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1. 发明授权

US08846334B2 Detection of acid-producing bacteria 有权
标题翻译：检测产酸菌
公开(公告)号：US08846334B2
公开(公告)日：2014-09-30
申请号：US13377952
申请日：2010-06-15
申请人： Robert F. Young , Patrick A. Mach , Michael E. Hughes , Christine A. Binsfeld , Jason W. Bjork , Mara S. Reif-Wenner , Henry J. Lubrant
发明人： Robert F. Young , Patrick A. Mach , Michael E. Hughes , Christine A. Binsfeld , Jason W. Bjork , Mara S. Reif-Wenner , Henry J. Lubrant
IPC分类号： C12Q1/04 , C12Q1/02 , C12Q1/06 , C12N1/20 , C12N1/38 , C12N1/00 , C12N1/36 , G01N33/84
CPC分类号： C12Q1/04 , C12M23/04 , C12M23/20 , C12M23/34 , C12M25/06 , C12M41/36
摘要： The disclosure provides culture devices and methods useful for detecting acid-producing bacteria in a sample. The devices include a nutrient medium and a pH indicator to detect and differentiate acid-producing microorganisms, such as lactic acid bacteria. Methods of use include detecting or enumerating acid-producing microorganisms. The methods further provide for the detection of gas-producing acid-producing bacteria.
摘要翻译：本公开提供了用于检测样品中产酸细菌的培养装置和方法。该装置包括营养培养基和pH指示剂以检测和分解产酸微生物如乳酸菌。使用方法包括检测或列举产酸微生物。该方法进一步提供产气产酸细菌的检测。

2. 发明申请

US20120094327A1 DETECTION OF ACID-PRODUCING BACTERIA 有权
标题翻译：检测产酸菌
公开(公告)号：US20120094327A1
公开(公告)日：2012-04-19
申请号：US13377952
申请日：2010-06-15
申请人： Robert F. Young , Patrick A. Mach , Michael E. Hughes , Christine A. Binsfeld , Jason W. Bjork , Mara S. Reif-Wenner , Henry J. Lubrant
发明人： Robert F. Young , Patrick A. Mach , Michael E. Hughes , Christine A. Binsfeld , Jason W. Bjork , Mara S. Reif-Wenner , Henry J. Lubrant
IPC分类号： C12Q1/04 , C12Q1/06
CPC分类号： C12Q1/04 , C12M23/04 , C12M23/20 , C12M23/34 , C12M25/06 , C12M41/36
摘要： The disclosure provides culture devices and methods useful for detecting acid-producing bacteria in a sample. The devices include a nutrient medium and a pH indicator to detect and differentiate acid-producing microorganisms, such as lactic acid bacteria. Methods of use include detecting or enumerating acid-producing microorganisms. The methods further provide for the detection of gas-producing acid-producing bacteria.
摘要翻译：本公开提供了用于检测样品中产酸细菌的培养装置和方法。该装置包括营养培养基和pH指示剂以检测和分解产酸微生物如乳酸菌。使用方法包括检测或列举产酸微生物。该方法进一步提供产气产酸细菌的检测。

3. 发明申请

US20100129837A1 METHODS OF CAPTURING BACTERIAL WHOLE CELLS AND METHODS OF ANALYZING SAMPLES FOR BACTERIA 审中-公开
标题翻译：细菌感染细菌的方法及细菌分析方法
公开(公告)号：US20100129837A1
公开(公告)日：2010-05-27
申请号：US12515779
申请日：2007-11-20
申请人： Patrick A. Mach , Sridhar V. Dasaratha , Jason W. Bjork , Mara S. Reif-Wenner , Chunmei Guo , Heather M. Webb , G. Marco Bommarito , Brinda B. Badri , Jörg Siekmöller
发明人： Patrick A. Mach , Sridhar V. Dasaratha , Jason W. Bjork , Mara S. Reif-Wenner , Chunmei Guo , Heather M. Webb , G. Marco Bommarito , Brinda B. Badri , Jörg Siekmöller
IPC分类号： G01N33/569 , G01N33/53
CPC分类号： G01N33/56911 , G01N33/54326 , G01N33/56938
摘要： In certain embodiments, the invention relates to methods of capturing bacterial whole cells that includes the use of two or more antibodies having antigenic specificities for two or more distinct analytes characteristic of the specific bacterium. In certain embodiments, the invention relates to methods of analyzing a sample for a bacterium of interest. In particular, the methods are useful for detecting one or more analytes characteristic of a bacterium of interest, such as components of cell walls that are characteristic of a bacterium, particularly Staphylococcus aureus.
摘要翻译：在某些实施方案中，本发明涉及捕获细菌全细胞的方法，所述方法包括使用具有针对特定细菌特征性的两种或更多种不同分析物的抗原特异性的两种或更多种抗体。在某些实施方案中，本发明涉及分析感兴趣的细菌的样品的方法。特别地，所述方法可用于检测感兴趣的细菌特征性的一种或多种分析物，例如细菌特征的细胞壁的组分，特别是金黄色葡萄球菌。

4. 发明申请

US20110177523A1 METHODS OF ANALYZING SAMPLES FOR BACTERIA USING WHOLE CELL CAPTURE AND ATP ANALYSIS 审中-公开
标题翻译：使用全细胞捕获和ATP分析分析细菌样品的方法
公开(公告)号：US20110177523A1
公开(公告)日：2011-07-21
申请号：US12867317
申请日：2009-02-19
申请人： G. Marco Bommarito , Joseph J. Stoffel , Sridhar V. Dasaratha , Jason W. Bjork , Patrick A. Mach , Mara S. Reif-Wenner , Chunmet Guo , Heather M. Webb
发明人： G. Marco Bommarito , Joseph J. Stoffel , Sridhar V. Dasaratha , Jason W. Bjork , Patrick A. Mach , Mara S. Reif-Wenner , Chunmet Guo , Heather M. Webb
IPC分类号： G01N33/53
CPC分类号： G01N33/56938 , G01N33/5735
摘要： The invention relates to methods of capturing bacterial whole cells that includes the use of one or more antibodies having antigenic specificities for one or more distinct analytes characteristic of the specific bacterium, followed by analyzing the target whole cells using a direct or indirect ATP assay.
摘要翻译：本发明涉及捕获细菌全细胞的方法，其包括使用一种或多种具有抗原特异性的特异性特征的一种或多种不同分析物的抗体，然后使用直接或间接ATP测定法分析目标全细胞。

5. 发明申请

US20130266955A1 EFFERVESCENT COMPOSITIONS AND USES THEREOF 有权
标题翻译：有效的组合物及其用途
公开(公告)号：US20130266955A1
公开(公告)日：2013-10-10
申请号：US13989922
申请日：2011-12-22
申请人： Wensheng Xia , Patrick A. Mach , Joseph M. Beaurline , Jason W. Bjork , Jie J. Liu
发明人： Wensheng Xia , Patrick A. Mach , Joseph M. Beaurline , Jason W. Bjork , Jie J. Liu
IPC分类号： C12Q1/04
CPC分类号： C12Q1/045 , C12N1/14 , C12N1/20 , C12N1/38 , C12Q1/04 , C12Q1/689
摘要： A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
摘要翻译：公开了包含选择剂的潜伏泡腾体。还公开了在选择性富集目标微生物的方法中使用潜在泡腾体的方法。该方法包括提供样品，培养基和潜在泡腾体。该方法还包括使样品，培养基和潜在泡腾体在有助于靶微生物生长的条件下接触。该方法还包括从潜在泡腾体释放选择剂。任选地，该方法包括检测微生物。

6. 发明授权

US09243279B2 Effervescent compositions and uses thereof 有权
标题翻译：泡腾组合物及其用途
公开(公告)号：US09243279B2
公开(公告)日：2016-01-26
申请号：US13989922
申请日：2011-12-22
申请人： Wensheng Xia , Patrick A. Mach , Joseph M. Beaurline , Jason W. Bjork , Jie J. Liu
发明人： Wensheng Xia , Patrick A. Mach , Joseph M. Beaurline , Jason W. Bjork , Jie J. Liu
IPC分类号： C12Q1/04 , C12N1/14 , C12N1/20
CPC分类号： C12Q1/045 , C12N1/14 , C12N1/20 , C12N1/38 , C12Q1/04 , C12Q1/689
摘要： A latent effervescent body comprising a selective agent is disclosed. A method of using the latent effervescent body in a method to selectively enrich a target microorganism is also disclosed. The method comprises providing a sample, a culture medium, and the latent effervescent body. The method further comprises contacting the sample, the culture medium, and the latent effervescent body under conditions to facilitate growth of the target microorganism. The method further comprises releasing the selective agent from the latent effervescent body. Optionally, the method includes detecting a microorganism.
摘要翻译：公开了包含选择剂的潜伏泡腾体。还公开了在选择性富集目标微生物的方法中使用潜在泡腾体的方法。该方法包括提供样品，培养基和潜在泡腾体。该方法还包括使样品，培养基和潜在泡腾体在有助于靶微生物生长的条件下接触。该方法还包括从潜在泡腾体释放选择剂。任选地，该方法包括检测微生物。

7. 发明申请

US20140174258A1 CAP HANDLING TOOLS AND METHODS OF USE 有权
标题翻译： CAP处理工具和使用方法
公开(公告)号：US20140174258A1
公开(公告)日：2014-06-26
申请号：US14234743
申请日：2012-08-02
申请人： Cheryl A. Bartholomew , Jason W. Bjork , Neil Percy , Gregorey W. Sitton
发明人： Cheryl A. Bartholomew , Jason W. Bjork , Neil Percy , Gregorey W. Sitton
IPC分类号： B67B7/02 , B67B1/04 , B01L9/00
CPC分类号： B67B7/02 , B01L3/50853 , B01L3/50855 , B01L9/00 , B01L99/00 , B25B33/00 , B67B1/045
摘要： Tools (100) are provided for use in uncapping one or more of a plurality of linearly-oriented, spaced-apart tubes; each cap having a cap upper surface with a depression. The tools comprise a body (30) having first portion (40) for engagement by a user and a second portion (50) for engaging a plurality of caps. The second portion comprises a plurality of spaced-apart projections (60). Each projection is configured for releasably engaging a cap. The projection may comprise two or more spaced-apart projection elements (62,64). Optionally, the first portion is configured in a non-coplanar relationship with respect to the second portion. Methods of use are also provided.
摘要翻译：工具（100）被提供用于打开多个线性取向的间隔开的管中的一个或多个管; 每个盖具有带有凹陷的盖上表面。工具包括具有用于与使用者接合的第一部分（40）和用于接合多个盖的第二部分（50）的主体（30）。第二部分包括多个间隔开的突起（60）。每个突起构造成可释放地接合盖。突起可以包括两个或更多个间隔开的投影元件（62,64）。可选地，第一部分被配置为相对于第二部分的非共面关系。还提供了使用方法。

8. 发明申请

US20130230876A1 METHODS AND COMPOSITIONS TO DETECT A BIOLOGICAL ACTIVITY 有权
标题翻译：检测生物活性的方法和组合物
公开(公告)号：US20130230876A1
公开(公告)日：2013-09-05
申请号：US13883620
申请日：2011-10-28
申请人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
发明人： Stephen B. Roscoe , Kurt J. Halverson , Jesse D. Miller , Stephanie J. Moeller , Jason W. Bjork
IPC分类号： G01N21/64
CPC分类号： G01N21/6486 , C12Q1/04
摘要： Compositions that comprise water, a first indicator reagent that can be converted by a first biological activity to a first biological derivative, and a plurality of particles are provided. The first indicator reagent can comprise a fluorogenic enzyme substrate having a fluorophore selected from the group consisting of umbelliferone, 7-aminocoumarin, β-naphthylamine, β-naphthol, fluorescein, resorufin, 9H-(1,3-dichloro-9,9-dimethyl acridin-2-one), rhodamine 110, a derivative of any of the foregoing fluorophores, and a combination of any of the foregoing fluorophores. The particles are capable of receiving and retaining the first biological derivative from an aqueous liquid. The first biological derivative can be indicative of a microorganism. The compositions further can comprise a gelling agent. Methods of using the compositions to detect the presence or absence of a microorganism in a sample are also provided.
摘要翻译：提供了包含水，可以通过第一生物活性转化为第一生物衍生物的第一指示剂试剂和多个颗粒的组合物。第一指示剂可以包括具有选自伞形酮，7-氨基香豆素，β-萘胺，β-萘酚，荧光素，再次吸收的9H-（1,3-二氯-9,9-四氢 - 二甲基吖啶-2-酮），罗丹明110，任何前述荧光团的衍生物，以及任何上述荧光团的组合。颗粒能够从水性液体中接收和保留第一生物衍生物。第一种生物衍生物可以指示微生物。组合物还可以包含胶凝剂。还提供了使用组合物来检测样品中微生物的存在或不存在的方法。

9. 发明申请

US20100151553A1 METHOD OF DETECTION OF BIOANALYTES BY ACOUSTO-MECHANICAL DETECTION SYSTEMS COMPRISING THE ADDITION OF LIPOSOMES 审中-公开
标题翻译：通过包含脂质体添加剂的机械检测系统检测生物质的方法
公开(公告)号：US20100151553A1
公开(公告)日：2010-06-17
申请号：US12521611
申请日：2007-12-28
申请人： Jason W. Bjork , Samuel J. Gason , Michael C. Palazzotto , Stephen B. Roscoe
发明人： Jason W. Bjork , Samuel J. Gason , Michael C. Palazzotto , Stephen B. Roscoe
IPC分类号： C12N13/00
CPC分类号： G01N33/54373 , G01N29/022 , G01N29/30 , G01N2291/0255 , G01N2291/0256 , G01N2291/0422 , G01N2291/0423
摘要： Methods for detecting target biological analytes within sample material using acousto-mechanical energy generated by a sensor are disclosed. The acousto-mechanical energy may be provided using an acousto-mechanical sensor, e.g., a surface acoustic wave sensor such as, e.g., a shear horizontal surface acoustic wave sensor (e.g., a LSH-SAW sensor). The detection of the target biological analytes in sample material are enhanced by contacting the target biological analyte and/or the sensor surface with liposomes that amplify the sensor sensitivity by (1) modifying the rheological properties of the fluid near the sensor surface; (2) changing the mass attached to the surface; and/or (3) modifying the dielectric properties of the fluid near the sensor surface, the sensor surface itself and/or any intervening layers on the sensor surface.
摘要翻译：公开了使用由传感器产生的声 - 机械能来检测样品材料内的目标生物分析物的方法。声机械能可以使用诸如例如剪切水平声表面波传感器（例如LSH-SAW传感器）的表面声波传感器的声 - 机械传感器来提供。通过使目标生物分析物和/或传感器表面与通过（1）修改传感器表面附近的流体的流变特性来扩大传感器灵敏度的脂质体接触来增强样品材料中目标生物分析物的检测; （2）改变附着在表面上的质量; 和/或（3）修改传感器表面附近的流体的介电特性，传感器表面本身和/或传感器表面上的任何中间层。

10. 发明授权

US09434975B2 Fluorogenic or fluorophoric compounds and uses thereof 有权
标题翻译：荧光或荧光化合物及其用途
公开(公告)号：US09434975B2
公开(公告)日：2016-09-06
申请号：US14008905
申请日：2012-03-05
申请人： Stephen B. Roscoe , Shih-Hung Chou , Stephanie J. Moeller , Jesse D. Miller , Kurt J. Halverson , Jason W. Bjork
发明人： Stephen B. Roscoe , Shih-Hung Chou , Stephanie J. Moeller , Jesse D. Miller , Kurt J. Halverson , Jason W. Bjork
IPC分类号： C12Q1/04 , C07D311/16 , C07D405/04 , C07D409/04 , C07H17/075 , G01N33/52 , G01N33/58
CPC分类号： C12Q1/04 , C07D311/16 , C07D405/04 , C07D409/04 , C07H17/075 , C09B57/02 , C12Q1/045 , G01N33/525 , G01N33/582
摘要： Compounds are provided that are either fluorogenic or fluorophoric. Compositions and articles that include the compounds are also provided. Additionally, methods of detecting a microorganism using the compounds are provided. The compounds are fluorinated and can be used advantageously under acidic conditions.
摘要翻译：提供了荧光或荧光的化合物。还提供了包含化合物的组合物和制品。另外，提供使用该化合物检测微生物的方法。化合物是氟化的，并且可以在酸性条件下有利地使用。

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