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1. 发明授权

US5609576A Fluid flow impedance monitoring system 失效
标题翻译：流体阻抗监测系统
公开(公告)号：US5609576A
公开(公告)日：1997-03-11
申请号：US305904
申请日：1994-09-13
申请人： Gregory I. Voss , Robert D. Butterfield , Gail D. Baura , Casper W. Barnes
发明人： Gregory I. Voss , Robert D. Butterfield , Gail D. Baura , Casper W. Barnes
IPC分类号： A61M5/00 , A61M5/168 , A61M31/00
CPC分类号： A61M5/16859 , Y10S128/13 , Y10S128/925
摘要： Impedance to fluid flow in a fluid delivery line is measured. Two techniques are used depending on the flow rate selected. For high flow rates, the pump is controlled to vary the flow rate and the change in pressure is divided by the change in flow to directly determine the resistance. For low flow rates, a processor controls the pump to pump flow quantities in accordance with a pseudo-random binary code. The resulting pressure signal sensed at the conduit is decoded in accordance with that code. Pressures received during code periods of no flow are subtracted from pressures received during code periods of flow. Pressure offset is also removed and a least squares estimation approach is used with a linear prediction model to determine impedance. The coefficients determined in the model are used to calculate the resistance to fluid flow of the system. A quality supervisor monitors the resistance determination process and controls the display of resistance depending on the quality determined. A resistance display continuously displays the resistance of the system.
摘要翻译：测量流体输送管线中的流体流动的阻抗。取决于所选择的流量，使用两种技术。对于高流量，泵被控制以改变流量，并且压力变化除以流量的变化以直接确定阻力。对于低流量，处理器根据伪随机二进制码控制泵泵流量。根据该代码对在管道处感测到的压力信号进行解码。在流量代码期间收到的压力中，从无流量代码期间收到的压力减去。还消除了压力偏移，并且使用最小二乘估计方法与线性预测模型来确定阻抗。在模型中确定的系数用于计算系统对流体流动的阻力。质量监督人员监控电阻确定过程，并根据所确定的质量控制电阻显示。电阻显示连续显示系统的电阻。

2. 发明授权

US5716194A System for increasing flow uniformity 失效
标题翻译：增加流动均匀性的系统
公开(公告)号：US5716194A
公开(公告)日：1998-02-10
申请号：US305677
申请日：1994-09-12
申请人： Robert D. Butterfield , Gregory I. Voss
发明人： Robert D. Butterfield , Gregory I. Voss
IPC分类号： A61M5/168 , F04B43/08 , F04B43/12 , F04B49/06 , F04B49/00
CPC分类号： F04B43/082 , A61M5/16831 , F04B49/065 , F04B2203/0213
摘要： A pumping mechanism moving in movement increments is controlled to space those movement increments in direct proportion to the volume resulting from each movement increment. In a further aspect, movement increments are grouped to result in approximately equal volumes per group. The mechanism moves continuously through the movement increments in each group. Groups are spaced to result in approximately equal flow volumes per group. The number of groups decreases as the flow rate increases. The number of movement increments in each group and the volume of each group increase as the flow rate increases.
摘要翻译：控制以移动增量移动的抽吸机构，以便将这些运动增量与每个运动增量产生的体积成比例地放置。在另一方面，运动增量被分组以导致每组大致相等的体积。机构通过每组运动增量连续移动。组间隔以导致每组大致相等的流量。随着流量的增加，组数减少。每组中运动增量的数量和每组的体积随着流量的增加而增加。

3. 发明授权

US07955267B2 Apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的装置
公开(公告)号：US07955267B2
公开(公告)日：2011-06-07
申请号：US11300019
申请日：2005-12-13
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

4. 发明授权

US08597195B2 Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics 失效
公开(公告)号：US08597195B2
公开(公告)日：2013-12-03
申请号：US12987928
申请日：2011-01-10
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.

5. 发明申请

US20100049023A1 Non-invasive method and system for determining physiological characteristics 审中-公开
标题翻译：用于确定生理特征的非侵入性方法和系统
公开(公告)号：US20100049023A1
公开(公告)日：2010-02-25
申请号：US12229158
申请日：2008-08-20
申请人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
发明人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
IPC分类号： A61B5/1491
CPC分类号： A61B5/6816 , A61B5/14551 , A61B5/6826 , A61B5/6838
摘要： A non-invasive method of determining a physiological characteristic, comprising providing at least one physiological sensor that is adapted to measure at least one physiological characteristic at a target measurement site on a subject's body, heating an extended tissue region on the subject's body, whereby blood perfusion of the tissue region is enhanced, and measuring at least one physiological characteristic with the physiological sensor during or within a predetermined period after heating the extended tissue region.
摘要翻译：一种确定生理特征的非侵入性方法，包括提供至少一个生理传感器，其适于测量受试者身体上的目标测量部位上的至少一种生理特征，加热受试者身体上延伸的组织区域，由此血液增强组织区域的灌注，并且在加热延伸的组织区域之后或期间的预定时间段内测量与生理传感器的至少一个生理特征。

6. 发明授权

US08945016B2 Methods and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US08945016B2
公开(公告)日：2015-02-03
申请号：US13154315
申请日：2011-06-06
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02 , A61B5/022 , A61B5/00
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

7. 发明申请

US20110166458A1 METHOD AND APPARATUS FOR NON-INVASIVELY MEASURING HEMODYNAMIC PARAMETERS USING PARAMETRICS 失效
标题翻译：使用参数非自主测量血液动力学参数的方法和装置
公开(公告)号：US20110166458A1
公开(公告)日：2011-07-07
申请号：US12987928
申请日：2011-01-10
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/021
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.
摘要翻译：一种用于非侵入性评估与生物体的循环系统相关联的一个或多个血液动力学参数的改进的方法和装置。在一个方面，本发明包括通过压缩或压缩靠近所关注的血管的组织的部分直到达到所需条件，然后测量血液动力学参数来测量血液动力学参数（例如，动脉血压）的方法。这种扁平化有效地减轻了靠近血管的组织产生的转移和其它损失，从而有助于准确和稳健的测量计量。还描述了适于维持最佳压平水平的算法。还公开了基于受试者生理学来缩放这种血液动力学参数测量以及基于测量参数向对象提供治疗的方法和装置。

8. 发明授权

US07867170B2 Method and apparatus for non-invasively measuring hemodynamic parameters using parametrics 有权
标题翻译：使用参数非侵入性测量血液动力学参数的方法和装置
公开(公告)号：US07867170B2
公开(公告)日：2011-01-11
申请号：US10838404
申请日：2004-05-03
申请人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
发明人： Stuart L. Gallant , Gregory I. Voss , William H. Markle
IPC分类号： A61B5/02
CPC分类号： A61B5/021 , A61B5/6843 , A61B2562/02 , A61B2562/0247 , G06F19/00
摘要： An improved method and apparatus for non-invasively assessing one or more hemodynamic parameters associated with the circulatory system of a living organism. In one aspect, the invention comprises a method of measuring a hemodynamic parameter (e.g., arterial blood pressure) by applanating or compressing portions of tissue proximate to the blood vessel of concern until a desired condition is achieved, and then measuring the hemodynamic parameter. Such applanation effectively mitigates transfer and other losses created by the tissue proximate to the blood vessel, thereby facilitating accurate and robust tonometric measurement. An algorithm adapted to maintain optimal levels of applanation is also described. Methods and apparatus for scaling such hemodynamic parameter measurements based on subject physiology, and providing treatment to the subject based on the measured parameters, are also disclosed.
摘要翻译：一种用于非侵入性评估与生物体的循环系统相关联的一个或多个血液动力学参数的改进的方法和装置。在一个方面，本发明包括通过压缩或压缩靠近所关注的血管的组织的部分直到达到所需条件，然后测量血液动力学参数来测量血液动力学参数（例如，动脉血压）的方法。这种扁平化有效地减轻了靠近血管的组织产生的转移和其它损失，从而有助于准确和稳健的测量计量。还描述了适于维持最佳压平水平的算法。还公开了基于受试者生理学来缩放这种血液动力学参数测量以及基于测量参数向对象提供治疗的方法和装置。

9. 发明申请

US20100152547A1 Method and system for determining cardiac performance 审中-公开
标题翻译：用于确定心脏性能的方法和系统
公开(公告)号：US20100152547A1
公开(公告)日：2010-06-17
申请号：US12459570
申请日：2009-07-02
申请人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
发明人： Bernhard B. Sterling , Andrew R. Lawrence , Gregory I. Voss , James M. Perry , Rankin A. Clinton, III
IPC分类号： A61B5/02
CPC分类号： A61B5/029
摘要： Methods and associated algorithms for determining cardiac and/or cardiovascular performance that are based on at least one cardiac function determinant associated with or at least in part, reflective of preload, contractility and afterload.
摘要翻译：基于与预负荷，收缩性和后负荷相关联或至少部分地反映预负荷，收缩性和后负荷的至少一个心脏功能决定因素来确定心脏和/或心血管性能的方法和相关算法。

10. 发明授权

US06228034B1 Apparatus and method for non-invasively monitoring a subjects arterial blood pressure 失效
标题翻译：非侵入性监测受试者动脉血压的装置和方法
公开(公告)号：US06228034B1
公开(公告)日：2001-05-08
申请号：US09120069
申请日：1998-07-20
申请人： Gregory I. Voss , Alvis J. Somerville , Stephen H. O'Leary
发明人： Gregory I. Voss , Alvis J. Somerville , Stephen H. O'Leary
IPC分类号： A61B502
CPC分类号： A61B5/022
摘要： Apparatus is disclosed for non-invasively monitoring a subject's blood pressure, in which a pressure sensor assembly that includes a pressure transducer is compressed against tissue overlying an artery, with sufficient force to compress the artery. A motor first servo control system optimizes the amount of artery compression, which occurs at a mean transmural pressure of about zero, by modulating one side of a lever arm compressing the assembly against the tissue, creating a pressure signal indicative of transmural pressure. Since different pressure effects are realized according to the amount of artery compression, an appropriate control signal can be produced that provides for a second motor to adjust the other side of the lever arm to provide the optimum compression of the assembly into the tissue overlying the artery. The apparatus is optimally positioned over an artery by including an ultrasonic blood flow sensor configured to sense the flow of blood under the pressure transducer.
摘要翻译：公开了用于非侵入性地监测受试者的血压的装置，其中包括压力换能器的压力传感器组件被压缩在动脉上方的组织上，具有足够的力来压缩动脉。电动机第一伺服控制系统通过调节杠杆臂的一侧压缩组件抵抗组织来优化在平均透壁压力约为零时发生的动脉压缩量，产生指示透壁压的压力信号。由于根据动脉压力的量实现了不同的压力效应，因此可以产生适当的控制信号，其提供第二电动机以调节杠杆臂的另一侧，以将组件的最佳压缩提供到覆盖动脉的组织中。该装置通过包括构造成感测压力传感器下方的血液流动的超声波血流传感器而优选地定位在动脉上。

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