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1. 发明授权

US5286895A Cholesterol lowering compounds 失效
标题翻译：胆固醇降低化合物
公开(公告)号：US5286895A
公开(公告)日：1994-02-15
申请号：US987094
申请日：1992-12-07
申请人： Guy H. Harris , Henry Joshua , Deborah L. Zink
发明人： Guy H. Harris , Henry Joshua , Deborah L. Zink
IPC分类号： A61K31/19 , A61K31/22 , A61K31/365 , A61K31/405 , A61K31/455 , A61K31/785 , A61K45/06 , C07C59/48 , C07C69/732 , C07C69/76
CPC分类号： C07C69/732 , A61K31/19 , A61K31/22 , A61K31/365 , A61K31/405 , A61K31/455 , A61K31/785 , A61K45/06 , C07C59/48
摘要： An acyclic tricarboxylic compound has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
摘要翻译：已经从MF5453的培养物中分离出无环三羧酸化合物。该化合物及其衍生物作为角鲨烯合成酶抑制剂是有活性的，可用于治疗高胆固醇血症。

2. 发明授权

US5801172A Antifungal agent from sporomiella minimoides 失效
标题翻译：来自孢子虫的抗真菌剂
公开(公告)号：US5801172A
公开(公告)日：1998-09-01
申请号：US890772
申请日：1997-07-11
申请人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
发明人： Wendy H. Clapp-Shapiro , Bruce W. Burgess , Robert A. Giacobbe , Guy H. Harris , Suzanne Mandala , Jon Polishook , Mark Rattray , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello , Maria Teresa Diez , Isabel Martin , Fernando Pelaez
IPC分类号： A01N43/90 , A01N63/04 , C07K5/097 , C07D471/00 , A01N43/58
CPC分类号： C07K5/0821 , A01N43/90 , A01N63/04
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译：公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。

3. 发明授权

US5686637A Antifungal agent 失效
标题翻译：抗真菌剂
公开(公告)号：US5686637A
公开(公告)日：1997-11-11
申请号：US371171
申请日：1995-01-10
申请人： Gerald F. Bills , James E. Curotto , S. Dreikorn , Robert A. Giacobbe , Guy H. Harris , Suzanne Miller Mandala , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello Arroyo , Fernando Pelaez Perez , Teresa Diez Matas , Francisca Vicente Perez
发明人： Gerald F. Bills , James E. Curotto , S. Dreikorn , Robert A. Giacobbe , Guy H. Harris , Suzanne Miller Mandala , Rosemary A. Thornton , Deborah L. Zink , Angeles Cabello Arroyo , Fernando Pelaez Perez , Teresa Diez Matas , Francisca Vicente Perez
IPC分类号： C07C69/738 , C12P7/64 , C07C59/147
CPC分类号： C12P7/6463 , C07C69/738
摘要： There is disclosed a novel compound having the formula ##STR1## which exhibits antifungal activity.
摘要翻译：公开了具有抗真菌活性的具有式（I）＆lt; IMAGE＆gt;的式的新化合物。

4. 发明授权

US5597806A Antifungal agents 失效
标题翻译：抗真菌剂
公开(公告)号：US5597806A
公开(公告)日：1997-01-28
申请号：US437718
申请日：1995-05-09
申请人： Wendy H. Clapp , Guy H. Harris , Gerald F. Bills , James E. Curotto , Anne W. Dombrowski , Sarah J. Driekorn , Myra B. Kurtz , Maria S. Meinz , Janet C. Onishi , Jon D. Polishook , Stanley L. Streicher , John R. Thompson , Marie Williams , Deborah L. Zink
发明人： Wendy H. Clapp , Guy H. Harris , Gerald F. Bills , James E. Curotto , Anne W. Dombrowski , Sarah J. Driekorn , Myra B. Kurtz , Maria S. Meinz , Janet C. Onishi , Jon D. Polishook , Stanley L. Streicher , John R. Thompson , Marie Williams , Deborah L. Zink
IPC分类号： C07H15/256 , C07J17/00 , C12P19/56 , A61K31/71 , C07J19/00
CPC分类号： C07J17/005 , C07H15/256 , C12P19/56 , Y10S435/822
摘要： There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
摘要翻译：公开了具有抗真菌活性的具有式（I）和（IMA）（II）的式的新化合物。

5. 发明授权

US5972994A Microbial transformation products with antifungal properties 失效
标题翻译：具有抗菌性的微生物转化产物
公开(公告)号：US5972994A
公开(公告)日：1999-10-26
申请号：US47255
申请日：1998-03-24
申请人： Ali Shafiee , Guy H. Harris , Deborah L. Zink , Janet M. Sigmund , Mark J. Rosenbach , Suzanne Miller Mandala
发明人： Ali Shafiee , Guy H. Harris , Deborah L. Zink , Janet M. Sigmund , Mark J. Rosenbach , Suzanne Miller Mandala
IPC分类号： C07D313/00 , A61K31/335
CPC分类号： C07D313/00
摘要： Biotransformation products of a fermentation with Streptomyces sp., (Merck Culture Collection MA7165) ATCC No. 55946 are potent antifungal agents. These products may be useful in the treatment of diseases caused by fungal pathogens such as Candida sp. and Cryptococcus neoformans.
摘要翻译：使用链霉菌属（Merck Culture Collection MA7165）ATCC No.55946的发酵的生物转化产物是有效的抗真菌剂。这些产品可用于治疗由真菌病原体引起的疾病，例如假丝酵母属（Candida sp。）。和新生隐球菌。

6. 发明授权

US5262435A Cholesterol lowering compounds 失效
标题翻译：胆固醇降低化合物
公开(公告)号：US5262435A
公开(公告)日：1993-11-16
申请号：US833282
申请日：1992-02-10
申请人： Henry Joshua , Guy H. Harris
发明人： Henry Joshua , Guy H. Harris
IPC分类号： C07D493/08 , A61K31/335 , C07D319/08
CPC分类号： C07D493/08
摘要： A new Zaragozic acid analog has been isolated from a culture of MF5453. The compound and its derivatives are active as squalene synthetase inhibitors and are useful in the treatment of hypercholesterolemia.
摘要翻译：已经从MF5453的培养物中分离出新的萨拉哥孜酸类似物。该化合物及其衍生物作为角鲨烯合成酶抑制剂是有活性的，可用于治疗高胆固醇血症。

7. 发明授权

US5853571A Pyrite depressant useful in flotation separation 失效
标题翻译：用于浮选分离的黄铁矿抑制剂
公开(公告)号：US5853571A
公开(公告)日：1998-12-29
申请号：US877321
申请日：1997-06-17
申请人： Guy H. Harris , Douglas W. Fuerstenau
发明人： Guy H. Harris , Douglas W. Fuerstenau
IPC分类号： B03D1/012 , B03D1/014 , B03D1/01 , B03D1/06
CPC分类号： B03D1/012 , B03D1/014 , B03D2201/06 , B03D2203/02
摘要： The present invention relates to a process for separating pyrite from sulfide ores and coal during flotation separation which comprises the depressing of pyrite with from about 0.05 to 0.75 kilograms per ton of concentrate solids using a pyrite depressant compounds selected from the group consisting of R1, R2, R3 N.sup.+ O.sub.2 H.sub.4 SR4X.sup.- (I) where R1, R2 and R3 are lower alkyls wherein the final sum of the carbon atoms is in a range of 3 to 6, R4 is selected from a group consisting of hydrogen (H) and amidine and X is chlorine, bromine or iodine, ##STR1## where Ro is a lower alkyl having carbon atoms in a range of 3 to 8 with 3 to 6 being preferred and a final pH in a range of 4 to 9 depending on the ore being processed, and therafter recovering the flotation concentrate thus obtained. As to group (I) compounds, 2-trimethylammonium-ethane isothiuronium dichloride (TMAE) as a pyrite depressant is surprisingly effective in pyrite removal being substantially independent of the pH values of the treated ore or coal, compatible with conventional collector reagents such as xanthates in the case of copper sulfide bearing ores as well as being substantially unobtrusive in not depressing other useful ore sulfides, including but limited to chalcopyrite, bornite chalcosite. Group (II) are more pH sensitive.
摘要翻译：本发明涉及一种在浮选分离过程中从硫化矿石和煤中分离黄铁矿的方法，其中包括使用选自由R1，R2组成的组的黄铁矿抑制剂化合物，每吨浓缩固体用约0.05至0.75千克的黄铁矿压制，R3N + O2H4SR4X-（I）其中R1，R2和R3是低级烷基，其中碳原子的最终总和在3至6的范围内，R4选自氢（H）和脒，以及 X是氯，溴或碘，其中Ro是碳原子在3至8范围内的低级烷基，其中3至6是优选的，最终pH在4至9的范围内，这取决于矿石被处理，并且回收由此获得的浮选精矿。对于（I）族化合物，作为黄铁矿抑制剂的2-三甲基铵 - 乙烷异硫脲二氯化物（TMAE）在黄铁矿去除方面令人惊奇地有效，其实质上与经处理的矿石或煤的pH值无关，与常规的收集剂如黄原酸酯相容在含有硫化铜的矿石的情况下，以及在不抑制其它有用的硫化物（包括但限于黄铜矿，黑曲霉硫化物）基本不引人注目的情况。组（II）对pH敏感。

8. 发明授权

US5441987A Antifungal agent 失效
标题翻译：抗真菌剂
公开(公告)号：US5441987A
公开(公告)日：1995-08-15
申请号：US289863
申请日：1994-08-12
申请人： Guy H. Harris , James E. Curotto , Robert A. Giacobbe , Suzanne M. Mandala , Richard L. Monaghan , Richard K. Jansson , Joan A. Lasota
发明人： Guy H. Harris , James E. Curotto , Robert A. Giacobbe , Suzanne M. Mandala , Richard L. Monaghan , Richard K. Jansson , Joan A. Lasota
IPC分类号： C07C49/733 , A61K31/12
CPC分类号： C07C49/733
摘要： A compound having the formula ##STR1## which is useful as an antifungal agent and for the treatment and control of several agricultural phytopathogens, including Phytophthora infestans, is disclosed.
摘要翻译：公开了具有式（I）的化合物，其可用作抗真菌剂，并用于治疗和控制几种农业植物病原体，包括致病疫霉（Phytophthora infestans）。

9. 发明授权

US4793852A Process for the recovery of non-ferrous metal sulfides 失效
标题翻译：回收有色金属硫化物的方法
公开(公告)号：US4793852A
公开(公告)日：1988-12-27
申请号：US791803
申请日：1985-10-28
申请人： Guy H. Harris , Patrice K. Ackerman , Frank F. Aplan
发明人： Guy H. Harris , Patrice K. Ackerman , Frank F. Aplan
IPC分类号： B03D1/012 , C01G1/12 , C22B1/00
CPC分类号： C01G1/12 , B03D1/012 , B03D2201/02 , B03D2203/02
摘要： This invention relates to a method of recovering non-ferrous metal sulfides from a metal ore which comprises subjecting the metal ore, in the form of an aqueous pulp, to a froth flotation process in the presence of a flotating amount of a flotation collector wherein the collector comprises a compound which corresponds to one of the formulas ##STR1## wherein R.sup.1 is alkyl, aryl or aralkyl group wherein the aryl and aralkyl can be substituted with a halo or alkyl moiety;R.sup.2 is alkyl, aryl or aralkyl group wherein the aryl or aralkyl can be substituted with a halo or alkyl moiety;R.sup.3 is aryl or aralkyl unsubstituted or substituted with a halo or alkyl moiety;R.sup.4 is alkyl, aryl or aralkyl group wherein the aryl or aralkyl can be substituted with a halo or alkyl moiety; with the proviso that at least one of R.sup.1 and R.sup.2 must be aryl or aralkyl unsubstituted or substituted;under conditions such that the metal sulfide values are recovered in the froth.The collectors of this process are useful under alkaline, neutral and acidic conditions. Such collectors give good recoveries of the mineral sulfide values, with a high selectivity toward the non-ferrous metal sulfide values over the ferrous containing minerals.The novel collectors of this invention result in surprisingly high recovery of nonferrous metal values or sulfidized metal oxide values, and a surprisingly high selectivity toward such nonferrous metal values when such metal values are found in the presence of ferrous-containing metal sulfides. These collectors demonstrate good recovery and good kinetics.
摘要翻译：本发明涉及一种从金属矿石中回收有色金属硫化物的方法，该方法包括在浮选量为浮选收集器存在的情况下，以含水纸浆形式的金属矿石进行泡沫浮选工艺，其中，收集器包括对应于下式之一的化合物，其中R 1是烷基，芳基或芳烷基，其中芳基和芳烷基可以被卤素或烷基部分取代; R2是烷基，芳基或芳烷基，其中芳基或芳烷基可以被卤素或烷基部分取代; R3是未被取代或被卤素或烷基部分取代的芳基或芳烷基; R 4是烷基，芳基或芳烷基，其中芳基或芳烷基可以被卤素或烷基部分取代; 条件是R 1和R 2中的至少一个必须是未取代或取代的芳基或芳烷基; 在使得金属硫化物值在泡沫中回收的条件下。该方法的收集器在碱性，中性和酸性条件下是有用的。这种收集器对矿物硫化物值的回收率良好，对含铁矿物的有色金属硫化物值具有很高的选择性。本发明的新型收集器导致有色金属值或硫化金属氧化物值的令人惊讶的高回收率，以及当在含亚铁金属硫化物存在下发现这种金属值时，对这种有色金属值的惊人的高选择性。这些收集者表现出良好的恢复和良好的动力学。

10. 发明授权

US06228622B1 11-hydroxysordarin and a process for producing it using actinomyces SSP 失效
标题翻译： 11-羟基司他林及其使用放线菌SSP生产的方法
公开(公告)号：US06228622B1
公开(公告)日：2001-05-08
申请号：US09427242
申请日：1999-10-26
申请人： Michael G. Sturr , Michel M. Chartrain , Guy H. Harris , Jennifer Nielsen-Kahn , Brian Heimbuch
发明人： Michael G. Sturr , Michel M. Chartrain , Guy H. Harris , Jennifer Nielsen-Kahn , Brian Heimbuch
IPC分类号： C12P1944
CPC分类号： C07D309/10
摘要： 11-hydroxysordarin, biotransformation product of a fermentation with sordarin and Actinomyces spp., (Merck Culture Collection MA7235) ATCC No. 202103 is an antifungal agent. This compound may be useful in the treatment of diseases caused by fungal pathogens such as Candida albicans.
摘要翻译： 11-羟基ys arin素，发酵与sordarin和放线菌属（Merck Culture Collection MA7235）ATCC No. 202103的生物转化产物是抗真菌剂。该化合物可用于治疗由真菌病原体如白色念珠菌引起的疾病。

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