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1. 发明授权

US06963807B2 Automated identification of peptides 失效
标题翻译：肽的自动鉴定
公开(公告)号：US06963807B2
公开(公告)日：2005-11-08
申请号：US09950313
申请日：2001-09-10
申请人： Robert Reid Townsend , Andrew William Robinson
发明人： Robert Reid Townsend , Andrew William Robinson
IPC分类号： G01N33/68 , G06F19/22 , G06K9/00 , G06F17/00 , G06F17/30
CPC分类号： G01N33/6848 , G01N33/6818 , G06F19/22 , G06K9/00536 , Y10T436/24
摘要： A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a corresponding peptide sequence in a peptide database. The method identifies the corresponding sequence if it is present in the database, without the need for a skilled observer to choose from amongst a list of possible matches. By using an automated back-read process, the present method can uniquely identify a corresponding peptide sequence in a database based on a single matching peptide sequence. The method also permits mapping of mass spectral data to sequences in peptide or nucleotide databases for unambiguous identification of exons; determining a correct reading frame; identifying artefacts and errors in sequences; identifying mutations and polymorphisms; identifying post-translational modifications; and identifying exon-intron boundaries.
摘要翻译：描述了一种完全自动的，与用户无关的方法，用于计算机介导的通过实验肽的质谱法衍生的数据的解释，以鉴定和表征肽数据库中相应的肽序列。如果方法存在于数据库中，则该方法识别相应的序列，而不需要熟练的观察者从可能的匹配列表中进行选择。通过使用自动回读过程，本方法可以基于单个匹配的肽序列唯一地识别数据库中相应的肽序列。该方法还允许将质谱数据映射到肽或核苷酸数据库中的序列，以明确识别外显子; 确定正确的阅读框架; 识别序列中的人为因素和错误; 识别突变和多态性; 识别翻译后修饰; 并识别外显子 - 内含子边界。

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