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1. 发明授权

US6063745A Mutli-purpose contact lens care compositions 失效
标题翻译：多用途隐形眼镜护理组合物
公开(公告)号：US6063745A
公开(公告)日：2000-05-16
申请号：US980033
申请日：1997-11-26
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： G02C13/00 , A61L2/18 , A61L12/14 , A61K31/155 , A01N55/00 , C11D3/06
CPC分类号： A61L12/141 , A61L12/142
摘要： Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于隐形眼镜护理的多功能解决方案提供了大量的镜片佩戴者/使用者的舒适性和/或可接受性。这种溶液包括水性液体介质; 抗微生物组分，优选以小于约5ppm的量存在的双胍聚合物; 表面活性剂组分，优选聚（氧乙烯） - 聚（氧丙烯）嵌段共聚物表面活性剂; 有效量的磷酸盐缓冲剂组分; 粘度诱导组分，优选选自纤维素衍生物;有效量; 和有效量的张力成分。这样的解决方案具有显着的性能，舒适性和可接受性的优点，这最终导致眼睛健康的优点和避免由隐形眼镜磨损引起的问题。

2. 发明授权

US06319883B1 Multi-purpose contact lens care compositions 有权
标题翻译：多用途隐形眼镜护理组合物
公开(公告)号：US06319883B1
公开(公告)日：2001-11-20
申请号：US09417526
申请日：1999-10-13
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： C11D1722
CPC分类号： A61L12/141 , A61L12/142
摘要： Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于隐形眼镜护理的多功能解决方案提供了大量的镜片佩戴者/使用者的舒适性和/或可接受性。这种溶液包括水性液体介质; 抗微生物组分，优选以小于约5ppm的量存在的双胍聚合物; 表面活性剂组分，优选聚（氧乙烯） - 聚（氧丙烯）嵌段共聚物表面活性剂; 有效量的磷酸盐缓冲剂组分; 粘度诱导组分，优选选自纤维素衍生物;有效量; 和有效量的张力成分。这样的解决方案具有显着的性能，舒适性和可接受性的优点，这最终导致眼睛健康的优点和避免由隐形眼镜磨损引起的问题。

3. 发明授权

US06586377B2 Contact lens cleaning compositions 有权
标题翻译：隐形眼镜清洁剂
公开(公告)号：US06586377B2
公开(公告)日：2003-07-01
申请号：US10005638
申请日：2001-12-03
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： C11D1722
CPC分类号： C11D3/0078 , C11D1/008 , C11D1/29 , C11D1/667 , C11D1/72 , C11D1/722 , C11D3/225
摘要： Solutions useful to clean contact lenses include a surfactant component in an effective amount; and a viscosity inducing component, preferably selected from cellulosic derivatives and more preferably hydroxypropylmethyl cellulose, in an effective amount. Such solutions, which may include one or more additional components, have substantial contact lens cleaning benefits which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于清洁隐形眼镜的溶液包括有效量的表面活性剂组分; 和优选选自纤维素衍生物，更优选羟丙基甲基纤维素的粘度诱导组分。可以包括一个或多个另外的组件的这种解决方案具有显着的隐形眼镜清洁益处，其最终导致眼睛健康优点和避免由隐形眼镜磨损引起的问题。

4. 发明授权

US08512717B2 Compositions for delivery of therapeutics into the eyes and methods for making and using same 有权
公开(公告)号：US08512717B2
公开(公告)日：2013-08-20
申请号：US10911966
申请日：2004-08-05
申请人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
发明人： Joseph G. Vehige , James N. Chang , Richard Graham , Robert T. Lyons , Teresa H. Kuan , Chin-Ming Chang
IPC分类号： A61K9/00 , A61K31/40
CPC分类号： A61K31/407 , A61K9/0048 , A61K31/00 , A61K47/38
摘要： The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.

5. 发明授权

US06482781B2 Multi-purpose contact lens care compositions 有权
标题翻译：多用途隐形眼镜护理组合物
公开(公告)号：US06482781B2
公开(公告)日：2002-11-19
申请号：US09968253
申请日：2001-10-01
申请人： Richard Graham , Joseph G. Vehige
发明人： Richard Graham , Joseph G. Vehige
IPC分类号： C11D1722
CPC分类号： A61L12/141 , A61L12/142
摘要： Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and-acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于隐形眼镜护理的多功能解决方案提供了大量的镜片佩戴者/使用者的舒适性和/或可接受性这种溶液包括水性液体介质; 抗微生物组分，优选以小于约5ppm的量存在的双胍聚合物; 表面活性剂组分，优选聚（氧乙烯） - 聚（氧丙烯）嵌段共聚物表面活性剂; 有效量的磷酸盐缓冲剂组分; 粘度诱导组分，优选选自纤维素衍生物;有效量; 和有效量的张力成分。这样的解决方案具有显着的性能，舒适性和可接受性的优点，其最终导致眼睛健康优点并避免由隐形眼镜磨损引起的问题。

6. 发明授权

US08952051B2 Ophthalmic formulations containing substituted gamma lactams and methods for use thereof 有权
标题翻译：含有取代的γ-内酰胺类的眼用制剂及其使用方法
公开(公告)号：US08952051B2
公开(公告)日：2015-02-10
申请号：US12939846
申请日：2010-11-04
申请人： Anuradha V. Gore , Robert S. Jordan , Ajay Parashar , Chetan Pujara , Richard Graham , Mu-Lan Lee
发明人： Anuradha V. Gore , Robert S. Jordan , Ajay Parashar , Chetan Pujara , Richard Graham , Mu-Lan Lee
IPC分类号： A61K31/4025 , A61K9/00 , A61K47/10 , A61K47/26
CPC分类号： A61K9/0048 , A61K31/4025 , A61K47/10 , A61K47/26
摘要： The invention provides ophthalmic formulations containing well-defined substituted gamma lactams. The formulations described herein are useful in treating a variety of ocular diseases related to ocular hypertension, such as for example, glaucoma.
摘要翻译：本发明提供含有明确定义的取代的γ-内酰胺的眼用制剂。本文所述的制剂可用于治疗与眼高压相关的各种眼部疾病，例如青光眼。

7. 发明申请

US20110105581A1 OPHTHALMIC FORMULATIONS CONTAINING SUBSTITUTED GAMMA LACTAMS AND METHODS FOR USE THEREOF 有权
标题翻译：含有取代的伽玛胶囊的眼用配方及其使用方法
公开(公告)号：US20110105581A1
公开(公告)日：2011-05-05
申请号：US12939846
申请日：2010-11-04
申请人： Anuradha V. Gore , Robert S. Jordan , Ajay Parashar , Chetan Pujara , Richard Graham , Mu-Lan Lee
发明人： Anuradha V. Gore , Robert S. Jordan , Ajay Parashar , Chetan Pujara , Richard Graham , Mu-Lan Lee
IPC分类号： A61K31/4025 , A61P27/02
CPC分类号： A61K9/0048 , A61K31/4025 , A61K47/10 , A61K47/26
摘要： The invention provides ophthalmic formulations containing well-defined substituted gamma lactams. The formulations described herein are useful in treating a variety of ocular diseases related to ocular hypertension, such as for example, glaucoma.
摘要翻译：本发明提供含有明确定义的取代的γ-内酰胺的眼用制剂。本文所述的制剂可用于治疗与眼高压相关的各种眼部疾病，例如青光眼。

8. 发明申请

US20070087962A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLOSPORINS 审中-公开
标题翻译：包含环磷酰胺的药物组合物
公开(公告)号：US20070087962A1
公开(公告)日：2007-04-19
申请号：US11470923
申请日：2006-09-07
申请人： Walter Tien , Richard Graham , James Chang
发明人： Walter Tien , Richard Graham , James Chang
IPC分类号： A61K38/13 , A61K31/355
CPC分类号： A61K38/13 , A61K31/355
摘要： A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an emulsion. is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
摘要翻译：包含治疗有效浓度的环孢菌素和维生素E生育酚聚乙二醇琥珀酸酯的液体，其中所述液体是乳液。在此公开。使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

9. 发明申请

US20070059332A1 MULTI PURPOSE CONTACT LENS CARE COMPOSITIONS INCLUDING PROPYLENE GLYCOL OR GLYCERIN 审中-公开
标题翻译：多用途接触眼镜护理组合物，包括丙二醇或甘油
公开(公告)号：US20070059332A1
公开(公告)日：2007-03-15
申请号：US11554702
申请日：2006-10-31
申请人： Richard Graham , Lam Tran
发明人： Richard Graham , Lam Tran
IPC分类号： A01N25/00
CPC分类号： C11D3/48 , A01N47/44 , A61L12/14 , A61L12/141 , A61L12/142 , A61L12/143 , C11D1/008 , C11D3/0078 , C11D3/2003 , C11D3/2044 , C11D3/2065 , A01N25/02 , A01N2300/00
摘要： Multi-purpose solutions for contact lens care provide substantial lens wearer/user comfort and/or acceptability. Such solutions include an aqueous liquid medium; an antimicrobial component, preferably a biguanide polymer present in an amount of less than about 5 ppm; propylene glycol or glycerin in an amount sufficient to increase antimicrobial activity; a surfactant component, preferably a poly(oxyethylene)-poly(oxypropylene) block copolymer surfactant, in an effective amount; a phosphate buffer component in an effective amount; a viscosity inducing component, preferably selected from cellulosic derivatives, in an effective amount; and a tonicity component in an effective amount. Such solutions have substantial performance, comfort and acceptability benefits, which, ultimately, lead to ocular health advantages and avoidance of problems caused by contact lens wear.
摘要翻译：用于隐形眼镜护理的多功能解决方案提供了大量的镜片佩戴者/使用者的舒适性和/或可接受性这种溶液包括水性液体介质; 抗微生物组分，优选以小于约5ppm的量存在的双胍聚合物; 丙二醇或甘油，其量足以增加抗菌活性; 表面活性剂组分，优选聚（氧乙烯） - 聚（氧丙烯）嵌段共聚物表面活性剂; 有效量的磷酸盐缓冲剂组分; 粘度诱导组分，优选选自纤维素衍生物;有效量; 和有效量的张力成分。这样的解决方案具有显着的性能，舒适性和可接受性的优点，这最终导致眼睛健康的优点和避免由隐形眼镜磨损引起的问题。

10. 发明申请

US20060046958A1 Compositions and methods comprising prostaglandin related compounds and trefoil factor family peptides for the treatment of glaucoma with reduced hyperemia 失效
标题翻译：包含前列腺素相关化合物和三叶因子家族肽用于治疗青光眼与降低充血的组合物和方法
公开(公告)号：US20060046958A1
公开(公告)日：2006-03-02
申请号：US10521367
申请日：2004-08-25
申请人： Peter Bakhit , Richard Graham , Orest Olejnik
发明人： Peter Bakhit , Richard Graham , Orest Olejnik
IPC分类号： A61K38/17 , A61K31/715 , A61K31/557
CPC分类号： A61K38/17 , A61K31/557 , A61K31/5575 , A61K31/715 , A61K38/1709 , A61K2300/00
摘要： Compositions, methods, and pharmaceutical products related to prostaglandin-related compounds and trefoil factor family peptides are disclosed herein. Of particular interest are compositions and methods useful for the treatment of glaucoma with a reduced occurrence of hyperemia.
摘要翻译：本文公开了与前列腺素相关化合物和三叶因子家族肽相关的组合物，方法和药物产品。特别感兴趣的是用于治疗青光眼的组合物和方法，其中发生充血发生。

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