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1. 发明授权

US6156726A Voltage-gated calcium channel antagonist and method 失效
公开(公告)号：US6156726A
公开(公告)日：2000-12-05
申请号：US904431
申请日：1997-08-01
申请人： Robert Newcomb , Andrew L. Palma , Balazs G. Szoke , Katalin Tarczy-Hornoch , William F. Hopkins , Ruth L. Cong , George P. Miljanich , Robin Dean , Laszlo Nadasdi , Laszlo Urge , Stephen Scott Bowersox
发明人： Robert Newcomb , Andrew L. Palma , Balazs G. Szoke , Katalin Tarczy-Hornoch , William F. Hopkins , Ruth L. Cong , George P. Miljanich , Robin Dean , Laszlo Nadasdi , Laszlo Urge , Stephen Scott Bowersox
IPC分类号： C12N15/09 , A61K38/00 , A61P5/06 , A61P5/10 , A61P15/06 , A61P15/14 , A61P25/08 , C07K14/435 , C12N15/12 , A61K38/02 , A61K38/17 , C07K2/00
CPC分类号： C07K14/43513 , A61K38/00 , Y10S530/858
摘要： A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of producing blocking class E channels using the peptides. HG peptides have utility, for example, in inhibiting oxytocin release and for use as anticonvulsants.

2. 发明授权

US06653460B1 Voltage-gated calcium channel antagonist and method 失效
标题翻译：电压门控钙通道拮抗剂及方法
公开(公告)号：US06653460B1
公开(公告)日：2003-11-25
申请号：US09640957
申请日：2000-08-16
申请人： Robert Newcomb , Andrew L. Palma , Balazs G. Szoke , Katalin Tarczy-Hornoch , William F. Hopkins , Ruth L. Cong , George P. Miljanich , Robin Dean , Laszlo Nadasdi , Laszlo Urge , Stephen Scott Bowersox
发明人： Robert Newcomb , Andrew L. Palma , Balazs G. Szoke , Katalin Tarczy-Hornoch , William F. Hopkins , Ruth L. Cong , George P. Miljanich , Robin Dean , Laszlo Nadasdi , Laszlo Urge , Stephen Scott Bowersox
IPC分类号： C07H2102
CPC分类号： C07K14/43513 , A61K38/00 , Y10S530/858
摘要： A novel class of peptides selectively block class E voltage-gated calcium channels. The class is exemplified by HG peptides such as HG-1, which is isolated from the venom-producing cells of the tarantula Hysterocrates gigas. Also disclosed are methods of producing blocking class E channels using the peptides. HG peptides have utility, for example, in inhibiting oxytocin release and for use as anticonvulsants.
摘要翻译：一类新颖的肽选择性阻断E型电压门控钙通道。该类以HG肽例如HG-1为例，该HG肽是从狼蛛Hysterocrates gigas的毒液产生细胞中分离出来的。还公开了使用肽产生阻断E类通道的方法。 HG肽具有例如抑制催产素释放和用作抗惊厥药的效用。

3. 外观设计

USD369498S Pocket organizer for beach chair 失效
公开(公告)号：USD369498S
公开(公告)日：1996-05-07
申请号：US34345
申请日：1995-02-02
申请人： Robert Newcomb
设计人： Robert Newcomb

4. 发明授权

US08839576B1 Gabled-roof skylight and ventilation means 有权
标题翻译：屋顶天窗和通风装置
公开(公告)号：US08839576B1
公开(公告)日：2014-09-23
申请号：US13960043
申请日：2013-08-06
申请人： Robert Newcomb
发明人： Robert Newcomb
IPC分类号： E04B7/18 , E04D13/03
CPC分类号： E04D13/0325 , E04D13/174
摘要： An multi-layered roof skylight is provided that allows for natural light to enter through the peak of a gabled roof, while blocking ultraviolet light and offering an optional means to vent hot air and gases from inside the structure. The skylight comprises a first and second polycarbonate base layer attached to a structure's roof, wherein a polycarbonate roof cap is disposed thereabove and over the peak of the roof. The layers are sandwiched together by a line of fasteners on each side of the roof, while a first and second venting layer may further be provided between the base layers and the cap to allow air to vent therethrough. The cap is an angled member or one that has a defined shape incorporating vents in its design. Further provided is a method of installing the vented skylight on a gabled roof.
摘要翻译：提供了一个多层屋顶天窗，可以让自然光线通过山墙屋顶的峰顶进入，同时阻挡紫外线，并提供可选的方法，从结构内部排出热空气和气体。天窗包括附接到结构的屋顶的第一和第二聚碳酸酯基层，其中聚碳酸酯顶盖设置在屋顶的上方和顶部的顶部。这些层通过在屋顶的每一侧上的紧固件线夹在一起，而第一和第二排气层可以进一步设置在基层和盖之间，以允许空气通过其排出。盖子是成角度的构件，或者在其设计中具有限定形状的通风孔。进一步提供的是将通风天窗安装在屋顶的屋顶上的方法。

5. 发明授权

US06310093B1 Method of preventing neuronal death 失效
标题翻译：防止神经元死亡的方法
公开(公告)号：US06310093B1
公开(公告)日：2001-10-30
申请号：US09141881
申请日：1998-08-27
申请人： Robert Newcomb
发明人： Robert Newcomb
IPC分类号： A61K31195
CPC分类号： A61K31/198 , A61K31/00 , A61K31/185
摘要： Disclosed is a method for preventing neuronal cell death subsequent to an injury to neuronal tissue, particularly central nervous tissue exposed to an ischemic or hypoxic event, to trauma or to a chronic neurodegenerative disorder. The method includes exposing the cells to a glutaminase inhibitor that is relatively impermeant to healthy, intact cell membranes, and which is preferably a specific inhibitor of the form of glutaminase that is widely present in brain tissue.
摘要翻译：公开了一种用于在损伤神经元组织，特别是暴露于缺血或缺氧事件的中枢神经组织对创伤或慢性神经变性疾病的损伤之后预防神经元细胞死亡的方法。该方法包括将细胞暴露于健康的完整细胞膜相对不渗透的谷氨酰胺酶抑制剂，并且其优选地是广泛存在于脑组织中的谷氨酰胺酶形式的特异性抑制剂。

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