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1. 发明申请

US20050251215A1 Cardiac rhythm management system with defibrillation threshold prediction 有权
标题翻译：心脏节律管理系统除颤阈值预测
公开(公告)号：US20050251215A1
公开(公告)日：2005-11-10
申请号：US11061315
申请日：2005-02-18
申请人： Richard Dujmovic , Phil Foshee , Richard Fogoros , Joseph Smith , Douglas Daum , Weimin Sun
发明人： Richard Dujmovic , Phil Foshee , Richard Fogoros , Joseph Smith , Douglas Daum , Weimin Sun
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

2. 发明授权

US08036744B2 Cardiac rhythm management system with defibrillation threshold prediction 有权
标题翻译：心脏节律管理系统除颤阈值预测
公开(公告)号：US08036744B2
公开(公告)日：2011-10-11
申请号：US12631944
申请日：2009-12-07
申请人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
发明人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
IPC分类号： A61N1/08 , A61N1/39 , A61N1/365
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

3. 发明授权

US07643877B2 Cardiac rhythm management system with defibrillation threshold prediction 有权
标题翻译：心脏节律管理系统除颤阈值预测
公开(公告)号：US07643877B2
公开(公告)日：2010-01-05
申请号：US11061315
申请日：2005-02-18
申请人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
发明人： Richard Milon Dujmovic, Jr. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
IPC分类号： A61N1/08 , A61N1/39 , A61N1/365
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

4. 发明申请

US20100087884A1 CARDIAC RHYTHM MANAGEMENT SYSTEM WITH DEFIBRILLATION THRESHOLD PREDICTION 有权
标题翻译： CARDIAC RHYTHM管理系统与定律阈值预测
公开(公告)号：US20100087884A1
公开(公告)日：2010-04-08
申请号：US12631944
申请日：2009-12-07
申请人： Richard Milon Dujmovic, JR. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
发明人： Richard Milon Dujmovic, JR. , Phil Foshee , Richard Fogoros , Joseph M. Smith , Douglas R. Daum , Weimin Sun
IPC分类号： A61N1/39
CPC分类号： A61N1/3937 , A61N1/3943
摘要： A cardiac rhythm management device predicts defibrillation thresholds without any need to apply defibrillation shocks or subjecting the patient to fibrillation. Intravascular defibrillation electrodes are implanted in a heart. By applying a small test energy, an electric field near one of the defibrillation electrodes is determined by measuring a voltage at a sensing electrode offset from the defibrillation electrode by a known distance. A desired minimum value of electric field at the heart periphery is established. A distance between a defibrillation electrodes and the heart periphery is measured, either fluoroscopically or by measuring a voltage at an electrode at or near the heart periphery. Using the measured electric field and the measured distance to the periphery of the heart, the defibrillation energy needed to obtain the desired electric field at the heart periphery is estimated. In an example, the device also includes a defibrillation shock circuit and a stimulation circuit.
摘要翻译：心律管理装置预测除颤阈值，而不需要施加除颤电击或使患者起颤。血管内除颤电极植入心脏。通过施加小的测试能量，通过测量从除颤电极偏移已知距离的感测电极处的电压来确定除颤电极之一附近的电场。建立心脏周围电场的期望最小值。测量除颤电极和心脏周边之间的距离，通过荧光透视或通过测量心脏周围处或附近的电极处的电压。使用测量的电场和到心脏外围的测量距离，估计在心脏周边获得所需电场所需的除颤能量。在一个示例中，该装置还包括除颤电击电路和刺激电路。

5. 发明授权

US08755475B1 Maintaining linear beamforming weights in communications systems 有权
标题翻译：在通信系统中维持线性波束成形权重
公开(公告)号：US08755475B1
公开(公告)日：2014-06-17
申请号：US13411507
申请日：2012-03-02
申请人： Matthew C. Bromberg , Dale A. Branlund , Weimin Sun
发明人： Matthew C. Bromberg , Dale A. Branlund , Weimin Sun
IPC分类号： H03D1/04 , H03D1/06 , H03K5/01 , H03K6/04 , H04B1/10 , H04L1/00 , H04L25/08
CPC分类号： H04B7/0851 , H04B7/0617 , H04B17/345 , H04L1/0071 , H04L25/0234 , H04L25/03 , H04L25/03949
摘要： Methods and systems that enhance interference cancellation in communication channels are described. Samples are obtained from stacked carriers in a received signal and a data vector is created from the samples. Stacked carriers are selected using a steering vector received during synchronization of the receiver. The steering vector is calculated to obtain cancellation of interference from another receiver and is calculated based on time domain channel estimation. Specialized time domain training sequences and simple cross correlation are used to obtain a channel estimate for use in stacked carrier beamforming and/or for use in OFDM based spatial beamforming. State space or filter-based modeled interpolators or whitening matrix-filters in the frequency or time domain are used for interpolation of the channels to maintain linear beamforming weights as a function of time or frequency. Space time adaptive processing facilitates beamforming of communications signals for OFDM and 802.16 (WiMax) systems.
摘要翻译：描述了在通信信道中增强干扰消除的方法和系统。在接收信号中从堆叠载波获取样本，并从样本创建数据向量。使用在接收机同步期间接收到的导向矢量来选择堆叠的载波。计算导向矢量以获得来自另一接收机的干扰的抵消，并且基于时域信道估计来计算。使用专用时域训练序列和简单的互相关来获得用于堆叠载波波束成形和/或用于基于OFDM的空间波束形成中的信道估计。在频率或时域中的状态空间或基于滤波器的建模的内插器或白化矩阵滤波器被用于信道的插值，以维持作为时间或频率的函数的线性波束成形权重。空时自适应处理有利于OFDM和802.16（WiMax）系统的通信信号的波束成形。

6. 发明授权

US08494632B2 Self-calibrating rate-adaptive pacemaker 失效
公开(公告)号：US08494632B2
公开(公告)日：2013-07-23
申请号：US13230563
申请日：2011-09-12
申请人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
发明人： Weimin Sun , Bruce R. Jones , Douglas J. Lang , Donald L. Hopper
IPC分类号： A61N1/18
CPC分类号： A61N1/365 , A61N1/36585
摘要： A system and method for automatically adjusting the operating parameters of a rate-adaptive cardiac pacemaker. In accordance with the method, maximum exertion levels attained by the patient are measured at periodic intervals and stored. The stored maximum exertion levels may then be used to update a long-term maximal exertion level, and the slope of the rate-response curve is adjusted to map the updated long-term maximal exertion level to a maximum allowable pacing rate. The stored maximum exertion levels may also be used to update a sensor target rate which is used to adjust the slope of the rate response curve.

7. 发明申请

US20110008790A1 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE MUTATIONS 有权
公开(公告)号：US20110008790A1
公开(公告)日：2011-01-13
申请号：US12847960
申请日：2010-07-30
申请人： Weimin Sun , Matthew J. McGinniss , Donghui Huang , Arlene Buller , Raymond Fenwick , Mei Peng , Franklin Quan
发明人： Weimin Sun , Matthew J. McGinniss , Donghui Huang , Arlene Buller , Raymond Fenwick , Mei Peng , Franklin Quan
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/6872 , G01N33/6893 , G01N2333/705 , G01N2800/382 , G01N2800/50 , Y10T436/143333
摘要： The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided.
摘要翻译：本发明提供了与囊性纤维化相关的CFTR基因或与囊性纤维化有关的病症的新突变。还提供了用于检测突变体序列的探针。进一步提供鉴定个体是否具有在CFTR基因中含有一个或多个突变的基因型的方法。

8. 发明申请

US20080171332A1 CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR GENE MUTATIONS 有权
公开(公告)号：US20080171332A1
公开(公告)日：2008-07-17
申请号：US11938138
申请日：2007-11-09
申请人： Weimin Sun , Matthew J. McGinniss , Donghui Huang , Arlene Buller , Raymond Fenwick , Mei Peng , Franklin Quan
发明人： Weimin Sun , Matthew J. McGinniss , Donghui Huang , Arlene Buller , Raymond Fenwick , Mei Peng , Franklin Quan
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/6872 , G01N33/6893 , G01N2333/705 , G01N2800/382 , G01N2800/50 , Y10T436/143333
摘要： The present invention provides novel mutations of the CFTR gene related to cystic fibrosis or to conditions associated with cystic fibrosis. Also provided are probes for detecting the mutant sequences. Methods of identifying if an individual has a genotype containing one or more mutations in the CFTR gene are further provided.

9. 发明授权

US07353060B2 Adaptive anti-tachycardia therapy apparatus and method 有权
标题翻译：适应性抗心动过速治疗仪及方法
公开(公告)号：US07353060B2
公开(公告)日：2008-04-01
申请号：US10953081
申请日：2004-09-29
申请人： Weimin Sun , Bruce H. KenKnight , Martin Tze , Yatheendhar Manicka
发明人： Weimin Sun , Bruce H. KenKnight , Martin Tze , Yatheendhar Manicka
IPC分类号： A61N1/362
CPC分类号： A61N1/3962
摘要： A method and apparatus for delivering anti-tachycardia pacing in an adaptive manner is disclosed. A cardiac rhythm management device, such as an implantable pacemaker, having anti-tachycardia pacing capability delivers anti-tachycardia pacing therapy in accordance with a selected pacing protocol upon detection of a terminable arrhythmia. The protocol is selected from a library of available protocols. A record of the successes and failures of each available protocol in converting tachyarrhythmias is maintained in a result table for use in selecting the protocol.
摘要翻译：公开了以自适应方式递送抗心动过速起搏的方法和装置。具有抗心动过速起搏能力的心脏节律管理装置，例如可植入心脏起搏器，在检测到可终止的心律失常时，根据选定的起搏方案提供抗心动过速起搏治疗。协议从可用协议库中选择。在用于选择协议的结果表中保留了每种可用协议在转换快速性心律失常方面的成功和失败的记录。

10. 发明授权

US06230055B1 Method and apparatus for adaptive tachycardia and fibrillation discrimination 有权
标题翻译：适应性心动过速和原纤维化鉴别的方法和装置
公开(公告)号：US06230055B1
公开(公告)日：2001-05-08
申请号：US09378591
申请日：1999-08-20
申请人： Weimin Sun , Martin Tze , Bruce H. KenKnight , Yatheendhar Manicka
发明人： Weimin Sun , Martin Tze , Bruce H. KenKnight , Yatheendhar Manicka
IPC分类号： A61N137
CPC分类号： A61N1/3622 , A61N1/3962
摘要： An implantable cardioverter/defibrillator with antitachycardia pacing capability and method for operating same in which the detection zone boundary used to discriminate between tachycardia and fibrillation is adaptively adjusted based upon operating experience. Rate zones are provided for further classifying detected episodes of tachycardia and fibrillation according to the certainty of their being correctly identified based upon past operating experience. Adjustments of the rate zones and the fibrillation detection zone boundary are made based upon the results of antitachycardia pacing in attempting to terminate arrhythmic episodes.
摘要翻译：一种具有抗心动过速起搏能力的植入式心律转复除颤器及其操作方法，其中基于操作经验自适应调整用于区分心动过速和颤动的检测区边界。提供速率区，用于根据过去的操作经验正确识别检测到的心动过速和颤动发作进一步分类。基于抗心律失常起搏试图终止心律失常发作的结果，进行速率区和原纤维化检测区边界的调整。

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