，通道或凹槽，并且被设计成增加液体如血液通过支架的流动中的湍流或停滞，和/或促进渗透的生长细胞以有组织的模式。或者，本发明支架可以在植入之前填充活细胞，并且可以从外部能量源加热，从而从向内生长细胞诱导治疗性生物活性剂的产生。本发明还提供了一种可植入的可加热支架，用于通过测量当热源移除时响应于血液流动而被加热的支架冷却的速率，通过测量支架植入其中的内腔来经皮监测流体的流动。

9. 发明授权

US06605061B2 Catheter for drug injection in cardiovascular system 失效
标题翻译：心血管系统药物注射导管
公开(公告)号：US06605061B2
公开(公告)日：2003-08-12
申请号：US09880575
申请日：2001-06-13
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61M5178
CPC分类号： A61M25/0068 , A61B2017/00247 , A61B2018/00392 , A61M25/008 , A61M25/0084 , A61M2025/009
摘要： A catheter for injecting medicants into the endocardium, myocardium or other portions of the cardiovascular system is presented where the catheter has apertures therein for ejection and retraction of a needle. The catheter is designed for the apertures in the catheter to press against the tissue to be injected in the heart while the heart is beating. A needle for inserting a prescribed dose of a medicant is ejected through the aperture and a plunger, pump, or diaphragm is moved to deliver a dose of the medicant to tissue adjacent the aperture. By use of the catheter gene therapy, wherein a small does of a gene are injected into the endocardium of the right or left ventricle, can be used to grow new blood vessels in the injected area of a damaged heart. The apertures in the catheter can be spaced at a prescribed distance for the dosage of medicant to form a precise pattern of injections in the area to be treated. The catheters may be used for any treatments of a human or animal patient where injections are required in the heart, veins or arteries of the cardiovascular system.
摘要翻译：提供用于将药剂注射到心内膜，心肌或心血管系统的其它部分的导管，其中导管在其中具有孔，用于针的弹出和缩回。该导管被设计用于在心脏跳动时将导管中的孔压在组织上以被注射到心脏中。用于插入规定剂量的药剂的针通过孔排出，移动柱塞，泵或隔膜以将剂量的药剂递送到邻近孔的组织。通过使用其中将小的基因注入右心室或左心室的导管基因治疗可用于在损伤的心脏的注射区域中生长新的血管。导管中的孔可以间隔规定的距离，用于药物的剂量以在待治疗的区域中形成精确的注射模式。导管可用于需要在心血管系统的心脏，静脉或动脉中注射的人或动物患者的任何治疗。

10. 发明授权

US06371942B1 Automatic manifold for vascular catheter 失效
公开(公告)号：US06371942B1
公开(公告)日：2002-04-16
申请号：US09159008
申请日：1998-09-23
申请人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
发明人： Robert S. Schwartz , David R. Holmes , David Berry , Donald G. Ellis
IPC分类号： A61M500
CPC分类号： A61M39/24 , A61M2039/2473 , A61M2039/2486 , A61M2039/2493 , Y10T137/87571 , Y10T137/87652 , Y10T137/87684 , Y10T137/88054
摘要： An automatic manifold for a catheter assembly. Valve means automatically open and close flow between a liquid supply port for connection to injection means and a liquid delivery port for communication with the catheter assembly. A pressure sensor is integrated into the manifold. The manifold also includes a quick-disconnect coupling mechanism for a liquid supply port.

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