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1. 发明授权

US08945912B2 DNA sequencing and amplification systems using nanoscale field effect sensor arrays 有权
标题翻译：使用纳米尺度场效应传感器阵列的DNA测序和扩增系统
公开(公告)号：US08945912B2
公开(公告)日：2015-02-03
申请号：US13120710
申请日：2009-09-29
申请人： Rashid Bashir , Ashraf Alam , Demir Akin , Oguz Hasan Elibol , Bobby Reddy , Donald E. Bergstrom , Yi-Shao Liu
发明人： Rashid Bashir , Ashraf Alam , Demir Akin , Oguz Hasan Elibol , Bobby Reddy , Donald E. Bergstrom , Yi-Shao Liu
IPC分类号： C12M1/36 , C12P19/34 , G01N27/414 , C40B20/00 , B82Y15/00 , B82Y35/00
CPC分类号： G01N27/414 , B82Y15/00 , B82Y35/00 , G01N27/4145 , G01N27/4148
摘要： In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another aspect, described herein are methods useful for amplification of target molecules by PCR.
摘要翻译：在一个方面，本文描述了可用于化学和/或生物化学感测的场效应化学传感器装置。本文还提供了用于单分子检测的方法。在另一方面，本文所述是通过PCR扩增靶分子的方法。

2. 发明申请

US20120021918A1 DNA Sequencing and Amplification Systems Using Nanoscale Field Effect Sensor Arrays 有权
标题翻译：使用纳米尺度场效应传感器阵列的DNA测序和扩增系统
公开(公告)号：US20120021918A1
公开(公告)日：2012-01-26
申请号：US13120710
申请日：2009-09-29
申请人： Rashid Bashir , Ashraf Alam , Demir Akin , Oguz Hasan Elibol , Bobby Reddy , Donald E. Bergstrom , Yi-Shao Liu
发明人： Rashid Bashir , Ashraf Alam , Demir Akin , Oguz Hasan Elibol , Bobby Reddy , Donald E. Bergstrom , Yi-Shao Liu
IPC分类号： C40B20/00 , G01R27/28 , G01N27/414 , C12P19/34 , C40B60/10
CPC分类号： G01N27/414 , B82Y15/00 , B82Y35/00 , G01N27/4145 , G01N27/4148
摘要： In one aspect, described herein are field effect chemical sensor devices useful for chemical and/or biochemical sensing. Also provided herein are methods for single molecule detection. In another aspect, described herein are methods useful for amplification of target molecules by PCR.
摘要翻译：在一个方面，本文描述了可用于化学和/或生物化学感测的场效应化学传感器装置。本文还提供了用于单分子检测的方法。在另一方面，本文所述是通过PCR扩增靶分子的方法。

3. 发明申请

US20080280776A1 Method and apparatus for detection of molecules using a sensor array 审中-公开
标题翻译：使用传感器阵列检测分子的方法和装置
公开(公告)号：US20080280776A1
公开(公告)日：2008-11-13
申请号：US11999215
申请日：2007-12-04
申请人： Rashid Bashir , Oguz Elibol , Pradeep Ramachandran Nair , Donald Bergstrom , Ashraf Alam , Bobby Reddy, JR.
发明人： Rashid Bashir , Oguz Elibol , Pradeep Ramachandran Nair , Donald Bergstrom , Ashraf Alam , Bobby Reddy, JR.
IPC分类号： C40B30/04 , C40B50/18 , C40B60/12 , C12N1/06 , G01N33/48 , C12P19/34 , H05B3/02
CPC分类号： G01N27/127
摘要： Apparatus and methods for detecting molecules in a fluidic environment are provided, including nanodevices and methods for fabricating, functionalizing, and operating such nanodevices. At least one of the methods includes selective heating of nanodevices in an array.
摘要翻译：提供了用于在流体环境中检测分子的装置和方法，包括用于制造，功能化和操作这种纳米器件的纳米器件和方法。至少一种方法包括选择性加热阵列中的纳米器件。

4. 发明授权

US08852875B2 Methods for counting cells 有权
标题翻译：细胞计数方法
公开(公告)号：US08852875B2
公开(公告)日：2014-10-07
申请号：US12596768
申请日：2008-04-21
申请人： Mehmet Toner , Rashid Bashir , Xuanhong Cheng , Utkan Demirci , Daniel Irimia , William R. Rodriguez , Liju Yang , Lee Zamir , Yi-Shao Liu
发明人： Mehmet Toner , Rashid Bashir , Xuanhong Cheng , Utkan Demirci , Daniel Irimia , William R. Rodriguez , Liju Yang , Lee Zamir , Yi-Shao Liu
IPC分类号： G01N33/567 , G01N33/50 , G01N33/84 , G01N15/10 , G01N15/14
CPC分类号： G01N33/5005 , G01N15/1031 , G01N15/1056 , G01N15/1484 , G01N33/84 , G01N2015/1006 , G01N2015/1062 , Y02A50/58
摘要： The invention features methods of quantifying cells in a sample by lysing the cells followed by the measurement of at least one intracellular component. Methods of the invention are especially useful for quantifying small numbers of cells, e.g., over a large surface area or volume compared to the cell size. In a preferred embodiment, methods of the invention are performed using a microfluidic device.
摘要翻译：本发明的特征在于通过裂解细胞然后测量至少一种细胞内成分来定量样品中细胞的方法。本发明的方法对于量化小数量的细胞特别有用，例如，与细胞大小相比，在大的表面积或体积上。在优选的实施方案中，使用微流体装置进行本发明的方法。

5. 发明申请

US20120003687A1 METHODS FOR COUNTING CELLS 有权
标题翻译：计数细胞的方法
公开(公告)号：US20120003687A1
公开(公告)日：2012-01-05
申请号：US12596768
申请日：2008-04-21
申请人： Mehmet Toner , Rashid Bashir , Xuanhong Cheng , Utkan Demirci , Daniel Irimia , William R. Rodriguez , Liju Yang , Lee Zamir , Yi-Shao Liu
发明人： Mehmet Toner , Rashid Bashir , Xuanhong Cheng , Utkan Demirci , Daniel Irimia , William R. Rodriguez , Liju Yang , Lee Zamir , Yi-Shao Liu
IPC分类号： C12Q1/06
CPC分类号： G01N33/5005 , G01N15/1031 , G01N15/1056 , G01N15/1484 , G01N33/84 , G01N2015/1006 , G01N2015/1062 , Y02A50/58
摘要： The invention features methods of quantifying cells in a sample by lysing the cells followed by the measurement of at least one intracellular component. Methods of the invention are especially useful for quantifying small numbers of cells, e.g., over a large surface area or volume compared to the cell size. In a preferred embodiment, methods of the invention are performed using a microfluidic device.
摘要翻译：本发明的特征在于通过裂解细胞然后测量至少一种细胞内成分来定量样品中细胞的方法。本发明的方法对于量化小数量的细胞特别有用，例如，与细胞大小相比，在大的表面积或体积上。在优选的实施方案中，使用微流体装置进行本发明的方法。

6. 发明授权

US09376713B2 Label free detection of nucleic acid amplification 有权
标题翻译：无标记检测核酸扩增
公开(公告)号：US09376713B2
公开(公告)日：2016-06-28
申请号：US12888917
申请日：2010-09-23
申请人： Rashid Bashir , Yi-Shao Liu , Eric Salm , Woo-Jin Chang , Nicholas N. Watkins
发明人： Rashid Bashir , Yi-Shao Liu , Eric Salm , Woo-Jin Chang , Nicholas N. Watkins
IPC分类号： C12Q1/68 , B01L3/00 , B01L7/00 , B03C5/02 , B01L3/02
CPC分类号： C12Q1/6825 , B01L3/0241 , B01L3/5027 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L7/52 , B01L2200/0668 , B01L2200/10 , B01L2200/143 , B01L2200/147 , B01L2300/0645 , B01L2300/0681 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/0418 , B01L2400/0424 , B01L2400/084 , B03C5/026
摘要： Provided are methods and devices for label-free detection of nucleic acids that are amplified by polymerase chain reaction. A solution containing the components necessary for a PCR is introduced to a microfluidic amplification chamber and an electric field applied to a confined region in which PCR occurs. PCR product generated in the confined region is detected by measuring an electrical parameter that is, for example, solution impedance. The devices and methods provided herein are used, for example, in assays to detect one or more pathogens or for point-of-care tests. In an aspect, the PCR product is confined to droplets and the assay relates to detecting an electrical parameter of a flowing droplet, thereby detecting PCR product without a label. In an aspect, the PCR occurs in the droplet.
摘要翻译：提供了通过聚合酶链反应扩增的用于无标记检测核酸的方法和装置。将含有PCR所需组分的溶液引入微流体扩增室，并施加到发生PCR的限制区域的电场。通过测量例如溶液阻抗的电参数来检测在限制区域中产生的PCR产物。本文提供的装置和方法例如用于检测一种或多种病原体或用于点护理测试的测定中。在一方面，PCR产物被限制在液滴中，并且该测定涉及检测流动液滴的电参数，从而检测没有标签的PCR产物。在一方面，PCR在液滴中发生。

7. 发明授权

US09835634B2 Coupled heterogeneous devices for pH sensing 有权
公开(公告)号：US09835634B2
公开(公告)日：2017-12-05
申请号：US14075557
申请日：2013-11-08
申请人： Rashid Bashir , Bobby Reddy , Muhammad A Alam , Pradeep R Nair , Jonghyun Go
发明人： Rashid Bashir , Bobby Reddy , Muhammad A Alam , Pradeep R Nair , Jonghyun Go
IPC分类号： G01R19/00 , G01N33/84 , C12Q1/25 , G01N33/50 , G01N33/543 , G01N33/573 , G01N33/574 , G01N33/94 , G01N27/414
CPC分类号： G01N33/84 , C12Q1/25 , G01N27/414 , G01N33/5091 , G01N33/5438 , G01N33/573 , G01N33/574 , G01N33/94 , G01N2800/709
摘要： Provided herein are methods and devices for measuring pH and for amplifying a pH signal to obtain ultrasensitive detection of changes in pH. This is achieved by providing a sensor and a transducer, wherein the sensor transconductance is sensitive to changes in pH and the transducer transconductance is not affected by pH change. The transducer instead compensates for changes in the sensor transconductance arising from pH change. The unique configuration of the sensor and transducer with respect to each other provides substantial increases in a pH amplification factor, thereby providing pH sensing devices with a giant Nernst response and, therefore, effectively increased pH sensitivity.

8. 发明申请

US20140054651A1 RELIABLE NANOFET BIOSENSOR PROCESS WITH HIGH-K DIELECTRIC 审中-公开
标题翻译：具有高K电介质的可靠的纳米ZnO生物传感器工艺
公开(公告)号：US20140054651A1
公开(公告)日：2014-02-27
申请号：US13992217
申请日：2011-11-18
申请人： Rashid Bashir , Bobby Reddy , Brian Ross Dorvel
发明人： Rashid Bashir , Bobby Reddy , Brian Ross Dorvel
IPC分类号： G01N27/414
CPC分类号： G01N27/4145
摘要： Provided are semiconductor field effect sensors including a high-k thin film gate dielectric. The semiconductor field effect sensors described herein exhibit high detection sensitivity and enhanced reliability when placed in contact with liquids. Also disclosed are semiconductor field effect sensors having optimized fluid gate electrode voltages and/or back gate electrode voltages for improved detection sensitivity.
摘要翻译：提供了包括高k薄膜栅极电介质的半导体场效应传感器。当与液体接触时，本文所述的半导体场效应传感器表现出高检测灵敏度和增强的可靠性。还公开了具有优化的流体栅电极电压和/或背栅电极电压的半导体场效应传感器，以提高检测灵敏度。

9. 发明授权

US06362064B1 Elimination of walkout in high voltage trench isolated devices 失效
公开(公告)号：US06362064B1
公开(公告)日：2002-03-26
申请号：US09063074
申请日：1998-04-21
申请人： Joel M. McGregor , Rashid Bashir , Wipawan Yindeepol
发明人： Joel M. McGregor , Rashid Bashir , Wipawan Yindeepol
IPC分类号： H01L21331
摘要： Walkout in high voltage trench isolated semiconductor devices is inhibited by applying a voltage bias signal directly to epitaxial silicon surrounding the device. Voltage applied to the surrounding epitaxial silicon elevates the initial breakdown voltage of the device and eliminates walkout. This is because voltage applied to the surrounding epitaxial silicon reduces the strength of the electric field between the silicon of the device and the surrounding silicon. Specifically, application of a positive voltage bias signal to surrounding epitaxial silicon equal to or more positive than the most positive potential occurring at the collector during normal operation of the device ensures that no walkout will occur.

10. 发明授权

US06346452B1 Method for controlling an N-type dopant concentration depth profile in bipolar transistor epitaxial layers 有权
标题翻译：用于控制双极晶体管外延层中的N型掺杂浓度深度分布的方法
公开(公告)号：US06346452B1
公开(公告)日：2002-02-12
申请号：US09303957
申请日：1999-05-03
申请人： Abul Ehsanul Kabir , Rashid Bashir
发明人： Abul Ehsanul Kabir , Rashid Bashir
IPC分类号： H01L218222
CPC分类号： H01L29/66242 , H01L29/36 , H01L29/66272
摘要： Process for the formation of epitaxial layers with controlled n-type dopant concentration depth profiles for use in NPN bipolar transistors. The process includes first providing a semiconductor substrate (e.g. a [100]-oriented silicon wafer substrate) with an n-type collector precursor region formed on its surface, followed by forming an n-type (e.g. phosphorous or arsenic) in-situ doped epitaxial layer of a thickness t1 on the n-type collector precursor region. Next, an undoped epitaxial layer of a thickness t2 is formed on the n-type in-situ doped epitaxial layer. A p-type (e.g. boron) in-situ doped epitaxial base layer is subsequently formed on the undoped epitaxial layer. The process can also include the sequential formation of an undoped Si1−xGex epitaxial layer and a p-type in-situ doped Si1−xGex epitaxial layer between the undoped epitaxial layer and the p-type in-situ doped epitaxial base layer. Accumulation of the n-type dopant concentration in p-type epitaxial layers (such as the p-type in-situ doped epitaxial base layer or the p-type in-situ doped Si1−xGex epitaxial layer) that are formed subsequent to a non-p-type epitaxial layer (such as the undoped epitaxial layer or undoped Si1−xGex epitaxial layer, respectively) is controlled by manipulating the thickness ratio of t2 to t1, while keeping the thickness of N-layer fixed at t (i.e. t1+t2).
摘要翻译：用于形成具有用于NPN双极晶体管的受控n型掺杂浓度深度分布的外延层的工艺。该方法包括首先在其表面上形成n型集电极前体区，然后形成n型（例如磷或砷）原位掺杂的半导体衬底（例如[100]取向硅晶片衬底）在n型集电极前体区域上具有厚度t1的外延层。接下来，在n型原位掺杂外延层上形成厚度为t2的未掺杂的外延层。随后在未掺杂的外延层上形成p型（例如硼）原位掺杂的外延基底层。该工艺还可以包括在未掺杂的外延层和p型原位掺杂的外延基底层之间顺序地形成未掺杂的Si1-xGex外延层和p型原位掺杂的Si1-xGex外延层。 p型外延层（例如p型原位掺杂外延基底层或p型原位掺杂的Si1-xGex外延层）中的n型掺杂剂浓度的积累是在非 - p型外延层（例如未掺杂的外延层或未掺杂的Si1-xGex外延层）分别通过操纵t2至t1的厚度比来控制，同时保持N层的厚度固定在t（即t1 + t2）。

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