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1. 发明授权

US5328920A Substituted (pyridinylamino)-indoles 失效
标题翻译：取代（吡啶基氨基） - 吲哚
公开(公告)号：US5328920A
公开(公告)日：1994-07-12
申请号：US964546
申请日：1992-10-21
申请人： Richard C. Effland , Joseph T. Klein , Lawrence L. Martin , Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Richard C. Effland , Joseph T. Klein , Lawrence L. Martin , Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： A61K31/44 , A61K31/423 , A61K31/428 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12
CPC分类号： C07D413/12 , C07D401/12 , C07D409/12 , C07D413/10 , C07D417/12
摘要： There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antiemetics, and for the treatment of personality disorders such as obsessive compulsive disorder.
摘要翻译：公开了下式的各种化合物，其中R，R 1，W，X，Y和Z如说明书中所定义; 其可用于缓解诸如阿尔茨海默病的各种记忆功能障碍，作为神经递质功能如5-羟色胺能和肾上腺素能的调节剂，并且因此可用作抗抑郁药，抗焦虑药，非典型抗精神病药，止吐药和用于治疗人格障碍如强迫症紊乱。

2. 发明授权

US6022880A Substituted pyridylamino indoles 失效
标题翻译：取代的吡啶基氨基吲哚
公开(公告)号：US6022880A
公开(公告)日：2000-02-08
申请号：US901557
申请日：1997-07-28
申请人： Richard Charles Effland , Joseph Thomas Klein , Lawrence Leo Martin , Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Richard Charles Effland , Joseph Thomas Klein , Lawrence Leo Martin , Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： A61K31/44 , A61K31/42 , A61K31/425 , A61K31/4427 , A61K31/4433 , A61K31/47 , A61P1/08 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/26 , A61P25/28 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D401/12 , C07D409/12 , C07D413/10 , C07D417/12
摘要： There are disclosed various compounds of the formula below, ##STR1## where R, R.sub.1, W, X, Y and Z are as defined in the specification; which are useful for alleviating various memory dysfunctions such as Alzheimer's disease, as modulators of neurotransmitter functions such as serotonergic and adrenergic, and as such are useful as antidepressants, anxiolytics, atypical antipsychotics, antienmtics, and for the treatment of personality disorders such as obsessive compulsive disorder.
摘要翻译：公开了下式的各种化合物，其中R，R 1，W，X，Y和Z如说明书中所定义; 其可用于缓解诸如阿尔茨海默病的各种记忆功能障碍，作为神经递质功能如5-羟色胺能和肾上腺素能的调节剂，并且因此可用作抗抑郁药，抗焦虑药，非典型抗精神病药，抗宁药物和治疗人格障碍如强迫症紊乱。

3. 发明授权

US5264576A Pyrazolo[4,3-c]pyridines which are intermediates 失效
标题翻译：吡唑并[4,3-c]吡啶，它们是中间体
公开(公告)号：US5264576A
公开(公告)日：1993-11-23
申请号：US964690
申请日：1992-10-22
申请人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D471/04
CPC分类号： C07D471/04
摘要： There are disclosed novel pyrazolo[4,3-c]pyridines of the formula ##STR1## where Ar and R.sub.1 are as defined in the specification, which are useful as serotonin reuptake inhibitors and as such may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.

4. 发明授权

US5380847A Synthesis of certain 1-(1-methylpiperidin-4-y1)-3-phenylpyrazolo[4,3-C]pyridines 失效
标题翻译：某些1-（1-甲基哌啶-4-基）-3-苯基吡唑并[4,3-C]吡啶的合成
公开(公告)号：US5380847A
公开(公告)日：1995-01-10
申请号：US181147
申请日：1994-01-12
申请人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D471/04
CPC分类号： C07D471/04
摘要： There are disclosed novel pyrazolo[4,3-c]pyridines of the formula ##STR1## where Ar and R.sub.1 are as defined in the specification, which are useful as serotonin reuptake inhibitors and as such may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
摘要翻译：公开了式（IMAGE）的新颖的吡唑并[4,3-c]吡啶，其中Ar和R 1如说明书中所定义，其可用作5-羟色胺再摄取抑制剂，因此可用于治疗抑郁症，强迫症 - 疲劳障碍，口吃和拔毛病。

5. 发明授权

US4994452A Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds 失效
标题翻译：六氢-1H-喹啉[4,3,2-ef] [1,4]苯并氧氮杂及相关化合物
公开(公告)号：US4994452A
公开(公告)日：1991-02-19
申请号：US443288
申请日：1989-11-28
申请人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： A61K31/55 , A61P25/28 , C07D219/10 , C07D221/16 , C07D498/06 , C07D513/06
CPC分类号： C07D513/06 , C07D219/10
摘要： Novel hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds, intermediates for the preparation thereof, and a method for relieving memory dysfunction, utilizing the compounds are disclosed.

6. 发明授权

US5428169A Pharmaceutically useful (3-phenyl-1H-pyrazolo[4,3-C]pyridin-1-yl)-acetonitrile 失效
标题翻译：药用（3-苯基-1H-吡唑并[4,3-C]吡啶-1-基） - 乙腈
公开(公告)号：US5428169A
公开(公告)日：1995-06-27
申请号：US306294
申请日：1994-09-15
申请人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D471/04
CPC分类号： C07D471/04
摘要： There are disclosed novel pyrazolo[4,3-c]pyridines of the formula ##STR1## where Ar and R.sub.1 are as defined in the specification, which are useful as serotonin reuptake inhibitors and as such may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
摘要翻译：公开了式（IMAGE）的新颖的吡唑并[4,3-c]吡啶，其中Ar和R 1如说明书中所定义，其可用作5-羟色胺再摄取抑制剂，因此可用于治疗抑郁症，强迫症 - 疲劳障碍，口吃和拔毛病。

7. 发明授权

US5296491A Pyrazolo[4,3-c]pyridines and their use as serotonin reuptake inhibitors 失效
标题翻译：吡唑并[4,3-c]吡啶及其作为5-羟色胺再摄取抑制剂的用途
公开(公告)号：US5296491A
公开(公告)日：1994-03-22
申请号：US106953
申请日：1993-08-17
申请人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： A61K31/435 , A61K31/44 , A61K31/445 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , C07D471/04
CPC分类号： C07D471/04
摘要： There are disclosed novel pyrazolo[4,3-c]pyridines of the formula ##STR1## where Ar and R.sub.1 are as defined in the specification, which are useful as serotonin reuptake inhibitors and as such may be useful for the treatment of depression, obsessive-compulsive disorders, stuttering and trichotillomania.
摘要翻译：公开了式（IMAGE）的新颖的吡唑并[4,3-c]吡啶，其中Ar和R 1如说明书中所定义，其可用作5-羟色胺再摄取抑制剂，因此可用于治疗抑郁症，强迫症 - 疲劳障碍，口吃和拔毛病。

8. 发明授权

US5112829A Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds 失效
标题翻译：六氢-1H-喹啉[4,3,2-ef] [1,4]苯并氧氮杂及相关化合物
公开(公告)号：US5112829A
公开(公告)日：1992-05-12
申请号：US563141
申请日：1990-08-06
申请人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
发明人： Gregory M. Shutske , Kevin J. Kapples , John D. Tomer, IV
IPC分类号： C07D219/10 , C07D498/06 , C07D513/06
CPC分类号： C07D513/06 , C07D219/10
摘要： Novel 9-amino-1,2,3,4-tetrahydroacridines and related compounds of the formula ##STR1## wherein R.sup.1 is H, loweralkyl, or benzyl; R.sup.3 is H, loweralkyl, a group of the formula CH.sub.2 CHR.sup.2 Hal wherein R.sup.2 is hydrogen, loweralkyl, or phenyl and Hal is chloro, bromo, or iodo, or a group of the formula CHR.sup.2 CO.sub.2 R.sup.5 wherein R.sup.2 is as above and R.sup.5 is H or loweralkyl; Z is O or S; X is H, halogen, loweralkoxy, loweralkyl, or trifluoromethyl; n is 1, 2, or 3; the group ZR.sup.3 is bound to either the A- or B-position of the heteroaromatic nucleus; the pharmaceutically acceptable salts thereof; and the optical isomers thereof, useful as intermediates for the preparation of memory dysfunction relieving hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines are related compounds and for relieving memory dysfunction are disclosed.
摘要翻译：新型9-氨基-1,2,3,4-四氢rid啶及其相关化合物，其中R 1为H，低级烷基或苄基; R3是H，低级烷基，式CH2CHR2Hal的基团，其中R2是氢，低级烷基或苯基，Hal是氯，溴或碘，或式CHR2CO2R5的基团，其中R2如上，R5是H或低级烷基; Z是O或S; X是H，卤素，低级烷氧基，低级烷基或三氟甲基; n为1,2或3; ZR3基团与杂芳族核的A-位或B-位结合; 其药学上可接受的盐; 及其旋光异构体，可用作缓冲六氢-1H-喹啉[4,3,2-ef] [1,4]苯并氧氮杂记忆功能障碍的中间体是相关化合物，并且用于缓解记忆功能障碍。

9. 发明授权

US5948798A Pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles 失效
标题翻译：吡啶亚氨基-1,2-苯并异恶唑和 - 苯并异噻唑
公开(公告)号：US5948798A
公开(公告)日：1999-09-07
申请号：US961298
申请日：1997-10-30
申请人： David M. Fink , Barbara E. Kurys , Gregory M. Shutske , John D. Tomer, IV
发明人： David M. Fink , Barbara E. Kurys , Gregory M. Shutske , John D. Tomer, IV
IPC分类号： A61K31/44 , A61K31/4439 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/551 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/28 , C07D231/56 , C07D261/20 , C07D275/04 , C07D403/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
CPC分类号： C07D413/12 , C07D413/14 , C07D417/12
摘要： Novel pyridiniminyl-1,2-benzisoxazoles and -benzisothiazoles, intermediates and processes for the preparation thereof, and methods of relieving memory dysfunction and treating depression utilizing the 1,2-benzisoxazoles and -benzisothiazoles and intermediates, or compositions thereof are disclosed.
摘要翻译：公开了新的吡啶亚甲基-1,2-苯并异恶唑和 - 苯并异噻唑，其制备方法和方法，以及利用1,2-苯并异恶唑和 - 苯并异噻唑及其中间体缓解记忆功能障碍和治疗抑郁症的方法或其组合物。

10. 发明授权

US5686483A Aminoalkyloximes 失效
公开(公告)号：US5686483A
公开(公告)日：1997-11-11
申请号：US457422
申请日：1995-06-01
申请人： Gregory M. Shutske , Brian S. Freed , John D. Tomer, IV , R. Richard L. Hamer
发明人： Gregory M. Shutske , Brian S. Freed , John D. Tomer, IV , R. Richard L. Hamer
IPC分类号： C07D233/60 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/445 , A61K31/454 , A61P25/00 , A61P25/20 , A61P25/24 , A61P25/26 , C07D211/14 , C07D211/32 , C07D233/54 , C07D233/61 , C07D235/26 , C07D401/04 , C07D401/12 , C07D521/00 , C07D295/13 , C07D207/08 , C07D403/04 , C07D403/12
CPC分类号： C07D233/64 , C07D211/14 , C07D211/32 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04
摘要： Novel aminoalkyloximes, precursors and processes for the preparation thereof, and methods of treating depression and obsessive compulsive disorders are described.

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