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1. 发明授权

US07994278B1 Biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) 有权
标题翻译：衍生自命名为雌激素（MA）的新型早期妊娠因子的生物活性多肽
公开(公告)号：US07994278B1
公开(公告)日：2011-08-09
申请号：US09632831
申请日：2000-08-04
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lundardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lundardi-Iskandar
IPC分类号： A61K38/00 , A61K38/04
CPC分类号： C07K16/26 , A61K38/00 , A61K48/00 , C07K14/59 , C07K2319/00
摘要： The invention relates to therapeutic polypeptides isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.
摘要翻译：本发明涉及从人类早孕尿中发现的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽，现在合成产生并命名为Maternin。治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。

2. 发明授权

US5968513A Method of promoting hematopoiesis using derivatives of human chorionic gonadotropin 失效
标题翻译：使用人绒毛膜促性腺激素衍生物促进造血的方法
公开(公告)号：US5968513A
公开(公告)日：1999-10-19
申请号：US709924
申请日：1996-09-09
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A61K38/00 , A61K38/24 , A61K48/00 , A61K38/12 , C07K7/64
CPC分类号： A61K38/24 , A61K48/00 , Y10S514/885
摘要： The present invention relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of human chorionic gonadotropin, .beta.-human chorionic gonadotropin or a peptide containing a sequence of a portion of .beta.-human chorionic gonadotropin. The invention also relates to methods of treating or preventing diseases or disorders associated with hematopoietic deficiency by administration of hematopoietic cells, the numbers of which have been increased by contacting the cells with human chorionic gonadotropin, .beta.-human chorionic gonadotropin or a peptide containing a sequence of a portion of .beta.-human chorionic gonadotropin. The invention also provides assays for the utility of particular human chorionic gonadotropin preparations in the treatment or prevention of hematopoietic deficiencies or in the increasing of hematopoietic cell numbers in vitro. Pharmaceutical compositions and methods of administration of are also provided.
摘要翻译：本发明涉及通过施用人绒毛膜促性腺激素，β-人绒毛膜促性腺激素或含有一部分β-人绒毛膜促性腺激素序列的肽来治疗或预防与造血缺陷相关的疾病或病症的方法。本发明还涉及通过给予造血细胞来治疗或预防与造血缺陷相关的疾病或病症的方法，所述造血细胞的数量通过使细胞与人绒毛膜促性腺激素接触而增加，β-人绒毛膜促性腺激素或含有序列的肽的一部分β-人绒毛膜促性腺激素。本发明还提供特异性人绒毛膜促性腺激素制剂用于治疗或预防造血缺陷或增加体外造血细胞数量的测定。还提供了药物组合物和给药方法。

3. 发明授权

US06699834B1 Method for treating cancer 有权
标题翻译：癌症治疗方法
公开(公告)号：US06699834B1
公开(公告)日：2004-03-02
申请号：US09675362
申请日：2000-09-29
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A01N3718
CPC分类号： C07K14/59
摘要： The present invention relates to peptides of one or more portions of the human chorionic gonadotropin &bgr;-chain as well as methods for treatment of cancer, using human chorionic gonadotropin, employing the &bgr;-chain of human chorionic gonadotropin, peptides containing a sequence of one or more portions of the &bgr;-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or preparations of human chorionic gonadotropin, such as fractions of human early pregnancy urine, which fractions have anti-cancer activity. The present invention further relates to pharmaceutical compositions for treating cancer.
摘要翻译：本发明涉及人绒毛膜促性腺激素β链的一个或多个部分的肽以及使用人绒毛膜促性腺激素治疗癌症的方法，其使用人绒毛膜促性腺激素的β-链，含有一个或多个序列的肽人绒毛膜促性腺激素的β-链的更多部分及其衍生物和类似物。本发明还涉及人类绒毛膜促性腺激素的来源和/或制剂的分数，例如人类早孕尿的部分，其部分具有抗癌活性。本发明还涉及用于治疗癌症的药物组合物。

4. 发明授权

US5997871A Treatment and prevention of cancer by administration of derivatives of human chorionic gonadotropin 失效
标题翻译：通过施用人绒毛膜促性腺激素衍生物治疗和预防癌症
公开(公告)号：US5997871A
公开(公告)日：1999-12-07
申请号：US709925
申请日：1996-09-09
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A61K38/00 , A61P35/00 , C07K14/59 , A61K39/00 , A61K38/03 , A61K38/24
CPC分类号： C07K14/59 , A61K38/00
摘要： The present invention relates to methods of treating or preventing cancer by administration of human chorionic gonadotropin, .beta.-human chorionic gonadotropin or a peptide containing a sequence of a portion of .beta.-human chorionic gonadotropin. In a preferred embodiment, the invention provides methods of treating or preventing Kaposi's Sarcoma, breast cancer or prostate cancer. in another preferred embodiment, the invention relates to .beta.-human chorionic gonadotropin peptides for treatment or prevention of cancer. The invention further provides assays for the utility of particular human chorionic gonadotropin preparations in the treatment or prevention of cancer. Pharmaceutical compositions and methods of administration are also provided.
摘要翻译：本发明涉及通过给予人绒毛膜促性腺激素，β-人绒毛膜促性腺激素或含有一部分β-人绒毛膜促性腺激素序列的肽来治疗或预防癌症的方法。在优选的实施方案中，本发明提供了治疗或预防卡波西氏肉瘤，乳腺癌或前列腺癌的方法。在另一个优选的实施方案中，本发明涉及用于治疗或预防癌症的β-人绒毛膜促性腺激素肽。本发明还提供了用于特定人绒毛膜促性腺激素制剂用于治疗或预防癌症的测定。还提供了药物组合物和给药方法。

5. 发明授权

US06699656B2 Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin 有权
标题翻译：通过施用人绒毛膜促性腺激素衍生物治疗和预防HIV感染
公开(公告)号：US06699656B2
公开(公告)日：2004-03-02
申请号：US10050875
申请日：2001-11-20
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： C12Q170
CPC分类号： C07K14/59 , A61K38/00 , Y10S435/974
摘要： The present invention relates to &bgr;-hCG, particularly &bgr;-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention of HIV infection by administration of a therapeutic compound of the invention. Such therapeutic compounds include hCG, &bgr;-hCG and &bgr;-hCG peptides, analogs and derivatives of hCG, &bgr;-hCG and &bgr;-hCG peptides, and nucleic acids encoding hCG, &bgr;-hCG and &bgr;-hCG peptides. In a preferred embodiment, &bgr;-hCG peptides, particularly &bgr;-hCG peptides of amino acids 47-53, 45-57 or 45-58 are administered to a subject for treatment or prevention of HIV infection in that subject. The invention also provides methods for screening hCG preparations for activity in treating or preventing HIV infection. Pharmaceutical compositions and methods of administration of Therapeutics are also provided.
摘要翻译：本发明涉及β-hCG，特别是具有41-54,45-54,47-53,45-57和45-58位氨基酸序列的β-hCG蛋白及其类似物和衍生物。本发明还涉及通过施用本发明的治疗化合物治疗和预防HIV感染的方法。这些治疗化合物包括hCG，β-hCG和β-hCG肽，hCG，β-hCG和β-hCG肽的类似物和衍生物，以及编码hCG，β-hCG和β-hCG肽的核酸。在优选的实施方案中，将Aβ-hCG肽，特别是氨基酸47-53,45-57或45-58的β-hCG肽施用于受试者，以治疗或预防该受试者的HIV感染。本发明还提供了用于筛选用于治疗或预防HIV感染的活性的hCG制剂的方法。还提供药物组合物和治疗剂的施用方法。

6. 发明申请

US20120083587A1 BIOLOGICALLY ACTIVE POLYPEPTIDES DERIVED FROM A NOVEL EARLY STAGE PREGNANCY FACTOR DESIGNATED MATERNIN (MA) 审中-公开
标题翻译：从一个新的早期阶段产生的生物活性多肽被指定的MATERNIN（MA）
公开(公告)号：US20120083587A1
公开(公告)日：2012-04-05
申请号：US13159285
申请日：2011-06-13
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： C07K16/18 , C07K16/42 , C12N1/21 , C12N5/16 , C12N15/12 , C12N15/63
CPC分类号： C07K16/26 , A61K38/00 , A61K48/00 , C07K14/59 , C07K2319/00
摘要： The invention relates to therapeutic polypeptides isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.
摘要翻译：本发明涉及从人类早孕尿中发现的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽，现在合成产生并命名为Maternin。治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。

7. 发明授权

US06596688B1 Method for promoting hematopoiesis 失效
标题翻译：促进造血的方法
公开(公告)号：US06596688B1
公开(公告)日：2003-07-22
申请号：US09675776
申请日：2000-09-29
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A01N3718
CPC分类号： C07K14/59
摘要： The present invention relates to peptides of one or more portions of the human chorionic gonadotropin &bgr;-chain as well as methods of promoting hematopoiesis, using human chorionic gonadotropin, employing the &bgr;-chain of human chorionic gonadotropin, peptides containing a sequence of one or more portions of the &bgr;-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or perparations of human chorionic gonadotropin, such as fractions of humna early pregnancy urine, which fractions have pro-hematopoietic activity. The present invention further relates to pharmaceutical compositions for promoting hematopoiesis.
摘要翻译：本发明涉及人绒毛膜促性腺激素β链的一个或多个部分的肽以及使用人绒毛膜促性腺激素促进造血的方法，其使用人绒毛膜促性腺激素的β链，含有一个或多个人绒毛膜促性腺激素的β-链的部分及其衍生物和类似物。本发明进一步涉及人绒毛膜促性腺激素的来源和/或起始部分，例如妊娠期尿液的部分，这些部分具有促造血活性。本发明还涉及用于促进造血作用的药物组合物。

8. 发明授权

US06319504B1 Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin 失效
标题翻译：通过施用人绒毛膜促性腺激素衍生物治疗和预防HIV感染
公开(公告)号：US06319504B1
公开(公告)日：2001-11-20
申请号：US08709948
申请日：1996-09-09
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A61K3900
CPC分类号： C07K14/59 , A61K38/00 , Y10S435/974
摘要： The present invention relates to &bgr;-hCG, particularly &bgr;-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention of HIV infection by administration of a therapeutic compound of the invention. Such therapeutic compounds include hCG, &bgr;-hCG and &bgr;-hCG peptides, analogs and derivatives of hCG, &bgr;-hCG and &bgr;-hCG peptides, and nucleic acids encoding hCG, &bgr;-hCG and &bgr;-hCG peptides. In a preferred embodiment, &bgr;-hCG peptides, particularly &bgr;-hCG peptides of amino acids 47-53, 45-57 or 45-58 are administered to a subject for treatment or prevention of HIV infection in that subject. The invention also provides methods for screening hCG preparations for activity in treating or preventing HIV infection. Pharmaceutical compositions and methods of administration of Therapeutics are also provided.
摘要翻译：本发明涉及β-hCG，特别是具有41-54,45-54,47-53,45-57和45-58位氨基酸序列的β-hCG蛋白及其类似物和衍生物。本发明还涉及通过施用本发明的治疗化合物治疗和预防HIV感染的方法。这些治疗化合物包括hCG，β-hCG和β-hCG肽，hCG，β-hCG和β-hCG肽的类似物和衍生物，以及编码hCG，β-hCG和β-hCG肽的核酸。在优选的实施方案中，将Aβ-hCG肽，特别是氨基酸47-53,45-57或45-58的β-hCG肽施用于受试者，以治疗或预防该受试者的HIV感染。本发明还提供了用于筛选用于治疗或预防HIV感染的活性的hCG制剂的方法。还提供药物组合物和治疗剂的施用方法。

9. 发明授权

US09175077B2 Nucleic acids encoding biologically active polypeptides derived from a novel early stage pregnancy factor designated maternin (MA) 有权
标题翻译：编码生物活性多肽的核酸衍生自命名为雌激素（MA）的新型早期妊娠因子
公开(公告)号：US09175077B2
公开(公告)日：2015-11-03
申请号：US13159285
申请日：2011-06-13
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： C07H21/02 , A61K38/00 , A61K38/04 , C12N1/20 , C12N15/00 , C07K16/26 , C07K14/59 , A61K48/00
CPC分类号： C07K16/26 , A61K38/00 , A61K48/00 , C07K14/59 , C07K2319/00
摘要： The invention relates to nucleotides encoding therapeutic polypeptides and fragments thereof isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.
摘要翻译：本发明涉及编码从人类早孕尿中发现的现在合成产生并命名为Maternin的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽及其片段的核苷酸。治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。

10. 发明授权

US06805882B1 Therapeutic fractions of sources of HCG 有权
$Therapeutic fractions of sources of HCG$
标题翻译： HCG来源的治疗分数
公开(公告)号：US06805882B1
公开(公告)日：2004-10-19
申请号：US09677152
申请日：2000-10-02
申请人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
发明人： Robert C. Gallo , Joseph Bryant , Yanto Lunardi-Iskandar
IPC分类号： A61K3522
CPC分类号： C07K14/59
摘要： The present invention relates to fractions of sources and or preparations of human chorionic gonadotropin, such as fractions of human early pregnancy urine, which fractions have anti-HIV activity. The present invention further relates to pharmaceutical compositions comprising such fractions for treating the effects of HIV infection.
摘要翻译：本发明涉及人类绒毛膜促性腺激素的来源和/或制剂的分数，例如人类早孕尿的部分，其部分具有抗HIV活性。本发明还涉及包含用于治疗HIV感染作用的这些级分的药物组合物。

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