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1. 发明申请

US20110263991A1 METHOD AND APPARATUS FOR CONTROL OF NON-INVASIVE PARAMETER MEASUREMENTS 有权
标题翻译：用于控制非入侵参数测量的方法和装置
公开(公告)号：US20110263991A1
公开(公告)日：2011-10-27
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/021 , A61B5/026 , A61B5/02
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

2. 发明授权

US07291112B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US07291112B2
公开(公告)日：2007-11-06
申请号：US10393660
申请日：2003-03-20
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

3. 发明授权

US06974419B1 Method and apparatus for control of non-invasive parameter measurements 失效
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US06974419B1
公开(公告)日：2005-12-13
申请号：US10211115
申请日：2002-08-01
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

4. 发明授权

US5204914A Character recognition method using optimally weighted correlation 失效
标题翻译：使用最优加权相关的字符识别方法
公开(公告)号：US5204914A
公开(公告)日：1993-04-20
申请号：US753150
申请日：1991-08-30
申请人： James A. Mason , Gregory J. Martin , Robert Y. Chen , John F. Cook
发明人： James A. Mason , Gregory J. Martin , Robert Y. Chen , John F. Cook
IPC分类号： G06K9/64
CPC分类号： G06K9/6202
摘要： A character recognition method comprising the following steps: (1) acquiring a two dimensional array of pixels, (2) locating an unknown character in the two dimensional array, (3) computing weighted correlation coefficients between the unknown character and a trained set of characters (i.e. a font), (4) recognizing the unknown character as the trained character with the highest weighted correlation coefficient above a threshold. The weights in the correlation calculations are adjusted to place more emphasis on those areas of a trained character that distinguishes it from all other trained characters in the training set. A method for optimally adjusting these weights is described herein.
摘要翻译：一种字符识别方法，包括以下步骤：（1）获取像素的二维阵列，（2）在二维阵列中定位未知角色，（3）计算未知字符与经训练的字符集之间的加权相关系数（即字体），（4）将未知字符识别为具有高于阈值的最高加权相关系数的训练角色。调整相关计算中的权重以更加强调训练角色的区域与训练集中的所有其他训练角色的区域。本文描述了用于最佳调节这些权重的方法。

5. 发明授权

US08945016B2 Methods and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US08945016B2
公开(公告)日：2015-02-03
申请号：US13154315
申请日：2011-06-06
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/02 , A61B5/022 , A61B5/00
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进装置，所述装置通常包括压力传感器和与计算机程序相关联的处理器，所述计算机程序定义与感测的压力数据有关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

6. 发明授权

US5159644A Character recognition method using statistically weighted correlation 失效
标题翻译：使用统计加权相关的字符识别方法
公开(公告)号：US5159644A
公开(公告)日：1992-10-27
申请号：US752800
申请日：1991-08-30
申请人： Gregory J. Martin , Robert Y. Chen , John F. Cook , James A. Mason
发明人： Gregory J. Martin , Robert Y. Chen , John F. Cook , James A. Mason
IPC分类号： G06K9/62 , G06K9/64
CPC分类号： G06K9/6202 , G06K9/6217
摘要： A character recognition method comprising the following steps: (1) acquiring a two dimensional array of pixels, (2) locating an unknown character in the two dimensional array, (3) computing statistically weighted correlation coefficients between the unknown character and a trained set of characters (i.e. a font), (4) recognizing the unknown character as the trained character with the highest correlation coefficient above a threshold. The weights in the correlation calculations are adjusted to place more emphasis on those areas of a character that exhibit less noise and less emphasis on those areas of the character that exhibit more noise. A method for determining and using these weights is described herein.
摘要翻译：一种字符识别方法，包括以下步骤：（1）获取像素的二维阵列，（2）在二维阵列中定位未知角色，（3）计算未知字符与训练集合的统计学加权相关系数字符（即字体），（4）将未知字符识别为具有高于阈值的最高相关系数的经训练的字符。调整相关计算中的权重以更加强调那些表现出较小噪音的角色的那些区域，并且较少强调那些表现出更多噪音的角色区域。本文描述了用于确定和使用这些权重的方法。

7. 发明授权

US5150425A Character recognition method using correlation search 失效
标题翻译：使用相关搜索的字符识别方法
公开(公告)号：US5150425A
公开(公告)日：1992-09-22
申请号：US752801
申请日：1991-08-30
申请人： Gregory J. Martin , Robert Y. Chen , John F. Cook , James A. Mason
发明人： Gregory J. Martin , Robert Y. Chen , John F. Cook , James A. Mason
IPC分类号： G06K9/68
CPC分类号： G06K9/68
摘要： A character recognition method comprising the following steps: (1) acquiring a two dimensional array of pixels, (2) locating an unknown character in the two dimensional array, (3) computing correlation coefficients between an unknown character and a trained set of characters (i.e., a font), (4) recognizing the unknown character as the trained character with the highest correlation coefficient above a threshold. The manner in which trained characters are chosen is described herein as a correlation search. Correlation search results in a fast means of correctly classifying an unknown character from a large training set, often on the second or third try, depending on the inner-correlations of the trained characters.
摘要翻译：一种字符识别方法，包括以下步骤：（1）获取像素的二维阵列，（2）在二维阵列中定位未知角色，（3）计算未知字符与经训练的字符集之间的相关系数（即，字体），（4）将未知字符识别为具有高于阈值的最高相关系数的经训练的字符。训练过的字符被选择的方式在本文中被描述为相关搜索。相关搜索结果是根据训练有素的人物的内在相关性，通常在第二或第三尝试中，从一个大的训练集中正确分类一个未知角色的快速手段。

8. 发明授权

US08961426B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US08961426B2
公开(公告)日：2015-02-24
申请号：US13180315
申请日：2011-07-11
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02 , A61B5/00 , A61B5/021
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

9. 发明申请

US20110237961A1 METHODS AND APPARATUS FOR CONTROL OF NON-INVASIVE PARAMETER MEASUREMENTS 有权
标题翻译：用于控制非入侵参数测量的方法和装置
公开(公告)号：US20110237961A1
公开(公告)日：2011-09-29
申请号：US13154315
申请日：2011-06-06
申请人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
发明人： Gregory I. Voss , Gregory J. Martin , Manouchehr Goharlaee
IPC分类号： A61B5/021
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02028 , A61B5/024 , A61B5/684 , A61B5/6843 , A61B5/7203 , A61B5/7207 , A61B5/7264
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.
摘要翻译：用于非侵入性评估与诸如活体的循环系统的流体系统相关联的一个或多个参数的改进的方法和装置。在第一方面，公开了一种从可压缩容器连续测量压力的改进方法，其中使用容器的压缩水平的扰动（例如，调制）来实现和维持容器的基本上最佳的压缩水平。在一个示例性实施例中，根据伪随机二进制序列（PBRS）进行调制。在第二方面，公开了一种用于确定活体的血压的改进的装置，该装置通常包括压力传感器和与计算机程序相关联的处理器，该计算机程序定义与感测的压力数据相关的多个操作状态。还公开了压力波形校正和再吸收的方法以及使用本发明的处理。

10. 发明授权

US07976471B2 Method and apparatus for control of non-invasive parameter measurements 有权
标题翻译：用于控制非侵入性参数测量的方法和装置
公开(公告)号：US07976471B2
公开(公告)日：2011-07-12
申请号：US11982975
申请日：2007-11-05
申请人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
发明人： Gregory J. Martin , Gregory I. Voss , Manouchehr Goharlaee , Stuart L. Gallant , Warren Craycroft
IPC分类号： A61B5/02
CPC分类号： A61B5/721 , A61B5/0048 , A61B5/02007 , A61B5/021 , A61B5/0225 , A61B5/7207 , A61B5/7264 , A61B5/7282 , A61B5/7285
摘要： Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g., occlusive or other), such classification allowing the system to appropriately tailor its response to the event.
摘要翻译：改进的方法和装置，用于非侵入性地评估与流体系统相关联的一个或多个参数，例如活体的循环系统，当这些参数可能受到其他并发事件的影响时。在一个示例性实施例中，公开了用于补偿与参数测量位置同侧出现的闭塞事件（例如，压力袖带充气）的装置和方法。在被动检测由事件导致的信号劣化时，该装置选择性地进入“等待状态”，其中暂停血液动力学数据的进一步处理，直到降解事件消退。该行为减轻了事件可能对由系统产生的测量的血液动力学参数的表示的准确性的任何不利影响。在另一个示例性实施例中，分析测量数据以便将事件的类型（例如，闭塞或其他）分类，允许系统适当地定制其对事件的响应。

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