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1. 发明授权

US06200624B1 Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids 失效
标题翻译：含有花生四烯酸和二十二碳六烯酸的肠内配方或营养补充剂
公开(公告)号：US06200624B1
公开(公告)日：2001-03-13
申请号：US08592832
申请日：1996-01-26
申请人： Terrence Bruce Mazer , Robert Alan Miller , Charles Allan McCombs , Scott Donald Barnicki , James Cecil Phillips , Charles Edwan Sumner, Jr.
发明人： Terrence Bruce Mazer , Robert Alan Miller , Charles Allan McCombs , Scott Donald Barnicki , James Cecil Phillips , Charles Edwan Sumner, Jr.
IPC分类号： A23L200
CPC分类号： A23L33/17 , A23L33/12 , A23L33/40 , Y10S426/80 , Y10S426/801
摘要： This invention is directed to the use of triglycerides containing fatty ester moieties that include arachidonic acid (AA) and docosahexaenoic acid (DHA) in enteral nutritionals or nutritional supplements. These triglycerides are derived from lipid mixtures which have high levels of sterols and phosphorous. A preferred embodiment of the invention comprises an infant or enteral nutritional, or nutritional supplement, that comprises a lipid source derived from egg yolk. The lipid source derived from egg yolk is prepared by transesterification or hydrolysis, subjecting the mixture to distillation, and esterification with glycerin to result in a triglyceride containing the desired fatty acids of AA and DHA and little or no sterols and phosphorus.
摘要翻译：本发明涉及含有花生四烯酸（AA）和二十二碳六烯酸（DHA）的脂肪酸酯部分的甘油三酯在肠内营养或营养补充剂中的用途。这些甘油三酯衍生自具有高水平的甾醇和磷的脂质混合物。本发明的优选实施方案包括婴儿或肠内营养或营养补充剂，其包含源自蛋黄的脂质源。来自蛋黄的脂质源通过酯交换或水解制备，使混合物蒸馏，并用甘油进行酯化，得到含有所需的AA和DHA脂肪酸的甘油三酯，很少或没有固醇和磷。

2. 发明授权

US6063946A Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds 失效
标题翻译：用于从含有甾醇和磷化合物的复杂混合物中分离多不饱和脂肪酸及其酯的方法
公开(公告)号：US6063946A
公开(公告)日：2000-05-16
申请号：US592797
申请日：1996-01-26
申请人： Robert Alan Miller , Terrence Bruce Mazer , Scott Donald Barnicki , Charles Edwan Sumner, Jr.
发明人： Robert Alan Miller , Terrence Bruce Mazer , Scott Donald Barnicki , Charles Edwan Sumner, Jr.
IPC分类号： A23L5/20 , C11C1/02 , C11C1/10 , C11C3/00 , C11C3/02 , C11C1/00
CPC分类号： C11C3/02 , C11C1/025 , C11C1/10 , C11C3/003
摘要： This invention relates to a process for the isolation of fatty acids and fatty acid esters from complex naturally occurring mixtures which contain sterols, triglycerides and phospholipids. A preferred embodiment of the invention comprises extracting lipids from egg yolk solids with methanol; separating lipids including sterols from insoluble egg yolk components; submitting the methanolic solution of lipids to (a) alkaline hydrolysis and subsequent neutralization to convert lipids to free fatty acids together with sterols; (b) separating the said sterols and acids from an aqueous phase formed in the hydrolysis reaction; (c) heating said free fatty acids and sterols to convert the sterols to fatty acid sterol esters; (d) subjecting the mixture to distillation to separate the sterol esters from the free fatty acids; and (e) subjecting the said acids to esterification in the presence of glycerol to produce triglycerides of said fatty acids wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus. An enteral nutritional formula containing the triglycerides produced in the above process is also disclosed.
摘要翻译：本发明涉及从含有甾醇，甘油三酯和磷脂的复杂天然存在的混合物中分离脂肪酸和脂肪酸酯的方法。本发明的优选实施方案包括用甲醇从蛋黄固体中提取脂质; 分离包括固醇的脂质不溶于蛋黄成分; 将脂质的甲醇溶液（a）碱性水解并随后中和，将脂质与甾醇一起转化为游离脂肪酸; （b）将所述甾醇和酸与水解反应中形成的水相分离; （c）加热所述游离脂肪酸和甾醇以将甾醇转化为脂肪酸甾醇酯; （d）使混合物进行蒸馏以将固醇酯与游离脂肪酸分离; 和（e）在甘油存在下使所述酸进行酯化以产生所述脂肪酸的甘油三酯，其中所得甘油三酸酯含有降低量的甾醇和磷。还公开了含有在上述方法中生产的甘油三酯的肠内营养配方。

3. 发明授权

US5883273A Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds 失效
标题翻译：多不饱和脂肪酸和不含甾醇和磷化合物的脂肪酸酯
公开(公告)号：US5883273A
公开(公告)日：1999-03-16
申请号：US592831
申请日：1996-01-26
申请人： Robert Alan Miller , Terrence Bruce Mazer , Charles Allan McCombs
发明人： Robert Alan Miller , Terrence Bruce Mazer , Charles Allan McCombs
IPC分类号： C11B3/12 , C11B7/00 , C11C3/04 , C11C3/10 , C11C1/00
CPC分类号： C11B3/12 , C11B7/0008 , C11C3/04 , C11C3/10
摘要： Fatty acid esters such as those containing arachidonic acid (AA) and docosahexaenoic acid (DHA) derived from lipid mixtures are prepared with reduced levels of sterols and phosphorus. A preferred embodiment of the invention comprises extracting lipids from egg with methanol; separating lipids including sterols from insoluble egg components; submitting the methanolic solution of lipids to transesterification and subsequent neutralization to convert the lipids to methyl esters of said free fatty acids together with sterols; separating the said sterols and esters from an aqueous phase including phosphorus compounds formed in the transesterification; subjecting the said fatty acid esters and sterols to distillation to separate sterols from the fatty acid esters; and subjecting the said esters to transesterification in the presence of glycerol to produce triglycerides of said esters thereof including that of AA and DHA wherein the resulting triglycerides contain reduced quantities of sterols and phosphorus.
摘要翻译：脂肪酸酯如含有花生四烯酸（AA）和来源于脂质混合物的二十二碳六烯酸（DHA）的脂肪酸酯被制备成具有降低水平的固醇和磷。本发明的优选实施方案包括用甲醇从鸡蛋中提取脂质; 分离包括固醇的脂质不溶于蛋组分; 将脂质的甲醇溶液酯交换并随后中和，将脂质与甾醇一起转化成所述游离脂肪酸的甲酯; 将所述甾醇和酯与包含在酯交换中形成的磷化合物的水相分离; 对所述脂肪酸酯和甾醇进行蒸馏以将甾醇与脂肪酸酯分离; 并在所述甘油存在下使所述酯进行酯交换反应以产生所述酯的甘油三酸酯，其包括AA和DHA的甘油三酯，其中所得甘油三酸酯含有减少量的甾醇和磷。

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