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1. 发明授权

US06091985A Detection of cancer and precancerous conditions in tissues and/or cells using native fluorescence excitation spectroscopy 失效
标题翻译：使用天然荧光激发光谱法检测组织和/或细胞中的癌症和癌前病症
公开(公告)号：US06091985A
公开(公告)日：2000-07-18
申请号：US12482
申请日：1998-01-23
申请人： Robert R. Alfano , Singaravelu Ganesan , Alvin Katz , Yang Yuanlong
发明人： Robert R. Alfano , Singaravelu Ganesan , Alvin Katz , Yang Yuanlong
IPC分类号： G01N21/64 , A61B5/00
CPC分类号： G01N21/6486 , G01N2021/6419 , G01N2021/6421
摘要： A method of detecting cancer or precancerous conditions in a tissue or cell using fluorescence excitation spectroscopy. According to one embodiment of the method, a tissue is tested for cancer or a precancerous condition by exciting the tissue with substantially monochromatic light at 268 nm and then at 289 nm, with the resultant native fluorescence emitted from the tissue following each excitation being measured. A ratio of the fluorescence intensities, e.g., I.sub.289 /I.sub.268, is then calculated. If I.sub.289 /I.sub.268 is greater than 1.5, the tissue is cancerous or precancerous whereas if I.sub.289 /I.sub.268 is less than 1.5, the tissue is not cancerous or precancerous.
摘要翻译：使用荧光激发光谱法检测组织或细胞中的癌症或癌前病症的方法。根据该方法的一个实施例，通过在268nm处然后在289nm处以基本上单色的光激发组织来测试组织的癌症或癌前病症，在每个激发后测量从组织发射的所得天然荧光。然后计算荧光强度的比例，例如I289 / I268。如果I289 / I268大于1.5，则组织是癌性或癌前病变，而如果I289 / I268小于1.5，则组织不是癌或癌前病变。

2. 发明授权

US6080584A Method and apparatus for detecting the presence of cancerous and precancerous cells in a smear using native fluorescence spectroscopy 失效
标题翻译：使用天然荧光光谱法检测涂片中癌和癌前细胞的存在的方法和装置
公开(公告)号：US6080584A
公开(公告)日：2000-06-27
申请号：US982947
申请日：1997-12-02
申请人： Robert R. Alfano , Singaravelu Ganesan , Yury Budansky
发明人： Robert R. Alfano , Singaravelu Ganesan , Yury Budansky
IPC分类号： C12M1/34 , G01N1/28 , G01N15/14 , G01N21/64 , G01N33/574
CPC分类号： G01N21/6486 , G01N21/6456 , G01N33/57415 , G01N1/2813 , G01N2015/1472 , G01N2015/1486 , G01N2021/6421 , G01N2021/6423
摘要： A method and apparatus for examining a cell smear for the purpose of detecting the presence of cancerous and precancerous cells located therein. In a preferred embodiment, the method comprises illuminating at least a portion of the cell smear with light of a first wavelength, whereby native fluorescence is emitted therefrom. Next, the intensity of native fluorescence emitted from the illuminated area is measured at a second wavelength and at a third wavelength as a function of location within the illuminated area. The first, second and third wavelengths are chosen so that the ratio of fluorescence intensities at the second and third wavelengths is indicative of a carcinomatous condition. Next, the ratio of intensities measured at the second and third wavelengths is determined to obtain a value for each location within the illuminated area. Finally, a map is generated of all the cells present within the illuminated area using the calculated values. The map not only shows the spatial distribution of cells located within the area but also indicates by color coding or shading the carcinomatous condition of each cell therein.
摘要翻译：用于检测细胞涂片以检测位于其中的癌和癌前细胞的存在的目的的方法和装置。在优选实施方案中，该方法包括用第一波长的光照射至少一部分细胞涂片，由此从其发射天然荧光。接下来，在照明区域内作为位置的函数在第二波长和第三波长处测量从照明区域发射的天然荧光的强度。选择第一，第二和第三波长，使得在第二和第三波长处的荧光强度的比率表示癌症状况。接下来，确定在第二和第三波长处测量的强度比，以获得在照明区域内的每个位置的值。最后，使用所计算的值生成在照明区域内存在的所有细胞的图。该图不仅显示位于该区域内的细胞的空间分布，而且还通过颜色编码或阴影其中每个细胞的癌症状况来表示。

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