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1. 发明申请

US20050192265A1 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 审中-公开
公开(公告)号：US20050192265A1
公开(公告)日：2005-09-01
申请号：US11002922
申请日：2004-12-03
申请人： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
发明人： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
IPC分类号： A61K31/445 , A61K31/4706 , A61K31/473 , A61K31/55
CPC分类号： A61K31/445 , A61K31/4706 , A61K31/473 , A61K31/55
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

2. 发明申请

US20050267150A1 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 审中-公开
标题翻译：环烷基，内酰胺，内酯和相关化合物，包含其的药物组合物，以及通过使用这些化合物抑制β-淀粉样蛋白肽释放和/或其合成的方法
公开(公告)号：US20050267150A1
公开(公告)日：2005-12-01
申请号：US11002921
申请日：2004-12-03
申请人： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
发明人： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
IPC分类号： A61K31/445 , A61K31/4706 , A61K31/501 , A61K31/55 , A61K38/00 , C07D401/12 , C07D403/12 , C07K5/097
CPC分类号： C07D401/12 , A61K38/00 , C07D403/12 , C07K5/0821 , C07K5/0823
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.
摘要翻译：公开了抑制β-淀粉样蛋白肽释放和/或其合成的化合物，因此具有治疗阿尔茨海默病的效用。还公开了包含抑制β-淀粉样蛋白肽释放和/或其合成的化合物的药物组合物以及预防性和治疗性地用这种药物组合物治疗阿尔茨海默病的方法。

3. 发明申请

US20050192269A1 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds 审中-公开
公开(公告)号：US20050192269A1
公开(公告)日：2005-09-01
申请号：US11002951
申请日：2004-12-03
申请人： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
发明人： Richard Thompson , Stephen Wilkie , Douglas Stack , Eldon Vanmeter , Qing Shi , Thomas Britton , James Audia , Jon Reel , Thomas Mabry , Bruce Dressman , Cynthia Cwi , Steven Henry , Stacey McDaniel , Russell Stucky , Warren Porter
IPC分类号： A61K31/445 , A61K31/4706 , A61K31/501 , A61K31/55 , A61K38/00 , C07D401/12 , C07D403/12 , C07K5/097
CPC分类号： C07D401/12 , A61K38/00 , C07D403/12 , C07K5/0821 , C07K5/0823
摘要： Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

4. 发明申请

US20070219123A1 SELECTIVE N-ACYLATION OF A82846 GLYCOPEPTIDE ANALOGS 失效
标题翻译： A82846糖蛋白类似物的选择性N-取代
公开(公告)号：US20070219123A1
公开(公告)日：2007-09-20
申请号：US10203533
申请日：2001-02-12
申请人： Richard Thompson , Stephen Wilkie , Mark Zweifel
发明人： Richard Thompson , Stephen Wilkie , Mark Zweifel
IPC分类号： A61K38/14 , C07K9/00
CPC分类号： C07K9/008 , A61K38/00
摘要： The present invention provides a process for selectively acylating an A82846A, A82846B, A82846C or PA-42867-A glycopeptide at the N1, N2 or N3 positions and the monoacylated compounds prepared therefrom.
摘要翻译：本发明提供了在N1，N2或N3位置选择性酰化A82846A，A82846B，A82846C或PA-42867-A糖肽的方法和由其制备的单酰化化合物。

5. 发明申请

US20050037950A1 N1-modified glycopeptides 失效
标题翻译： N1修饰的糖肽
公开(公告)号：US20050037950A1
公开(公告)日：2005-02-17
申请号：US10717163
申请日：2003-11-18
申请人： Richard Thompson , Stephen Wilkie
发明人： Richard Thompson , Stephen Wilkie
IPC分类号： A61K38/00 , A61P31/04 , C07K7/06 , C07K9/00 , A61K38/12
CPC分类号： C07K9/008 , A61K38/00
摘要： The present invention is directed to N1-acylated derivatives of desleucylA82846B. These derivatives are useful as antibacterials.
摘要翻译：本发明涉及脱氨基A82846B的N 1 - 酰化衍生物。这些衍生物可用作抗菌剂。

6. 发明申请

US20100303916A1 ENHANCED DRUG DELIVERY WITH ORIENTABLE PARTICLES 审中-公开
标题翻译：使用方便的颗粒加强药物输送
公开(公告)号：US20100303916A1
公开(公告)日：2010-12-02
申请号：US12678105
申请日：2008-09-23
申请人： Warren H. Finlay , Andrew R. Martin , Helen Orzanska , Richard Thompson
发明人： Warren H. Finlay , Andrew R. Martin , Helen Orzanska , Richard Thompson
IPC分类号： A61K9/14 , A61K31/353 , A61P11/00 , A61M37/00
CPC分类号： A61M15/02 , A61K9/0009 , A61K9/0078 , A61M2202/064 , A61M2205/0244 , A61M2205/3317
摘要： Small airway deposition of orientable drug particles in the lung due to interception is increased through alignment of these particles with an externally applied force such as a magnetic field. Drug particles in one embodiment are made magnetically responsive by loading them with magnetic nanoparticles. Elongated particles have a natural tendency to align parallel to the direction of flow through an airway, and therefore also parallel to airway walls; accordingly, alignment with a magnetic field to any other orientation increases interception, with a maximum increase for alignment perpendicular to airway walls. By positioning a magnetic field across a specific site within the lung, for example in the area of a tumor, the increase in deposition by interception allows localized targeting of inhaled drug particles to that area.
摘要翻译：通过这些颗粒与外部施加的力（例如磁场）的对准，增加了通过拦截导致肺中定向药物颗粒在肺中的小气道沉积。一个实施方案中的药物颗粒通过用磁性纳米颗粒加载而被制成磁性响应。细长的颗粒具有平行于通过气道的流动方向平行排列并因此也平行于气道壁的自然趋势; 因此，与任何其它方向的磁场对准增加截取，垂直于气道壁的对准最大增加。通过将磁场定位在肺内的特定部位（例如在肿瘤区域中），通过截取的沉积增加允许将吸入的药物颗粒定位到该区域。

7. 发明申请

US20070244382A1 Blood Analyte Determinations 审中-公开
标题翻译：血液分析物测定
公开(公告)号：US20070244382A1
公开(公告)日：2007-10-18
申请号：US11679839
申请日：2007-02-28
申请人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
发明人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
IPC分类号： A61B5/157
CPC分类号： A61B5/150961 , A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150366 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M1/1692 , A61M1/34 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2230/201
摘要： The present invention comprises methods and apparatuses that can provide measurement of glucose and other analytes with a variety of sensors without many of the performance-degrading problems of conventional approaches. An apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the removed blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system. A method according to the present invention comprises removing blood from a body, using an analyte sensor to measure an analyte in the removed blood, and infusing at least a portion of the removed blood back into the body. The use of a non-contact sensor with a closed system creates a system will minimal infection risk.
摘要翻译：本发明包括可以提供葡萄糖和其他分析物与各种传感器的测量而不是常规方法的许多性能降级问题的方法和装置。根据本发明的装置包括血液存取系统，其适于从身体去除血液并且将至少一部分去除的血液注入体内。这种装置还包括安装有血液存取系统的分析物传感器，使得分析物传感器测量已经通过血液存取系统从体内除去的血液中的分析物。根据本发明的方法包括从身体去除血液，使用分析物传感器来测量去除的血液中的分析物，并将至少一部分去除的血液输入体内。使用具有封闭系统的非接触式传感器创建的系统将会最小的感染风险。

8. 发明申请

US20060165844A1 Preparation of yogurt containing confectionery pieces and product thereof 有权
标题翻译：含糖果糕及其制品的酸奶的制备
公开(公告)号：US20060165844A1
公开(公告)日：2006-07-27
申请号：US11388857
申请日：2006-03-24
申请人： Heidi O'Sullivan , Jennifer Maack , Leslie Miller , Joana Montenegro , Lisa Pannell , Richard Thompson
发明人： Heidi O'Sullivan , Jennifer Maack , Leslie Miller , Joana Montenegro , Lisa Pannell , Richard Thompson
IPC分类号： A23C9/12
CPC分类号： A23G1/46 , A23C9/1307 , A23C9/137 , A23C2210/30 , A23G1/54 , A23G3/2007 , A23G3/46 , A23G3/54
摘要： Methods of preparation for cultured milk based products and products prepared thereby are provided wherein a yogurt is produced containing 0.1% to about 5% confectionery filaments. The process involves providing a cooled fermented yogurt base at a temperature of 0° C. to 5° C.; injecting a liquid fat-bearing compound having a total fat concentration of 24% to about 40% into the cooled yogurt base; whereby the liquid fat-bearing compound is shattered into filaments upon contact with the cooled fermented yogurt.
摘要翻译：提供了制备培养的乳基产品和由此制备的产品的方法，其中制备含有0.1％至约5％糖果细丝的酸奶。该方法包括在0℃至5℃的温度下提供冷却的发酵酸奶基料。将总脂肪浓度为24％至约40％的含脂肪的化合物注射到冷却的酸奶基料中; 由此液体含脂化合物在与冷却的发酵酸奶接触时被粉碎成长丝。

9. 发明申请

US20060084780A1 Modified copolyesters and optical films including modified copolyesters 有权
标题翻译：改性共聚酯和包括改性共聚酯的光学膜
公开(公告)号：US20060084780A1
公开(公告)日：2006-04-20
申请号：US10967582
申请日：2004-10-18
申请人： Timothy Hebrink , Martin Denker , Bert Chien , Matthew Johnson , Richard Thompson , Kristopher Derks , William Merrill , Fuming Li
发明人： Timothy Hebrink , Martin Denker , Bert Chien , Matthew Johnson , Richard Thompson , Kristopher Derks , William Merrill , Fuming Li
IPC分类号： C08G63/02
CPC分类号： C08G63/189 , B32B27/36 , C08G63/181 , C08G63/183 , Y10T428/24942 , Y10T428/2495 , Y10T428/31507 , Y10T428/31786
摘要： Modified copolyesters having relatively low refractive indices and relatively high glass transition temperatures are disclosed. These modified copolyesters can be used in forming one or more layers in an optical film, such as a multilayer polymer film.
摘要翻译：公开了具有相对低的折射率和相对高的玻璃化转变温度的改性共聚酯。这些改性共聚酯可用于在诸如多层聚合物膜的光学膜中形成一层或多层。

10. 发明申请

US20060078814A1 Toner processes and compositions thereof 失效
标题翻译：调色剂方法及其组合物
公开(公告)号：US20060078814A1
公开(公告)日：2006-04-13
申请号：US10963088
申请日：2004-10-12
申请人： Bing Hsieh , Richard Thompson
发明人： Bing Hsieh , Richard Thompson
IPC分类号： G03G9/08
CPC分类号： G03G9/09783 , G03G9/0804 , G03G9/0812 , G03G9/0819 , G03G9/08782 , G03G9/09 , G03G9/0926 , G03G9/09716 , G03G9/09725 , G03G9/09741 , G03G9/0975
摘要： The invention relates to color toner compositions prepared from a process for the preparation of a dry toner powder from an aqueous pigment concentrate dispersion comprising: blending at least an aqueous-based pigment concentrate dispersion and a resin to produce a paste; charging the paste to an extruder to generate an extruded pigment/resin mixture; dispersing the extruded pigment/resin mixture in a low boiling organic medium to create an organic phase; dispersing the organic phase in an aqueous phase containing a particulate stabilizer and mixing the organic phase and the aqueous phase at elevated temperature and under shear force to form toner particles of a controlled size and shape; removing the organic solvent and particulate stabilizer from the formed particles; and washing, drying, and collecting the particles for use as a dry toner powder.
摘要翻译：本发明涉及由水性颜料浓缩物分散体制备干燥调色剂粉末的方法制备的彩色调色剂组合物，包括：至少混合水基颜料浓缩物分散体和树脂以产生糊状物; 将糊料装入挤出机以产生挤出的颜料/树脂混合物; 将挤出的颜料/树脂混合物分散在低沸点有机介质中以产生有机相; 将有机相分散在含有颗粒稳定剂的水相中，并在高温和剪切力下混合有机相和水相以形成受控尺寸和形状的调色剂颗粒; 从形成的颗粒中除去有机溶剂和颗粒稳定剂; 并洗涤，干燥和收集颗粒以用作干燥调色剂粉末。

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