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1. 发明申请

US20110143380A1 ALZHEIMER'S DISEASE BIOMARKERS AND METHODS OF USE 审中-公开
标题翻译：阿尔茨海默病的生物标志物和使用方法
公开(公告)号：US20110143380A1
公开(公告)日：2011-06-16
申请号：US12954259
申请日：2010-11-24
申请人： David Holtzman , Yan Hu , Robert Reid Townsend , Richard J. Perrin , Anne Fagan Niven , Rebecca Craig-Schapiro
发明人： David Holtzman , Yan Hu , Robert Reid Townsend , Richard J. Perrin , Anne Fagan Niven , Rebecca Craig-Schapiro
IPC分类号： G01N33/53 , C07K2/00
CPC分类号： G01N33/6896 , G01N2333/924
摘要： The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD.
摘要翻译：本发明包括用于AD的生物标志物，用于检测AD的方法，监测AD的方法和用于定量AD的生物标志物的试剂盒。

2. 发明授权

US06582965B1 Method for de novo peptide sequence determination 失效
标题翻译：从头肽序列测定方法
公开(公告)号：US06582965B1
公开(公告)日：2003-06-24
申请号：US08877605
申请日：1997-06-18
申请人： Robert Reid Townsend , Raj Bhikhu Parekh , Sally Barbara Prime , Nick Sinclair Wedd
发明人： Robert Reid Townsend , Raj Bhikhu Parekh , Sally Barbara Prime , Nick Sinclair Wedd
IPC分类号： G01N3300
CPC分类号： G01N33/6848 , G01N33/6818 , H01J49/0036 , H01J49/0045
摘要： The present invention relates to a method for generating a library of peptides based on a peptide of a predetermined molecular mass and to a method of determining the amino acid sequence of the peptide from the library. A set of amino acids that can be present in the peptide are defined, and an allowed library of all possible sequences of the amino acids in the set having a total mass equal to the predetermined molecular mass, allowing for water lost in forming peptide bonds and for protonation, is generated. The allowed library may be generated by first generating a set of all combinations of amino acids having a total mass equal to the predetermined molecular mass of the peptide and then calculating all linear permutations of all amino acids in each such combination. Generally, the molecular mass is determined using a mass spectrometer. A theoretical fragmentation spectrum for every amino acid sequence in the allowed set may also be calculated for use in determining the amino acid sequence of the peptide. The fragmentation spectra may be of any type known in the art, such as a mass spectrum or a protease or chemical fragmentation spectrum. The theoretical fragmentation spectra calculated for each member of the allowed peptide library may be compared to an experimental fragmentation spectrum for the unknown peptide to determine the amino acid sequence of the unknown peptide.
摘要翻译：本发明涉及一种基于预定分子量的肽产生肽文库的方法和从该文库确定肽的氨基酸序列的方法。定义了可以存在于肽中的一组氨基酸，并且所述组中氨基酸的所有可能序列的允许文库具有等于预定分子量的总质量，允许在形成肽键时失去水分，产生质子。可以通过首先产生具有等于肽的预定分子量的总质量的氨基酸的所有组合的集合，然后计算每个这样的组合中所有氨基酸的所有线性排列来产生所允许的文库。通常使用质谱仪测定分子量。也可以计算允许集合中每个氨基酸序列的理论碎片谱，以用于确定肽的氨基酸序列。碎裂光谱可以是本领域已知的任何类型，例如质谱或蛋白酶或化学断裂谱。可以将允许的肽文库的每个成员计算的理论碎片谱与未知肽的实验碎片谱进行比较，以确定未知肽的氨基酸序列。

3. 发明申请

US20090263829A1 ALZHEIMER'S DISEASE BIOMARKERS AND METHODS OF USE 审中-公开
标题翻译：阿尔茨海默病的生物标志物和使用方法
公开(公告)号：US20090263829A1
公开(公告)日：2009-10-22
申请号：US12282799
申请日：2007-03-12
申请人： David Holtzman , Yan Hu , Robert Reid Townsend
发明人： David Holtzman , Yan Hu , Robert Reid Townsend
IPC分类号： G01N33/573 , C07K14/00 , C12N9/48 , G01N33/53
CPC分类号： G01N33/6896 , G01N2800/2821
摘要： The invention encompasses biomarkers for AD, a method for detecting AD, a method of monitoring AD, and a kit for quantifying biomarkers for AD.
摘要翻译：本发明包括用于AD的生物标志物，用于检测AD的方法，监测AD的方法和用于定量AD的生物标志物的试剂盒。

4. 发明申请

US20090124519A1 Liquid delivery apparatus and method 审中-公开
标题翻译：液体输送装置及方法
公开(公告)号：US20090124519A1
公开(公告)日：2009-05-14
申请号：US12287042
申请日：2008-10-03
申请人： Albert Edward Platt , Robert Reid Townsend
发明人： Albert Edward Platt , Robert Reid Townsend
IPC分类号： C40B50/14 , C40B60/14
CPC分类号： G01N35/109 , B01J2219/00367 , B01J2219/00369 , B01J2219/00378 , B01J2219/00547 , B01J2219/00596 , B01J2219/00605 , B01J2219/00612 , B01J2219/00659 , B01J2219/00702 , B01J2219/00725 , B01J2219/00727 , B01J2219/00729 , C40B40/10 , C40B60/14 , C40B70/00
摘要： Liquid delivery apparatus and methods, in particular for the production of high-density arrays, wherein a partial drop of liquid is deposited from a capillary (1) onto a substrate (12), the capillary (1) and substrate (12) being capable of x, y and z movements relative to one another under the control of a translation mechanism.
摘要翻译：液体输送装置和方法，特别是用于生产高密度阵列，其中部分液滴从毛细管（1）沉积到基底（12）上，毛细管（1）和基底（12）能够在转换机制的控制下，x，y和z相对于彼此移动。

5. 发明授权

US06963807B2 Automated identification of peptides 失效
标题翻译：肽的自动鉴定
公开(公告)号：US06963807B2
公开(公告)日：2005-11-08
申请号：US09950313
申请日：2001-09-10
申请人： Robert Reid Townsend , Andrew William Robinson
发明人： Robert Reid Townsend , Andrew William Robinson
IPC分类号： G01N33/68 , G06F19/22 , G06K9/00 , G06F17/00 , G06F17/30
CPC分类号： G01N33/6848 , G01N33/6818 , G06F19/22 , G06K9/00536 , Y10T436/24
摘要： A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a corresponding peptide sequence in a peptide database. The method identifies the corresponding sequence if it is present in the database, without the need for a skilled observer to choose from amongst a list of possible matches. By using an automated back-read process, the present method can uniquely identify a corresponding peptide sequence in a database based on a single matching peptide sequence. The method also permits mapping of mass spectral data to sequences in peptide or nucleotide databases for unambiguous identification of exons; determining a correct reading frame; identifying artefacts and errors in sequences; identifying mutations and polymorphisms; identifying post-translational modifications; and identifying exon-intron boundaries.
摘要翻译：描述了一种完全自动的，与用户无关的方法，用于计算机介导的通过实验肽的质谱法衍生的数据的解释，以鉴定和表征肽数据库中相应的肽序列。如果方法存在于数据库中，则该方法识别相应的序列，而不需要熟练的观察者从可能的匹配列表中进行选择。通过使用自动回读过程，本方法可以基于单个匹配的肽序列唯一地识别数据库中相应的肽序列。该方法还允许将质谱数据映射到肽或核苷酸数据库中的序列，以明确识别外显子; 确定正确的阅读框架; 识别序列中的人为因素和错误; 识别突变和多态性; 识别翻译后修饰; 并识别外显子 - 内含子边界。

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