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1. 发明授权

US07112219B2 Devices and methods for heart valve treatment 有权
标题翻译：心脏瓣膜治疗的装置和方法
公开(公告)号：US07112219B2
公开(公告)日：2006-09-26
申请号：US10704143
申请日：2003-11-10
申请人： Robert M. Vidlund , Cyril J. Schweich, Jr. , Todd J. Mortier , Richard Schroeder , Craig Ekvall , Jason Kalgreen , Edward Matthees , David Kusz
发明人： Robert M. Vidlund , Cyril J. Schweich, Jr. , Todd J. Mortier , Richard Schroeder , Craig Ekvall , Jason Kalgreen , Edward Matthees , David Kusz
IPC分类号： A61F2/24
CPC分类号： A61F2/2481 , A61B17/00234 , A61B17/04 , A61B17/1325 , A61B17/32053 , A61B2017/00243 , A61B2017/0404 , A61B2017/0412 , A61B2017/0464 , A61B2017/0496 , A61F2/2442 , Y10S623/904
摘要： Devices and methods for improving the function of a valve (e.g., mitral valve) by positioning a spacing filling device outside and adjacent the heart wall such that the device applies an inward force against the heart wall acting on the valve. A substantially equal and opposite force may be provided by securing the device to the heart wall, and/or a substantially equal and opposite outward force may be applied against anatomical structure outside the heart wall. The inward force is sufficient to change the function of the valve, and may increase coaptation of the leaflets, for example. The space filling device may be implanted by a surgical approach, a transthoracic approach, or a transluminal approach, for example. The space filling portion may be delivered utilizing a delivery catheter navigated via the selected approach, and the space filling portion may be expandable between a smaller delivery configuration and a larger deployed configuration.
摘要翻译：通过将间隔填充装置定位在心壁周围和邻近心壁的位置使得该装置向作用在瓣膜上的心壁施加向内的力来改善瓣膜（例如二尖瓣）的功能的装置和方法。可以通过将装置固定到心脏壁来提供基本上相等且相反的力，和/或可以对心壁外部的解剖结构施加基本上相等且相反的向外的力。向内的力足以改变阀的功能，并且例如可以增加传单的接合。空间填充装置可以通过例如外科手术，经胸腔手术或经腔手术植入。空间填充部分可以利用经由所选择的方法导航的递送导管来传送，空间填充部分可以在较小的传送配置和更大的部署配置之间扩展。

2. 发明授权

US07666224B2 Devices and methods for heart valve treatment 有权
标题翻译：心脏瓣膜治疗的装置和方法
公开(公告)号：US07666224B2
公开(公告)日：2010-02-23
申请号：US11175270
申请日：2005-07-07
申请人： Robert M. Vidlund , Cyril J. Schweich, Jr. , Todd J. Mortier , Richard Schroeder , Craig Ekvall , Jason Kalgreen , Edward Matthees , David Kusz
发明人： Robert M. Vidlund , Cyril J. Schweich, Jr. , Todd J. Mortier , Richard Schroeder , Craig Ekvall , Jason Kalgreen , Edward Matthees , David Kusz
IPC分类号： A61F2/24
CPC分类号： A61F2/2481 , A61B17/00234 , A61B17/04 , A61B17/1325 , A61B17/32053 , A61B2017/00243 , A61B2017/0404 , A61B2017/0412 , A61B2017/0464 , A61B2017/0496 , A61F2/2442 , Y10S623/904
摘要： Devices and methods for improving the function of a valve (e.g., mitral valve) by positioning a spacing filling device outside and adjacent the heart wall such that the device applies an inward force against the heart wall acting on the valve. A substantially equal and opposite force may be provided by securing the device to the heart wall, and/or a substantially equal and opposite outward force may be applied against anatomical structure outside the heart wall. The inward force is sufficient to change the function of the valve, and may increase coaptation of the leaflets, for example. The space filling device may be implanted by a surgical approach, a transthoracic approach, or a transluminal approach, for example. The space filling portion may be delivered utilizing a delivery catheter navigated via the selected approach, and the space filling portion may be expandable between a smaller delivery configuration and a larger deployed configuration.
摘要翻译：通过将间隔填充装置定位在心壁周围和邻近心壁的位置使得该装置向作用在瓣膜上的心壁施加向内的力来改善瓣膜（例如二尖瓣）的功能的装置和方法。可以通过将装置固定到心脏壁来提供基本上相等且相反的力，和/或可以对心壁外部的解剖结构施加基本相等且相反的向外的力。向内的力足以改变阀的功能，并且例如可以增加传单的接合。空间填充装置可以通过例如外科手术，经胸腔手术或经腔手术植入。空间填充部分可以利用经由所选择的方法导航的递送导管来传送，空间填充部分可以在较小的传送配置和更大的部署配置之间扩展。

3. 发明申请

US20060036317A1 Decives and methods for heart valve treatment 有权
标题翻译：心脏瓣膜治疗的方法和方法
公开(公告)号：US20060036317A1
公开(公告)日：2006-02-16
申请号：US11175270
申请日：2005-07-07
申请人： Robert Vidlund , Cyril Schweich , Todd Mortier , Richard Schroeder , Craig Ekvall , Jason Kalgreen , Edward Matthees , David Kusz
发明人： Robert Vidlund , Cyril Schweich , Todd Mortier , Richard Schroeder , Craig Ekvall , Jason Kalgreen , Edward Matthees , David Kusz
IPC分类号： A61F2/24
CPC分类号： A61F2/2481 , A61B17/00234 , A61B17/04 , A61B17/1325 , A61B17/32053 , A61B2017/00243 , A61B2017/0404 , A61B2017/0412 , A61B2017/0464 , A61B2017/0496 , A61F2/2442 , Y10S623/904
摘要： Devices and methods for improving the function of a valve (e.g., mitral valve) by positioning a spacing filling device outside and adjacent the heart wall such that the device applies an inward force against the heart wall acting on the valve. A substantially equal and opposite force may be provided by securing the device to the heart wall, and/or a substantially equal and opposite outward force may be applied against anatomical structure outside the heart wall. The inward force is sufficient to change the function of the valve, and may increase coaptation of the leaflets, for example. The space filling device may be implanted by a surgical approach, a transthoracic approach, or a transluminal approach, for example. The space filling portion may be delivered utilizing a delivery catheter navigated via the selected approach, and the space filling portion may be expandable between a smaller delivery configuration and a larger deployed configuration.
摘要翻译：通过将间隔填充装置定位在心壁周围和邻近心壁的位置使得该装置向作用在瓣膜上的心壁施加向内的力来改善瓣膜（例如二尖瓣）的功能的装置和方法。可以通过将装置固定到心脏壁来提供基本上相等且相反的力，和/或可以对心壁外部的解剖结构施加基本上相等且相反的向外的力。向内的力足以改变阀的功能，并且例如可以增加传单的接合。空间填充装置可以通过例如外科手术，经胸腔手术或经腔手术植入。空间填充部分可以利用经由所选择的方法导航的递送导管来传送，空间填充部分可以在较小的传送配置和更大的部署配置之间扩展。

4. 发明申请

US20130079701A1 Methods and Apparatus for Delivering Ocular Implants Into the Eye 有权
公开(公告)号：US20130079701A1
公开(公告)日：2013-03-28
申请号：US13681365
申请日：2012-11-19
申请人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
发明人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61M25/0068 , A61M25/01 , A61M31/00 , A61M2025/0004
摘要： A method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.

5. 发明授权

US08337509B2 Methods and apparatus for delivering ocular implants into the eye 有权
标题翻译：将眼部植入物投入眼睛的方法和装置
公开(公告)号：US08337509B2
公开(公告)日：2012-12-25
申请号：US12632738
申请日：2009-12-07
申请人： Andrew T. Schieber , John L Wardle , Edward Matthees , Charles L. Euteneuer
发明人： Andrew T. Schieber , John L Wardle , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F11/00
CPC分类号： A61F9/00781 , A61M25/0068 , A61M25/01 , A61M31/00 , A61M2025/0004
摘要： A cannula for an ocular implant delivery system. In some embodiments, the cannula includes a tubular member having a curved portion, a distal opening surrounded by a distal opening surface, and a distal tip, the distal tip being adapted to be inserted into an anterior chamber of a human subject's eye, through trabecular meshwork and into Schlemm's canal of the eye, a proximal portion of the tubular member being adapted to extend from a location exterior to the eye when the distal tip is in Schlemm's canal of the eye, the cannula being further adapted to cooperate with an advancement mechanism to advance an ocular implant through the tubular member toward and through the distal opening into Schlemm's canal of the eye when the distal tip is disposed in Schlemm's canal. The invention also includes a method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.
摘要翻译：用于眼部植入物输送系统的插管。在一些实施例中，套管包括管状构件，其具有弯曲部分，由远侧开口表面包围的远侧开口和远侧末端，远侧末端适于通过小梁插入人类受试者眼睛的前房中网状物并进入眼睛的施莱姆氏管，管状构件的近端部分适于当远侧末端位于眼睛的施莱姆氏管中时从眼睛外部延伸，套管还适于与前进机构配合当远侧末端设置在施莱姆氏管中时，将眼部植入物穿过管状构件朝向并穿过远端开口进入眼睛的施莱姆氏管。本发明还包括将眼部植入物部署到人眼的施莱姆氏管中的方法，包括以下步骤：将眼睛的前房中的输送工具的远端通过眼睛的小梁网插入眼睛的施莱姆氏管 ; 并且将眼睛植入物推进通过输送工具的弯曲部分和远端开口，以将眼部植入物的主体部分放置在施莱姆氏管中，并将眼部植入物的入口部分放置在前房中。

6. 发明申请

US20130338563A1 Methods and Apparatus for Delivering Ocular Implants Into the Eye 有权
标题翻译：眼睛植入眼睛的方法和装置
公开(公告)号：US20130338563A1
公开(公告)日：2013-12-19
申请号：US13973864
申请日：2013-08-22
申请人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
发明人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61B17/3417 , A61B17/3468 , A61F2/148 , A61F2/15
摘要： A method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.
摘要翻译：一种将眼部植入物部署到人眼的施莱姆氏管中的方法，包括以下步骤：将眼睛的前房中的输送工具的远端通过眼睛的小梁网插入眼睛的施莱姆氏管中; 并且将眼睛植入物推进通过输送工具的弯曲部分和远端开口，以将眼部植入物的主体部分放置在施莱姆氏管中，并将眼部植入物的入口部分放置在前房中。

7. 发明授权

US08551166B2 Methods and apparatus for delivering ocular implants into the eye 有权
公开(公告)号：US08551166B2
公开(公告)日：2013-10-08
申请号：US13681365
申请日：2012-11-19
申请人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
发明人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F2/16
CPC分类号： A61F9/00781 , A61M25/0068 , A61M25/01 , A61M31/00 , A61M2025/0004
摘要： A method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.

8. 发明授权

US08512404B2 Ocular implant delivery system and method 有权
标题翻译：眼植入物输送系统及方法
公开(公告)号：US08512404B2
公开(公告)日：2013-08-20
申请号：US11943289
申请日：2007-11-20
申请人： Duane Frion , Rebecca McCarville , Andrew T. Schieber , Nathaniel Zenz-Olson , Diane Feehan , Edward Matthees , Charles L. Euteneuer
发明人： Duane Frion , Rebecca McCarville , Andrew T. Schieber , Nathaniel Zenz-Olson , Diane Feehan , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F2/16
CPC分类号： A61F9/00781
摘要： A method of inserting an ocular implant into a patient's eye, the ocular implant being mounted on a carrier, the method comprising: inserting a cannula into an anterior chamber of the eye; moving a distal exit port of the cannula into communication with Schlemm's canal; and advancing the ocular implant and carrier through an exit port of the cannula into Schlemm's canal. The invention also provides an ocular implant and delivery system comprising: a cannula comprising a distal exit port adapted to be inserted into a Schlemm's canal portion of an eye; an ocular implant; a carrier disposed within the implant and movable with the implant within the cannula; and a proximal control adapted to be operated from exterior to an eye to move at least one of the carrier and the implant when the distal exit port of the cannula is within the eye.
摘要翻译：一种将眼部植入物插入患者眼睛中的方法，所述眼部植入物安装在载体上，所述方法包括：将插管插入眼睛的前房; 将插管的远端出口移动与施莱姆氏管连通; 并将眼部植入物和载体通过套管的出口延伸进入施莱姆氏管。本发明还提供一种眼部植入物和递送系统，包括：套管，其包括适于插入眼睛的施莱姆氏管部分的远端出口; 眼部植入物; 布置在所述植入物内并与所述植入物在所述插管内移动的载体; 以及当所述套管的远端出口在眼睛内时适于从外部操作到眼睛以移动载体和植入物中的至少一个的近端控制器。

9. 发明申请

US20090132040A1 Ocular Implant Delivery System and Method 有权
标题翻译：眼植入物输送系统及方法
公开(公告)号：US20090132040A1
公开(公告)日：2009-05-21
申请号：US11943289
申请日：2007-11-20
申请人： Duane Frion , Rebecca McCarville , Andrew T. Schieber , Nathaniel Zenz-Olson , Diane Feehan , Edward Matthees , Charles L. Euteneuer
发明人： Duane Frion , Rebecca McCarville , Andrew T. Schieber , Nathaniel Zenz-Olson , Diane Feehan , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F2/16 , A61M5/00
CPC分类号： A61F9/00781
摘要： A method of inserting an ocular implant into a patient's eye, the ocular implant being mounted on a carrier, the method comprising: inserting a cannula into an anterior chamber of the eye; moving a distal exit port of the cannula into communication with Schlemm's canal; and advancing the ocular implant and carrier through an exit port of the cannula into Schlemm's canal. The invention also provides an ocular implant and delivery system comprising: a cannula comprising a distal exit port adapted to be inserted into a Schlemm's canal portion of an eye; an ocular implant; a carrier disposed within the implant and movable with the implant within the cannula; and a proximal control adapted to be operated from exterior to an eye to move at least one of the carrier and the implant when the distal exit port of the cannula is within the eye.
摘要翻译：一种将眼部植入物插入患者眼睛中的方法，所述眼部植入物安装在载体上，所述方法包括：将插管插入眼睛的前房; 将插管的远端出口移动与施莱姆氏管连通; 并将眼部植入物和载体通过套管的出口延伸进入施莱姆氏管。本发明还提供一种眼部植入物和递送系统，包括：套管，其包括适于插入眼睛的施莱姆氏管部分的远端出口; 眼部植入物; 布置在所述植入物内并与所述植入物在所述插管内移动的载体; 以及当所述套管的远端出口在眼睛内时适于从外部操作到眼睛以移动载体和植入物中的至少一个的近端控制器。

10. 发明申请

US20100121342A1 Methods and Apparatus for Delivering Ocular Implants Into the Eye 有权
标题翻译：眼睛植入眼睛的方法和装置
公开(公告)号：US20100121342A1
公开(公告)日：2010-05-13
申请号：US12632738
申请日：2009-12-07
申请人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
发明人： Andrew T. Schieber , John Wardle , Edward Matthees , Charles L. Euteneuer
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61M25/0068 , A61M25/01 , A61M31/00 , A61M2025/0004
摘要： A cannula for an ocular implant delivery system. In some embodiments, the cannula includes a tubular member having a curved portion, a distal opening surrounded by a distal opening surface, and a distal tip, the distal tip being adapted to be inserted into an anterior chamber of a human subject's eye, through trabecular meshwork and into Schlemm's canal of the eye, a proximal portion of the tubular member being adapted to extend from a location exterior to the eye when the distal tip is in Schlemm's canal of the eye, the cannula being further adapted to cooperate with an advancement mechanism to advance an ocular implant through the tubular member toward and through the distal opening into Schlemm's canal of the eye when the distal tip is disposed in Schlemm's canal. The invention also includes a method of deploying an ocular implant into Schlemm's canal of a human eye including the following steps: inserting a distal tip of a delivery tool within an anterior chamber of the eye through trabecular meshwork of the eye into Schlemm's canal of the eye; and advancing an ocular implant through a curved portion and a distal opening of the delivery tool to place a body portion of the ocular implant in Schlemm's canal and an inlet portion of the ocular implant in the anterior chamber.
摘要翻译：用于眼部植入物输送系统的插管。在一些实施例中，套管包括管状构件，其具有弯曲部分，由远侧开口表面包围的远侧开口和远侧末端，远侧末端适于通过小梁插入人类受试者眼睛的前房中网状物并进入眼睛的施莱姆氏管，管状构件的近端部分适于当远侧末端位于眼睛的施莱姆氏管中时从眼睛外部延伸，套管还适于与前进机构配合当远侧末端设置在施莱姆氏管中时，将眼部植入物穿过管状构件朝向并穿过远端开口进入眼睛的施莱姆氏管。本发明还包括将眼部植入物部署到人眼的施莱姆氏管中的方法，包括以下步骤：将眼睛的前房中的输送工具的远端通过眼睛的小梁网插入眼睛的施莱姆氏管 ; 并且将眼睛植入物推进通过输送工具的弯曲部分和远端开口，以将眼部植入物的主体部分放置在施莱姆氏管中，并将眼部植入物的入口部分放置在前房中。

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