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1. 发明授权

US5531681A Apparatus for altering composition of nutritional product during enteral tube feeding 失效
标题翻译：用于改变肠管喂养期间营养产品组成的装置
公开(公告)号：US5531681A
公开(公告)日：1996-07-02
申请号：US372407
申请日：1995-01-13
申请人： Joseph E. Walton , Terrence B. Mazer , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Joseph E. Walton , Terrence B. Mazer , Ronita K. Geckle , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
IPC分类号： A61J15/00 , A61M5/00 , A61M5/14 , A61M31/00 , A61M37/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： An apparatus is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply thereof, such as a hangable container, to a feeding tube delivering the liquid enteral nutritional product to the gastrointestinal tract of a patient. The apparatus has at least one formulation chamber, such as a drip chamber, with at least one controlled release dosage form unit in the form of a coated tablet, osmotically driven device, coated capsule, microencapsulated microspheres, agglomerated molecular sieving type material, or a quantity of fine hollow permeable fibers located therein. The controlled release dosage form unit or units contain at least one beneficial agent selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, to any of which a physiologically acceptable marker dye in controlled release dosage form and/or the same or different beneficial agent not in controlled release dosage form may be added. A liquid nutritional product flows through the formulation chamber during enteral tube feeding of a patient.
摘要翻译：公开了一种用于在将液体肠内营养产品从其供应源（例如可吊起的容器）递送到将食用液体肠营养产品输送到患者的胃肠道的进料管中的情况下将液体肠内营养产品改性的装置。该装置具有至少一个配方腔室，例如滴注室，其中至少一个以包衣片剂，渗透驱动装置，包衣胶囊，微胶囊化微球，聚集分子筛型材料形式的控释剂型单元，或在其中的细中空可渗透纤维的数量。控制释放剂型单元或单元含有至少一种选自营养物质，药物，益生菌或诊断剂或其混合物的有益剂，其中任何一种生物学可接受的控制释放剂型标记染料和/或相同或不同可以加入不在控释剂型中的有益剂。在患者的肠管喂养期间，液体营养产品流过制剂室。

2. 发明授权

US5318543A Laparoscopic jejunostomy instrumentation kit 失效
标题翻译：腹腔镜空肠造口仪
公开(公告)号：US5318543A
公开(公告)日：1994-06-07
申请号：US958409
申请日：1992-10-08
申请人： Jeffrey R. Ross , Mark A. McCamish , Andrea L. Senokozliff-Englehart , Roger G. Danis
发明人： Jeffrey R. Ross , Mark A. McCamish , Andrea L. Senokozliff-Englehart , Roger G. Danis
IPC分类号： A61B17/04 , A61B17/34 , A61B19/02 , A61J15/00 , A61M5/00
CPC分类号： A61B17/3415 , A61B17/0469 , A61B50/33 , A61J15/0023 , A61J15/0061 , A61J15/0069 , A61B2017/0416 , A61B2017/0417 , A61B2017/0479 , A61B2050/0065 , A61B2050/314 , A61J15/0007 , A61J2205/00
摘要： A laparoscopic jejunostomy instrumentation kit includes components for securing a patient's intestine in apposition to the patient's abdominal wall and for creating a stoma through the patient's abdominal wall and intestinal wall, a jejunostomy tube, and an enclosure for containing the other components of the kit. In preferred embodiments the kit includes T-Fastener assemblies, needles, syringes, a dilator, a peel-away sheath and a gastrostomy tube.
摘要翻译：腹腔镜空肠造口术仪器套件包括用于将患者肠道固定在患者腹壁上并通过患者的腹壁和肠壁创建造口的部件，空肠造口管和用于容纳试剂盒的其它成分的外壳。在优选实施方案中，试剂盒包括T紧固件组件，针，注射器，扩张器，剥离鞘和胃造口管。

3. 发明授权

US5263490A Muscle function assessment 失效
标题翻译：肌肉功能评估
公开(公告)号：US5263490A
公开(公告)日：1993-11-23
申请号：US920080
申请日：1992-07-27
申请人： James P. Hayes , James L. Tiefenthal , Mark A. McCamish , Jeffrey R. Ross
发明人： James P. Hayes , James L. Tiefenthal , Mark A. McCamish , Jeffrey R. Ross
IPC分类号： A61B5/11 , A61B5/05
CPC分类号： A61B5/1106 , A61B5/4519 , A61B5/6826
摘要： An apparatus may be employed for determining the relaxation rate of a muscle which has been caused to contract in response to an electrical stimulus. The relaxation rate may be used in evaluating a person's nutritional status. The apparatus has support for supporting the forearm and wrist of a person in a palm-up position with the wrist extended. An electrical stimulus is applied to the person's ulnar nerve, and the force exerted upon a load cell by the person's thumb is measured. A computer is employed for receiving, storing, plotting and analyzing the force data collected by a transducer.
摘要翻译：可以使用装置来确定响应于电刺激而已经收缩的肌肉的松弛率。放松率可用于评估一个人的营养状况。该装置具有支撑，用于支撑手腕延伸的手掌向上位置的人的前臂和手腕。对人的尺神经施加电刺激，并且测量由人的拇指施加在称重传感器上的力。计算机用于接收，存储，绘制和分析由换能器收集的力数据。

4. 发明授权

US5508308A Use of pyruvylglycine to treat ischemia/reperfusion injury following myocardial infarction 失效
标题翻译：使用丙酮酰甘氨酸治疗心肌梗塞后的缺血/再灌注损伤
公开(公告)号：US5508308A
公开(公告)日：1996-04-16
申请号：US381256
申请日：1995-01-31
申请人： Robert H. Miller , Mark A. McCamish , Ronald T. Stanko
发明人： Robert H. Miller , Mark A. McCamish , Ronald T. Stanko
IPC分类号： A61K31/195 , A61K31/40
CPC分类号： A61K31/40 , A61K31/195
摘要： A therapeutic method is provided to reduce ischemia/reperfusion injury to the heart muscle by perfusing pyruvylglycine into the circulatory system of a patient who has had a heart attack or suffered coronary occlusion.
摘要翻译：提供一种治疗方法，通过将丙酮酰甘氨酸灌注到患有心脏病发作或患冠状动脉闭塞的患者的循环系统中来减少对心肌的缺血/再灌注损伤。

5. 发明申请

US20110200588A1 METHODS FOR GENETIC ANALYSIS 审中-公开
标题翻译：遗传分析方法
公开(公告)号：US20110200588A1
公开(公告)日：2011-08-18
申请号：US13094903
申请日：2011-04-27
申请人： David R. Cox , Mark A. McCamish
发明人： David R. Cox , Mark A. McCamish
IPC分类号： A61K39/395 , A61K31/7088 , C12Q1/68 , A61P43/00
CPC分类号： G16B20/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , G06F19/34 , G16H50/20
摘要： Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing the score to at least one threshold value, wherein the result of the comparison is indicative of a beneficial response to a treatment, and providing a suitable treatment to the individual.
摘要翻译：公开了治疗呈现医疗状况的个体的方法。所述方法包括基于个人的基因型信息来确定个体的得分，将得分与至少一个阈值进行比较，其中比较结果指示对治疗的有益应答，并为个体提供适当的治疗。

6. 发明申请

US20090087854A1 METHODS FOR GENETIC ANALYSIS 审中-公开
标题翻译：遗传分析方法
公开(公告)号：US20090087854A1
公开(公告)日：2009-04-02
申请号：US12236036
申请日：2008-09-23
申请人： David R. Cox , Mark A. McCamish
发明人： David R. Cox , Mark A. McCamish
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G16B20/00 , C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/16 , G06F19/34 , G16H50/20
摘要： Methods of treating an individual exhibiting a medical condition are disclosed. The methods involve determining a score of an individual based on the individual's genotypic information, comparing the score to at least one threshold value, wherein the result of the comparison is indicative of a beneficial response to a treatment, and providing a suitable treatment to the individual.
摘要翻译：公开了治疗呈现医疗状况的个体的方法。所述方法包括基于个人的基因型信息来确定个体的得分，将得分与至少一个阈值进行比较，其中比较结果指示对治疗的有益反应，并且向个体提供适当的治疗。

7. 发明申请

US20080280955A1 Methods and compositions for screening and treatment of disorders of blood glucose regulation 审中-公开
标题翻译：用于筛选和治疗血糖调节障碍的方法和组合物
公开(公告)号：US20080280955A1
公开(公告)日：2008-11-13
申请号：US11541495
申请日：2006-09-29
申请人： Mark A. McCamish
发明人： Mark A. McCamish
IPC分类号： A61K31/4436 , C12Q1/68 , C07H21/04 , C07K2/00
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： In one aspect, the invention provides a method of screening and, optionally, treatment of an individual suffering from an insulin resistance disorder by screening an individual in need of treatment for an insulin resistance disorder for one or more genetic variations indicating a predisposition to a response to an insulin sensitizer; and, optionally, administering or not administering an insulin sensitizer to the individual based on the results of the screening. The insulin sensitizer for which the individual is screened and the insulin sensitizer that is administered or not administered may be the same or different. In another aspect, the invention provides methods comprising identifying one or more genetic variations, e.g., one or more single nucleotide polymorphisms, that at least partly differentiate between a subset of a plurality of individuals who experience a response when administered an insulin sensitizer, and a subset of said plurality of individuals who do not experience a response when administered the insulin sensitizer. The invention also provides nucleic acids, polypeptides, antibodies, kits, and business methods associated with these screening and association methods.
摘要翻译：在一个方面，本发明提供了筛选和任选地治疗患有胰岛素抵抗障碍的个体的方法，其通过筛选需要治疗胰岛素抵抗障碍的个体对一种或多种指示反应倾向的遗传变异胰岛素敏化剂; 以及任选地，基于筛选结果向个体施用或不施用胰岛素敏化剂。筛选个体的胰岛素敏化剂和施用或未施用的胰岛素敏化剂可以相同或不同。在另一方面，本发明提供了包括鉴定一种或多种遗传变异（例如，一种或多种单核苷酸多态性）的方法，其在施用胰岛素敏化剂时经历响应的多个个体的亚组中的至少一部分区别，以及在施用胰岛素敏化剂时不经历反应的所述多个个体的子集。本发明还提供与这些筛选和结合方法相关联的核酸，多肽，抗体，试剂盒和商业方法。

8. 发明授权

US5531734A Method of altering composition of nutritional product during enteral tube feeding 失效
标题翻译：改变肠管喂养期间营养产品组成的方法
公开(公告)号：US5531734A
公开(公告)日：1996-07-02
申请号：US372408
申请日：1995-01-13
申请人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
发明人： Ronita K. Geckle , Terrence B. Mazer , Joseph E. Walton , Carl J. Piontek , Susan B. Duel , Andre Daab-Krzykowski , Mark A. McCamish , Robert L. Joseph , William G. Pierson
IPC分类号： A61J15/00 , A61K9/22 , A61M5/00 , A61M5/14 , A61M31/00
CPC分类号： A61M31/002 , A61J15/0026 , A61J15/0069 , A61M5/007 , A61M5/1407 , A61J15/00
摘要： A method is disclosed for modifying a liquid enteral nutritional product during delivery thereof from a supply container to a feeding tube delivering the nutritional product to the gastrointestinal tract of a patient. During enteral tube feeding the nutritional product passes through a formulation chamber, e.g., a drip chamber, having located therein at least one controlled release dosage form unit containing at least one beneficial agent. The beneficial agent may be selected from nutrients, medicaments, probiotics, or diagnostic agents or mixtures thereof, and any such together with a physiologically acceptable marker dye in controlled release dosage form and/or the same or different additional beneficial agent not in controlled release dosage form. Controlled release dosage forms may be of a conventional sustained release type or an osmotically driven delivery device.
摘要翻译：公开了一种用于在将液体肠内营养产品从供应容器输送到将营养产品输送到患者的胃肠道的进料管中时，用于改变液体肠内营养产品的方法。在肠管喂养期间，营养产品通过配制室，例如滴注室，其中至少含有至少一种含有至少一种有益剂的控释剂型单元。有益药物可以选自营养物，药物，益生菌或诊断剂或其混合物，以及任何这些与控制释放剂型中的生理学上可接受的标记染料和/或不是控制释放剂量的相同或不同的附加有益剂形成。受控释放剂型可以是常规的缓释型或渗透驱动的输送装置。

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