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1. 发明授权

US06949087B2 Apparatus with weeping tip and method of use 失效
公开(公告)号：US06949087B2
公开(公告)日：2005-09-27
申请号：US10855026
申请日：2004-05-26
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.

2. 发明授权

US06241710B1 Hypodermic needle with weeping tip and method of use 失效
标题翻译：皮下注射针头及其使用方法
公开(公告)号：US06241710B1
公开(公告)日：2001-06-05
申请号：US09468688
申请日：1999-12-20
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

3. 发明授权

US06855132B2 Apparatus with weeping tip and method of use 失效
标题翻译：具有啜饮尖端和使用方法的设备
公开(公告)号：US06855132B2
公开(公告)日：2005-02-15
申请号：US10342023
申请日：2003-01-14
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： C12N15/09 , A61K31/711 , A61K48/00 , A61M5/158 , A61M5/32 , A61M25/00 , A61M31/00 , A61P43/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

4. 发明授权

US06547769B2 Catheter apparatus with weeping tip and method of use 失效
标题翻译：导管器具有eping嘴和使用方法
公开(公告)号：US06547769B2
公开(公告)日：2003-04-15
申请号：US09829022
申请日：2001-04-09
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M532
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

5. 发明授权

US07252654B2 Apparatus with weeping tip and method of use 有权
标题翻译：具有啜饮尖端和使用方法的设备
公开(公告)号：US07252654B2
公开(公告)日：2007-08-07
申请号：US11218700
申请日：2005-09-02
申请人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Robert A. VanTassel , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61M5/32 , A61M25/00
CPC分类号： A61M5/3286 , A61M5/3291 , A61M25/0068 , A61M2025/0057 , A61M2025/0073
摘要： The invention provides surgical needles with a porous distal portion from which a liquid injectate will weep or ooze multidirectionally under injection pressure while the porous distal portion of the needle is inserted into a body surface. The porous distal portion of the needle can be fabricated from a porous carbon, metal, ceramic or polymer and preferably has a decreasing gradient of impedance to fluid flowing to the point of the needle to compensate for the falling off of injection pressure as fluid moves towards the point, thereby ensuring uniform weeping of the injectate along the injection course. The needle is adapted for attachment to a catheter or syringe. In another embodiment, a surgical assemblage is provided wherein a porous distal portion having similar fluid flow characteristics is located along the distal end of a catheter, and a needle point is attached to the distal end of the catheter (e.g., a steerable catheter) for piercing tissue. A guidance catheter can be used to direct the invention devices to a remote internal injection site. The invention devices and methods can be used to inject fluids (including those containing nucleic acids for gene therapy) into interior body walls or tissue, such as a beating heart, without substantial loss of fluid and without substantial damage to tissue caused by injectate.
摘要翻译：本发明提供具有多孔远端部分的手术针头，其中注射的液体将在注射压力下多次地渗漏或渗出，同时针的多孔远端部分插入体表面。针的多孔远端部分可以由多孔碳，金属，陶瓷或聚合物制成，并且优选地具有减小的流向梯度的流体流向针的位置以补偿注射压力随着流体朝向这点，从而确保注射过程中注射剂的均匀渗漏。该针适于附接到导管或注射器。在另一个实施例中，提供了一种手术组合件，其中具有类似流体流动特征的多孔远侧部分沿着导管的远端定位，并且针尖附接到导管的远端（例如，可导向的导管），用于刺穿组织。引导导管可用于将本发明装置引导到远程内部注射部位。本发明的装置和方法可用于将流体（包括含有用于基因治疗的核酸的那些）注射到内部体壁或组织（例如打浆心脏）中，而没有明显的流体损失，并且对注射造成的组织没有实质的损害。

6. 发明授权

US6126649A Steerable catheter with external guidewire as catheter tip deflector 有权
标题翻译：可导向导管，外导管作为导管尖端导流器
公开(公告)号：US6126649A
公开(公告)日：2000-10-03
申请号：US329386
申请日：1999-06-10
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61M25/01 , A61M25/09
CPC分类号： A61M25/0138 , A61M25/0147 , A61B2017/22041 , A61B2017/22045 , A61M2025/0177
摘要： A steerable catheter in which a guidewire can serve a dual purpose of deflecting a bendable element at a distal end of the steerable catheter and as a guidewire to facilitate the placement of a working catheter within the vascular system. The guidewire is adapted to be slidingly received within routing eyelets or the like where one of such eyelets is disposed at a distal end of the bendable element and another near the proximal end thereof. The guidewire can be readily advanced in the distal direction relative to the steerable catheter, but tensioning of the guidewire at its proximal end serves to deflect and bend the bendable element.
摘要翻译：可导向的导管，其中导丝可以用于在可操纵导管的远端处偏转可弯曲元件的双重目的，并且用作导丝，以便于在血管系统内放置工作导管。导丝适于滑动地容纳在布置孔眼等内，其中这些孔眼之一设置在可弯曲元件的远端，另一个靠近其近端。导丝可以相对于可导向导管在远端方向上容易地前进，但是导丝在其近端处的张紧用于使可弯曲元件偏转和弯曲。

7. 发明授权

US06645143B2 Pressure/temperature/flow monitor device for vascular implantation 失效
公开(公告)号：US06645143B2
公开(公告)日：2003-11-11
申请号：US09961564
申请日：2001-09-20
申请人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
发明人： Robert A. VanTassel , Robert S. Schwartz , David R. Holmes
IPC分类号： A61B500
CPC分类号： A61F2/82 , A61B5/0031 , A61B5/02055 , A61B5/0215 , A61B5/026 , A61B5/413 , A61B5/6882 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00623
摘要： A medical monitoring apparatus designed to be implanted in the vascular system is capable of sensing and transmitting via a telemetry link to an external monitor both pressure and temperature information. An internally or externally powered microcircuit component is supported on a stent-like structure and adapted to be placed in the vascular system. Placement in the ventricular septum permits measurement of pressure and temperature in the left ventricle without introducing thrombus generating materials in the left ventricle.

8. 发明授权

US06699280B2 Multi-section stent 有权
标题翻译：多段支架
公开(公告)号：US06699280B2
公开(公告)日：2004-03-02
申请号：US10282691
申请日：2002-10-29
申请人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz , Timothy D. Argo
发明人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz , Timothy D. Argo
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/826 , A61F2002/828 , A61F2210/0004 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61F2250/0071 , A61F2250/0098
摘要： A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.
摘要翻译：支架包括第一支架部分，第二支架部分和至少一个连接部件。连接构件具有附接到第一支架部分的第一端，附接到第二支架部分的第二端和物理上可分离的部分。

9. 发明授权

US06485510B1 Multi-section stent 有权
标题翻译：多段支架
公开(公告)号：US06485510B1
公开(公告)日：2002-11-26
申请号：US09549681
申请日：2000-04-14
申请人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz
发明人： Allan R. Camrud , David R. Holmes, Jr. , Robert S. Schwartz
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/826 , A61F2002/828 , A61F2210/0004 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61F2250/0071 , A61F2250/0098
摘要： A stent includes a first stent section, a second stent section, and at least one connecting member. The connecting member has a first end attached to the first stent section, a second end attached to the second stent section and a physically separable portion.
摘要翻译：支架包括第一支架部分，第二支架部分和至少一个连接部件。连接构件具有附接到第一支架部分的第一端，附接到第二支架部分的第二端和物理上可分离的部分。

10. 发明授权

US06258117B1 Multi-section stent 有权
标题翻译：多段支架
公开(公告)号：US06258117B1
公开(公告)日：2001-07-10
申请号：US09292558
申请日：1999-04-15
申请人： Allen R. Camrud , Robert S. Schwartz , David R. Holmes, Jr. , Timothy D. Argo , David Berry
发明人： Allen R. Camrud , Robert S. Schwartz , David R. Holmes, Jr. , Timothy D. Argo , David Berry
IPC分类号： A61F206
CPC分类号： A61F2/88 , A61F2/07 , A61F2/82 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2002/826 , A61F2002/828 , A61F2210/0004 , A61F2250/0031 , A61F2250/0039 , A61F2250/0067 , A61F2250/0071 , A61F2250/0098
摘要： A multi-section stent includes a connecting structure that allows the stent sections to move and flex relative to one another. For deployment and positioning, the connecting structure connects the multiple stent sections and holds the stent sections substantially stationary relative to one another. Following deployment, the connecting structure allows the multiple stent sections to move relative to one another. Movable stent sections enable flexure of the stent upon deployment within a body lumen. This flexing structure allows better conformance of the stent to the shape of the body lumen, and exerts less overall pressure against the lumen wall, reducing the potential for trauma. Upon deployment, the multiple stent sections may be completely detached from one another. Alternatively, the stent sections may remain partially connected in a manner that allows substantial independent movement. The connecting structure can be manufactured to separate upon deployment, for example, by breaking or degrading within the body lumen in which the stent is positioned.
摘要翻译：多部分支架包括允许支架部分相对于彼此移动和弯曲的连接结构。为了部署和定位，连接结构连接多个支架部分并且将支架部分相对于彼此基本上保持固定。在部署之后，连接结构允许多个支架部分相对于彼此移动。可移动支架部分能够在展开在体腔内时使支架挠曲。该弯曲结构允许支架更好地符合体腔的形状，并且对腔壁施加较小的整体压力，降低创伤的可能性。在部署时，多个支架部分可以彼此完全分离。或者，支架部分可以以允许基本独立运动的方式保持部分连接。连接结构可以被制造成在展开时分离，例如通过在支架所在的体腔内破碎或降解。

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