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1. 发明授权

US6036669A Apparatus for altering composition of nutritional product during enteral tube feeding 失效
标题翻译：用于改变肠管喂养期间营养产品组成的装置
公开(公告)号：US6036669A
公开(公告)日：2000-03-14
申请号：US32070
申请日：1998-02-27
申请人： Rhonda L. Cole , Ronita K. Geckle , John J. Kropczynski, Jr. , Terrence B. Mazer , Joseph E. Walton , Daniel Zevchik
发明人： Rhonda L. Cole , Ronita K. Geckle , John J. Kropczynski, Jr. , Terrence B. Mazer , Joseph E. Walton , Daniel Zevchik
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M5/007 , A61J15/0026 , A61M31/002 , A61M5/1407 , A61M5/1409 , A61J15/00 , A61J15/0069
摘要： An apparatus for modifying a liquid enteral nutritional product. The apparatus includes a feeding set having an inlet and an outlet. The inlet is constructed for fluid connection to a supply container. The feeding set defines an interior space. The apparatus further includes a canister disposed in the interior space defined by the feeding set. The canister includes a wall portion that defines an aperture therethrough. The canister is constructed to receive one or more beneficial agents in an interior chamber defined therein. At least one beneficial agent disposed in the interior chamber defined by the canister.
摘要翻译：一种用于改变液体肠内营养产品的装置。该装置包括具有入口和出口的进料组。入口构造成用于流体连接到供应容器。饲养组定义了一个内部空间。该装置还包括设置在由进给组限定的内部空间中的罐。罐包括限定穿过其中的孔的壁部分。罐被构造成在其中限定的内部室中接收一种或多种有益剂。设置在由罐限定的内部室中的至少一个有益剂。

2. 发明授权

US6080132A Apparatus for altering characteristics of a fluid 失效
标题翻译：用于改变流体特性的装置
公开(公告)号：US6080132A
公开(公告)日：2000-06-27
申请号：US32106
申请日：1998-02-27
申请人： Rhonda L. Cole , Ronita K. Geckle , John J. Kropczynski, Jr. , Terrence B. Mazer , Joseph E. Walton
发明人： Rhonda L. Cole , Ronita K. Geckle , John J. Kropczynski, Jr. , Terrence B. Mazer , Joseph E. Walton
IPC分类号： A61M5/14 , A61M5/168 , A61M37/00 , A61B19/00
CPC分类号： A61M5/1409 , A61M2202/0482
摘要： An apparatus for altering characteristics of a fluid. The apparatus includes a first perimeter wall defining an internal chamber therein. The first perimeter wall defines a first opening and a second opening therethrough. The first opening is constructed to be fluidly connected to a fluid source. The internal chamber defined in said first perimeter wall is constructed to contain a beneficial agent therein. A beneficial agent is disposed in the internal chamber defined in the first perimeter wall, the beneficial agent being dispersible in a fluid flowing from the first opening to the second opening through the internal chamber defined in the first perimeter wall.
摘要翻译：用于改变流体特性的装置。该装置包括在其中限定内部室的第一周边壁。第一周边壁限定了通过其中的第一开口和第二开口。第一开口构造成流体地连接到流体源。限定在所述第一周边壁中的内部室被构造成在其中容纳有益剂。有益剂被设置在限定在第一周边壁中的内室中，有益剂可分散在通过限定在第一周边壁中的内室从第一开口流到第二开口的流体中。

3. 发明授权

US06620434B2 Sustained release dosage form unit having latex coating and method of making the same 失效
标题翻译：具有胶乳涂层的缓释剂型单元及其制备方法
公开(公告)号：US06620434B2
公开(公告)日：2003-09-16
申请号：US09852364
申请日：2001-05-10
申请人： Terrence B. Mazer , Joseph E. Walton , Barbara S. Arnholt , Monty L. Evans , Ronita K. Geckle , Daniel Hamilton , John J. Kropczynski, Jr. , Frank A. Murawski , Larry G. Tucker , Sherri A. Walker , Michael V. Walsh , Rhonda Cole Walsh
发明人： Terrence B. Mazer , Joseph E. Walton , Barbara S. Arnholt , Monty L. Evans , Ronita K. Geckle , Daniel Hamilton , John J. Kropczynski, Jr. , Frank A. Murawski , Larry G. Tucker , Sherri A. Walker , Michael V. Walsh , Rhonda Cole Walsh
IPC分类号： A61K936
CPC分类号： A61K9/286 , A61K9/2054 , A61K9/209 , A61K9/2866
摘要： Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.
摘要翻译：提供剂量形式单元以将一种或多种有益剂递送到流体中，例如液体肠内营养产品。剂型单元包括含有可分散在流体中的至少一种有益试剂，优选标记染料的核心。核心还含有一种相容的结合剂以将有益剂结合在一起。芯的另外的组分可以包括增塑剂，标准流动剂，润滑剂，另外的压片助剂和至少一种亲水剂。乳胶涂层包裹核心。胶乳涂层包括含有基本上疏水的基材的混合物，优选由乙酸纤维素微球的乳液形成，其能够限定基质型膜，以及至少一种可分散在流体中的亲水组分。作为胶乳涂料的亲水组分之一，优选可分散的有益剂，以便立即从其中释放有益剂。还提供了制备剂型单元的方法。

4. 发明授权

US06251432B1 Sustained release dosage form unit having latex coating and method of making the same 有权
标题翻译：具有胶乳涂层的缓释剂型单元及其制备方法
公开(公告)号：US06251432B1
公开(公告)日：2001-06-26
申请号：US09345915
申请日：1999-07-01
申请人： Terrence B. Mazer , Joseph E. Walton , Barbara S. Arnholt , Monty L. Evans , Ronita K. Geckle , Daniel Hamilton , John J. Kropczynski, Jr. , Frank A. Murawski , Larry G. Tucker , Sherri A. Walker , Michael V. Walsh , Rhonda Cole Walsh
发明人： Terrence B. Mazer , Joseph E. Walton , Barbara S. Arnholt , Monty L. Evans , Ronita K. Geckle , Daniel Hamilton , John J. Kropczynski, Jr. , Frank A. Murawski , Larry G. Tucker , Sherri A. Walker , Michael V. Walsh , Rhonda Cole Walsh
IPC分类号： A61K930
CPC分类号： A61K9/286 , A61K9/2054 , A61K9/209 , A61K9/2866
摘要： Dosage form unit is provided to deliver one or more beneficial agents into a fluid, such as liquid enteral nutritional product. The dosage form unit includes a core containing at least one beneficial agent, preferably a marker dye, which is dispersible in the fluid. The core also contains a compatible binding agent to bind the beneficial agent together. Additional components of the core may include a plasticizer, a standard flow agent, a lubricant, additional tableting aids and at least one hydrophilic agent. A latex coating encases the core. The latex coating includes a mixture containing a substantially hydrophobic base material, preferably formed from an emulsion of cellulose acetate microspheres, which is capable of defining a matrix-type membrane, and at least one hydrophilic component being dispersible in the fluid. A dispersible beneficial agent is preferred as one of the hydrophilic components of the latex coating to allow immediate release of the beneficial agent therefrom. A method of making the dosage form unit also is provided.
摘要翻译：提供剂量形式单元以将一种或多种有益剂递送到流体中，例如液体肠内营养产品。剂型单元包括含有可分散在流体中的至少一种有益试剂，优选标记染料的核心。核心还含有一种相容的结合剂以将有益剂结合在一起。芯的另外的组分可以包括增塑剂，标准流动剂，润滑剂，另外的压片助剂和至少一种亲水剂。乳胶涂层包裹核心。胶乳涂层包括含有基本上疏水的基材的混合物，优选由乙酸纤维素微球的乳液形成，其能够限定基质型膜，以及至少一种可分散在流体中的亲水组分。作为胶乳涂料的亲水组分之一，优选可分散的有益剂，以便立即从其中释放有益剂。还提供了制备剂型单元的方法。

5. 发明授权

US06309373B1 Apparatus for altering the characteristics of a fluid 有权
标题翻译：用于改变流体特性的装置
公开(公告)号：US06309373B1
公开(公告)日：2001-10-30
申请号：US09132888
申请日：1998-08-12
申请人： Robert A. Shalwitz , Rhonda L. Cole , Ronita K. Geckle , John J. Kropczynski , Terrence B. Mazer , Joseph E. Walton
发明人： Robert A. Shalwitz , Rhonda L. Cole , Ronita K. Geckle , John J. Kropczynski , Terrence B. Mazer , Joseph E. Walton
IPC分类号： A61M3700
CPC分类号： A61M5/1409 , A61M2202/0482
摘要： An apparatus for altering characteristics of a fluid. The apparatus includes a canister having a side wall, a first end wall, and a second end wall defining a chamber therein. A beneficial agent is disposed in the chamber. The end walls define apertures therethrough. The apparatus further includes a tubing portion defining a first end portion constructed for connection to a fluid source and an outlet portion. The tubing portion also defines a canister-receiving portion intermediate the first end portion and the outlet portion. The canister-receiving portion defines a first fluid flow channel fluidly connecting the first end portion and the second outlet portion of said tubing portion. The canister-receiving portion also defines first and second fluid flow orifices therethrough. The canister-receiving portion is constructed to be selectively connectable to the canister such that fluid from the tubing portion can be selectively directed through the canister chamber, thereby causing the beneficial agent to become dispersed in the flowing fluid.
摘要翻译：用于改变流体特性的装置。该装置包括具有侧壁，第一端壁和在其中限定室的第二端壁的罐。有益剂置于室内。端壁限定穿过其中的孔。该装置还包括一个管道部分，其限定了构造成连接到流体源和出口部分的第一端部。管道部分还限定了在第一端部和出口部分之间的罐接收部分。容器容纳部分限定了流体地连接所述管道部分的第一端部部分和第二出口部分的第一流体流动通道。罐容纳部分还限定了通过其中的第一和第二流体流动孔。罐接收部被构造为可选择性地连接到罐，使得来自管部分的流体可以选择性地引导通过罐室，从而使有益剂分散在流动的流体中。

6. 发明授权

US06277092B1 Apparatus for altering composition of nutritional product during enteral tube feeding 失效
标题翻译：用于改变肠管喂养期间营养产品组成的装置
公开(公告)号：US06277092B1
公开(公告)日：2001-08-21
申请号：US09032072
申请日：1998-02-27
申请人： Rhonda L. Cole , Ronita K. Geckle , Terrence B. Mazer , Frank A. Murawski , Carl J. Piontek , Gregory James Stephens , Joseph E. Walton
发明人： Rhonda L. Cole , Ronita K. Geckle , Terrence B. Mazer , Frank A. Murawski , Carl J. Piontek , Gregory James Stephens , Joseph E. Walton
IPC分类号： A61M3700
CPC分类号： A61M5/007 , A61J15/00 , A61J15/0026 , A61J15/0069 , A61M5/1407 , A61M5/1409 , A61M31/002
摘要： An apparatus for modifying a liquid enteral nutritional product. The apparatus includes a chamber having an inlet and an outlet. The inlet of the chamber is constructed to be fluidly connected to a supply container containing a liquid enteral nutritional. The chamber defines an interior space. The apparatus further includes a retainer disposed in the interior space defined by the chamber. The retainer is constructed to receive one or more dosage form units of beneficial agent therein. The apparatus further includes at least one dosage form unit of beneficial agent retained by the retainer.
摘要翻译：一种用于改变液体肠内营养产品的装置。该装置包括具有入口和出口的室。腔室的入口被构造成流体连接到容纳液体肠内营养的供应容器。室定义了一个内部空间。该装置还包括设置在由腔限定的内部空间中的保持器。保持器构造成在其中接收一种或多种有益剂的剂型单元。该装置还包括由保持器保留的有益剂的至少一个剂型单元。

7. 发明授权

US5531681A Apparatus for altering composition of nutritional product during enteral tube feeding 失效
标题翻译：用于改变肠管喂养期间营养产品组成的装置
公开(公告)号：US5531681A
公开(公告)日：1996-07-02
申请号：US372407
申请日：1995-01-13
申请人： Joseph E. Walton , Terrence B. Mazer , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Joseph E. Walton , Terrence B. Mazer , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added. A liquid nutritional product flows through the formulation chamber during enteral tube feeding of a patient.
摘要翻译：公开了一种用于在将液体肠内营养产品从其供应源（例如可吊起的容器）递送到将食用液体肠营养产品输送到患者的胃肠道的进料管中的情况下将液体肠内营养产品改性的装置。该装置具有至少一个配方腔室，例如滴注室，其中至少一个以包衣片剂，渗透驱动装置，包衣胶囊，微胶囊化微球，聚集分子筛型材料形式的控释剂型单元，或在其中的细中空可渗透纤维的数量。控制释放剂型单元或单元含有至少一种选自营养物质，药物，益生菌或诊断剂或其混合物的有益剂，其中任何一种生物学可接受的控制释放剂型标记染料和/或相同或不同可以加入不在控释剂型中的有益剂。在患者的肠管喂养期间，液体营养产品流过制剂室。

8. 发明授权

US5549550A Method of adding marker dye to nutritional product during enteral tube feeding 失效
标题翻译：在肠管喂养期间向营养产品添加标记染料的方法
公开(公告)号：US5549550A
公开(公告)日：1996-08-27
申请号：US372613
申请日：1995-01-13
申请人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
发明人： Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Robert L. Joseph , William G. Pierson , Thomas D. Loughrin , Thomas W. Osip
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method for dye marking a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient includes the steps of: (1) providing apparatus such as a formulation chamber, e.g., a drip chamber, connectable to the supply container, with at least one sustained release reservoir containing a physiologically acceptable and dispersible marker dye positioned within the formulation chamber, and, liquid communication means connecting the formulation chamber to the feeding tube of a patient; (2) providing a supply container containing the nutritional product; (3) connecting the formulation chamber to the supply container and the liquid commmunication means to the feeding tube; and (4) flowing the dye-marked nutritional product through the apparatus and into the feeding tube. The sustained release reservoir may be a conventional slow release coated tablet, microspheres, or capsule type or an osmotically driven device. The marker dye may be a colorant dye or a fluorescing dye or a mixture thereof. If quick coloration is desired, the sustained release reservoir may be coated with a soluble layer of the marker dye or marker dye not in a sustained release reservoir may be placed in the formulation chamber along with a sustained release reservoir containing dye.
摘要翻译：一种将液体肠内营养产品从供应容器输送至将营养产品输送到患者的胃肠道的喂食管中的染色标记方法包括以下步骤：（1）提供诸如配制室的装置，可连接到供应容器的滴水室与至少一个包含位于配制室内的生理上可接受和可分散的标记染料的缓释储存器，以及将配制室连接到患者的进料管的液体连通装置; （2）提供容纳营养产品的供应容器; （3）将制剂室与供给容器和液体通信装置连接到进料管; 和（4）使染料标记的营养产品通过设备流入饲管。持续释放储存器可以是常规的缓释包衣片剂，微球体或胶囊型或渗透驱动装置。标记染料可以是着色剂染料或荧光染料或其混合物。如果需要快速着色，则持续释放储存器可以涂覆有标记染料的可溶层或不在持续释放储存器中的标记染料，可以与含有染料的持续释放储存器一起放置在配制室中。

9. 发明授权

US5533973A Alteration of nutritional product during enteral tube feeding 失效
标题翻译：肠管喂养期间营养产品的改变
公开(公告)号：US5533973A
公开(公告)日：1996-07-09
申请号：US372624
申请日：1995-01-13
申请人： Carl J. Piontek , Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle
发明人： Carl J. Piontek , Terrence B. Mazer , Joseph E. Walton , Ronita K. Geckle
IPC分类号： A61J15/00 , A61M5/14 , A61M37/00
CPC分类号： A61M5/1409 , A61J15/0026 , A61J15/0069 , A61J15/00
摘要： An apparatus and method are disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply to a feeding tube delivering the modified liquid enteral nutritional product to the gastrointestinal tract of a patient. At least one beneficial agent not in controlled release dosage form in a useful, dose unit, amount, is disposed within a formulation chamber so as to be taken up in a liquid enteral nutritional product traversing the formulation chamber while feeding the modified nutritional product into the gastrointestinal tract of a patient. The beneficial additive(s) are selected from nutrients, medicaments, probiotics, or diagnostic agents, or mixtures thereof, each in a dosage form that is dispersible in the medium of the liquid enteral nutritional product in less than two hours.
摘要翻译：公开了一种用于在将液体肠内营养产品从供应管道输送到患者的胃肠道的供给管中的过程中改变液体肠内营养产品的装置和方法。至少一种不是控制释放剂型的有益药剂以有用的剂量单位量配置在制剂室内，以便在经过配制室的液体肠内营养产品中吸收，同时将改良的营养产品喂入患者的胃肠道。有益的添加剂选自营养物质，药物，益生菌或诊断剂或其混合物，各自为可在不到两小时内分散于液体肠内营养产品的介质中的剂型。

10. 发明授权

US5531734A Method of altering composition of nutritional product during enteral tube feeding 失效
标题翻译：改变肠管喂养期间营养产品组成的方法
公开(公告)号：US5531734A
公开(公告)日：1996-07-02
申请号：US372408
申请日：1995-01-13
申请人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
IPC分类号： A61J15/00 , A61K9/22 , A61M5/00 , A61M5/14 , A61M31/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.
摘要翻译：公开了一种用于在将液体肠内营养产品从供应容器输送到将营养产品输送到患者的胃肠道的进料管中时，用于改变液体肠内营养产品的方法。在肠管喂养期间，营养产品通过配制室，例如滴注室，其中至少含有至少一种含有至少一种有益剂的控释剂型单元。有益药物可以选自营养物，药物，益生菌或诊断剂或其混合物，以及任何这些与控制释放剂型中的生理学上可接受的标记染料和/或不是控制释放剂量的相同或不同的附加有益剂形成。受控释放剂型可以是常规的缓释型或渗透驱动的输送装置。

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