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1. 发明授权

US4467651A Method for determining acceleration 失效
标题翻译：确定加速度的方法
公开(公告)号：US4467651A
公开(公告)日：1984-08-28
申请号：US456255
申请日：1983-01-06
申请人： Rex B. Peters , Arnold Malametz , Jeffrey F. Tonn , Charles K. Lee , Aleksandar M. Gogic , Victor B. Corey
发明人： Rex B. Peters , Arnold Malametz , Jeffrey F. Tonn , Charles K. Lee , Aleksandar M. Gogic , Victor B. Corey
IPC分类号： G01P15/08 , G01P15/097 , G01P15/10
CPC分类号： G01P15/097 , Y10S73/01
摘要： An accelerometer has two proof masses each constrained from movement by a beam resonant force transducer. The proof mass-force transducer systems are mounted with the sensitive axes of the proof masses aligned and the force transducers arranged so that their resonant frequencies f.sub.1 and f.sub.2 vary oppositely with a change in acceleration. The acceleration is determined in accordance with the relationa=A.sub.1 f.sub.1 -A.sub.2 f.sub.3 +A.sub.0ora=A.sub.1 f.sub.1.sup.2 -A.sub.2 f.sub.2.sup.2 +A.sub.0where a is the acceleration and A.sub.1, A.sub.2 and A.sub.0 are calibration coefficients.
摘要翻译：一个加速度计具有两个证明质量，每个质量体均受光束共振力传感器的移动约束。检测质量传感器系统安装有检测质量对照的敏感轴，力传感器的布置使得它们的共振频率f1和f2与加速度的变化相反。加速度根据a = A1f1-A2f3 + A0或a = A1f12-A2f22 + A0的关系确定，其中a是加速度，A1，A2和A0是校准系数。

2. 发明授权

US4517841A Accelerometer with beam resonator force transducer 失效
标题翻译：加速度计与光束谐振器力传感器
公开(公告)号：US4517841A
公开(公告)日：1985-05-21
申请号：US456254
申请日：1983-01-06
申请人： Rex B. Peters , Jeffrey F. Tonn , Arnold Malametz , Richard A. Hilliker , Victor B. Corey
发明人： Rex B. Peters , Jeffrey F. Tonn , Arnold Malametz , Richard A. Hilliker , Victor B. Corey
IPC分类号： G01P15/02 , G01P15/097 , G01P15/10
CPC分类号： G01P15/097 , G01P2015/0828 , Y10S73/01
摘要： An accelerometer includes a hinged proof mass constrained from movement by a beam resonator force transducer. To afford greater movement of the proof mass and greater latitude in positioning mechanical stops, one end of the force transducer is connected with the accelerometer base through a compliant mount. The other end of the force transducer is connected with the proof mass at the center of percussion of the proof mass. Adjacent surfaces of the proof mass and base provide squeeze film viscous gas damping. A pair of proof mass-force transducer systems are mounted on a carrier in opposite positions with the sensitive axes of the proof masses aligned and the proof mass hinge axes parallel and opposed to each other.
摘要翻译：一个加速度计包括一个由梁谐振器力传感器运动限制的铰接证明质量。为了在定位机械止动件时提供更大的检测质量的运动和更大的纬度，力传感器的一端通过柔性支架与加速度计基座连接。力传感器的另一端与检验质量的撞击中心的检测质量块相连。证明质量和基体的相邻表面提供挤压膜粘性气体阻尼。一对检测质量传感器系统以相对的位置安装在载体上，其中检测质量块的敏感轴对齐，并且检验质量铰链轴彼此平行和相对。

3. 发明授权

US5212984A Mounting system for an accelerometer 失效
标题翻译：用于加速度计的安装系统
公开(公告)号：US5212984A
公开(公告)日：1993-05-25
申请号：US930473
申请日：1992-08-13
申请人： Brian L. Norling , Jeffrey F. Tonn
发明人： Brian L. Norling , Jeffrey F. Tonn
IPC分类号： G01D11/30 , G01P1/02
CPC分类号： G01D11/30 , G01P1/023
摘要： The mounting system of the present invention is adapted to support a precision transducer (14) in spaced alignment with a supporting case (12). The mounting system comprises a plurality of mounting elements (30), each mounting element having one end (34), an opposite end (32) and a resilient intermediate portion (36). One end is adapted to be connected to the transducer, and the opposite end is adapted to be connected to the case. Adjacent mounting elements are joined to one another by bridge sections (38) to form a continuous mounting ring (16) and to define a plurality of gaps (56). At least the end connected to the transducer and bridge sections is composed of a substance that has a coefficient of thermal expansion approximately equal to the coefficient of thermal expansion of the transducer. Each intermediate portion is configured to provide a low resistance to relative movement between the transducer and case in a radial direction, and a high resistance to relative movement in other directions.
摘要翻译：本发明的安装系统适于支撑与支撑壳体（12）间隔对准的精密换能器（14）。安装系统包括多个安装元件（30），每个安装元件具有一端（34），相对端（32）和弹性中间部分（36）。一端适于连接到换能器，并且相对端适于连接到壳体。相邻的安装元件通过桥接部分（38）彼此连接以形成连续的安装环（16）并且限定多个间隙（56）。至少连接到换能器和桥接部分的端部由具有大约等于换能器的热膨胀系数的热膨胀系数的物质组成。每个中间部分构造成对径向方向上的换能器和壳体之间的相对运动提供低阻力，并且对其它方向的相对运动具有高阻力。

4. 发明授权

US07648835B2 System and method for heating, cooling and heat cycling on microfluidic device 有权
标题翻译：微流体装置上加热，冷却和热循环的系统和方法
公开(公告)号：US07648835B2
公开(公告)日：2010-01-19
申请号：US12199613
申请日：2008-08-27
申请人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
发明人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/5027 , B01L7/52 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2300/185 , B01L2300/1877
摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.
摘要翻译：微流控卡上集成的热交换系统。根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。微流控卡包括一个或多个含有放热或吸热材料的储存器。一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。可以在单个卡上包括多个储存器以提供变化的温度。测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予独立电路中的分析流体。根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

5. 发明授权

US4706259A Mounting and isolation system for tuning fork temperature sensor 失效
标题翻译：音叉温度传感器的安装和隔离系统
公开(公告)号：US4706259A
公开(公告)日：1987-11-10
申请号：US815352
申请日：1985-12-30
申请人： Jerome M. Paros , Jeffrey F. Tonn , Richard B. Wearn, Jr.
发明人： Jerome M. Paros , Jeffrey F. Tonn , Richard B. Wearn, Jr.
IPC分类号： G01K7/32 , G01K11/22
CPC分类号： G01K7/32
摘要： Prior mounting systems for tuning fork temperature sensors have resulted in unpredictable activity dips within the sensor operating ranges. This problem is eliminated by the mounting and isolation system (32) of the present invention that is adapted to mount temperature sensitive tuning fork (20) to a support structure. The mounting system comprises a mounting member (34) adapted for rigid connection to the support structure, and support means (36) connecting the tuning fork base to the mounting member such that the tuning fork is supported solely by the support means. The support means comprises a low pass mechanical filter that transmits only vibration frequencies that are less than the operating range of frequencies of the tuning fork.
摘要翻译：用于音叉温度传感器的现有安装系统导致传感器工作范围内的不可预测的活动下降。通过适用于将温度敏感音叉（20）安装到支撑结构的本发明的安装和隔离系统（32）来消除这个问题。安装系统包括适于刚性连接到支撑结构的安装构件（34）和将音叉基座连接到安装构件的支撑装置（36），使得音叉仅由支撑装置支撑。支撑装置包括仅传送小于音叉的频率的操作范围的振动频率的低通机械滤波器。

6. 发明申请

US20090081771A1 SYSTEM AND METHOD FOR HEATING, COOLING AND HEAT CYCLING ON MICROFLUIDIC DEVICE 有权
标题翻译：用于加热，冷却和热循环的微流控装置的系统和方法
公开(公告)号：US20090081771A1
公开(公告)日：2009-03-26
申请号：US12199613
申请日：2008-08-27
申请人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
发明人： Wayne L. Breidford , Christy A. Lancaster , Jon W. Hayenga , Ronald L. Bardell , Jeffrey F. Tonn , Bernhard H. Weigl
IPC分类号： C12M1/40
CPC分类号： B01L3/5027 , B01L7/52 , B01L2200/147 , B01L2300/0816 , B01L2300/0887 , B01L2300/1822 , B01L2300/185 , B01L2300/1877
摘要： An integrated heat exchange system on a microfluidic card. According to one aspect of the invention, the portable microfluidic card has a heating, cooling and heat cycling system on-board such that the card can be used portably. The microfluidic card includes one or more reservoirs containing exothermic or endothermic material. Once the chemical process of the reservoir material is activated, the reservoir provides heat or cooling to specific locations of the microfluidic card. Multiple reservoirs may be included on a single card to provide varying temperatures. The assay chemicals can be moved to the various reservoirs to create a thermal cycle useful in many biological reactions, for example, Polymerase Chain Reaction (PCR) or rtPCR. According to another aspect of the invention, the integrated heat exchanger is an adjacent microfluidic circuit containing fluid that is either independently heated or cooled, or is an exothermic or endothermic material, such that the fluid in the adjacent circuit imparts a change in temperature to the assay fluid in an independent circuit. According to yet another aspect of the invention, a thermal electric cooler (TEC) is used for thermocycling the amplification chamber of a disposable microfluidic card.
摘要翻译：微流控卡上集成的热交换系统。根据本发明的一个方面，便携式微流控卡具有板上的加热，冷却和热循环系统，使得卡可以可移动地使用。微流控卡包括一个或多个含有放热或吸热材料的储存器。一旦储存器材料的化学过程被激活，储存器就向微流控卡的特定位置提供热量或冷却。可以在单个卡上包括多个储存器以提供变化的温度。测定化学品可以移动到各种储存器以产生可用于许多生物反应的热循环，例如聚合酶链式反应（PCR）或rtPCR。根据本发明的另一方面，集成热交换器是包含独立加热或冷却的流体的相邻微流体回路，或者是放热或吸热材料，使得相邻回路中的流体将温度变化赋予独立电路中的分析流体。根据本发明的另一方面，热电冷却器（TEC）用于热循环一次性微流控卡的放大室。

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