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1. 发明授权

US08541174B2 Multi-array, multi-specific electrochemiluminescence testing 失效
标题翻译：多阵列，多特异性电化学发光测试
公开(公告)号：US08541174B2
公开(公告)日：2013-09-24
申请号：US11300808
申请日：2005-12-14
申请人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
发明人： Jacob N. Wohlstadter , James L. Wilbur , George B. Sigal , Mark T. Martin , Liang-Hong Guo , Alan Fischer , Jon Leland , Mark A. Billadeau
IPC分类号： G01N33/53
CPC分类号： G01N21/66 , B82Y15/00 , B82Y30/00 , G01N21/76 , G01N33/54313 , G01N33/5438 , G01N33/582 , G01N33/585 , Y10S435/808 , Y10S435/81 , Y10S435/968 , Y10S435/975 , Y10S436/805
摘要： Materials and methods are provided for producing patterned multi-array, multi-specific surfaces for use in diagnostics. The invention provides for electrochemiluminescence methods for detecting or measuring an analyte of interest. It also provides for novel electrodes for ECL assays. Materials and methods are provided for the chemical and/or physical control of conducting domains and reagent deposition for use multiply specific testing procedures.
摘要翻译：提供材料和方法用于生产用于诊断的图案化多阵列多特异性表面。本发明提供了用于检测或测量感兴趣分析物的电化学发光方法。它还提供用于ECL测定的新型电极。提供材料和方法用于化学和/或物理控制导电域和试剂沉积，以便使用多重特定的测试程序。

2. 发明申请

US20120165209A1 METHODS AND COMPOSITIONS FOR DIRECTED MICROWAVE CHEMISTRY 失效
标题翻译：用于方向微波化学的方法和组合物
公开(公告)号：US20120165209A1
公开(公告)日：2012-06-28
申请号：US13341109
申请日：2011-12-30
申请人： Mark T. Martin
发明人： Mark T. Martin
IPC分类号： G01N21/76 , G01N21/64 , C40B30/04
CPC分类号： C12N11/00 , C12N13/00 , G01N33/5436 , G01N33/54393
摘要： The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special cartridges using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many chemical transformations including those used in protein chemistry, in nucleic acid chemistry, in analytical chemistry, and in the polymerase chain reaction.
摘要翻译：本发明涉及可以制备化学制剂的新型方法。使用微波能量的特殊墨盒可以加速反应。这些芯片含有有效吸收微波能量的材料，导致化学反应速率增加。本发明在许多化学转化中是重要的，包括在蛋白质化学，核酸化学，分析化学和聚合酶链反应中使用的化学转化。

3. 发明授权

US07682788B2 Method and apparatus for improved luminescence assays using microparticles 失效
标题翻译：用于使用微粒改进发光测定的方法和装置
公开(公告)号：US07682788B2
公开(公告)日：2010-03-23
申请号：US10884536
申请日：2004-07-02
申请人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
发明人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
IPC分类号： C12Q1/68
CPC分类号： G01N33/54346 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , G01N33/532 , G01N33/533 , G01N33/54306 , G01N33/54366 , G01N33/5438 , G01N33/552 , G01N33/553 , G01N33/582 , G01N33/587 , G01N2458/30 , C12Q2563/149 , C12Q2563/113 , C12Q2537/125
摘要： A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.
摘要翻译：提出了一种用于进行电化学发光测定的方法和装置。在本发明的示例性实施方案中，一种装置包括其上固定有第一测定配体的ECL非活性电极表面和其上固定有第二测定配体的ECL活性微粒。在本发明的示例性实施方案中，方法包括（a）形成包含电化学发光标记和其上固定有第一测定配体的微粒的混合物，（b）在所述混合物存在下将电化学能施加到电极表面，以及（c）测量发射的电化学发光，其中微粒是ECL-活性的，并且当在所述混合物的存在下施加电化学能时，电极表面是ECL-无活性的。

4. 发明授权

US07169894B2 Methods and compositions for reverse translation 失效
标题翻译：反向翻译的方法和组成
公开(公告)号：US07169894B2
公开(公告)日：2007-01-30
申请号：US10286796
申请日：2002-11-04
申请人： Mark T. Martin
发明人： Mark T. Martin
IPC分类号： C07K1/00 , C07K14/00 , C07K17/00 , G01N33/53 , C07H21/04
CPC分类号： G01N33/6803
摘要： A process is disclosed by which a polynucleotide is directly synthesized from the peptide or protein that it encodes without the need for sequencing (or sequence analysis) of the peptide or protein. Information contained in the sequence of the peptide or protein is directly coupled, by the process of reverse translation, to the synthesis of the polynucleotide. The usefulness of reverse translation is that it facilitates the amplification of information held in the amino acid sequence (the primary structure) of an unknown protein or peptide. Amplification is useful for, among other things, the identification and/or scientific investigation of the peptide or protein.
摘要翻译：公开了一种方法，通过该方法，多核苷酸从其编码的肽或蛋白质直接合成，而不需要肽或蛋白质的测序（或序列分析）。肽或蛋白质序列中包含的信息通过反向翻译的过程与多核苷酸的合成直接偶联。反向翻译的有用性是它有助于扩增未知蛋白质或肽的氨基酸序列（一级结构）中保存的信息。除了别的以外，扩增可用于肽或蛋白质的鉴定和/或科学研究。

5. 发明授权

US06702705B1 Prodrugs activated by targeted catalytic proteins 失效
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US06702705B1
公开(公告)日：2004-03-09
申请号：US08392407
申请日：1995-02-22
申请人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
发明人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
IPC分类号： C12N900
CPC分类号： C07D207/404 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07C2601/04 , C07C2602/42 , C07D205/085 , C07F9/2408 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/4006 , C07F9/4075 , C07F9/5537 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K14/55 , C07K16/00 , C07K16/1063 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , C12Q1/25 , G01N33/5008 , G01N33/531 , G01N33/577 , G01N2333/16 , G01N2333/96472 , G01N2500/00
摘要： Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
摘要翻译：公开了催化抗体。催化抗体对前药化合物是特异性的。催化抗体增强了活性药物部分与前药残留物的切割，从而激活了药物。

6. 发明授权

US06316180B1 Electrochemiluminescent monitoring of compounds/electrochemiluminescence assays 失效
标题翻译：电化学发光监测化合物/电化学发光测定
公开(公告)号：US06316180B1
公开(公告)日：2001-11-13
申请号：US08880353
申请日：1997-06-23
申请人： Mark T. Martin
发明人： Mark T. Martin
IPC分类号： C12Q100
CPC分类号： C07D277/06 , C12Q1/34 , G01N2333/986 , G01N2415/00
摘要： Detectable compounds comprising a chemically-transformable first compound covalently linked to an electrochemiluminescent compound are provided. Such compounds are useful in processes and kits that monitor the status of the first compound and derive information from such monitoring. A rapid single step assay suitable for the detection or quantification of &bgr;-lactam antibiotics and &bgr;-lactamases. The assay can be performed directly on samples of food, such as milk and meat, blood or serum and is useful in determining the suitability of a particular antibiotic in treating a particular bacterial infection and in diagnosis of a bacterial infection. The assay is also useful in determining and quantifying &bgr;-lactam antibiotic resistance. The assay can be performed on an IGEN OrigenR Analyzer.
摘要翻译：提供了包含与电化学发光化合物共价连接的可化学转化的第一化合物的可检测化合物。这些化合物可用于监测第一化合物的状态并从这种监测中获得信息的方法和试剂盒。适用于检测或定量β-内酰胺抗生素和β-内酰胺酶的快速单步测定法。该测定可以直接对食物样品（例如牛奶和肉，血液或血清）进行，并且可用于确定特定抗生素在治疗特定细菌感染和细菌感染诊断中的适用性。该测定法也可用于测定和定量β-内酰胺抗生素抗性。该测定可以在IGEN OrigenR分析仪上进行。

7. 发明授权

US6121007A Reaction-based selection for expression of and concentration of catalytic moieties 失效
标题翻译：用于催化部分的表达和浓缩的基于反应的选择
公开(公告)号：US6121007A
公开(公告)日：2000-09-19
申请号：US747654
申请日：1996-11-13
申请人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
发明人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
IPC分类号： G01N33/53 , B01J20/281 , C12N5/10 , C12N7/02 , C12N15/10 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C40B40/02 , G01N30/88 , G01N33/569 , C12Q1/25
CPC分类号： C40B40/02 , C12N15/1037 , C12Q1/02 , C12Q1/6811 , C12Q1/70 , G01N33/56983
摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.
摘要翻译：公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。该方法采用基于反应的催化活性选择。该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

8. 发明授权

US5891648A Reaction-based selection for expression of and concentration of catalytic moieties 失效
公开(公告)号：US5891648A
公开(公告)日：1999-04-06
申请号：US748415
申请日：1996-11-13
申请人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
发明人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
IPC分类号： G01N33/53 , B01J20/281 , C12N5/10 , C12N7/02 , C12N15/10 , C12Q1/02 , C12Q1/68 , C12Q1/70 , C40B40/02 , G01N30/88 , G01N33/569 , C12Q1/25
CPC分类号： C40B40/02 , C12N15/1037 , C12Q1/02 , C12Q1/6811 , C12Q1/70 , G01N33/56983
摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.

9. 发明授权

US5855885A Isolation and production of catalytic antibodies using phage technology 失效
标题翻译：使用噬菌体技术分离和生产催化抗体
公开(公告)号：US5855885A
公开(公告)日：1999-01-05
申请号：US273146
申请日：1994-07-14
申请人： Rodger Smith , John McCafferty , David Chiswell , Michael J. Darsley , Kevin Fitzgerald , John H. Kenten , Mark T. Martin , Richard C. Titmas , Richard O. Williams
发明人： Rodger Smith , John McCafferty , David Chiswell , Michael J. Darsley , Kevin Fitzgerald , John H. Kenten , Mark T. Martin , Richard C. Titmas , Richard O. Williams
IPC分类号： C12N9/00 , A61K39/395 , A61K9/00 , A61K38/43
CPC分类号： C12N9/0002
摘要： Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation of catalytic antibodies. Also disclosed and claimed are the products themselves, the catalytic antibodies, made from the phage technology. In addition, catalytic antibodies produced from the phage technology and useful in prodrug activation are disclosed and claimed. And finally, the invention also understands the production of catalytic antibodies to phosphonates.
摘要翻译：公开并要求保护的是从噬菌体产生催化抗体，包括人类催化抗体的方法。该方法需要克隆，选择，筛选和分离催化抗体。还公开和要求的是产品本身，由噬菌体技术制成的催化抗体。此外，公开并要求保护从噬菌体技术产生并可用于前药活化的催化抗体。最后，本发明还了解了产生针对膦酸盐的催化抗体。

10. 发明授权

US5641623A Electrochemiluminescence assay 失效
标题翻译：电化学发光测定
公开(公告)号：US5641623A
公开(公告)日：1997-06-24
申请号：US368429
申请日：1995-01-04
申请人： Mark T. Martin
发明人： Mark T. Martin
IPC分类号： G01N33/15 , C07D277/06 , C07F15/00 , C09K11/07 , C12Q1/00 , C12Q1/02 , C12Q1/04 , C12Q1/06 , C12Q1/18 , C12Q1/34 , G01N33/53 , G01N33/554
CPC分类号： C12Q1/18 , C07D277/06 , C12Q1/34 , G01N2333/986 , G01N2415/00 , Y10S435/975
摘要： A rapid single step assay suitable for the detection or quantification of .beta.-lactam antibiotics and .beta.-lactamases. The assay can be performed directly on samples of food, such as milk and meat, blood or serum and is useful in determining the suitability of a particular antibiotic in treating a particular bacterial infection and in diagnosis of a bacterial infection. The assay is also useful in determining and quantifying .beta.-lactam antibiotic resistance. The assay can be performed on an IGEN Origen.sup.R Analyzer.
摘要翻译：适用于检测或定量β-内酰胺抗生素和β-内酰胺酶的快速单步测定。该测定可以直接对食物样品（例如牛奶和肉，血液或血清）进行，并且可用于确定特定抗生素在治疗特定细菌感染和细菌感染诊断中的适用性。该测定法也可用于测定和定量β-内酰胺抗生素抗性。该测定可以在IGEN OrigenR分析仪上进行。

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