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1. 发明授权

US08076639B2 Method and system for desorption atmospheric pressure chemical ionization 有权
标题翻译：解吸大气压化学电离方法与系统
公开(公告)号：US08076639B2
公开(公告)日：2011-12-13
申请号：US12481501
申请日：2009-06-09
申请人： Robert G. Cooks , Bogdan Gologan , Zoltan Takáts , Justin M. Wiseman , Ismael Cotte-Rodriguez
发明人： Robert G. Cooks , Bogdan Gologan , Zoltan Takáts , Justin M. Wiseman , Ismael Cotte-Rodriguez
IPC分类号： H01J49/26
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.
摘要翻译：解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。具有锥形尖端的电极连接到高压电源。锥形尖端从携带高速气体流的毛细管向外突出。将溶剂的蒸气混合到围绕针的环形气流中。通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它能够研究分析物的仪器。

2. 发明授权

US07544933B2 Method and system for desorption atmospheric pressure chemical ionization 有权
公开(公告)号：US07544933B2
公开(公告)日：2009-06-09
申请号：US11653569
申请日：2007-01-16
申请人： Robert G. Cooks , Bogdan Gologan , Zoltán Takáts , Justin M. Wiseman , Ismael Cotte-Rodriguez
发明人： Robert G. Cooks , Bogdan Gologan , Zoltán Takáts , Justin M. Wiseman , Ismael Cotte-Rodriguez
IPC分类号： H01J49/00
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

3. 发明申请

US20090309020A1 Method and system for desorption atmospheric pressure chemical ionization 有权
标题翻译：解吸大气压化学电离方法与系统
公开(公告)号：US20090309020A1
公开(公告)日：2009-12-17
申请号：US12481501
申请日：2009-06-09
申请人： Robert G. Cooks , Bogdan Gologan , Zoltan Takats , Justin M. Wiseman , Ismael Cotte-Rodriguez
发明人： Robert G. Cooks , Bogdan Gologan , Zoltan Takats , Justin M. Wiseman , Ismael Cotte-Rodriguez
IPC分类号： H01J49/26 , H01J27/00 , H01J49/04
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.
摘要翻译：解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。具有锥形尖端的电极连接到高压电源。锥形尖端从携带高速气体流的毛细管向外突出。将溶剂的蒸气混合到围绕针的环形气流中。通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它能够研究分析物的仪器。

4. 发明申请

US20070187589A1 Method and system for desorption atmospheric pressure chemical ionization 有权
标题翻译：解吸大气压化学电离方法与系统
公开(公告)号：US20070187589A1
公开(公告)日：2007-08-16
申请号：US11653569
申请日：2007-01-16
申请人： Robert Cooks , Bogdan Gologan , Zoltan Takats , Justin Wiseman , Ismael Cotte-Rodriguez
发明人： Robert Cooks , Bogdan Gologan , Zoltan Takats , Justin Wiseman , Ismael Cotte-Rodriguez
IPC分类号： H01J49/00
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.
摘要翻译：解吸大气压化学电离（DAPCI）系统将由惰性高速气体和溶剂离子组成的初级离子束传送到表面，以实现表面上存在的挥发性和非挥发性物质的解吸和离子化。具有锥形尖端的电极连接到高压电源。锥形尖端从携带高速气体流的毛细管向外突出。将溶剂的蒸气混合到围绕针的环形气流中。通过施加到电极的高电压，气态溶剂蒸气被离子化，紧邻锥形尖端。从毛细管向外延伸的气体和溶剂蒸汽离子的高速流动被引导到其上可能沉积感兴趣的分析物的基底。溶剂蒸汽离子可以覆盖分析物的表面，导致静电荷积聚，促进离子解吸，并且另外可以提供从衬底表面释放的分析物的阳离子加合物，其可以被引导到大气摄入的质谱仪或其它能够研究分析物的仪器。

5. 发明授权

US07335897B2 Method and system for desorption electrospray ionization 有权
标题翻译：解吸电喷雾离子化的方法和系统
公开(公告)号：US07335897B2
公开(公告)日：2008-02-26
申请号：US11090455
申请日：2005-03-25
申请人： Zoltán Takáts , Bogdan Gologan , Justin Michael Wiseman , Robert Graham Cooks
发明人： Zoltán Takáts , Bogdan Gologan , Justin Michael Wiseman , Robert Graham Cooks
IPC分类号： H01J27/00 , H01J49/10
CPC分类号： H01J49/142 , H01J49/0004 , H01J49/0404
摘要： A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.
摘要翻译：一种解吸电离的新方法和系统被描述和应用于各种化合物的电离，包括存在于金属，聚合物和矿物表面上的肽和蛋白质。通过将液体的带电液滴和/或离子引导到要分析的表面上来进行解吸电喷雾离子化（DESI）。带电粒子对表面的影响产生了最初存在于表面上的材料的气态离子。所得质谱与正常的ESI质谱相似，因为它们主要表现出分析物的单一或多重带电分子离子。在导电性和绝缘体表面以及通过极性化合物如肽和蛋白质从非极性小分子（如番茄红素，生物碱美西汀和小药物）的化合物观察到DESI现象。喷雾溶液中的变化可用于选择性地电离特定化合物，包括生物基质中的化合物。证明体内分析。

6. 发明申请

US20050230635A1 Method and system for desorption electrospray ionization 有权
标题翻译：解吸电喷雾离子化的方法和系统
公开(公告)号：US20050230635A1
公开(公告)日：2005-10-20
申请号：US11090455
申请日：2005-03-25
申请人： Zoltan Takats , Bogdan Gologan , Justin Wiseman , Robert Cooks
发明人： Zoltan Takats , Bogdan Gologan , Justin Wiseman , Robert Cooks
IPC分类号： H01J27/00 , H01J49/04
CPC分类号： H01J49/142 , H01J49/0004 , H01J49/0404
摘要： A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.
摘要翻译：一种解吸电离的新方法和系统被描述和应用于各种化合物的电离，包括存在于金属，聚合物和矿物表面上的肽和蛋白质。通过将液体的带电液滴和/或离子引导到要分析的表面上来进行解吸电喷雾离子化（DESI）。带电粒子对表面的影响产生了最初存在于表面上的材料的气态离子。所得质谱与正常的ESI质谱相似，因为它们主要表现出分析物的单一或多重带电分子离子。在导电性和绝缘体表面以及通过极性化合物如肽和蛋白质从非极性小分子（如番茄红素，生物碱美西汀和小药物）的化合物观察到DESI现象。喷雾溶液中的变化可用于选择性地电离特定化合物，包括生物基质中的化合物。证明体内分析。

7. 发明申请

US20060079002A1 System and method for landing of ions on a gas/liquid interface 审中-公开
标题翻译：离子在气/液界面上着陆的系统和方法
公开(公告)号：US20060079002A1
公开(公告)日：2006-04-13
申请号：US11228946
申请日：2005-09-16
申请人： Bogdan Gologan , Zoltan Takats , Zheng Ouyang , Robert Cooks
发明人： Bogdan Gologan , Zoltan Takats , Zheng Ouyang , Robert Cooks
IPC分类号： G01N1/00
CPC分类号： B82Y30/00 , H01J49/04 , Y10T436/25
摘要： A system for collecting gaseous ions from a mixture of molecules includes an ionizer, a separator, and a surface that is positioned in cooperative relationship with the separator. The ionizer converts at least a portion of the molecules into gas phase ions and the separator separates the ions. The ions land in a layer of liquid phase material on the surface.
摘要翻译：用于从分子混合物中收集气态离子的系统包括离子发生器，分离器和与分离器配合关系的表面。离子发生器将至少一部分分子转化为气相离子，分离器分离离子。离子落在表层的液相材料层中。

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