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1. 发明授权

US07151468B2 Stop alert warning system 失效
标题翻译：停止警报警告系统
公开(公告)号：US07151468B2
公开(公告)日：2006-12-19
申请号：US10958110
申请日：2004-10-04
申请人： Richard Cummings , Aaron Cummings
发明人： Richard Cummings , Aaron Cummings
IPC分类号： B60Q1/00 , G08G1/01 , G08G1/09 , G08G1/095 , G08G1/14 , G08G1/16
CPC分类号： G08G1/095 , G01S13/92 , G08G1/052
摘要： An on-site roadway warning system for alerting a driver of an approaching vehicle of a need to brake the vehicle. A transceiver radiates electromagnetic energy toward the approaching vehicle and receives reflected energy from the vehicle. A processor processes data about the reflected energy in relation to data about the radiated energy to yield data disclosing both range of the approaching vehicle from the transceiver and rate at which the vehicle is approaching the transceiver. The processor processes the data disclosing range of the approaching vehicle from the transceiver and rate at which the vehicle is approaching the transceiver in relation to the stored data, and activates a signaling device to signal the approaching vehicle when the data disclosing range of the approaching vehicle from the transceiver and rate at which the vehicle is approaching the transceiver correlates with stored data that identifies a potentially dangerous combination of range and rate.
摘要翻译：一个现场道路警告系统，用于警告需要刹车的接近车辆的驾驶员。收发器向接近的车辆辐射电磁能量并且接收来自车辆的反射能量。处理器处理关于与辐射能量的数据相关的反射能量的数据，以产生公开来自收发机的接近车辆的范围和车辆接近收发器的速率的数据。处理器处理来自收发器的接近车辆的数据公开范围以及车辆相对于所存储的数据接近收发器的速率，并且当接近车辆的数据公开范围时激活信号装置以通知接近的车辆从收发机和车辆接近收发机的速率与存储的数据相关联，该数据识别出潜在的危险的范围和速率的组合。

2. 发明申请

US20070071549A1 On-board-detectable passive pavement marking 审中-公开
标题翻译：车载可检测的被动路面标记
公开(公告)号：US20070071549A1
公开(公告)日：2007-03-29
申请号：US11604632
申请日：2006-11-27
申请人： Richard Cummings , Aaron Cummings
发明人： Richard Cummings , Aaron Cummings
IPC分类号： E01F9/08
CPC分类号： E01F9/30
摘要： Various embodiments of detectable passive markings are disclosed for application to a roadway pavement surface. Also disclosed are a system and method, using the markings, for warning cross-traffic on a roadway not having the right of way at an intersection of approaching traffic on a roadway that has the right-of-way at the intersection.
摘要翻译：公开了可检测的无源标记的各种实施例，以应用于道路路面。还公开了一种系统和方法，使用标记来在不具有在交叉口处具有右行驶道路的接近交通路口的道路上没有通行权的道路上的交叉路况的警告。

3. 发明授权

US07140803B2 Passive traffic lane marking for on-board detection of lane boundary 失效
公开(公告)号：US07140803B2
公开(公告)日：2006-11-28
申请号：US11055502
申请日：2005-02-10
申请人： Richard Cummings , Aaron Cummings
发明人： Richard Cummings , Aaron Cummings
IPC分类号： E01F9/04 , G01S13/00
CPC分类号： E01F9/30
摘要： A system and process for detecting a traffic lane boundary before it is potentially violated by a moving vehicle traveling in the lane. Passive RF tags or labels are embedded in a paint stripe running along pavement. A sensor in the vehicle emits an RF signal at a frequency to which the tags or labels are responsive. When the emitted signal is incident on a tag or label with strength indicative of straying of the vehicle from the lane toward incipient violation of the lane boundary defined by the stripe, the tag or label issues a return signal that is received by the sensor for on-board signaling of the potential violation to alter the driver so that corrective action can be taken.

4. 发明申请

US20060177265A1 Passive traffic lane marking for on-board detection of lane boundary 失效
标题翻译：被动行车道标识车道边界检测
公开(公告)号：US20060177265A1
公开(公告)日：2006-08-10
申请号：US11055502
申请日：2005-02-10
申请人： Richard Cummings , Aaron Cummings
发明人： Richard Cummings , Aaron Cummings
IPC分类号： E01F9/00
CPC分类号： E01F9/30
摘要： A system and process for detecting a traffic lane boundary before it is potentially violated by a moving vehicle traveling in the lane. Passive RF tags or labels are embedded in a paint stripe running along pavement. A sensor in the vehicle emits an RF signal at a frequency to which the tags or labels are responsive. When the emitted signal is incident on a tag or label with strength indicative of straying of the vehicle from the lane toward incipient violation of the lane boundary defined by the stripe, the tag or label issues a return signal that is received by the sensor for on-board signaling of the potential violation to alter the driver so that corrective action can be taken.
摘要翻译：一种用于在行车道被行驶的移动车辆潜在违反之前检测行车道边界的系统和过程。被动RF标签或标签嵌入在沿路面行驶的油漆条纹中。车辆中的传感器以标签或标签响应的频率发射RF信号。当发射的信号入射到具有指示车辆偏离车道的强度的标签或标签上，朝向由条纹限定的车道边界的初始违反时，标签或标签发出由传感器接收的返回信号 - 板信号的潜在违规，以改变司机，以便采取纠正措施。

5. 发明申请

US20060071814A1 Stop alert warining system 失效
标题翻译：停止警戒系统
公开(公告)号：US20060071814A1
公开(公告)日：2006-04-06
申请号：US10958110
申请日：2004-10-04
申请人： Richard Cummings , Aaron Cummings
发明人： Richard Cummings , Aaron Cummings
IPC分类号： G08G1/16
CPC分类号： G08G1/095 , G01S13/92 , G08G1/052
摘要： An on-site roadway warning system for alerting a driver of an approaching vehicle of a need to brake the vehicle. A transceiver radiates electromagnetic energy toward the approaching vehicle and receives reflected energy from the vehicle. A processor processes data about the reflected energy in relation to data about the radiated energy to yield data disclosing both range of the approaching vehicle from the transceiver and rate at which the vehicle is approaching the transceiver. The processor processes the data disclosing range of the approaching vehicle from the transceiver and rate at which the vehicle is approaching the transceiver in relation to the stored data, and activates a signaling device to signal the approaching vehicle when the data disclosing range of the approaching vehicle from the transceiver and rate at which the vehicle is approaching the transceiver correlates with stored data that identifies a potentially dangerous combination of range and rate.
摘要翻译：一个现场道路警告系统，用于警告需要刹车的接近车辆的驾驶员。收发器向接近的车辆辐射电磁能量并且接收来自车辆的反射能量。处理器处理关于与辐射能量的数据相关的反射能量的数据，以产生公开来自收发机的接近车辆的范围和车辆接近收发器的速率的数据。处理器处理来自收发器的接近车辆的数据公开范围以及车辆相对于所存储的数据接近收发器的速率，并且当接近车辆的数据公开范围时激活信号装置以通知接近的车辆从收发机和车辆接近收发机的速率与存储的数据相关联，该数据识别出潜在的危险的范围和速率的组合。

6. 发明申请

US20050282770A1 Synthetic glycosulfopeptides and methods of synthesis thereof 失效
标题翻译：合成糖磺肽及其合成方法
公开(公告)号：US20050282770A1
公开(公告)日：2005-12-22
申请号：US11121731
申请日：2005-05-04
申请人： Richard Cummings , Rodger McEver
发明人： Richard Cummings , Rodger McEver
IPC分类号： A61K31/739 , C07K9/00 , C07K14/705 , C08B37/00
CPC分类号： C07K14/70596 , C07K9/00
摘要： A new class of synthetic glycosulfopeptides (GSPs) which have one or more sulfated tyrosine residues and a glycan linked to the peptide, the glycan preferably including a sialyl Lewisx group or a sialyl Lewisa group. In a preferred version the GSPs have an O-glycan comprising a β1,6 linkage to a GalNAc. The present invention further contemplates in vitro methods of the synthesis of these GSPs without the use of the cells and methods of their use in vivo as powerful anti-inflammatory antithrombotic, or anti-metastatic compounds. The invention also contemplates a method of synthesizing oligosaccharides by cleaving the glycan from the GSP.
摘要翻译：一类具有一个或多个硫酸化酪氨酸残基的合成糖磺肽（GSP）和与该肽连接的聚糖，该聚糖优选包含唾液酸路易斯基团或唾液酸基路易斯 / SUP>组。在优选的版本中，GSP具有包含与GalNAc的β1,6键的O-聚糖。本发明还考虑了不使用细胞的这些GSP的合成的体外方法及其在体内用于强力抗炎抗凝血或抗转移化合物的方法。本发明还考虑了通过从GSP切割聚糖来合成寡糖的方法。

7. 发明申请

US20070167356A1 Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof 失效
公开(公告)号：US20070167356A1
公开(公告)日：2007-07-19
申请号：US11716922
申请日：2007-03-12
申请人： Richard Cummings , Rodger McEver
发明人： Richard Cummings , Rodger McEver
IPC分类号： A61K38/14 , C07K9/00
CPC分类号： C07H3/06 , A61K38/08 , A61K38/14 , C07K9/00 , C07K9/001 , C07K9/005 , C07K14/705 , C07K14/70596
摘要： Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopeptides may be conjugated or complexed to other compounds for enhancing serum half-life or for controlled release, for example. Examples of conditions treated include inflammation, ischemia-reperfusion injury, rheumatoid arthritis, atherosclerosis, leukocyte-mediated lung injury, restenosis, and thrombosis.

8. 发明申请

US20050245737A1 Apparatus and method for mixed-bed lectin chromatography 审中-公开
标题翻译：混合床凝集素色谱仪的设备和方法
公开(公告)号：US20050245737A1
公开(公告)日：2005-11-03
申请号：US11111322
申请日：2005-04-21
申请人： Richard Cummings
发明人： Richard Cummings
IPC分类号： C07H5/04 , C07H5/06 , C08B37/00
CPC分类号： C07H5/06 , C07H5/04
摘要： The present invention contemplates an apparatus and method for isolating glycoconjugates from mixtures or contaminated mixtures thereof. In the present invention, a bed or other support element comprising a mixture of immobilized lectins is provided. The mixture of glycoconjugates is passed over the mixed lectin bed wherein glycoconjugates which correspond to the lectins in the bed are bound thereto while non-glycoconjugates flow away. Thus, the method can be used to isolate glycoproteins from mixtures of glycoproteins and non-glycosylated proteins, glycopeptides from mixtures of glycopeptides and non-glycosylated peptides, glycolipids from non-glycosylated lipids, and free oligosaccharides from extracts or preparations. This invention solves the problem of isolating glycoconjugates from complex mixtures of glycoconjugates with non-gyconconjugates. For example, in most cells, a large fraction of the total macromolecules are not glycosylated. Glycomics and glycoproteomics specifically are concerned with macromolecules which contain carbohydrates. Thus, the mixed bed lectin chromatography described herein will expand both glycomics and glycoproteomics, which are currently hampered by lack of methods or devices or approaches able to be used to generally isolate all or most of the glycoconjugates in cells or extracts of cells in a simple and direct approach that has few steps.
摘要翻译：本发明考虑了用于从混合物或其污染混合物中分离糖缀合物的装置和方法。在本发明中，提供了包含固定化凝集素的混合物的床或其它支撑元件。将糖缀合物的混合物通过混合凝集素床，其中对应于床中的凝集素的糖缀合物与非糖缀合物流失。因此，该方法可用于从糖蛋白和非糖基化蛋白质的混合物中分离出糖蛋白，来自糖肽和非糖基化肽的糖肽，来自非糖基化脂质的糖脂和来自提取物或制剂的游离寡糖。本发明解决了糖缀合物与非结合共轭体的复合混合物分离糖缀合物的问题。例如，在大多数细胞中，大部分的总大分子不被糖基化。糖组学和糖蛋白组学专门涉及含有碳水化合物的大分子。因此，本文所述的混合床凝集素色谱法将扩展糖组学和糖蛋白组学，目前由于缺乏方法或装置或方法而阻碍，所述方法或装置或方法能够简单地分离细胞或细胞提取物中的全部或大部分糖缀合物和直接的方法有几个步骤。

9. 发明授权

US5381833A Insulated pipe assembly and pipe support therefor 失效
标题翻译：绝缘管总成及管道支撑
公开(公告)号：US5381833A
公开(公告)日：1995-01-17
申请号：US152909
申请日：1993-11-12
申请人： Richard Cummings , Lee J. Gee , John Warren
发明人： Richard Cummings , Lee J. Gee , John Warren
IPC分类号： F16L59/135 , F16L3/00
CPC分类号： F16L59/135
摘要： This invention is a pipe support for a pipe covered by a cylindrical bat of insulation. The insulated pipe is suspended by a pipe hanger having a clevis extending round and beneath the pipe. The pipe support comprises an upwardly concave saddle engageable with the underside of the pipe within the insulation. A pipe support base is secured to the clevis and comprises a bracket fixedly secured to the clevis by a lock bolt; alternatively, a portion of the clevis may serve as the pipe support base. Top and bottom ends of a vertical connector are secured respectively to the saddle and to the support base. A vertical connector extends through the insulation at the bottom of the pipe. The ends of the connector are fixedly secured respectively to the saddle and to the support base. In one embodiment, the connector is a single shaft or rod. In another embodiment, the connector is a rod removably telescopically assembled within a hollow sleeve. The connector transmits the weight load of the pipe directly from the saddle to the clevis, independently of the insulation. The concave configuration of the saddle holds the pipe against lateral misalignment; the fixed securement of the connector to the pipe support base maintains them in vertical alignment; and a snug fit between the telescopically assembled rod and sleeve, where used, prevents lateral misalignment.
摘要翻译：本发明是由圆柱形绝缘体棒覆盖的管道的管支撑件。绝缘管由具有在管道下方延伸的U形夹的管衣架悬挂。管支撑件包括可在绝缘体内与管子的下侧接合的向上凹的鞍座。管支撑基座固定到U形夹上，并包括通过锁定螺栓固定在U形夹上的托架; 或者，一部分U形夹可以用作管支撑底座。垂直连接器的顶端和底端分别固定到鞍座和支撑基座上。垂直连接器延伸穿过管道底部的绝缘体。连接器的端部分别牢固地固定到鞍座和支撑基座上。在一个实施例中，连接器是单个轴或杆。在另一个实施例中，连接器是可拆卸地组装在中空套筒内的杆。连接器将管道的重量负载直接从鞍座传递到U形夹，而与绝缘体无关。鞍座的凹形构造保持管道免受横向错位; 连接器到管支撑基座的固定固定使它们保持竖直对准; 并且在使用的可伸缩组装的杆和套筒之间的紧密配合防止横向错位。

10. 发明申请

US20060024779A1 Glycosulfopeptide inhibitors of leukocyte rolling and methods of use thereof 失效
公开(公告)号：US20060024779A1
公开(公告)日：2006-02-02
申请号：US11239576
申请日：2005-09-29
申请人： Richard Cummings , Rodger McEver
发明人： Richard Cummings , Rodger McEver
IPC分类号： C12P21/06 , A61K38/14
CPC分类号： C07H3/06 , A61K38/08 , A61K38/14 , C07K9/00 , C07K9/001 , C07K9/005 , C07K14/705 , C07K14/70596
摘要： Compounds, compositions and methods for treating conditions characterized by leukocyte rolling are described. The compounds contain glycosulfopeptide structures comprising sulfated tyrosines and sialyated, fucosylated N-acetyllactosamino glycans. The glycosulfopeptides may be conjugated or complexed to other compounds for enhancing serum half-life or for controlled release, for example. Examples of conditions treated include inflammation, ischemia-reperfusion injury, rheumatoid arthritis, atherosclerosis, leukocyte-mediated lung injury, restenosis, and thrombosis.

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