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1. 发明授权

US5316906A Enzymatic analysis using substrates that yield fluorescent precipitates 失效
标题翻译：使用产生荧光沉淀物的底物的酶分析
公开(公告)号：US5316906A
公开(公告)日：1994-05-31
申请号：US748860
申请日：1991-08-23
申请人： Richard P. Haugland , Yu-zhong Zhang , Stephen T. Yue , Ewald Terpetschnig , Nels A. Olson , John J. Naleway , Karen D. Larison , Zhijian Huang
发明人： Richard P. Haugland , Yu-zhong Zhang , Stephen T. Yue , Ewald Terpetschnig , Nels A. Olson , John J. Naleway , Karen D. Larison , Zhijian Huang
IPC分类号： C12Q1/00 , C07D215/14 , C07D235/18 , C07D239/91 , C07D263/56 , C07D263/57 , C07D277/64 , C07D277/66 , C07F9/6512 , C07F9/6541 , C07H15/04 , C07H15/26 , C07K4/00 , C08B37/00 , C12Q1/34 , C12Q1/42 , C12Q1/44 , C12Q1/68 , A61K37/02 , C04B35/00 , C08G63/48
CPC分类号： C07D263/57 , C07D235/18 , C07D239/91 , C07D277/66 , C07F9/65128 , C07F9/6541 , C07H15/26 , C12Q1/34 , C12Q1/42 , C12Q2334/00
摘要： Novel fluorescent precipitating substrates made from a class of fluorophores, generally including quinazolinones (quinazolones), benzimidazoles, benzothiazoles, benzoxazoles, quinolines, indolines, and phenanthridines, having the general formula: ##STR1## where carbon atoms of --C.sup.1 .dbd.C.sup.2 -- are further joined so as to complete a first 5- or 6-membered aromatic ring which may contain at least one of the hetero atoms N, O or S,where carbon atoms of --C.sup.4 --N.dbd.C.sup.3 -- are further joined so as to complete a second 5- or 6-membered aromatic ring that contains at least the nitrogen between C.sup.3 and C.sup.4 and may contain at least one additional hetero atom N, O or S,where the first and second aromatic rings may be joined by a 5- or 6-membered bridging ring that contains at least the C.sup.2 from the first aromatic ring and the C.sup.3 from the second aromatic ring, which bridging ring may be saturated or unsaturated and may contain a hetero atom N, O, or S,where each of the first and second aromatic rings may be fused to at least one additional aromatic ring that may contain at least one of the hetero atoms N, O or S, andwhere each of said aromatic rings may be further modified by substitution of any hydrogens on an aromatic carbon by substituents that are halogen, nitro, cyano, aryl, lower alkyl (1-4 carbons), perfluoroalkyl (1-4 carbons), or alkoxy (1-4 carbons), or any combination thereof; andX.sub.fl is covalently linked to the oxygen --O-- at C.sub.1.
摘要翻译：通常包括喹唑啉酮（喹唑啉酮），苯并咪唑，苯并噻唑，苯并恶唑，喹啉，吲哚啉和菲啶的一类荧光团制备的新型荧光沉淀基质，其具有-C1 = C2-的碳原子的通式为：以便完成可含有至少一个杂原子N，O或S的第一个5-或6-元芳环，其中-C4-N = C3-的碳原子进一步连接，以便完成一个第二个5-或6-元芳环，其至少包含C3和C4之间的氮，并且可以含有至少一个另外的杂原子N，O或S，其中第一和第二芳环可以通过5-或6 至少含有来自第一芳环的C2和来自第二芳环的C3，所述桥连环可以是饱和或不饱和的，并且可以含有杂原子N，O或S，其中第一个并且第二芳环可以稠合 o至少一个可以含有至少一个杂原子N，O或S的另外的芳环，并且其中每个所述芳环可以通过用芳基碳上的任何氢取代而被进一步修饰，所述取代基是卤素，硝基，氰基，芳基，低级烷基（1-4个碳），全氟烷基（1-4个碳）或烷氧基（1-4个碳），或其任何组合; 并且Xfl在C1处与氧-O-共价连接。

2. 发明申请

US20070281363A1 LUMINESCENT COMPOUNDS 审中-公开
标题翻译： LUMINESCENT化合物
公开(公告)号：US20070281363A1
公开(公告)日：2007-12-06
申请号：US11734748
申请日：2007-04-12
申请人： Leonid Patsenker , Ewald Terpetschnig , Irina Fedyunyaeva , Olga Kolosova , Alexey Klochko
发明人： Leonid Patsenker , Ewald Terpetschnig , Irina Fedyunyaeva , Olga Kolosova , Alexey Klochko
IPC分类号： G01N21/00 , C07D217/00 , C07D239/00 , C07D245/00 , C07D263/62 , C07D401/00 , C07D417/00 , C07D487/02 , C07H21/04 , C07K14/00 , C07K2/00
CPC分类号： C07H21/04 , C07D487/04
摘要： Reporter compounds based on cyanine dyes, among others, including reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, among others, where the reporter compounds relate generally to the following structure:
摘要翻译：基于花青染料的报道物化合物，其中包括用于合成报告化合物的反应性中间体，以及合成和使用报告化合物的方法，其中报告化合物一般涉及以下结构：

3. 发明申请

US20140200333A1 DENDRON REPORTER MOLECULES 审中-公开
标题翻译： DENDRON报告分子
公开(公告)号：US20140200333A1
公开(公告)日：2014-07-17
申请号：US14238829
申请日：2012-08-14
申请人： Ewald Terpetschnig , Inna G. Yermolenko , Olena M. Obukhova , Anatoliy Tatarets , Leonid D. Patsenker
发明人： Ewald Terpetschnig , Inna G. Yermolenko , Olena M. Obukhova , Anatoliy Tatarets , Leonid D. Patsenker
IPC分类号： C07D471/06 , C07D403/14
CPC分类号： C07D471/06 , C07D207/46 , C07D209/10 , C07D209/18 , C07D403/10 , C07D403/14 , C09K11/06
摘要： Dendronic reporters are described which incorporate a high density of luminescent or non-luminescent dyes at periphery sites and a focal point group that is reactive, ionic or a conjugated substance. Such dendronic reporters are capable of sensing analytes, or are otherwise useful in luminescent assays. Additionally, methods of synthesis are described.
摘要翻译：描述了在周边位置掺入高密度的发光或非发光染料的Dendronic报道器，以及作为反应性离子或共轭物质的焦点基团。这种树突状记录能够感测分析物，否则可用于发光测定。另外，描述了合成方法。

4. 发明申请

US20120123026A1 FUNCTIONALIZED COMPOSITIONS FOR IMPROVED IMMOBILIZATION 有权
标题翻译：功能化组合物，用于改善固化
公开(公告)号：US20120123026A1
公开(公告)日：2012-05-17
申请号：US12119203
申请日：2008-05-12
申请人： Ananda G. Lugade , Kurt D. Hoffacker , Adam J. Jenkins , Karri L. Michael-Ballard , Leonid Patsenker , Ewald Terpetschnig , Veronica D. Thomason , Ralph McDade
发明人： Ananda G. Lugade , Kurt D. Hoffacker , Adam J. Jenkins , Karri L. Michael-Ballard , Leonid Patsenker , Ewald Terpetschnig , Veronica D. Thomason , Ralph McDade
IPC分类号： C08F212/36 , C08K9/12 , C08H1/00 , B82Y5/00
CPC分类号： B82Y30/00 , C07B2200/11 , C07C243/28 , C07C303/22 , C07C303/32 , C07C315/04 , C07C319/18 , C07C319/22 , C07C381/02 , C07C2601/04 , C07D239/48 , C07K1/042 , C07K17/00 , G01N33/54353 , Y10S977/902 , C07C309/47 , C07C309/88 , C07C309/46 , C07C317/18 , C07C323/65 , C07C323/42 , C07C309/42
摘要： The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel reactive groups attached to linker groups of 2-1000 atoms length. The present invention also contemplates the use of bifunctional bridge molecules to link two or more entities, wherein the functional groups of the bridge molecules are the novel reactive groups of the present invention.
摘要翻译：本发明涉及两个或多个实体如生物分子，聚合物组合物，有机/无机分子/材料等的改进的共价偶联，包括其组合，通过连接到2-1000的连接基团上的一个或多个新的反应性基团原子长度。本发明还考虑使用双官能桥分子连接两个或多个实体，其中桥分子的官能团是本发明的新的反应性基团。

5. 发明申请

US20120035328A1 METHODS FOR FORMING DYED MICROSPHERES AND POPULATIONS OF DYED MICROSPHERES 有权
标题翻译：用于形成染色微球的人造粒的方法
公开(公告)号：US20120035328A1
公开(公告)日：2012-02-09
申请号：US13246486
申请日：2011-09-27
申请人： Kurt D. Hoffacker , Ananda G. Lugade , Ewald Terpetschnig
发明人： Kurt D. Hoffacker , Ananda G. Lugade , Ewald Terpetschnig
IPC分类号： C08F12/30 , C07D403/08 , C07C311/49
CPC分类号： C09B69/10 , C08F8/00 , C09B67/0097 , D06P1/008 , G01N33/585 , C08F212/08
摘要： Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.
摘要翻译：提供了形成染色微球的各种方法。一种方法包括使用热或光活化与染料偶联的化学结构，以在微球存在下形成反应中间体。反应中间体共价连接到微球的聚合物上，从而将染料偶联到聚合物上并形成染色的微球。提供用于形成耦合到分子的染色微球的其它方法。除了在染色的微球的外表面上合成分子之外，这些方法包括如上所述染色微球。还提供了一批染色微球。群体的每个染色的微球包括通过化学结构连接到每个染色微球的聚合物上的染料。由染料染色的微球体的染料特性的变异系数小于约10％。

6. 发明申请

US20080103061A1 FUNCTIONALIZED COMPOSITIONS FOR IMPROVED IMMOBILIZATION 有权
标题翻译：功能化组合物，用于改善固化
公开(公告)号：US20080103061A1
公开(公告)日：2008-05-01
申请号：US11621209
申请日：2007-01-09
申请人： Ananda G. Lugade , Kurt D. Hoffacker , Adam J. Jenkins , Karri L. Michael-Ballard , Leonid Patsenker , Ewald Terpetschnig , Veronica D. Thomason , Ralph McDade
发明人： Ananda G. Lugade , Kurt D. Hoffacker , Adam J. Jenkins , Karri L. Michael-Ballard , Leonid Patsenker , Ewald Terpetschnig , Veronica D. Thomason , Ralph McDade
IPC分类号： C40B40/04 , C40B40/06 , C40B40/10
CPC分类号： B82Y30/00 , C07B2200/11 , C07C243/28 , C07C303/22 , C07C303/32 , C07C315/04 , C07C319/18 , C07C319/22 , C07C381/02 , C07C2601/04 , C07D239/48 , C07K1/042 , C07K17/00 , G01N33/54353 , Y10S977/902 , C07C309/47 , C07C309/88 , C07C309/46 , C07C317/18 , C07C323/65 , C07C323/42 , C07C309/42
摘要： The present invention relates to improved covalent coupling of two or more entities such as biomolecules, polymer compositions, organic/inorganic molecules/materials, and the like, including their combinations, through one or more novel reactive groups attached to linker groups of 2-1000 atoms length. The present invention also contemplates the use of bifunctional bridge molecules to link two or more entities, wherein the functional groups of the bridge molecules are the novel reactive groups of the present invention.
摘要翻译：本发明涉及两个或多个实体如生物分子，聚合物组合物，有机/无机分子/材料等的改进的共价偶联，包括其组合，通过连接到2-1000的连接基团上的一个或多个新的反应性基团原子长度。本发明还考虑使用双官能桥分子连接两个或多个实体，其中桥分子的官能团是本发明的新的反应性基团。

7. 发明授权

US08361169B2 Methods for forming dyed microspheres and populations of dyed microspheres 有权
标题翻译：形成染色微球体和染色微球体群体的方法
公开(公告)号：US08361169B2
公开(公告)日：2013-01-29
申请号：US13246486
申请日：2011-09-27
申请人： Kurt D. Hoffacker , Ananda G. Lugade , Ewald Terpetschnig
发明人： Kurt D. Hoffacker , Ananda G. Lugade , Ewald Terpetschnig
IPC分类号： C07C247/00
CPC分类号： C09B69/10 , C08F8/00 , C09B67/0097 , D06P1/008 , G01N33/585 , C08F212/08
摘要： Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.
摘要翻译：提供了形成染色微球的各种方法。一种方法包括使用热或光活化与染料偶联的化学结构，以在微球存在下形成反应中间体。反应中间体共价连接到微球的聚合物上，从而将染料偶联到聚合物上并形成染色的微球。提供用于形成耦合到分子的染色微球的其它方法。除了在染色的微球的外表面上合成分子之外，这些方法包括如上所述染色微球。还提供了一批染色微球。群体的每个染色的微球包括通过化学结构连接到每个染色微球的聚合物上的染料。由染料染色的微球体的染料特性的变异系数小于约10％。

8. 发明申请

US20080076188A1 Luminescent compounds 审中-公开
标题翻译：发光化合物
公开(公告)号：US20080076188A1
公开(公告)日：2008-03-27
申请号：US11820508
申请日：2007-06-19
申请人： Leonid Patsenker , Inna Yermolenko , Irina Fedyunyaeva , Yelena Obukhova , Olga Semenova , Ewald Terpetschnig
发明人： Leonid Patsenker , Inna Yermolenko , Irina Fedyunyaeva , Yelena Obukhova , Olga Semenova , Ewald Terpetschnig
IPC分类号： G01N21/00 , C07C13/66 , C07C15/27 , C07C15/38 , C07C211/45 , C07C317/00 , C07C43/20 , C07C49/617 , C07D209/56 , C07D219/02 , C07D219/08 , C07D221/06 , C07D221/18 , C07D239/72 , C07D285/14 , C07D307/77 , C07D471/02 , C07D471/04 , C07D471/12 , C07D493/02 , C07F9/28 , C07H21/04 , C07K2/00
CPC分类号： C07C309/47 , C07C13/66 , C07C15/30 , C07C15/38 , C07C49/753 , C07C49/755 , C07C211/61 , C07C225/22 , C07C309/38 , C07C309/44 , C07C309/58 , C07C2603/24 , C07C2603/26 , C07C2603/40 , C07C2603/42 , C07C2603/48 , C07C2603/50 , C07D209/60 , C07D219/02 , C07D221/14 , C07D239/74 , C07D285/14 , C07D307/77 , C07D471/04 , C07D471/06 , C07D471/14 , C07F9/5449 , C09K11/06 , C09K2211/1007 , C09K2211/1011 , C09K2211/1014 , C09K2211/1029 , C09K2211/1044 , C09K2211/1051 , C09K2211/1088
摘要： Reporter compounds based on aromatic and heterocyclic compounds, including intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, where the reporter compounds generally have the structure: where at least one pair of adjacent substituents (Ra, Rb), (Rb, Rc), (Rc, Rd), (Rd, Re), (Re, Rf), (Rf, Ra) is either a substituted cyclic or polycyclic group; or at least one set of three substituents (Ra, Rb, Rc), (Rb, Rc, Rd), (Rc, Rd, Re), (Rd, Re, Rf), (Re, Rf, Ra) is a substituted cyclic or polycyclic group.
摘要翻译：报告基于芳族和杂环化合物的化合物，包括用于合成报告化合物的中间体，以及合成和使用报告化合物的方法，其中报告化合物通常具有以下结构：其中至少一对相邻的取代基（R“ a，b），（R b），R c），（R b），（R d，R e），（R e），R e， / SUP）），（R 1，R 2，S）O是取代的环状或多环基团; 或至少一组三个取代基（R a，R b，R b，R c），（R b），其中R 1，R 2，R 2，R d，R d，R d， SUP）），（R，D，R e，R f），（R e），R SUP R f是取代的环状或多环基团。

9. 发明申请

US20060085925A1 Methods for forming dyed microspheres and populations of dyed microspheres 有权
公开(公告)号：US20060085925A1
公开(公告)日：2006-04-27
申请号：US11247942
申请日：2005-10-11
申请人： Kurt Hoffacker , Ananda Lugade , Ewald Terpetschnig
发明人： Kurt Hoffacker , Ananda Lugade , Ewald Terpetschnig
IPC分类号： D06P5/00
CPC分类号： C09B69/10 , C08F8/00 , C09B67/0097 , D06P1/008 , G01N33/585 , C08F212/08
摘要： Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.

10. 发明申请

US20050202565A1 Luminescent compounds 有权
标题翻译：发光化合物
公开(公告)号：US20050202565A1
公开(公告)日：2005-09-15
申请号：US10986446
申请日：2004-11-10
申请人： Ewald Terpetschnig , Anatoliy Tatarets , Olga Galkina , Iryna Fedyunyaeva , Leonid Patsenker
发明人： Ewald Terpetschnig , Anatoliy Tatarets , Olga Galkina , Iryna Fedyunyaeva , Leonid Patsenker
IPC分类号： C07H21/00 , C09B23/01 , C09B23/02 , C09B57/00 , C09K11/06 , G01N33/58 , G01N33/00
CPC分类号： C07H21/00 , C09B23/0066 , C09B23/02 , C09B57/007 , C09K11/06 , C09K2211/1007 , C09K2211/1022 , C09K2211/1029 , C09K2211/1037 , C09K2211/1044 , C09K2211/1048 , C09K2211/1051 , C09K2211/1074 , C09K2211/1081 , G01N33/582 , Y10T436/13
摘要： The invention provides reporter compounds based on squaric, croconic, and/or rhodizonic acid, among others, reactive intermediates used to synthesize the reporter compounds, and methods of synthesizing and using the reporter compounds, among others. The reporter compounds relate generally to the following structure Here, Z is a four, five, or six-member aromatic ring, and A, B, C, D, E, and F are substituents of Z, where F is absent when Z is a five-member ring, and where E and F are absent when Z is a four-member ring. A, B, C, D, E, and F are selected from a variety of elements and groups, including but not necessarily limited to O, S, Se, Te, N—Ra, C(Rb)(Rc), W1, and W2.
摘要翻译：本发明提供了基于方圆，克罗克和/或铑酸等的报告化合物，其中包括用于合成报告化合物的反应性中间体，以及合成和使用报告化合物等的方法。报道化合物一般涉及以下结构：其中Z为四，五或六元芳环，A，B，C，D，E和F为Z的取代基，当Z为Z时，F不存在一个五元环，当Z是四元环时，E和F不存在。 A，B，C，D，E和F选自多种元素和基团，包括但不限于O，S，Se，Te，NR，C（R，（S），（B），（S），W＆lt; 1＆gt;和W 2。

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