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1. 发明申请

US20090308385A1 METHOD AND APPARATUS FOR METERED DOSE DISPENSING 有权
标题翻译：用于计量剂量分配的方法和装置
公开(公告)号：US20090308385A1
公开(公告)日：2009-12-17
申请号：US12281559
申请日：2007-03-01
申请人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
发明人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0065 , A61M15/0073 , G06M1/04
摘要： This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction. The cap is then moved in a second opposite direction, which causes the slider to move in a second opposite linear direction, which in turn causes rotation of the first counter ring through a second arc in the first circumferential direction about the axis of the container A sum of the first and second arcs of movement of the first counter ring defines a circumferential extent of movement of the first counter ring relative to the cap that indicates a single dose of aerosol medication dispensed from the container.
摘要翻译：本申请公开了一种用于在具有气溶胶容器和致动器的气溶胶分配组件上使用的剂量计数装置。剂量计数器装置用于指示通过在轴向上施加在气溶胶分配组件上的力引起的剂量的气溶胶药物的释放。剂量计数装置具有帽，滑块和第一计数器环。盖沿着容器的轴线沿第一方向移动，这导致滑块相对于容器的轴线在第一线性方向上相对于容器的轴线的移动，这是沿着第一方向的运动的函数。随着滑块在第一直线方向的移动，第一计数器环围绕容器的轴线在第一圆周方向上旋转通过第一弧。然后，盖沿第二相反方向移动，这导致滑块在第二相对的线性方向上移动，这又导致第一计数器环围绕容器A的轴线在第一圆周方向上旋转第二弧第一计数器环的第一和第二运动弧的总和限定了第一计数器环相对于帽的周向运动范围，其指示从容器分配的单剂量的气溶胶药物。

2. 发明授权

US08517019B2 Method and apparatus for metered dose dispensing 有权
标题翻译：计量剂量分配的方法和装置
公开(公告)号：US08517019B2
公开(公告)日：2013-08-27
申请号：US12281559
申请日：2007-03-01
申请人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
发明人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
IPC分类号： A62B7/00 , A62B9/00 , A61M11/00
CPC分类号： A61M15/009 , A61M15/0065 , A61M15/0073 , G06M1/04
摘要： This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction. The cap is then moved in a second opposite direction, which causes the slider to move in a second opposite linear direction, which in turn causes rotation of the first counter ring through a second arc in the first circumferential direction about the axis of the container. A sum of the first and second arcs of movement of the first counter ring defines a circumferential extent of movement of the first counter ring relative to the cap that indicates a single dose of aerosol medication dispensed from the container.
摘要翻译：本申请公开了一种用于在具有气溶胶容器和致动器的气溶胶分配组件上使用的剂量计数装置。剂量计数器装置用于指示通过在轴向上施加在气溶胶分配组件上的力引起的剂量的气溶胶药物的释放。剂量计数装置具有帽，滑块和第一计数器环。盖沿着容器的轴线沿第一方向移动，这导致滑块相对于容器的轴线在第一线性方向上相对于容器的轴线的移动，这是沿着第一方向的运动的函数。随着滑块在第一直线方向的移动，第一计数器环围绕容器的轴线在第一圆周方向上旋转通过第一弧。然后，盖沿第二相反方向移动，这导致滑块在第二相对的线性方向上移动，这又导致第一计数器环围绕容器的轴线沿第一圆周方向旋转第二弧。第一计数器环的第一和第二运动弧的总和限定了第一计数器环相对于盖的周向运动范围，其指示从容器分配的单剂量的气溶胶药物。

3. 发明申请

US20090173346A1 DOSE COUNTER 有权
标题翻译：剂量计数器
公开(公告)号：US20090173346A1
公开(公告)日：2009-07-09
申请号：US12297942
申请日：2007-04-20
申请人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
发明人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0073 , A61M15/0075 , A61M15/009 , B65D83/46 , B65D83/54 , B65D83/75 , G06M1/16 , G06M1/24
摘要： This application discloses a dose counter for use in connection with a device adapted for metered dispensing of a medication. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.
摘要翻译：本申请公开了一种与适用于药物计量分配的装置相结合使用的剂量计数器。剂量计数器具有第一计数指示器，其具有第一标记支承表面，第一计数指示器可围绕第一轴线旋转。剂量计数器还具有第二计数指示器，其具有第二标记支承表面，第二计数指示器可绕第二轴线旋转。第二轴相对于第一轴以钝角设置，并且第一和第二标记支承表面在共同的观察区域对齐，以共同呈现药物剂量计数的至少一部分。

4. 发明授权

US08479732B2 Dose counter 有权
公开(公告)号：US08479732B2
公开(公告)日：2013-07-09
申请号：US12297942
申请日：2007-04-20
申请人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
发明人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
IPC分类号： A62B9/00 , G09F9/00
CPC分类号： A61M15/0065 , A61M15/0073 , A61M15/0075 , A61M15/009 , B65D83/46 , B65D83/54 , B65D83/75 , G06M1/16 , G06M1/24
摘要： A dose counter for use in connection with a device adapted for metered dispensing of a medication is described. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.

5. 发明授权

US09067031B2 Metered dose valves and dispensers 有权
标题翻译：计量剂量阀和分配器
公开(公告)号：US09067031B2
公开(公告)日：2015-06-30
申请号：US12444864
申请日：2007-10-19
申请人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
发明人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
IPC分类号： A61M11/00 , A61M15/00 , B65D83/54 , B65D83/14
CPC分类号： A61M15/009 , A61M2205/75 , B65D83/54 , B65D83/754
摘要： A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, the at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.
摘要翻译：一种用于加压计量剂量分配器的计量剂量阀，用于分配计量剂量的气溶胶制剂，其包含悬浮在液化推进剂中的药物颗粒，任选地与一种或多种赋形剂组合，所述阀包括计量室和至少一种多孔的，可流体渗透的，颗粒状的半渗透体，所述至少一个多孔体位于所述阀的内部导管的区域内，例如位于所述计量室内，或预计量室和/或内部通道上游的计量室。

6. 发明申请

US20100199983A1 METERED DOSE VALVES AND DISPENSERS 有权
标题翻译：计量剂阀和分配器
公开(公告)号：US20100199983A1
公开(公告)日：2010-08-12
申请号：US12444864
申请日：2007-10-19
申请人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
发明人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
IPC分类号： B65D83/54 , A61M11/00
CPC分类号： A61M15/009 , A61M2205/75 , B65D83/54 , B65D83/754
摘要： A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, said valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, said at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.
摘要翻译：一种用于加压计量剂量分配器的计量剂量阀，用于分配计量剂量的气雾剂，其包含悬浮在液化推进剂中的药物颗粒，任选地与一种或多种赋形剂组合，所述阀包括计量室和至少一种所述至少一个多孔体位于所述阀的内部导管的区域内，例如位于所述计量室内，或预计量室和/或内部通道上游的计量室。

7. 发明申请

US20080202515A1 Inhalation Device 审中-公开
标题翻译：吸入装置
公开(公告)号：US20080202515A1
公开(公告)日：2008-08-28
申请号：US11721991
申请日：2005-12-12
申请人： Peter D. Hodson , Stephen J. Howgill , Graham R. Purkins
发明人： Peter D. Hodson , Stephen J. Howgill , Graham R. Purkins
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0026 , A61M15/0033 , A61M15/005 , A61M15/0051 , A61M15/0075 , A61M15/0091 , A61M15/0096 , A61M2205/581 , A61M2205/582 , A61M2205/8218
摘要： An inhalation device (1) comprising two or more hermetically sealed receptacles (39), each receptacle containing a single dose of a pressurized formulation comprising a pharmaceutically active ingredient and a liquefied aerosol propellant consisting of HFA 134a, HFA 227 or a mixture thereof and wherein at least a portion (39a) of each receptacle is perforable.
摘要翻译：一种吸入装置（1），包括两个或更多个气密密封的容器（39），每个容器包含单剂量的包含药物活性成分的加压制剂和由HFA134a，HFA222或其混合物组成的液化气溶胶推进剂，其中每个容器的至少一部分（39a）是可穿孔的。

8. 发明授权

US07234460B2 Metering valve for a metered dose inhaler providing consistent delivery 有权
标题翻译：用于计量剂量吸入器的计量阀，提供一致的输送
公开(公告)号：US07234460B2
公开(公告)日：2007-06-26
申请号：US10655196
申请日：2003-09-04
申请人： David J. Greenleaf , Peter D. Hodson , Graham R. Purkins , Gary D. Mahon , Heinz G. Klein
发明人： David J. Greenleaf , Peter D. Hodson , Graham R. Purkins , Gary D. Mahon , Heinz G. Klein
IPC分类号： B65B1/04
CPC分类号： B65D83/54 , A61M15/009
摘要： The present invention relates to a novel design for a metering valve that provides improved consistency of formulation delivery. Generally, the metering valve includes (a) a valve stem that generally defines a longitudinal axis and includes a body portion having a metering surface, wherein the longitudinal axis and a plane tangential to at least a portion of the metering surface define an angle from about 2° to about 90°; and (b) a valve body having an internal chamber defined at least in part by the body wall and includes a metering portion configured to substantially conform to the metering surface of the valve stem.
摘要翻译：本发明涉及一种计量阀的新型设计，其提供了改进的制剂输送一致性。通常，计量阀包括（a）大体上限定纵向轴线并且包括具有计量表面的主体部分的阀杆，其中纵向轴线和与计量表面的至少一部分切线的平面限定了从约 2°至约90°; 和（b）具有至少部分地由主体壁限定的内部室的阀体，并且包括被配置为基本上符合阀杆的计量表面的计量部分。

9. 发明授权

US08814009B2 Metered dose valve 有权
标题翻译：计量剂量阀
公开(公告)号：US08814009B2
公开(公告)日：2014-08-26
申请号：US12681280
申请日：2008-10-02
申请人： Peter D. Hodson , Matthew A. Goring , Stephen J. Howgill , John Fielding , Richard D. Brewer , Rachael V. Shaw , Paul A. Charnock , Stuart A. McGlasson , Stephen D. Helm , Graham V. Jackson , Anthony W. Balkwill , Jason A. Graves
发明人： Peter D. Hodson , Matthew A. Goring , Stephen J. Howgill , John Fielding , Richard D. Brewer , Rachael V. Shaw , Paul A. Charnock , Stuart A. McGlasson , Stephen D. Helm , Graham V. Jackson , Anthony W. Balkwill , Jason A. Graves
IPC分类号： B65D83/00
CPC分类号： A61M15/009 , B65D83/54
摘要： An aerosol metering valve comprising: (a) a valve stem movable between a rest position and a firing position comprising: a body portion comprising a circumferential sealing surface (b) a valve body comprising: a body wall, and an internal chamber defined at least in part by the body wall; and (c) a metering gasket having an inner periphery defining an aperture, being disposed near the most interior end of the internal chamber and being configured to be able to form a transient, substantially fluid-tight face seal against the circumferential sealing surface of the valve stem, where at the rest position of the valve stem, the body portion of the valve stem is located within the internal chamber and as the valve stem is moved from its rest position towards its firing position the circumferential sealing surface of the valve stem contacts the metering gasket to form a face seal thereby closing a metering chamber and thereafter further movement of the valve stem towards its firing position causes the metering gasket to deflect while maintaining the seal with the circumferential sealing surface of the valve stem; and wherein the metering gasket in an unbiased configuration is an annular disc having a substantially planar form and where the valve is constructed and arranged such that the inner periphery of the metering gasket is urged out of said substantially planar form at the rest position of the valve stem, or wherein the metering gasket is pre-biased into a dished-shape.
摘要翻译：一种气溶胶计量阀，包括：（a）可在静止位置和击发位置之间移动的阀杆，包括：主体部分，其包括周向密封表面（b）阀体，所述阀体包括：主体壁和至少限定的内部腔部分由身体壁; 和（c）具有限定孔的内周边的计量垫片，其设置在内室的最内端附近，并且构造成能够形成一个瞬时的，基本上是流体密封的，面对密封面阀杆，其中在阀杆的静止位置处，阀杆的主体部分位于内部腔室内，并且当阀杆从其静止位置朝向其击发位置移动时，阀杆的圆周密封表面接触计量垫圈以形成面密封件，从而封闭计量室，此后阀杆朝向其点火位置的进一步运动导致计量垫片偏转，同时保持与阀杆的周向密封表面的密封; 并且其中所述计量垫片为无偏置构型，是具有基本上平面形状的环形盘，并且所述阀被构造和布置成使得所述计量垫片的内周边在所述阀的静止位置处被推出所述基本平坦的形式杆，或其中计量垫片预偏置成碟形。

10. 发明申请

US20120132203A1 DRY POWDER INHALERS 有权
标题翻译：干粉吸入器
公开(公告)号：US20120132203A1
公开(公告)日：2012-05-31
申请号：US13320762
申请日：2010-05-18
申请人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
发明人： Peter D. Hodson , Stephen W. Stein , Herbert C. Chiou , Zhaolin Wang , Thomas S. Robison , Michael K. Domroese , Blake D. Walburg
IPC分类号： A61M15/00
CPC分类号： A61M15/0051 , A61M15/0005 , A61M15/0008 , A61M15/0021 , A61M15/0025 , A61M15/0026 , A61M15/0043 , A61M15/0045 , A61M15/0055 , A61M15/0065 , A61M15/0091 , A61M15/0096 , A61M2202/064 , A61M2205/0216 , A61M2205/0238 , A61M2205/19
摘要： Dry powder inhalers and dry powder inhaler storage cassettes including a compartment housing an elongate carrier preloaded with a plurality of doses of finely divided powder comprising a biologically active substance, the compartment being configured such that said preloaded doses are sealed within said compartment and such that the carrier may be advanced from the compartment to the chamber through an exit provided with a moisture barrier sealing system, wherein the moisture barrier sealing system is configured and arranged such that it is relaxable during advancement of the carrier, said sealing system being in sealing configuration prior to an advancement of the carrier, relaxed upon an advancement of the carrier and returned to its sealing configuration at the latest after release of the powder associated with said area of the carrier.
摘要翻译：干粉吸入器和干粉吸入器储存盒，其包括容纳预先装载有多个剂量的细分散粉末的细长载体的隔室，其包含生物活性物质，所述隔室被构造成使得所述预加载的剂量被密封在所述隔间内，载体可以通过设置有防潮密封系统的出口从隔室推进到室，其中防潮密封系统被构造和布置成使得其在载体的前进过程中可松弛，所述密封系统处于密封配置在载体的推进之后，随着载体的推进而放松，并且在释放与载体的所述区域相关联的粉末之后最后返回到其密封构造。

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