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1. 发明授权

US09067031B2 Metered dose valves and dispensers 有权
标题翻译：计量剂量阀和分配器
公开(公告)号：US09067031B2
公开(公告)日：2015-06-30
申请号：US12444864
申请日：2007-10-19
申请人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
发明人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
IPC分类号： A61M11/00 , A61M15/00 , B65D83/54 , B65D83/14
CPC分类号： A61M15/009 , A61M2205/75 , B65D83/54 , B65D83/754
摘要： A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, the valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, the at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.
摘要翻译：一种用于加压计量剂量分配器的计量剂量阀，用于分配计量剂量的气溶胶制剂，其包含悬浮在液化推进剂中的药物颗粒，任选地与一种或多种赋形剂组合，所述阀包括计量室和至少一种多孔的，可流体渗透的，颗粒状的半渗透体，所述至少一个多孔体位于所述阀的内部导管的区域内，例如位于所述计量室内，或预计量室和/或内部通道上游的计量室。

2. 发明申请

US20100199983A1 METERED DOSE VALVES AND DISPENSERS 有权
标题翻译：计量剂阀和分配器
公开(公告)号：US20100199983A1
公开(公告)日：2010-08-12
申请号：US12444864
申请日：2007-10-19
申请人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
发明人： Philip A. Jinks , Graham R. Purkins , Peter D. Hodson , Paul E. Hansen
IPC分类号： B65D83/54 , A61M11/00
CPC分类号： A61M15/009 , A61M2205/75 , B65D83/54 , B65D83/754
摘要： A metered dose valve for use in a pressurized metered dose dispenser for dispensing a metered dose of an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, optionally in combination with one or more excipients, said valve comprising a metering chamber and at least one porous, fluid permeable, particulate semi-permeable body, said at least one porous body being positioned within a region of the interior conduit of the valve, for example within the metering chamber, or a pre-metering chamber and/or an internal channel upstream of the metering chamber.
摘要翻译：一种用于加压计量剂量分配器的计量剂量阀，用于分配计量剂量的气雾剂，其包含悬浮在液化推进剂中的药物颗粒，任选地与一种或多种赋形剂组合，所述阀包括计量室和至少一种所述至少一个多孔体位于所述阀的内部导管的区域内，例如位于所述计量室内，或预计量室和/或内部通道上游的计量室。

3. 发明申请

US20090173346A1 DOSE COUNTER 有权
标题翻译：剂量计数器
公开(公告)号：US20090173346A1
公开(公告)日：2009-07-09
申请号：US12297942
申请日：2007-04-20
申请人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
发明人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0073 , A61M15/0075 , A61M15/009 , B65D83/46 , B65D83/54 , B65D83/75 , G06M1/16 , G06M1/24
摘要： This application discloses a dose counter for use in connection with a device adapted for metered dispensing of a medication. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.
摘要翻译：本申请公开了一种与适用于药物计量分配的装置相结合使用的剂量计数器。剂量计数器具有第一计数指示器，其具有第一标记支承表面，第一计数指示器可围绕第一轴线旋转。剂量计数器还具有第二计数指示器，其具有第二标记支承表面，第二计数指示器可绕第二轴线旋转。第二轴相对于第一轴以钝角设置，并且第一和第二标记支承表面在共同的观察区域对齐，以共同呈现药物剂量计数的至少一部分。

4. 发明申请

US20090308385A1 METHOD AND APPARATUS FOR METERED DOSE DISPENSING 有权
标题翻译：用于计量剂量分配的方法和装置
公开(公告)号：US20090308385A1
公开(公告)日：2009-12-17
申请号：US12281559
申请日：2007-03-01
申请人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
发明人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
IPC分类号： A61M15/00
CPC分类号： A61M15/009 , A61M15/0065 , A61M15/0073 , G06M1/04
摘要： This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction. The cap is then moved in a second opposite direction, which causes the slider to move in a second opposite linear direction, which in turn causes rotation of the first counter ring through a second arc in the first circumferential direction about the axis of the container A sum of the first and second arcs of movement of the first counter ring defines a circumferential extent of movement of the first counter ring relative to the cap that indicates a single dose of aerosol medication dispensed from the container.
摘要翻译：本申请公开了一种用于在具有气溶胶容器和致动器的气溶胶分配组件上使用的剂量计数装置。剂量计数器装置用于指示通过在轴向上施加在气溶胶分配组件上的力引起的剂量的气溶胶药物的释放。剂量计数装置具有帽，滑块和第一计数器环。盖沿着容器的轴线沿第一方向移动，这导致滑块相对于容器的轴线在第一线性方向上相对于容器的轴线的移动，这是沿着第一方向的运动的函数。随着滑块在第一直线方向的移动，第一计数器环围绕容器的轴线在第一圆周方向上旋转通过第一弧。然后，盖沿第二相反方向移动，这导致滑块在第二相对的线性方向上移动，这又导致第一计数器环围绕容器A的轴线在第一圆周方向上旋转第二弧第一计数器环的第一和第二运动弧的总和限定了第一计数器环相对于帽的周向运动范围，其指示从容器分配的单剂量的气溶胶药物。

5. 发明申请

US20080202515A1 Inhalation Device 审中-公开
标题翻译：吸入装置
公开(公告)号：US20080202515A1
公开(公告)日：2008-08-28
申请号：US11721991
申请日：2005-12-12
申请人： Peter D. Hodson , Stephen J. Howgill , Graham R. Purkins
发明人： Peter D. Hodson , Stephen J. Howgill , Graham R. Purkins
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0026 , A61M15/0033 , A61M15/005 , A61M15/0051 , A61M15/0075 , A61M15/0091 , A61M15/0096 , A61M2205/581 , A61M2205/582 , A61M2205/8218
摘要： An inhalation device (1) comprising two or more hermetically sealed receptacles (39), each receptacle containing a single dose of a pressurized formulation comprising a pharmaceutically active ingredient and a liquefied aerosol propellant consisting of HFA 134a, HFA 227 or a mixture thereof and wherein at least a portion (39a) of each receptacle is perforable.
摘要翻译：一种吸入装置（1），包括两个或更多个气密密封的容器（39），每个容器包含单剂量的包含药物活性成分的加压制剂和由HFA134a，HFA222或其混合物组成的液化气溶胶推进剂，其中每个容器的至少一部分（39a）是可穿孔的。

6. 发明授权

US07234460B2 Metering valve for a metered dose inhaler providing consistent delivery 有权
标题翻译：用于计量剂量吸入器的计量阀，提供一致的输送
公开(公告)号：US07234460B2
公开(公告)日：2007-06-26
申请号：US10655196
申请日：2003-09-04
申请人： David J. Greenleaf , Peter D. Hodson , Graham R. Purkins , Gary D. Mahon , Heinz G. Klein
发明人： David J. Greenleaf , Peter D. Hodson , Graham R. Purkins , Gary D. Mahon , Heinz G. Klein
IPC分类号： B65B1/04
CPC分类号： B65D83/54 , A61M15/009
摘要： The present invention relates to a novel design for a metering valve that provides improved consistency of formulation delivery. Generally, the metering valve includes (a) a valve stem that generally defines a longitudinal axis and includes a body portion having a metering surface, wherein the longitudinal axis and a plane tangential to at least a portion of the metering surface define an angle from about 2° to about 90°; and (b) a valve body having an internal chamber defined at least in part by the body wall and includes a metering portion configured to substantially conform to the metering surface of the valve stem.
摘要翻译：本发明涉及一种计量阀的新型设计，其提供了改进的制剂输送一致性。通常，计量阀包括（a）大体上限定纵向轴线并且包括具有计量表面的主体部分的阀杆，其中纵向轴线和与计量表面的至少一部分切线的平面限定了从约 2°至约90°; 和（b）具有至少部分地由主体壁限定的内部室的阀体，并且包括被配置为基本上符合阀杆的计量表面的计量部分。

7. 发明授权

US08517019B2 Method and apparatus for metered dose dispensing 有权
标题翻译：计量剂量分配的方法和装置
公开(公告)号：US08517019B2
公开(公告)日：2013-08-27
申请号：US12281559
申请日：2007-03-01
申请人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
发明人： Richard D. Brewer , Peter D. Hodson , Graham R. Purkins , David J.C. Steven
IPC分类号： A62B7/00 , A62B9/00 , A61M11/00
CPC分类号： A61M15/009 , A61M15/0065 , A61M15/0073 , G06M1/04
摘要： This application discloses a dose counter device of the type for use on an aerosol dispensing assembly having an aerosol container and an actuator. The dose counter device is used for indicating the release of a dose of aerosol medication caused by the application of a force, in an axial direction, on the aerosol dispensing assembly. The dose counter device has a cap, a slider and a first counter ring. The cap is moved in a first direction along an axis of the container, which causes movement of the slider in a first linear direction laterally, relative to the axis of the container, as a function of the movement of the cap in the first direction. The first counter ring is rotated through a first arc in a first circumferential direction about the axis of the container, as a function of the movement of the slider in the first linear direction. The cap is then moved in a second opposite direction, which causes the slider to move in a second opposite linear direction, which in turn causes rotation of the first counter ring through a second arc in the first circumferential direction about the axis of the container. A sum of the first and second arcs of movement of the first counter ring defines a circumferential extent of movement of the first counter ring relative to the cap that indicates a single dose of aerosol medication dispensed from the container.
摘要翻译：本申请公开了一种用于在具有气溶胶容器和致动器的气溶胶分配组件上使用的剂量计数装置。剂量计数器装置用于指示通过在轴向上施加在气溶胶分配组件上的力引起的剂量的气溶胶药物的释放。剂量计数装置具有帽，滑块和第一计数器环。盖沿着容器的轴线沿第一方向移动，这导致滑块相对于容器的轴线在第一线性方向上相对于容器的轴线的移动，这是沿着第一方向的运动的函数。随着滑块在第一直线方向的移动，第一计数器环围绕容器的轴线在第一圆周方向上旋转通过第一弧。然后，盖沿第二相反方向移动，这导致滑块在第二相对的线性方向上移动，这又导致第一计数器环围绕容器的轴线沿第一圆周方向旋转第二弧。第一计数器环的第一和第二运动弧的总和限定了第一计数器环相对于盖的周向运动范围，其指示从容器分配的单剂量的气溶胶药物。

8. 发明授权

US08479732B2 Dose counter 有权
公开(公告)号：US08479732B2
公开(公告)日：2013-07-09
申请号：US12297942
申请日：2007-04-20
申请人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
发明人： Adam J. Stuart , Graham R. Purkins , Rachel V. Striebig , Stephen J. Howgill , Peter D. Hodson , Richard D. Brewer , Benjamin J. Holden
IPC分类号： A62B9/00 , G09F9/00
CPC分类号： A61M15/0065 , A61M15/0073 , A61M15/0075 , A61M15/009 , B65D83/46 , B65D83/54 , B65D83/75 , G06M1/16 , G06M1/24
摘要： A dose counter for use in connection with a device adapted for metered dispensing of a medication is described. The dose counter has a first count indicator that has a first indicia bearing surface, with the first count indicator being rotatable about a first axis. The dose counter also has a second count indicator that has a second indicia bearing surface, with the second count indicator being rotatable about a second axis. The second axis is disposed at an obtuse angle with respect to the first axis, and the first and second indicia bearing surfaces align at a common viewing area to collectively present at least a portion of a medication dosage count.

9. 发明申请

US20130037021A1 INHALER 审中-公开
标题翻译：吸入器
公开(公告)号：US20130037021A1
公开(公告)日：2013-02-14
申请号：US13642737
申请日：2011-04-21
申请人： Richard D. Brewer , Craig Davidson , Graham R. Purkins , Stephen J. Howgill
发明人： Richard D. Brewer , Craig Davidson , Graham R. Purkins , Stephen J. Howgill
IPC分类号： A61M15/00 , A61M11/04 , A61M16/14 , A61M15/08
CPC分类号： A61M15/009 , A61M15/0025
摘要： An actuator (2) for an inhaler (1) comprising a longitudinally extending body (3), a delivery passage at (or near to) a first end of the body (3) and a retained cover (7) for the delivery passage, the actuator (2) having at least one profile (9) arranged to guide the cover (7) from a closed position occluding at least a user-opening (6) of the delivery passage to a remote location in which the user-opening (6) of the delivery passage is unoccluded wherein the cover (7) and the at least one profile (9) are configured and arranged such that, in use of the actuator (2), in the guided movement of the cover (7) from the closed position to the remote location, the cover (7) is glided by the user towards the second end of the body (3).
摘要翻译：一种用于吸入器（1）的致动器（2），包括纵向延伸的主体（3），位于主体（3）的第一端（或附近）的输送通道和用于输送通道的保持盖（7）所述致动器（2）具有至少一个轮廓（9），所述至少一个轮廓（9）布置成将所述盖（7）从封闭位置引导至少将所述输送通道的使用者开口（6）封闭到远程位置，在所述远程位置，所述使用者开口输送通道的未示出（6）不被覆盖，其中盖（7）和至少一个轮廓（9）被构造和布置成使得在使用致动器（2）时，盖（7）的引导运动对于远程位置的关闭位置，盖（7）被使用者滑向主体（3）的第二端。

10. 发明申请

US20080121666A1 Multi-Component Valve Stems 审中-公开
标题翻译：多组分阀杆
公开(公告)号：US20080121666A1
公开(公告)日：2008-05-29
申请号：US10561655
申请日：2004-06-14
申请人： Graham R. Purkins
发明人： Graham R. Purkins
IPC分类号： B65D83/14 , B29C45/00 , F16K21/16 , F16K51/00
CPC分类号： B65D83/54 , B29C45/14336 , B29C45/1671 , B29C45/1676 , B29C2045/14459 , B29K2221/003 , Y10T29/4941
摘要： A valve stem (13) for use with a metering valve, said valve stem (13) comprising an elongate stem element (12) having an elastomeric sleeve (9) molded onto at least a portion thereof and a sealing element (16) having an inner surface (7), said sealing element (16) being affixed onto the elongate stem element (12), such that at least a portion of the inner surface (7) of the sealing element (16) is overlying at least a portion of the elastomeric sleeve (9); as well as methods of manufacturing such a valve stem.
摘要翻译：一种与计量阀一起使用的阀杆（13），所述阀杆（13）包括细长的杆元件（12），其具有模制在其至少一部分上的弹性体套筒（9）和密封元件（16）内表面（7），所述密封元件（16）固定到细长杆元件（12）上，使得密封元件（16）的内表面（7）的至少一部分覆盖至少一部分弹性套筒（9）; 以及制造这种阀杆的方法。

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