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1. 发明申请

US20070083122A1 Phosphorescence and fluorescence spectroscopy for detection of cancer and pre-cancer from normal/benign regions 有权
标题翻译：用于从正常/良性区域检测癌症和癌前期的磷光和荧光光谱
公开(公告)号：US20070083122A1
公开(公告)日：2007-04-12
申请号：US11521170
申请日：2006-09-14
申请人： Robert Alfano , Aleksandra Alimova , Alvin Katz
发明人： Robert Alfano , Aleksandra Alimova , Alvin Katz
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0091
摘要： The present application is directed to methods for detecting cancerous, pre-cancerous and benign/normal tissue using phosphorescence or the combination of fluorescence and phosphorescence emission from the tissue excited in 280 to 340 nm range. In particular, the application describes methods using a ratio of intensity of fluorescence emission to intensity of phosphorescence emission to provide a rapid cancer, pre-cancer and benign detection method. Normal human breast and prostate tissue, excited in 270 to 300 nm range, express the emission signatures at 340 nm, 440 nm and 500 nm. Cancerous tissue shows only minor emissions at 500 nm, thus the ratio of 340 nm peak to 500 nm peak emission intensities provides information about malignancy of a tissue. Fiber optic based instrumentation can be used to collect the luminescence signal from an area of a tissue less than 1 mm in diameter and using the described method can be screened to determine the state of the tissue sample taken. The combination of fiber optics and 2D translation stage provides 2D maps of intensity's ratio of the tissue surface and aids in localizing the malignancy region of the tissue.
摘要翻译：本申请涉及使用磷光检测癌症，癌前和良性/正常组织或从280-340nm范围激发的组织的荧光和磷光发射的组合来检测的方法。特别地，本申请描述了使用荧光发射强度与磷光发射强度之比来提供快速癌症，癌前和良性检测方法的方法。在270〜300nm范围内激发的正常人体乳腺和前列腺组织在340nm，440nm和500nm处表达发射特征。癌组织在500nm处仅显示轻微的发射，因此340nm峰值与500nm峰值发射强度之比提供关于组织恶性肿瘤的信息。可以使用基于光纤的仪器从直径小于1mm的组织的区域收集发光信号，并且可以筛选所描述的方法以确定所采集的组织样品的状态。纤维光学和2D翻译平台的组合提供了强度比例的组织表面的2D图，并有助于定位组织的恶性肿瘤区域。

2. 发明授权

US07986989B2 Phosphorescence and fluorescence spectroscopy for detection of cancer and pre-cancer from normal/benign regions 有权
标题翻译：用于从正常/良性区域检测癌症和癌前期的磷光和荧光光谱
公开(公告)号：US07986989B2
公开(公告)日：2011-07-26
申请号：US11521170
申请日：2006-09-14
申请人： Robert R. Alfano , Aleksandra Alimova , Alvin Katz
发明人： Robert R. Alfano , Aleksandra Alimova , Alvin Katz
IPC分类号： A61B6/00 , G01N21/64 , G01N21/76
CPC分类号： A61B5/0059 , A61B5/0091
摘要： The present application is directed to methods for detecting cancerous, pre-cancerous and benign/normal tissue using phosphorescence or the combination of fluorescence and phosphorescence emission from the tissue excited in 280 to 340 nm range. In particular, the application describes methods using a ratio of intensity of fluorescence emission to intensity of phosphorescence emission to provide a rapid cancer, pre-cancer and benign detection method. Normal human breast and prostate tissue, excited in 270 to 300 nm range, express the emission signatures at 340 nm, 440 nm and 500 nm. Cancerous tissue shows only minor emissions at 500 nm, thus the ratio of 340 nm peak to 500 nm peak emission intensities provides information about malignancy of a tissue. Fiber optic based instrumentation can be used to collect the luminescence signal from an area of a tissue less than 1 mm in diameter and using the described method can be screened to determine the state of the tissue sample taken. The combination of fiber optics and 2D translation stage provides 2D maps of intensity's ratio of the tissue surface and aids in localizing the malignancy region of the tissue.
摘要翻译：本申请涉及使用磷光检测癌症，癌前和良性/正常组织或从280-340nm范围激发的组织的荧光和磷光发射的组合来检测的方法。特别地，本申请描述了使用荧光发射强度与磷光发射强度之比来提供快速癌症，癌前和良性检测方法的方法。在270〜300nm范围内激发的正常人体乳腺和前列腺组织在340nm，440nm和500nm处表达发射特征。癌组织在500nm处仅显示轻微的发射，因此340nm峰值与500nm峰值发射强度之比提供关于组织恶性肿瘤的信息。可以使用基于光纤的仪器从直径小于1mm的组织的区域收集发光信号，并且可以筛选所描述的方法以确定所采集的组织样品的状态。纤维光学和2D平移阶段的组合提供了组织表面强度比的2D图，并有助于定位组织的恶性肿瘤区域。

3. 发明授权

US08082024B2 Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy 有权
标题翻译：用于结合光学成像和点荧光光谱的体内医学诊断的微型紧凑型装置
公开(公告)号：US08082024B2
公开(公告)日：2011-12-20
申请号：US11037961
申请日：2005-01-18
申请人： Robert R. Alfano , Alvin Katz , Scott Alfano
发明人： Robert R. Alfano , Alvin Katz , Scott Alfano
IPC分类号： A61B6/00
CPC分类号： A61B1/043 , A61B1/041 , A61B1/0638 , A61B1/0684 , A61B5/0071 , A61B5/0084
摘要： An apparatus and method for medical practitioners to detect the presence of abnormal cells including cancerous and pre-cancerous cells by using a transport capsule containing an imaging apparatus including UV sources and fluorescence detectors for obtaining images and fluorescence data of biological cells and tissue. The method includes the steps of scanning biological tissue using an ultra-violet (UV) source to obtain fluorescence data, transferring fluorescence data and/or images using a radio frequency (RF) or other suitable means to a personal computer (PC) system, analyzing the image and/or fluorescence data in the PC, identifying -tissues with precancerous and cancerous cells, and optionally determining their precise location, and assessing the accuracy of the calculated fluoroscopic images.
摘要翻译：一种用于医学实验者通过使用包含用于获得生物细胞和组织的图像和荧光数据的UV源和荧光检测器的成像装置的运输胶囊来检测包括癌性和癌前细胞的异常细胞的存在的装置和方法。该方法包括以下步骤：使用紫外线（UV）源扫描生物组织以获得荧光数据，使用射频（RF）或其他合适方式将荧光数据和/或图像转移到个人计算机（PC）系统，分析PC中的图像和/或荧光数据，识别具有癌前和癌细胞的组织，并且可选地确定其精确位置，以及评估所计算的荧光透视图像的准确度。

4. 发明申请

US20050215911A1 Micro-scale compact device for in vivo medical diagnosis combining optical imaging and point fluorescence spectroscopy 有权
标题翻译：用于结合光学成像和点荧光光谱的体内医学诊断的微型紧凑型装置
公开(公告)号：US20050215911A1
公开(公告)日：2005-09-29
申请号：US11037961
申请日：2005-01-18
申请人： R. Alfano , Alvin Katz , Scott Alfano
发明人： R. Alfano , Alvin Katz , Scott Alfano
IPC分类号： A61B1/04 , A61B5/00 , A61B6/00
CPC分类号： A61B1/043 , A61B1/041 , A61B1/0638 , A61B1/0684 , A61B5/0071 , A61B5/0084
摘要： An apparatus and method for medical practitioners to detect the presence of abnormal cells including cancerous and pre-cancerous cells by using a transport capsule containing an imaging apparatus including UV sources and fluorescence detectors for obtaining images and fluorescence data of biological cells and tissue. The method includes the steps of scanning biological tissue using an ultra-violet (UV) source to obtain fluorescence data, transferring fluorescence data and/or images using a radio frequency (RF) or other suitable means to a personal computer (PC) system, analyzing the image and/or fluorescence data in the PC, identifying -tissues with precancerous and cancerous cells, and optionally determining their precise location, and assessing the accuracy of the calculated fluoroscopic images.
摘要翻译：一种用于医学实验者通过使用包含用于获得生物细胞和组织的图像和荧光数据的UV源和荧光检测器的成像装置的运输胶囊来检测包括癌性和癌前细胞的异常细胞的存在的装置和方法。该方法包括以下步骤：使用紫外线（UV）源扫描生物组织以获得荧光数据，使用射频（RF）或其他合适方式将荧光数据和/或图像转移到个人计算机（PC）系统，分析PC中的图像和/或荧光数据，识别具有癌前和癌细胞的组织，并且可选地确定其精确位置，以及评估所计算的荧光透视图像的准确度。

5. 发明授权

US06091985A Detection of cancer and precancerous conditions in tissues and/or cells using native fluorescence excitation spectroscopy 失效
标题翻译：使用天然荧光激发光谱法检测组织和/或细胞中的癌症和癌前病症
公开(公告)号：US06091985A
公开(公告)日：2000-07-18
申请号：US12482
申请日：1998-01-23
申请人： Robert R. Alfano , Singaravelu Ganesan , Alvin Katz , Yang Yuanlong
发明人： Robert R. Alfano , Singaravelu Ganesan , Alvin Katz , Yang Yuanlong
IPC分类号： G01N21/64 , A61B5/00
CPC分类号： G01N21/6486 , G01N2021/6419 , G01N2021/6421
摘要： A method of detecting cancer or precancerous conditions in a tissue or cell using fluorescence excitation spectroscopy. According to one embodiment of the method, a tissue is tested for cancer or a precancerous condition by exciting the tissue with substantially monochromatic light at 268 nm and then at 289 nm, with the resultant native fluorescence emitted from the tissue following each excitation being measured. A ratio of the fluorescence intensities, e.g., I.sub.289 /I.sub.268, is then calculated. If I.sub.289 /I.sub.268 is greater than 1.5, the tissue is cancerous or precancerous whereas if I.sub.289 /I.sub.268 is less than 1.5, the tissue is not cancerous or precancerous.
摘要翻译：使用荧光激发光谱法检测组织或细胞中的癌症或癌前病症的方法。根据该方法的一个实施例，通过在268nm处然后在289nm处以基本上单色的光激发组织来测试组织的癌症或癌前病症，在每个激发后测量从组织发射的所得天然荧光。然后计算荧光强度的比例，例如I289 / I268。如果I289 / I268大于1.5，则组织是癌性或癌前病变，而如果I289 / I268小于1.5，则组织不是癌或癌前病变。

6. 发明授权

US5769081A Method for detecting cancerous tissue using optical spectroscopy and fourier analysis 失效
标题翻译：使用光谱法和傅里叶分析法检测癌组织的方法
公开(公告)号：US5769081A
公开(公告)日：1998-06-23
申请号：US618459
申请日：1996-03-18
申请人： Robert R. Alfano , Alvin Katz , Yuanlong Yang
发明人： Robert R. Alfano , Alvin Katz , Yuanlong Yang
IPC分类号： A61B5/00 , G01N21/64 , A61B6/00
CPC分类号： G01N21/6486 , A61B5/0091 , A61B5/7257 , G01N2201/129
摘要： A method for detecting cancerous tissue using optical spectroscopy and Fourier analysis. According to a preferred embodiment, a tissue sample is illuminated with light at a wavelength of approximately 300 nm. Next, a fluorescence emission spectrum for the tissue sample is obtained by measuring the resultant fluorescence from the tissue sample over the spectral region from approximately 320 nm to approximately 580 nm. The phase and amplitude for the first three Fourier transform harmonics are then determined. The phase and amplitude determinations for one or more of the three harmonics are then compared to appropriate standards obtained from cancerous and non-cancerous tissue samples. The accuracy of the method can be improved further by comparing the phase and amplitude calculations for at least two harmonics.
摘要翻译：一种使用光谱和傅里叶分析检测癌组织的方法。根据优选实施方案，组织样品用约300nm波长的光照射。接下来，通过在约320nm至约580nm的光谱区域上测量来自组织样品的所得荧光获得组织样品的荧光发射光谱。然后确定前三个傅里叶变换谐波的相位和幅度。然后将三个谐波中的一个或多个的相位和幅度确定与从癌性和非癌性组织样品获得的适当标准进行比较。通过比较至少两个谐波的相位和幅度计算，可以进一步提高该方法的精度。

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