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1. 发明授权

US07544933B2 Method and system for desorption atmospheric pressure chemical ionization 有权
公开(公告)号：US07544933B2
公开(公告)日：2009-06-09
申请号：US11653569
申请日：2007-01-16
申请人： Robert G. Cooks , Bogdan Gologan , Zoltán Takáts , Justin M. Wiseman , Ismael Cotte-Rodriguez
发明人： Robert G. Cooks , Bogdan Gologan , Zoltán Takáts , Justin M. Wiseman , Ismael Cotte-Rodriguez
IPC分类号： H01J49/00
CPC分类号： H01J49/14
摘要： A desorption atmospheric pressure chemical ionization (DAPCI) system delivers a primary ion beam composed of an inert, high velocity gas and solvent ions to a surface to effect desorption and ionization of both volatile and non-volatile species present on surfaces. A electrode having a tapered tip is connected to a high voltage power supply. The tapered tip projects outward from a capillary carrying a high-speed flow of gas. A vapor of a solvent is mixed into the annular gas flow surrounding the needle. The gaseous solvent vapor is ionized in close proximity to the tapered tip by virtue of the high voltage applied to the electrode. The high-speed flow of gas and solvent vapor ions extending outward from the capillary is directed toward a substrate on which an analyte of interest may have been deposited. The solvent vapor ions can blanket the surface of the analyte causing a static charge build up that facilitates ion desorption and additionally can provide positive ion adducts of the analyte freed from the substrate surface that can be directed toward an atmospheric intake of a mass spectrometer or other instrument capable of studying the analyte.

2. 发明授权

US07335897B2 Method and system for desorption electrospray ionization 有权
标题翻译：解吸电喷雾离子化的方法和系统
公开(公告)号：US07335897B2
公开(公告)日：2008-02-26
申请号：US11090455
申请日：2005-03-25
申请人： Zoltán Takáts , Bogdan Gologan , Justin Michael Wiseman , Robert Graham Cooks
发明人： Zoltán Takáts , Bogdan Gologan , Justin Michael Wiseman , Robert Graham Cooks
IPC分类号： H01J27/00 , H01J49/10
CPC分类号： H01J49/142 , H01J49/0004 , H01J49/0404
摘要： A new method and system for desorption ionization is described and applied to the ionization of various compounds, including peptides and proteins present on metal, polymer, and mineral surfaces. Desorption electrospray ionization (DESI) is carried out by directing charged droplets and/or ions of a liquid onto the surface to be analyzed. The impact of the charged particles on the surface produces gaseous ions of material originally present on the surface. The resulting mass spectra are similar to normal ESI mass spectra in that they show mainly singly or multiply charged molecular ions of the analytes. The DESI phenomenon was observed both in the case of conductive and insulator surfaces and for compounds ranging from nonpolar small molecules such as lycopene, the alkaloid coniceine, and small drugs, through polar compounds such as peptides and proteins. Changes in the solution that is sprayed can be used to selectively ionize particular compounds, including those in biological matrices. In vivo analysis is demonstrated.
摘要翻译：一种解吸电离的新方法和系统被描述和应用于各种化合物的电离，包括存在于金属，聚合物和矿物表面上的肽和蛋白质。通过将液体的带电液滴和/或离子引导到要分析的表面上来进行解吸电喷雾离子化（DESI）。带电粒子对表面的影响产生了最初存在于表面上的材料的气态离子。所得质谱与正常的ESI质谱相似，因为它们主要表现出分析物的单一或多重带电分子离子。在导电性和绝缘体表面以及通过极性化合物如肽和蛋白质从非极性小分子（如番茄红素，生物碱美西汀和小药物）的化合物观察到DESI现象。喷雾溶液中的变化可用于选择性地电离特定化合物，包括生物基质中的化合物。证明体内分析。

3. 发明授权

US07015466B2 Electrosonic spray ionization method and device for the atmospheric ionization of molecules 有权
标题翻译：电喷雾电离法和分子大气电离装置
公开(公告)号：US07015466B2
公开(公告)日：2006-03-21
申请号：US10888869
申请日：2004-07-09
申请人： Zoltán Takáts , Robert G. Cooks
发明人： Zoltán Takáts , Robert G. Cooks
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/167 , B05B5/03
摘要： There is described a device and method for generating gaseous ions of a sample material such as molecules in solution at atmospheric pressure. The device includes a conduit for receiving a solution containing the material to be ionized and form a stream. A jet of gas at supersonic velocity is directed at the stream and interacts therewith. Droplets are formed and by the adiabatic expansion of the gas and vigorous evaporation of the solution gaseous ions are generated. In the method a stream of the sample solution is delivered from a conduit with an electric potential. A gas jet at supersonic velocity interacts with the delivered solution and through the action of adiabatic expansion of the gas and evaporation of the solution gaseous ions are formed.
摘要翻译：描述了用于产生样品材料的气体离子的装置和方法，例如在大气压下溶液中的分子。该装置包括用于接收含有待离子化材料并形成流的溶液的导管。超声速度的气体射流指向流并与其相互作用。形成液滴，并且通过气体的绝热膨胀和溶液的剧烈蒸发产生气态离子。在该方法中，样品溶液的流从具有电位的导管输送。超音速的气体射流与输送的溶液相互作用，并且通过气体的绝热膨胀的作用和溶液的蒸发形成气态离子。

4. 发明申请

US20090302211A1 METHOD AND DEVICE FOR DESORPTION IONIZATION BY LIQUID JET 有权
标题翻译：用液体喷射引发离子化的方法和装置
公开(公告)号：US20090302211A1
公开(公告)日：2009-12-10
申请号：US12302819
申请日：2007-05-31
申请人： Zoltán Takáts
发明人： Zoltán Takáts
IPC分类号： H01J49/26 , C12Q1/24
CPC分类号： G01N27/62 , G01N1/286 , G01N27/628 , H01J49/0463 , H01J49/142
摘要： The invention relates to method and apparatus for production of gaseous ions from components of a condensed phase sample and analysis thereof, wherein one or more liquid jet(s) is/are directed to the surface of the sample to be investigated, where the impact of the liquid jet on the sample surface produces droplets carrying sample particles which are turned into gaseous ions via the evaporation of liquid or, if desired, by a subsequent ionization after the evaporation and the obtained sample particles are analyzed by a known method.
摘要翻译：本发明涉及用于从冷凝相样品的组分生产气态离子的方法和装置及其分析，其中一个或多个液体射流被引导到待研究样品的表面，其中影响样品表面上的液体射流产生载有样品颗粒的液滴，其通过液体的蒸发而变成气态离子，或者如果需要，通过蒸发后的电离，并且通过已知方法分析所获得的样品颗粒。

5. 发明申请

US20130224785A1 METHOD AND DEVICE FOR DESORPTION IONIZATION 有权
标题翻译：用于解吸离子化的方法和装置
公开(公告)号：US20130224785A1
公开(公告)日：2013-08-29
申请号：US13680329
申请日：2012-11-19
申请人： Zoltán Takáts
发明人： Zoltán Takáts
IPC分类号： G01N27/62
CPC分类号： G01N27/62 , G01N1/286 , G01N27/628 , H01J49/0463 , H01J49/142
摘要： The invention relates to method and apparatus for production of gaseous ions from components of a condensed phase sample and analysis thereof, wherein one or more liquid jet(s) is/are directed to the surface of the sample to be investigated, where the impact of the liquid jet on the sample surface produces droplets carrying sample particles which are turned into gaseous ions via the evaporation of liquid or, if desired, by a subsequent ionization after the evaporation and the obtained sample particles are analyzed by a known method.
摘要翻译：本发明涉及用于从冷凝相样品的组分生产气态离子的方法和装置及其分析，其中一个或多个液体射流被引导到待研究样品的表面，其中影响样品表面上的液体射流产生载有样品颗粒的液滴，其通过液体的蒸发而变成气态离子，或者如果需要，通过蒸发后的电离，并且通过已知方法分析所获得的样品颗粒。

6. 发明授权

US08314382B2 Method and device for desorption ionization by liquid jet 有权
标题翻译：液体射流解吸电离的方法和装置
公开(公告)号：US08314382B2
公开(公告)日：2012-11-20
申请号：US12302819
申请日：2007-05-31
申请人： Zoltán Takáts
发明人： Zoltán Takáts
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： G01N27/62 , G01N1/286 , G01N27/628 , H01J49/0463 , H01J49/142
摘要： The invention relates to method and apparatus for production of gaseous ions from components of a condensed phase sample and analysis thereof, wherein one or more liquid jet(s) is/are directed to the surface of the sample to be investigated, where the impact of the liquid jet on the sample surface produces droplets carrying sample particles which are turned into gaseous ions via the evaporation of liquid or, if desired, by a subsequent ionization after the evaporation and the obtained sample particles are analyzed by a known method.
摘要翻译：本发明涉及用于从冷凝相样品的组分生产气态离子的方法和装置及其分析，其中一个或多个液体射流被引导到待研究样品的表面，其中影响样品表面上的液体射流产生载有样品颗粒的液滴，其通过液体的蒸发而变成气态离子，或者如果需要，通过蒸发后的电离，并且通过已知方法分析所获得的样品颗粒。

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