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1. 发明授权

US07392090B2 Data logging system for implantable medical device 有权
标题翻译：可植入医疗器械的数据记录系统
公开(公告)号：US07392090B2
公开(公告)日：2008-06-24
申请号：US10672315
申请日：2003-09-26
申请人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
发明人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
IPC分类号： A61N1/00
CPC分类号： A61B5/0031 , A61N1/30 , A61N1/3621
摘要： A data logging system and method in which an implantable medical device transmits logged data to an external data logging device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded data by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external data logging device. The data logging device then demodulates the sensed potentials to derive the digital data and stores the data in a data logging storage medium.
摘要翻译：一种数据记录系统和方法，其中可植入医疗设备将记录的数据发送到具有低能量电位信号的外部数据记录装置。可植入装置通过操作电流源产生用数字编码数据调制的电位信号，以引起可由外部数据记录装置在皮肤表面感测到的对应电位。数据记录装置然后解调所感测的电位以导出数字数据并将数据存储在数据记录存储介质中。

2. 发明授权

US06628985B2 Data logging system for implantable medical device 有权
公开(公告)号：US06628985B2
公开(公告)日：2003-09-30
申请号：US09740258
申请日：2000-12-18
申请人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
发明人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
IPC分类号： A61B504
CPC分类号： A61B5/0031 , A61N1/30 , A61N1/3621
摘要： A data logging system and method in which an implantable medical device transmits logged data to an external data logging device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded data by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external data logging device. The data logging device then demodulates the sensed potentials to derive the digital data and stores the data in a data logging storage medium.

3. 发明授权

US07425210B2 Drug delivery system for implantable medical device 有权
标题翻译：可植入医疗器械的药物输送系统
公开(公告)号：US07425210B2
公开(公告)日：2008-09-16
申请号：US10743507
申请日：2003-12-22
申请人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
发明人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
IPC分类号： A61K9/22
CPC分类号： A61N1/30 , A61M5/1723 , A61M2205/3507 , A61M2205/3561
摘要： A drug delivery system and method in which an implantable medical device communicates with and controls an external drug delivery device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded command information by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external drug delivery device. The drug delivery device then demodulates the sensed potentials and decodes the digital data to extract command information therefrom to deliver a drug accordingly.
摘要翻译：一种药物递送系统和方法，其中可植入医疗装置与具有低能量电位信号的外部药物递送装置通信并控制其。可植入装置通过操作电流源产生用数字编码命令信息调制的潜在信号，以引起可由外部药物递送装置在皮肤表面感测到的相应电位。药物递送装置然后解调所感测的电位并对数字数据进行解码以从中提取命令信息以递送药物。

4. 发明授权

US06689117B2 Drug delivery system for implantable medical device 有权
标题翻译：可植入医疗器械的药物输送系统
公开(公告)号：US06689117B2
公开(公告)日：2004-02-10
申请号：US09740129
申请日：2000-12-18
申请人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
发明人： Robert J. Sweeney , Avram Scheiner , Ronald W. Heil, Jr.
IPC分类号： A61M3100
CPC分类号： A61N1/30 , A61M5/1723 , A61M2205/3507 , A61M2205/3561
摘要： A drug delivery system and method in which an implantable medical device communicates with and controls an external drug delivery device with low energy potential signals. The implantable device generates potential signals modulated with digitally encoded command information by operating a current source to cause corresponding electrical potentials that can be sensed at the skin surface by the external drug delivery device. The drug delivery device then demodulates the sensed potentials and decodes the digital data to extract command information therefrom to deliver a drug accordingly.
摘要翻译：一种药物递送系统和方法，其中可植入医疗装置与具有低能量电位信号的外部药物递送装置通信并控制其。可植入装置通过操作电流源产生用数字编码命令信息调制的潜在信号，以引起可由外部药物输送装置在皮肤表面感测到的相应电位。药物递送装置然后解调所感测的电位并对数字数据进行解码以从中提取命令信息以递送药物。

5. 发明授权

US07201733B2 Drug delivery system for implantable cardiac device 失效
标题翻译：用于植入式心脏装置的药物递送系统
公开(公告)号：US07201733B2
公开(公告)日：2007-04-10
申请号：US09999260
申请日：2001-11-30
申请人： Avram Scheiner , Mark Herner , Ronald W. Heil, Jr. , Steven D. Girouard
发明人： Avram Scheiner , Mark Herner , Ronald W. Heil, Jr. , Steven D. Girouard
IPC分类号： A61M31/00
CPC分类号： A61N1/30 , A61N1/3621 , Y10S128/12 , Y10S128/13
摘要： A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.
摘要翻译：一种药物递送系统，其结合到心脏装置中，用于在检测到特定医疗状况时将药物的剂量递送给患者。心脏装置可以是例如通过射频链路与药物递送装置进行通信的可植入式心律转复器/除颤器，心脏起搏器或组合装置。药物递送装置优选是经电调制的透皮药物递送装置，用于根据从心脏装置接收的信号透皮地递送药物。

6. 发明授权

US08473076B2 Lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：用于刺激肺动脉中的压力感受器的铅
公开(公告)号：US08473076B2
公开(公告)日：2013-06-25
申请号：US13225769
申请日：2011-09-06
申请人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
发明人： Imad Libbus , Ronald W. Heil, Jr. , Avram Scheiner
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/0476 , A61N1/05 , A61N1/056 , A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The plurality of zones can be tested to determine which zone delivers the best baroreflex response. At least one of the electrode zones can be selected to deliver a stimulation signal based on the testing. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器到可膨胀电极。可膨胀电极包括多个电极区。可以测试多个区域以确定哪个区域提供最佳的压力反射响应。可以选择至少一个电极区域以基于测试传递刺激信号。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

7. 发明授权

US08126560B2 Stimulation lead for stimulating the baroreceptors in the pulmonary artery 有权
标题翻译：刺激肺动脉压力感受器的刺激
公开(公告)号：US08126560B2
公开(公告)日：2012-02-28
申请号：US10746852
申请日：2003-12-24
申请人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
发明人： Avram Scheiner , Ronald W. Heil, Jr. , Peter T. Kelley
IPC分类号： A61N1/18 , A61N1/362
CPC分类号： A61N1/057 , A61N1/36117
摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, the distal end having a biased portion having an outer diameter dimensioned to abut a wall of a pulmonary artery, an electrode coupled proximate the distal end, and an implantable pulse generator electrically coupled to the electrode. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.
摘要翻译：一种装置包括从近端延伸到远端的柔性引线体，所述远端具有偏压部分，所述偏压部分的外径尺寸设计成邻接肺动脉壁，邻近远端连接的电极和可植入脉冲发电机电耦合到电极。可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

8. 发明授权

US06212434B1 Single pass lead system 失效
公开(公告)号：US06212434B1
公开(公告)日：2001-04-03
申请号：US09120824
申请日：1998-07-22
申请人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
发明人： Avram Scheiner , William Hsu , David M. Flynn , Qingsheng Zhu , John E. Heil , Ronald W. Heil, Jr. , Curtis C. Lindstrom , Robert S. Booker, III , Yayun Lin , Peter T. Kelley , Jay A. Warren , Gerrard M. Carlson , Carol Werlein , Aaron W. Janke , Mary Lee Cole , Jeffrey T. Bartig , Gary W. Goebel , Douglas A. Heitkamp , Randall M. Peterfeso
IPC分类号： A61N105
CPC分类号： A61N1/0573 , A61N1/0563
摘要： A single-pass endocardial lead electrode adapted for implantation in, on or about the heart and for connection to a system for monitoring or stimulating cardiac activity includes a lead body which is adapted for implantation within a single chamber of the heart, or multiple chambers of the heart. The lead includes a first distal end electrode which has a first electrical conducting surface. The lead body also has a second electrode which has a second electrical conducting surface. The first and second electrodes are either passively or actively attached to the wall of the heart. The lead body also includes a curved portion which facilitates the positioning of the second electrode. The main lead body alternatively includes a recess into which an atrial lead body and an active fixation element attached to one end can travel from a recessed position to a position for fixation to the wall of the heart. The active fixation element can also be moved by turning the terminal pin. The lead body can also include multiple legs, each leg carrying an electrode. The lead is attached to a pulse generator for producing pulses to the multiple sites within the heart. A movement assembly for advancing a helix is also included within the legs and comprises an externally threaded collar which engages with an internally threaded housing or housing insert. The lead further includes a helical tip which has high impedance. The electrode has at least one features of the group: the helix having a coating of an insulating material on its surface, the helix having its surface beyond the distal end of the electrode and the distal end of the electrode having a porous conductive surface at a base of the helix, a porous conductive element at a base of the helix, and a porous conductive element at the end of the electrode having an insulating coating cover from 5-95% of the surface of the porous conductive element. The porous element may further provide a guiding mechanism for the helix as it travels out of the electrode for securing the electrode to the heart.

9. 发明授权

US07643875B2 Baroreflex stimulation system to reduce hypertension 有权
标题翻译： Baroreflex刺激系统可以降低高血压
公开(公告)号：US07643875B2
公开(公告)日：2010-01-05
申请号：US10746134
申请日：2003-12-24
申请人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
发明人： Ronald W. Heil, Jr. , Avram Scheiner , Imad Libbus
IPC分类号： A61N1/36
CPC分类号： A61N1/36117 , A61N1/3627 , A61N1/36564
摘要： Various aspects of the present subject matter provide an implantable medical device. In various embodiments, the device comprises a pulse generator, a lead, a sensor, and a controller. The pulse generator generates a baroreflex stimulation signal as part of a baroreflex therapy. The lead is adapted to be electrically connected to the pulse generator and to be intravascularly fed into a heart. The lead includes an electrode to be positioned in or proximate to the heart to deliver the baroreflex signal to a baroreceptor region in or proximate to the heart. The sensor senses a physiological parameter regarding an efficacy of the baroreflex therapy and provides a signal indicative of the efficacy. The controller is connected to the pulse generator to control the baroreflex stimulation signal and to the sensor to receive the signal indicative of the efficacy of the baroreflex therapy. Other aspects are provided herein.
摘要翻译：本主题的各个方面提供可植入医疗装置。在各种实施例中，装置包括脉冲发生器，引线，传感器和控制器。脉冲发生器产生压力反射刺激信号作为压力反射治疗的一部分。引线适于电连接到脉冲发生器并且被血管内馈送到心脏中。引线包括位于心脏中或靠近心脏的电极，以将压力反射信号传递到心脏中或心脏附近的压力感受器区域。传感器感测关于压力反射治疗的功效的生理参数，并提供指示功效的信号。控制器连接到脉冲发生器以控制压力反射刺激信号和传感器以接收指示压力反射治疗功效的信号。本文提供了其他方面。

10. 发明授权

US06361522B1 Drug delivery system for implantable cardiac device 有权
公开(公告)号：US06361522B1
公开(公告)日：2002-03-26
申请号：US09422433
申请日：1999-10-21
申请人： Avram Scheiner , Mark Herner , Ronald W. Heil, Jr. , Steven D. Girouard
发明人： Avram Scheiner , Mark Herner , Ronald W. Heil, Jr. , Steven D. Girouard
IPC分类号： A61M3100
CPC分类号： A61N1/30 , A61N1/3621 , Y10S128/12 , Y10S128/13
摘要： A drug delivery system incorporated into a cardiac device for delivering a dose of a drug to a patient upon detection of a particular medical condition. The cardiac device may be, for example, an implantable cardioverter/defibrillator, cardiac pacemaker, or combination device that communicates via a radio frequency link with a drug delivery device. The drug delivery device is preferably an electrically modulated transdermal drug delivery device for delivering the drug transdermally in accordance with a signal received from the cardiac device.

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