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1. 发明授权

US5202309A Antibiotic cyclopeptide fermentation product 失效
标题翻译：抗生素环肽发酵产品
公开(公告)号：US5202309A
公开(公告)日：1993-04-13
申请号：US749633
申请日：1991-08-19
申请人： Robert E. Schwartz , Jerrold M. Liesch , Raymond F. White , Otto D. Hensens , Henry Joshua , Dennis M. Schmatz
发明人： Robert E. Schwartz , Jerrold M. Liesch , Raymond F. White , Otto D. Hensens , Henry Joshua , Dennis M. Schmatz
IPC分类号： A61K38/00 , C07K7/56
CPC分类号： C07K7/56 , A61K38/00
摘要： An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.
摘要翻译：描述了通过培养作为对人类病原体具有非常高的活性且具有非常低的哺乳动物毒性的环状脂肽的Zalerion arboricola产生的抗生素。还描述了其生产和分离。

2. 发明授权

US5064856A Novel HMG-CoA synthase inhibitors 失效
标题翻译：新型HMG-COA合成酶抑制剂
公开(公告)号：US5064856A
公开(公告)日：1991-11-12
申请号：US387668
申请日：1989-07-31
申请人： George M. Garrity , Robert Giacobbe , Michael D. Greenspan , Otto D. Hensens , Henry Joshua , Maria T. D. Matas , Isabel Martin , James A. Milligan , Sagrario M. del Val , Walter Rozdilsky , Janet C. Onishi , Jerrold M. Liesch
发明人： George M. Garrity , Robert Giacobbe , Michael D. Greenspan , Otto D. Hensens , Henry Joshua , Maria T. D. Matas , Isabel Martin , James A. Milligan , Sagrario M. del Val , Walter Rozdilsky , Janet C. Onishi , Jerrold M. Liesch
IPC分类号： C12P17/02 , A61K31/34 , A61K31/365 , A61P3/06 , C07D303/40 , C07D493/10 , C07D493/20 , C12N1/14 , C12N9/99 , C12P17/18 , C12R1/00 , C12R1/645
CPC分类号： C07D493/10 , C07D303/40
摘要： Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity. ##STR1##

3. 发明授权

US5021453A 3-keto HMG-CoA reductase inhibitors 失效
标题翻译： 3-keto HMG-CoA还原酶抑制剂
公开(公告)号：US5021453A
公开(公告)日：1991-06-04
申请号：US533745
申请日：1990-06-06
申请人： Henry Joshua , Kenneth E. Wilson , Michael S. Schwartz , Ta J. Lee , Gerald E. Stokker
发明人： Henry Joshua , Kenneth E. Wilson , Michael S. Schwartz , Ta J. Lee , Gerald E. Stokker
IPC分类号： C07C59/90 , C07C69/738 , C07D309/30 , C07F7/18 , C12P7/62 , C12P17/06
CPC分类号： C07F7/1856 , C07C59/90 , C07C69/738 , C07D309/30 , C12P17/06 , C12P7/62 , Y10S514/824
摘要： Compounds of formula (I) and (II): ##STR1## are HMG-CoA reductase inhibitors.
摘要翻译：式（I）和（II）的化合物：HMG-CoA还原酶抑制剂。

4. 发明授权

US5262435A Cholesterol lowering compounds 失效
标题翻译：胆固醇降低化合物
公开(公告)号：US5262435A
公开(公告)日：1993-11-16
申请号：US833282
申请日：1992-02-10
申请人： Henry Joshua , Guy H. Harris
发明人： Henry Joshua , Guy H. Harris
IPC分类号： C07D493/08 , A61K31/335 , C07D319/08
CPC分类号： C07D493/08
摘要： A new Zaragozic acid analog has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
摘要翻译：已经从MF5453的培养物中分离出新的萨拉哥孜酸类似物。该化合物及其衍生物作为角鲨烯合成酶抑制剂是有活性的，可用于治疗高胆固醇血症。

5. 发明授权

US4714711A 6-hydroxy-2(2-hydroxy-4-methoxyphenyl)benzofuran derivatives to inhibit leukotriene biosynthesis 失效
标题翻译： 6-羟基-2-（2-羟基-4-甲氧基苯基）苯并呋喃衍生物以抑制白细胞三烯生物合成
公开(公告)号：US4714711A
公开(公告)日：1987-12-22
申请号：US927200
申请日：1986-11-05
申请人： Douglas K. Miller , Henry Joshua
发明人： Douglas K. Miller , Henry Joshua
IPC分类号： A61K31/34 , A61K31/36
CPC分类号： A61K31/34
摘要： 6-Hydroxy-2-(2-hydroxy-4-methoxyphenyl)benzofuran derivatives and related pharmaceutical compositions and methods of treatment are disclosed. The compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, they are useful therapuetic agents for treating allergic conditions, asthma, cardiovascular disorders and inflammation.
摘要翻译：公开了6-羟基-2-（2-羟基-4-甲氧基苯基）苯并呋喃衍生物及相关药物组合物和治疗方法。该化合物可用作哺乳动物白三烯生物合成的抑制剂。因此，它们是治疗过敏性疾病，哮喘，心血管疾病和炎症的有用的治疗剂。

6. 发明授权

US4966695A High pressure liquid chromatography column jacket 失效
标题翻译：高压液相色谱柱套
公开(公告)号：US4966695A
公开(公告)日：1990-10-30
申请号：US346782
申请日：1989-05-03
申请人： Henry Joshua
发明人： Henry Joshua
IPC分类号： B01D15/08 , G01N30/30 , G01N30/36 , G01N30/60
CPC分类号： B01D15/22 , G01N30/30 , G01N30/36 , G01N30/6047 , G01N30/6026 , G01N30/6082
摘要： A high pressure liquid chromatography jacket includes a rectangular, fluid-tight enclosure which has a removable cover on which a pair of tubing seal fittings are mounted. The fittings form a fluid-tight seal around the inlet and discharge tubes of a chromatographic column which is mounted in the enclosure. The enclosure is connected to a source of temperature controlled fluid which circulates through the enclosure and controls the temperature of the chromatographic column.In an alternative embodiment of the invention, a valve is provided which allows sample materials being loaded to enter a sample storage loop, which is exposed to the temperature controlled fluid. The sample, whose temperature has been controlled by the temperature controlled fluid, is then injected into a chromatographic column under high pressure.
摘要翻译：高压液相色谱夹套包括矩形的流体密封外壳，其具有可移除的盖，一对管密封配件安装在其上。配件在安装在外壳中的色谱柱的入口和放电管周围形成流体密封。外壳连接到温度控制流体源，循环通过外壳并控制色谱柱的温度。在本发明的替代实施例中，提供了一种阀，其允许加载样品材料进入暴露于受温度控制的流体的样品储存环路。然后将其温度由温度控制的流体控制的样品在高压下注入色谱柱。

7. 发明授权

US4523934A Filter-degasser 失效
标题翻译：过滤脱气机
公开(公告)号：US4523934A
公开(公告)日：1985-06-18
申请号：US586664
申请日：1984-03-06
申请人： Henry Joshua
发明人： Henry Joshua
IPC分类号： B01D36/00 , B01D29/00
CPC分类号： B01D36/00
摘要： An all-TEFLON filter-degasser for removing solids and gases from a solvent. The filter-degasser has a filtering portion, a vacuum application portion downstream of the filtering portion, and a solvent bottle connecting portion. The vacuum application portion includes an externally tapered male member, and the solvent bottle connecting portion includes an internally identically tapered female member. The male member can be inserted into and withdrawn from the female member without requiring any relative rotation therebetween, so that the filter-degasser can be connected hermetically airtight to the solvent bottle likewise without any rotation being required therebetween. This abstract is not to be taken either as a complete exposition or as a limitation of the present invention, however, the full nature and extent of the invention being discernible only by reference to and from the entire disclosure.
摘要翻译：全TEFLON过滤器 - 脱气机，用于从溶剂中除去固体和气体。过滤器脱气机具有过滤部分，过滤部分下游的真空施加部分和溶剂瓶连接部分。真空施加部分包括外锥形凸构件，并且溶剂瓶连接部分包括内部相同锥形的阴构件。阳构件可以插入阴构件中并从阴构件中取出，而不需要它们之间的任何相对旋转，使得过滤器脱气器可以气密地连接到溶剂瓶，同时不需要任何旋转。该摘要不应被视为完全阐述或作为本发明的限制，然而，本发明的完整性质和范围仅在参考和从整个公开内容中可以看出。

8. 发明授权

US4420491A Hypocholesteremic fermentation products and process of preparation 失效
标题翻译：低胆固醇发酵产物及其制备方法
公开(公告)号：US4420491A
公开(公告)日：1983-12-13
申请号：US267972
申请日：1981-05-28
申请人： George Albers-Schonberg , Henry Joshua , Maria B. Lopez
发明人： George Albers-Schonberg , Henry Joshua , Maria B. Lopez
IPC分类号： C07D309/30 , C12P7/62 , C12P17/06 , C07C69/28 , A61K31/22 , C07C69/76
CPC分类号： C12P17/06 , C07D309/30 , C12P7/62
摘要： Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
摘要翻译：在培养基中培养属于曲霉属的微生物后分离的物质包括具有以下结构的化合物：II与羧酸的盐和酯一起形成一类高活性的低胆固醇和降血药

9. 发明授权

US4294846A Hypocholesteremic fermentation products and products of preparation 失效
标题翻译：低胆固醇发酵产品及其制备产品
公开(公告)号：US4294846A
公开(公告)日：1981-10-13
申请号：US154157
申请日：1980-05-28
申请人： George Albers-Schonberg , Henry Joshua , Maria B. Lopez
发明人： George Albers-Schonberg , Henry Joshua , Maria B. Lopez
IPC分类号： C07D309/30 , C12P7/62 , C12P17/06 , A61K31/365
CPC分类号： C12P17/06 , C07D309/30 , C12P7/62
摘要： Substances isolated after cultivation of a microorganism belonging to the genus Aspergillus in a culture medium comprise compounds which have structures: ##STR1## Together with salts and esters of the carboxylic acid, these compounds form a class of highly active hypocholesteremic and hypolipemic medicaments.
摘要翻译：在培养基中培养属于曲霉属的微生物后分离的物质包括具有以下结构的化合物：II与羧酸的盐和酯一起形成一类高活性的低胆固醇和降血药

10. 发明授权

US5286895A Cholesterol lowering compounds 失效
标题翻译：胆固醇降低化合物
公开(公告)号：US5286895A
公开(公告)日：1994-02-15
申请号：US987094
申请日：1992-12-07
申请人： Guy H. Harris , Henry Joshua , Deborah L. Zink
发明人： Guy H. Harris , Henry Joshua , Deborah L. Zink
IPC分类号： A61K31/19 , A61K31/22 , A61K31/365 , A61K31/405 , A61K31/455 , A61K31/785 , A61K45/06 , C07C59/48 , C07C69/732 , C07C69/76
CPC分类号： C07C69/732 , A61K31/19 , A61K31/22 , A61K31/365 , A61K31/405 , A61K31/455 , A61K31/785 , A61K45/06 , C07C59/48
摘要： An acyclic tricarboxylic compound has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
摘要翻译：已经从MF5453的培养物中分离出无环三羧酸化合物。该化合物及其衍生物作为角鲨烯合成酶抑制剂是有活性的，可用于治疗高胆固醇血症。

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