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1. 发明申请

US20090274621A1 USE OF PYRENE TO CARRY NON-PEPTIDE AGENTS ACROSS THE BLOOD BRAIN BARRIER 审中-公开
标题翻译：使用丁苯来保护血脑屏障的非肽代谢物
公开(公告)号：US20090274621A1
公开(公告)日：2009-11-05
申请号：US12363221
申请日：2009-01-30
申请人： Renee Wegrzyn , Andrew Nyborg , D. Roxanne Duan , Alan Rudolph
发明人： Renee Wegrzyn , Andrew Nyborg , D. Roxanne Duan , Alan Rudolph
IPC分类号： A61K51/00 , A61K49/00 , A61B5/055 , A61K31/7088 , A61K31/015
CPC分类号： A61K47/54
摘要： Described are methods for delivering a non-peptide agent across the blood-brain barrier, comprising administering to a subject a conjugate comprising (i) a non-peptide agent and (ii) pyrene, and related detection and therapeutic method.
摘要翻译：描述了通过血脑屏障递送非肽试剂的方法，包括向受试者施用包含（i）非肽试剂和（ii）芘的缀合物以及相关的检测和治疗方法。

2. 发明申请

US20090238754A1 USE OF PYRENE TO CARRY PEPTIDES ACROSS THE BLOOD BRAIN BARRIER 审中-公开
标题翻译：使用紫罗兰在血液脑膜上携带胶囊
公开(公告)号：US20090238754A1
公开(公告)日：2009-09-24
申请号：US12363254
申请日：2009-01-30
申请人： Renee WEGRZYN , Andrew Nyborg , D. Roxanne Duan , Alan Rudolph
发明人： Renee WEGRZYN , Andrew Nyborg , D. Roxanne Duan , Alan Rudolph
IPC分类号： A61K51/00 , A61K49/00 , A61B5/055 , A61B5/00 , A61K39/395 , A61K38/16 , A61K31/015
CPC分类号： A61K49/0056 , A61K47/54 , A61K49/0021
摘要： Described are methods for delivering a peptide agent across the blood-brain barrier, comprising administering to a subject a conjugate comprising (i) a peptide agent and pyrene, and related detection and therapeutic methods.
摘要翻译：描述了通过血脑屏障递送肽试剂的方法，包括向受试者施用包含（i）肽剂和芘的缀合物以及相关的检测和治疗方法。

3. 发明申请

US20100233095A1 CONFORMATIONALLY DYNAMIC PEPTIDES 审中-公开
标题翻译：一致的动态肽
公开(公告)号：US20100233095A1
公开(公告)日：2010-09-16
申请号：US12695968
申请日：2010-01-28
申请人： D. Roxanne Duan , Jonathan R. Moll , Alan Rudolph , Renee Wegrzyn
发明人： D. Roxanne Duan , Jonathan R. Moll , Alan Rudolph , Renee Wegrzyn
IPC分类号： A61K49/04 , C07K7/06 , C07K7/08 , C07K14/00 , G01N33/53 , A61K49/14 , A61K49/22 , A61K38/08 , A61K38/10 , A61K38/16 , A61P25/28 , A61P25/16
CPC分类号： G01N33/582 , C07K14/001 , C07K14/4711 , C07K19/00 , G01N33/542 , G01N33/6896
摘要： Disclosed are novel peptides that are useful, for example, for detecting target proteins having a β-sheet secondary structure which may be associated with a disease, and for diagnosing and treating such a disease. Related methods and kits also are disclosed.
摘要翻译：公开了可用于例如用于检测具有可能与疾病相关的“一级”二级结构的靶蛋白以及用于诊断和治疗这种疾病的新型肽。还公开了相关方法和试剂盒。

4. 发明申请

US20150133632A1 CONFORMATIONALLY DYNAMIC PEPTIDES 有权
标题翻译：一致的动态肽
公开(公告)号：US20150133632A1
公开(公告)日：2015-05-14
申请号：US14299432
申请日：2014-06-09
申请人： D. Roxanne Duan , Jonathan R. Moll , Alan Rudolph , Renee Wegrzyn
发明人： D. Roxanne Duan , Jonathan R. Moll , Alan Rudolph , Renee Wegrzyn
IPC分类号： G01N33/58 , C07K19/00 , C07K14/00
CPC分类号： G01N33/582 , C07K14/001 , C07K14/4711 , C07K19/00 , G01N33/542 , G01N33/6896
摘要： Disclosed are novel peptides that are useful, for example, for detecting target proteins having a β-sheet secondary structure which may be associated with a disease, and for diagnosing and treating such a disease. Related methods and kits also are disclosed.
摘要翻译：公开了可用于例如用于检测具有可能与疾病相关的“一级”二级结构的靶蛋白以及用于诊断和治疗这种疾病的新型肽。还公开了相关方法和试剂盒。

5. 发明申请

US20120282169A1 DETECTION AND TREATMENT OF TRAUMATIC BRAIN INJURY 审中-公开
标题翻译： TRAUMATIC脑损伤的检测和治疗
公开(公告)号：US20120282169A1
公开(公告)日：2012-11-08
申请号：US13508212
申请日：2010-11-04
申请人： D. Roxanne Duan , Jonathan R. Moll , Alan Rudolph
发明人： D. Roxanne Duan , Jonathan R. Moll , Alan Rudolph
IPC分类号： G01N21/64 , A61K51/00 , A61K49/06 , A61K49/00
CPC分类号： G01N33/6896 , A61K49/0021 , A61K49/0056 , G01N33/542 , G01N2333/4709 , G01N2800/28
摘要： The present invention relates to the detection of traumatic brain injury by detecting Aβ protein aggregates associated with traumatic brain injury. These Aβ protein aggregates are detected using peptide and peptide mimic probes that preferentially associate with Aβ protein aggregates associated with traumatic brain injury.
摘要翻译：本发明涉及通过检测A＆Bgr检测创伤性脑损伤; 与创伤性脑损伤相关的蛋白质聚集体。这些A＆bgr 使用优先与A＆bgr相关联的肽和肽模拟物探针检测蛋白质聚集体; 与创伤性脑损伤相关的蛋白质聚集体。

6. 发明授权

US06903072B2 Keratinocyte growth factor-2 失效
公开(公告)号：US06903072B2
公开(公告)日：2005-06-07
申请号：US09345373
申请日：1999-07-01
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K38/00 , A61K48/00 , C07H21/00 , C07K14/50 , C12N5/02 , C12N15/18 , A61K38/18 , C12N1/21
CPC分类号： C07H21/00 , A61K38/00 , A61K48/00 , C07K14/50 , C12N2799/026 , Y10S514/925
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.

7. 发明授权

US06537966B1 Follistatin-3 有权
公开(公告)号：US06537966B1
公开(公告)日：2003-03-25
申请号：US09617804
申请日：2000-07-14
申请人： D. Roxanne Duan , Steven M. Ruben
发明人： D. Roxanne Duan , Steven M. Ruben
IPC分类号： A61K3822
CPC分类号： C07K14/4703 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/021 , C12N2799/026 , Y02A50/423
摘要： The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.

8. 发明授权

US06372454B2 Nucleic acid molecules encoding Follistatin-3 有权
标题翻译：编码Follistatin-3的核酸分子
公开(公告)号：US06372454B2
公开(公告)日：2002-04-16
申请号：US09141027
申请日：1998-08-27
申请人： D. Roxanne Duan , Steven M. Ruben
发明人： D. Roxanne Duan , Steven M. Ruben
IPC分类号： C12N510
CPC分类号： C07K14/4703 , A61K38/00 , A61K39/00 , A61K48/00 , C07K2319/00 , C12N2799/021 , C12N2799/026 , Y02A50/423
摘要： The present invention relates to a novel follistatin-3 protein which is a member of the family of inhibin-related proteins. In particular, isolated nucleic acid molecules are provided encoding the human follistatin-3 protein. Follistatin-3 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of follistatin-3 activity. Also provided are diagnostic methods for detecting reproductive system-related disorders and disorders of the regulation of cell growth and differentiation and therapeutic methods for treating reproductive system-related disorders and disorders of the regulation of cell growth and differentiation.
摘要翻译：本发明涉及作为抑制素相关蛋白家族成员的新型卵泡抑素-3蛋白。特别地，提供编码人卵泡抑素-3蛋白的分离的核酸分子。还提供了Follistatin-3多肽，载体，宿主细胞和用于制备它们的重组方法。本发明还涉及用于鉴定卵泡抑素-3活性的激动剂和拮抗剂的筛选方法。还提供了用于检测生殖系统相关疾病和细胞生长和分化调节紊乱的诊断方法以及用于治疗生殖系统相关疾病和调节细胞生长和分化的紊乱的治疗方法。

9. 发明申请

US20090203635A1 HXAAA01 Polynucleotides 审中-公开
标题翻译： HXAAA01多核苷酸
公开(公告)号：US20090203635A1
公开(公告)日：2009-08-13
申请号：US11968925
申请日：2008-01-03
申请人： Craig A. Rosen , George A. Komatsoulis , Kevin P. Baker , Michele Fiscella , Paul A. Moore , Ping Wei , D. Roxanne Duan , Yanggu Shi , Ram Gupta
发明人： Craig A. Rosen , George A. Komatsoulis , Kevin P. Baker , Michele Fiscella , Paul A. Moore , Ping Wei , D. Roxanne Duan , Yanggu Shi , Ram Gupta
IPC分类号： A61K31/711 , C12N15/12 , C12N15/13 , C07H21/04 , C12N15/85 , C12N15/64 , C12P21/02
CPC分类号： C07K14/47
摘要： The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
摘要翻译：本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。

10. 发明授权

US06693077B1 Keratinocyte growth factor-2 失效
标题翻译：角质形成细胞生长因子-2
公开(公告)号：US06693077B1
公开(公告)日：2004-02-17
申请号：US09610651
申请日：2000-06-30
申请人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
发明人： Steven M. Ruben , Pablo Jimenez , D. Roxanne Duan , Mark A. Rampy , Donna Mendrick , Jun Zhang , Jian NI , Paul A. Moore , Timothy A. Coleman , Joachim R. Gruber , Patrick J. Dillon , Reiner L. Gentz
IPC分类号： A61K3818
CPC分类号： C07K14/50 , A61K38/00 , A61K48/00 , C12N2799/026
摘要： This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
摘要翻译：本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。

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