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1. 发明申请

US20050277584A1 Pharmaceutical compositions comprising cyclosporins 审中-公开
标题翻译：包含环孢菌素的药物组合物
公开(公告)号：US20050277584A1
公开(公告)日：2005-12-15
申请号：US10865638
申请日：2004-06-09
申请人： Walter Tien , Richard Graham , James Chang
发明人： Walter Tien , Richard Graham , James Chang
IPC分类号： A61K9/00 , A61K9/08 , A61K31/355 , A61K38/13 , A61K47/22
CPC分类号： A61K9/0048 , A61K9/08 , A61K31/355 , A61K38/13 , A61K2300/00
摘要： A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an aqueous solution, and wherein no hydrophilic organic solvent is present at a concentration greater than half of that of the cyclosporin is also disclosed herein. A composition comprising a therapeutically effective concentration of cyclosporin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for ophthalmic use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. A composition comprising a therapeutically effective concentration of cyclosporin A and an effective amount of a vitamin E tocopherol polyethylene glycol succinate, wherein said composition is an aqueous liquid solution which is intended for parenteral use, and wherein no hydrophilic organic solvent is present at a mass concentration greater than or equal to that of the cyclosporin, is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
摘要翻译：包含治疗有效浓度的环孢菌素和维生素E生育酚聚乙二醇琥珀酸酯的液体，其中所述液体是水溶液，并且其中没有亲水性有机溶剂的浓度大于环孢菌素浓度的一半的浓度。一种组合物，其包含治疗有效浓度的环孢菌素A和有效量的维生素E生育酚聚乙二醇琥珀酸酯，其中所述组合物是旨在用于眼用的水性液体溶液，并且其中没有亲水性有机溶剂以质量浓度存在大于或等于环孢菌素的浓度。一种组合物，其包含治疗有效浓度的环孢菌素A和有效量的维生素E生育酚聚乙二醇琥珀酸酯，其中所述组合物是用于肠胃外使用的水性液体溶液，并且其中没有亲水性有机溶剂以质量浓度存在大于或等于环孢菌素的浓度。使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

2. 发明申请

US20070027072A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLOSPORINS 有权
标题翻译：包含环磷酰胺的药物组合物
公开(公告)号：US20070027072A1
公开(公告)日：2007-02-01
申请号：US11161218
申请日：2005-07-27
申请人： Walter Tien , Richard Graham , James Chang
发明人： Walter Tien , Richard Graham , James Chang
IPC分类号： A61K38/13 , A61K36/47 , A61K9/00
CPC分类号： A61K38/13 , A61K9/0019 , A61K9/0048
摘要： A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethylene stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
摘要翻译：本文描述了一种组合物，其包含环孢菌素A，聚山梨醇酯80，聚氧乙烯硬脂酸酯和油; 其中所述组合物是眼科可接受的乳液。使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

3. 发明申请

US20070087962A1 PHARMACEUTICAL COMPOSITIONS COMPRISING CYCLOSPORINS 审中-公开
标题翻译：包含环磷酰胺的药物组合物
公开(公告)号：US20070087962A1
公开(公告)日：2007-04-19
申请号：US11470923
申请日：2006-09-07
申请人： Walter Tien , Richard Graham , James Chang
发明人： Walter Tien , Richard Graham , James Chang
IPC分类号： A61K38/13 , A61K31/355
CPC分类号： A61K38/13 , A61K31/355
摘要： A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an emulsion. is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.
摘要翻译：包含治疗有效浓度的环孢菌素和维生素E生育酚聚乙二醇琥珀酸酯的液体，其中所述液体是乳液。在此公开。使用所述组合物治疗疾病或病症的方法及其相关药物也在本文中公开。

4. 发明申请

US20050031697A1 Compositions for delivery of therapeutics into the eyes and methods for making and using same 有权
标题翻译：用于将治疗剂递送到眼睛中的组合物及其制备和使用方法
公开(公告)号：US20050031697A1
公开(公告)日：2005-02-10
申请号：US10911966
申请日：2004-08-05
申请人： Joseph Vehige , James Chang , Richard Graham , Robert Lyons , Teresa Kuan , Chin-Ming Chang
发明人： Joseph Vehige , James Chang , Richard Graham , Robert Lyons , Teresa Kuan , Chin-Ming Chang
IPC分类号： A61K9/00 , A61K31/00 , A61K9/14
CPC分类号： A61K31/407 , A61K9/0048 , A61K31/00 , A61K47/38
摘要： The present invention provides for compositions for administering a therapeutically effective amount of a therapeutic component. The compositions may include an ophthalmically acceptable carrier component; a therapeutically effective amount of a therapeutic component; and a retention component which may be effective to reduce wettability, induce viscosity, increase muco-adhesion, increase meniscus height on a cornea of an eye and/or increase physical apposition to a cornea of an eye of a composition.
摘要翻译：本发明提供了用于施用治疗有效量的治疗成分的组合物。组合物可以包括眼科可接受的载体组分; 治疗有效量的治疗成分; 以及可以有效地降低润湿性，诱导粘度，增加粘膜粘附，增加眼睛角膜上的弯液面高度和/或增加与组合物的眼睛的角膜的物理连接的保留组分。

5. 发明授权

US08722097B2 Oil-in-water method for making polymeric implants containing a hypotensive lipid 有权
标题翻译：用于制造含有低血压脂质的聚合物植入物的水包油法
公开(公告)号：US08722097B2
公开(公告)日：2014-05-13
申请号：US11371118
申请日：2006-03-08
申请人： James Chang , Patrick Hughes , Chin-Ming Chang
发明人： James Chang , Patrick Hughes , Chin-Ming Chang
IPC分类号： A61K9/50 , B01J13/02 , B01J13/04
CPC分类号： A61K31/5575 , A61K9/0048 , A61K9/0051 , A61K9/107 , A61K9/1075 , A61K9/146 , A61K9/1647 , A61K9/1694 , A61K31/165 , A61K47/34 , B01J13/04 , B01J13/06
摘要： Biocompatible microparticles include an ophthalmically active cyclic lipid component and a biodegradable polymer that is effective, when placed into the subconjunctival space, in facilitating release of the cyclic lipid component into the anterior and posterior segments of an eye for an extended period of time. The cyclic lipid component can be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the cyclic lipid component can be encapsulated by the polymeric component. The present microparticles include oil-in-water emulsified microparticles. The subconjunctivally administered microparticles can be used to treat or to reduce at least one symptom of an ocular condition, such as glaucoma or age related macular degeneration.
摘要翻译：生物相容的微粒包括眼科活性的环状脂质组分和可生物降解的聚合物，当放置在结膜下空间中时，有效地促进环状脂质成分延长眼睛部分的时间。环状脂质组分可与可生物降解的聚合物基质相结合，例如两种可生物降解聚合物的基质。或者，环状脂质组分可以被聚合物组分包封。本发明的微粒包括水包油乳化微粒。结膜下施用的微粒可用于治疗或减少眼部疾病如青光眼或年龄相关性黄斑变性的至少一种症状。

6. 发明申请

US20090035165A1 Addressable Multi-Channel Peristaltic Pump 有权
标题翻译：可寻址多通道蠕动泵
公开(公告)号：US20090035165A1
公开(公告)日：2009-02-05
申请号：US11833493
申请日：2007-08-03
申请人： James Chang
发明人： James Chang
IPC分类号： F04B43/12
CPC分类号： F04B43/1292 , F04B43/0072 , F04B43/0081
摘要： The present invention provides an addressable multi-channel peristaltic pump. According to the invention, this pump design allows for selection and operation of one or more pump heads on a drive shaft, while locking other non-selected pump heads in a stationary position. It is possible to operate the multi-channel pump using a limited number of motors, preferably two motors: a selector motor and a dispense motor. Thus, the pump provides for pumping or dispensing of one or more fluids without the need for multiple pumps. Likewise, compared with typical single motor multi-channel systems, where all pump heads on the drive shaft must rotate at the same time, the present invention provides for selective dispensing of one or more fluids. The pumps of the present invention are suitable for any multiple fluid transfer application, including in automated multi-channel reagent dispensing systems, such as nucleic acid purification systems.
摘要翻译：本发明提供一种可寻址的多通道蠕动泵。根据本发明，该泵设计允许在驱动轴上选择和操作一个或多个泵头，同时将其它未选择的泵头锁定在静止位置。可以使用有限数量的电动机，优选两个电动机来操作多通道泵：选择器电动机和分配电动机。因此，泵提供一个或多个流体的泵送或分配，而不需要多个泵。同样，与典型的单电动机多通道系统相比，驱动轴上的所有泵头必须同时旋转，本发明提供了一种或多种流体的选择性分配。本发明的泵适用于任何多种流体转移应用，包括在自动多通道试剂分配系统中，例如核酸纯化系统。

7. 发明申请

US20080070834A1 Cyclosporin Compositions 有权
标题翻译：环孢菌素组合物
公开(公告)号：US20080070834A1
公开(公告)日：2008-03-20
申请号：US11940652
申请日：2007-11-15
申请人： James Chang , Orest Olejnik , Bruce Firestone
发明人： James Chang , Orest Olejnik , Bruce Firestone
IPC分类号： A61K38/13 , A61P27/02
CPC分类号： A61K47/44 , A61K9/0048 , A61K9/107 , A61K38/13 , Y10S514/912 , Y10S514/975
摘要： A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.
摘要翻译：本文公开了包含约0.001％至约0.4％的环孢菌素A，表面活性剂和比重为0.8至0.95的油的组合物。

8. 发明申请

US20070216213A1 Apparatus For Supporting a Person and Method of Forming Thereof 失效
标题翻译：支持人员的设备及其形成方法
公开(公告)号：US20070216213A1
公开(公告)日：2007-09-20
申请号：US11381706
申请日：2006-05-04
申请人： James Chang
发明人： James Chang
IPC分类号： A47C7/22 , D04B1/18 , D04B7/16 , D04B11/12 , D04B21/14
CPC分类号： A47C7/282 , A47C5/04 , Y10T442/413
摘要： An apparatus having a fabric and method of forming thereof. The fabric's load bearing surface for supporting a load, comprising: at least one layer(s) (Ln) wherein n=0, −1, −2, . . . −i, wherein n=0 represents the at least one layer(s) (Ln) of the load bearing surface that contacts the load. An n=−1, −2, . . . −i, represents successive underlying at least one layer(s) (Ln) of the load bearing surface. An n=−i, represents a bottom underlying at least one layer(s) (Ln). The fabric consists essentially of a polyurethane fiber and a fiber that is chemically different from the polyurethane fiber, and wherein the fabric has been stretched to the point just before encountering the Young's Modulus. The method comprising: cutting the fabric to a predetermined pattern; and stretching the fabric to the point just before encountering the Young's Modulus.
摘要翻译：一种具有织物的装置及其形成方法。用于支撑负载的织物的承载表面，包括：至少一个层（L n n n），其中n = 0，-1，-2。。。 -i，其中n = 0表示与负载接触的承载表面的至少一个层（L n n N）。 n = -1，-2，。。。 -i表示承载表面的连续的下层的至少一层（L n n N）。 n = -i表示至少一层（L）下的底层。织物基本上由聚氨酯纤维和与聚氨酯纤维在化学上不同的纤维组成，并且其中织物已经被拉伸到遇到杨氏模量之前的点。该方法包括：将织物切割成预定图案; 并将织物拉伸到刚刚遇到杨氏模量之前。

9. 发明申请

US20070117507A1 Integrated direct conversion satellite tuner 有权
标题翻译：集成直接转换卫星调谐器
公开(公告)号：US20070117507A1
公开(公告)日：2007-05-24
申请号：US11580228
申请日：2006-10-13
申请人： Myles Wakayama , Dana Laub , Frank Carr , Afshin Mellati , David Ho , Hsiang-Bin Lee , Chun-Ying Chen , James Chang , Lawrence Burns , Young Shin , Patrick Pai , Iconomos Koullias , Ron Lipka , Luke Steigerwald , Alexandre Kral
发明人： Myles Wakayama , Dana Laub , Frank Carr , Afshin Mellati , David Ho , Hsiang-Bin Lee , Chun-Ying Chen , James Chang , Lawrence Burns , Young Shin , Patrick Pai , Iconomos Koullias , Ron Lipka , Luke Steigerwald , Alexandre Kral
IPC分类号： H04H1/00 , H04B1/28
CPC分类号： H03H11/04 , H03D3/008 , H03D7/1441 , H03D7/1458 , H03D7/1483 , H03D7/165 , H03D2200/0025 , H03D2200/0043 , H03D2200/0047 , H04B1/30
摘要： A direct conversion satellite tuner is fully integrated on a common substrate. The integrated tuner receives an RF signal having a plurality of channels and down-converts a selected channel directly to baseband for further processing. The integrated tuner includes on-chip local oscillator generation, tunable baseband filters, and DC Offset cancellation. The integrated tuner can be implemented in a completely differential I/Q configuration for improved electrical performance. The entire direct conversion satellite tuner can be fabricated on a single semiconductor substrate using standard CMOS processing, with minimal off-chip components. The tuner configuration described herein is not limited to processing TV signals, and can be utilized to down-convert other RF signals to an IF frequency or baseband.
摘要翻译：直接转换卫星调谐器完全集成在公共基板上。集成调谐器接收具有多个信道的RF信号，并将所选择的信道直接下变频到基带用于进一步处理。集成调谐器包括片上本地振荡器产生，可调谐基带滤波器和DC偏移消除。集成调谐器可以以完全差分的I / Q配置来实现，以改善电气性能。整个直接转换卫星调谐器可以使用标准CMOS处理在单个半导体衬底上制造，具有最小的片外部件。这里描述的调谐器配置不限于处理TV信号，并且可以用于将其它RF信号下变频到IF频率或基带。

10. 发明申请

US20060233860A1 Alpha-2 agonist polymeric drug delivery systems 有权
公开(公告)号：US20060233860A1
公开(公告)日：2006-10-19
申请号：US11394765
申请日：2006-03-31
申请人： James Chang , Lon Spada , Wendy Blanda , Werhner Orilla , James Burke , Patrick Hughes
发明人： James Chang , Lon Spada , Wendy Blanda , Werhner Orilla , James Burke , Patrick Hughes
IPC分类号： A61K31/498 , A61F2/00
CPC分类号： A61K9/0051 , A61K31/498 , A61L27/18 , A61L27/26 , A61L27/54 , A61L27/58 , A61L2300/604 , A61L2430/16 , Y02A50/401 , C08L67/04
摘要： Biocompatible intraocular implants include an alpha-2 adrenergic receptor agonist and a polymer associated with the alpha-2 adrenergic receptor agonist to facilitate release of the alpha-2 adrenergic receptor agonist into an eye for an extended period of time. The alpha-2 adrenergic receptor agonist may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. The implants can be placed in an eye to treat one or more ocular conditions, such as an ocular vasculopathy or glaucoma, including reduction of an elevated intraocular pressure.

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