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1. 发明授权

US06258360B1 Prodrugs activated by targeted catalytic proteins 失效
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US06258360B1
公开(公告)日：2001-07-10
申请号：US08325554
申请日：1994-10-18
申请人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
发明人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
IPC分类号： A61K3944
CPC分类号： C07H15/252 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H19/04 , C07K14/55 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , G01N33/5008 , G01N2500/00
摘要： Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.
摘要翻译：提供由与结合肿瘤细胞群的部分缀合的催化抗体活化并与其缀合的前药。

2. 发明授权

US06177270B1 Reaction-based selection for expression of and concentration of catalytic moieties 失效
标题翻译：用于催化部分的表达和浓缩的基于反应的选择
公开(公告)号：US06177270B1
公开(公告)日：2001-01-23
申请号：US09235353
申请日：1999-01-21
申请人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
发明人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
IPC分类号： C12N700
CPC分类号： C40B40/02 , C12N15/1037 , C12Q1/02 , C12Q1/6811 , C12Q1/70 , G01N33/56983
摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.
摘要翻译：公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。该方法采用基于反应的催化活性选择。该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

3. 发明授权

US6121007A Reaction-based selection for expression of and concentration of catalytic moieties 失效
标题翻译：用于催化部分的表达和浓缩的基于反应的选择
公开(公告)号：US6121007A
公开(公告)日：2000-09-19
申请号：US747654
申请日：1996-11-13
申请人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
发明人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
IPC分类号： G01N33/53 , B01J20/281 , C12N5/10 , C12N7/02 , C12N15/10 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C40B40/02 , G01N30/88 , G01N33/569 , C12Q1/25
CPC分类号： C40B40/02 , C12N15/1037 , C12Q1/02 , C12Q1/6811 , C12Q1/70 , G01N33/56983
摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.
摘要翻译：公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。该方法采用基于反应的催化活性选择。该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

4. 发明授权

US5891648A Reaction-based selection for expression of and concentration of catalytic moieties 失效
公开(公告)号：US5891648A
公开(公告)日：1999-04-06
申请号：US748415
申请日：1996-11-13
申请人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
发明人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
IPC分类号： G01N33/53 , B01J20/281 , C12N5/10 , C12N7/02 , C12N15/10 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C40B40/02 , G01N30/88 , G01N33/569 , C12Q1/25
CPC分类号： C40B40/02 , C12N15/1037 , C12Q1/02 , C12Q1/6811 , C12Q1/70 , G01N33/56983
摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.

5. 发明授权

US5631137A Reaction-based selection for expression of and concentration of catalytic moieties 失效
标题翻译：用于催化部分的表达和浓缩的基于反应的选择
公开(公告)号：US5631137A
公开(公告)日：1997-05-20
申请号：US377495
申请日：1995-01-24
申请人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
发明人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
IPC分类号： G01N33/53 , B01J20/281 , C12N5/10 , C12N7/02 , C12N15/10 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C40B40/02 , G01N30/88 , G01N33/569 , C12Q1/25 , C12N9/00
CPC分类号： C40B40/02 , C12N15/1037 , C12Q1/02 , C12Q1/6811 , C12Q1/70 , G01N33/56983
摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.
摘要翻译：公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。该方法采用基于反应的催化活性选择。该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

6. 发明授权

US07883105B2 Vehicle seat assembly with deflector inner panel air bag guide retainer 有权
标题翻译：汽车座椅组件带有导流板内部面板气囊导向架
公开(公告)号：US07883105B2
公开(公告)日：2011-02-08
申请号：US12057760
申请日：2008-03-28
申请人： Rodger G. Smith
发明人： Rodger G. Smith
IPC分类号： B60R21/207
CPC分类号： B60R21/207 , B60R2021/161
摘要： In at least certain embodiments, the vehicle seat assembly comprises a vehicle seat assembly comprising an air bag guide including an inner panel, an outer panel, and a deflector member, with the and outer panels being made of flexible material and the inner deflector member being made of a rigid material, with the deflector member having a leg member secured to the air bag assembly and a finger member, extending away from the leg member spaced from the release seam.
摘要翻译：在至少某些实施例中，车辆座椅组件包括车辆座椅组件，该车辆座椅组件包括气囊导向器，该气囊导向器包括内部面板，外部面板和偏转构件，其中外部面板由柔性材料制成，并且内部偏转构件为由刚性材料制成，其中所述偏转器构件具有固定到所述气囊组件的腿部构件和指状构件，所述指状构件远离所述腿构件与所述释放缝隔开。

7. 发明授权

US07490896B2 Stowable component for a vehicle and a method for stowing a vehicular component 有权
标题翻译：用于车辆的可存储部件和用于收集车辆部件的方法
公开(公告)号：US07490896B2
公开(公告)日：2009-02-17
申请号：US11733532
申请日：2007-04-10
申请人： Rodger G. Smith
发明人： Rodger G. Smith
IPC分类号： A47C15/00 , A47C7/62
CPC分类号： B60N2/3011 , B60N2/3043 , B60N2205/35
摘要： The present invention relates to a stowable seat assembly and a method for stowing a vehicular component. In at least one embodiment, the assembly and the vehicular component comprise a stowable seat assembly secured to the vehicle. Having a first seat back and a first seat base, which is adjacent to a longitudinal bar defining in part an opening and a cavity. The assembly also has adjacent to the first seat, a second seat having a second seat base with a bottom side and a second seat back foldable adjacent to the second seat base, and a pivot arm with a first end connected to the second seat base. A second end of the pivot arm is connected to the longitudinal bar, and is positionable on the bar allowing the folded second seat, to pass by the first seat back when pivoted laterally into the opening during stowing of the second seat.
摘要翻译：本发明涉及一种收起座椅组件和一种用于收起车辆部件的方法。在至少一个实施例中，组件和车辆部件包括固定到车辆的可收起的座椅组件。具有第一座椅靠背和第一座椅底座，其与部分地限定开口和空腔的纵向杆相邻。组件还邻近第一座椅，具有第二座椅底座的第二座椅具有底侧，第二座椅靠背可相对于第二座椅底座可折叠;以及枢转臂，第一端部连接到第二座椅底座。枢转臂的第二端连接到纵向杆，并且当在第二座椅的收起期间枢转到横向开口时，可以将第一座椅靠背穿过允许折叠的第二座椅的杆上。

8. 发明申请

US20090029914A1 Albumin Fusion Proteins 有权
标题翻译：白蛋白融合蛋白
公开(公告)号：US20090029914A1
公开(公告)日：2009-01-29
申请号：US11759843
申请日：2007-06-07
申请人： Craig A. Rosen , Adam Bell , David W. LaFleur , Douglas B. Woods , Ping Feng , Rodger G. Smith , Baiqin Teng
发明人： Craig A. Rosen , Adam Bell , David W. LaFleur , Douglas B. Woods , Ping Feng , Rodger G. Smith , Baiqin Teng
IPC分类号： A61K38/00 , C07K14/00 , C07K1/00 , C12N15/11 , C12N15/00 , C12N5/06 , A61P43/00
CPC分类号： C12N9/96 , A61K38/00 , C07K14/765 , C07K2319/00 , C12N15/62
摘要： The present invention encompasses albumin fusion proteins. Nucleic acid molecules encoding the albumin fusion proteins of the invention are also encompassed by the invention, as are vectors containing these nucleic acids, host cells transformed with these nucleic acids vectors, and methods of making the albumin fusion proteins of the invention and using these nucleic acids, vectors, and/or host cells. Additionally the present invention encompasses pharmaceutical compositions comprising albumin fusion proteins and methods of treating, preventing, or ameliorating diseases, disorders or conditions using albumin fusion proteins of the invention.
摘要翻译：本发明包括白蛋白融合蛋白。编码本发明的白蛋白融合蛋白的核酸分子也包括在本发明中，载体含有这些核酸，用这些核酸载体转化的宿主细胞，以及制备本发明的白蛋白融合蛋白并使用这些核酸的方法酸，载体和/或宿主细胞。另外，本发明包括包含白蛋白融合蛋白的药物组合物以及使用本发明的白蛋白融合蛋白来治疗，预防或改善疾病，病症或病症的方法。

9. 发明申请

US20090243263A1 VEHICLE SEAT ASSEMBLY WITH TWO-PART, CLIPPED AIR BAG GUIDE RETAINER 有权
标题翻译：车身座椅组件，两部分，夹子气囊导向夹
公开(公告)号：US20090243263A1
公开(公告)日：2009-10-01
申请号：US12057703
申请日：2008-03-28
申请人： Rodger G. Smith
发明人： Rodger G. Smith
IPC分类号： B60R21/207
CPC分类号： B60R21/207 , B60R2021/161
摘要： In at least certain embodiments, the vehicle seat assembly comprises an air bag guide including a first inner panel, a second inner panel, and an outer panel, with each of the panels being made of flexible material and having forward and rearward extremities, and a rigid plastic connector assembly for releasably securing the first and second inner panels to each other adjacent the air bag assembly, with the rigid connector comprising at least two releasably connected members, and with at least one of the connected members having at least one stop for inhibiting relative lateral movement of the connected members.
摘要翻译：在至少某些实施例中，车辆座椅组件包括气囊导向器，其包括第一内板，第二内板和外板，其中每个板由柔性材料制成并具有前后两端，并且刚性塑料连接器组件，用于将第一和第二内板可释放地固定在靠近气囊组件的彼此之间，刚性连接器包括至少两个可释放地连接的构件，并且连接构件中的至少一个具有至少一个用于抑制连接构件的相对侧向运动。

10. 发明授权

US5405190A Cover for vehicle head restraint 失效
标题翻译：车顶保护盖
公开(公告)号：US5405190A
公开(公告)日：1995-04-11
申请号：US5892
申请日：1993-01-15
申请人： Keith Jeffcoat , Rodger G. Smith
发明人： Keith Jeffcoat , Rodger G. Smith
IPC分类号： A47C7/38 , B60N2/48 , A47C7/36
CPC分类号： B60N2/48 , B29L2031/3023 , Y10S297/01
摘要： A vehicle seat head restraint has a framework stiffened resilient core and a fabric covering formed from at least one three-dimensional knitted fabric piece secured around the core.
摘要翻译：汽车座椅头枕具有框架加强的弹性芯和由固定在芯周围的至少一个三维针织织物片形成的织物覆盖物。

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