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1. 发明授权

US5951597A Coronary sinus lead having expandable matrix anchor 失效
标题翻译：冠状窦导线具有可扩张的基质锚
公开(公告)号：US5951597A
公开(公告)日：1999-09-14
申请号：US59786
申请日：1998-04-14
申请人： Randy W. Westlund , Bruce A. Tockman , Ronald W. Heil, Jr.
发明人： Randy W. Westlund , Bruce A. Tockman , Ronald W. Heil, Jr.
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N2001/0585
摘要： An intravenous lead for use with a cardiac device for implantation in the coronary venous system of the heart includes a lead body that is adapted to be routed through the vascular system into the coronary sinus with the distal end portion of the lead placed in the great cardiac vein or branch vein. The lead body includes a fixation member disposed just proximal of its tip. The fixation member comprises a radially expandable polymeric matrix that incorporates an osmotic agent so that when placed in a aqueous medium it will swell. Thus, when placed in a cardiac vein, the swelling of the fixation member will anchor the lead against longitudinal displacement due to body motion, blood flow and the beating action of the heart.
摘要翻译：用于心脏装置用于植入心脏冠状静脉系统的静脉导管包括引线体，其适于通过血管系统引导到冠状窦中，将引线的远端部分放置在大心脏中静脉或分支静脉。引线体包括设置在其尖端附近的固定部件。固定构件包括可渗透的聚合物基质，其包含渗透剂，使得当放置在水性介质中时，其将溶胀。因此，当放置在心静脉中时，固定构件的肿胀将由于身体运动，血液流动和心脏的打动作用而使引线抵抗纵向移位。

2. 发明授权

US5755765A Pacing lead having detachable positioning member 失效
标题翻译：起搏线具有可拆卸的定位部件
公开(公告)号：US5755765A
公开(公告)日：1998-05-26
申请号：US787287
申请日：1997-01-24
申请人： Gregory M. Hyde , Stuart R. Chastain , Bruce A. Tockman , Randy W. Westlund , Ronald W. Heil, Jr. , David M. Flynn , Randall M. Peterfeso
发明人： Gregory M. Hyde , Stuart R. Chastain , Bruce A. Tockman , Randy W. Westlund , Ronald W. Heil, Jr. , David M. Flynn , Randall M. Peterfeso
IPC分类号： A61N1/05 , A61N1/04
CPC分类号： A61N1/056 , A61N2001/0585
摘要： Intravenous cardiac leads having at least one electrode intended to be implanted within the coronary veins are disclosed. Also disclosed are structures and techniques for advancing such leads through the atrium and coronary sinus into the coronary veins.
摘要翻译：公开了具有至少一个待植入冠状静脉内的电极的静脉内心脏引线。还公开了用于将这种引线通过心房和冠状窦进入冠状静脉的结构和技术。

3. 发明授权

US5935160A Left ventricular access lead for heart failure pacing 失效
标题翻译：心律失常起搏的左心室通路
公开(公告)号：US5935160A
公开(公告)日：1999-08-10
申请号：US787274
申请日：1997-01-24
申请人： Angelo Auricchio , Rodney W. Salo , Bruce A. Tockman , Ronald W. Heil, Jr. , Randy Westlund , Stuart R. Chastain
发明人： Angelo Auricchio , Rodney W. Salo , Bruce A. Tockman , Ronald W. Heil, Jr. , Randy Westlund , Stuart R. Chastain
IPC分类号： A61N1/368 , A61N1/05
CPC分类号： A61N1/056 , A61N2001/0585
摘要： An elongated monopolar or bipolar coronary vein lead having a reduced outer diameter and especially adapted to be advanced into a selected coronary vein for delivering a pacing signal to a predetermined region of a patient's heart, such as the left ventricle. A method of using the lead for pacing a patient's heart in the treatment of heart failure is also described. The method for pacing the heart includes advancing the coronary vein lead through both the coronary sinus and into a selected coronary vein of a patient's heart, connecting the lead to an electrical pacing source and applying electrical stimulation to a particular chamber of the patient's heart via the implanted lead. The lead includes a flexible tip and transition ring that enhances the ability to guide the lead through the coronary veins.
摘要翻译：具有减小的外径的细长单极或双极冠状静脉引线，并且特别适于前进到选定的冠状静脉以将起搏信号传送到患者心脏例如左心室的预定区域。还描述了使用引线将患者心脏起搏治疗心力衰竭的方法。用于起搏心脏的方法包括将冠状静脉导管穿过冠状窦并进入患者心脏的选定的冠状静脉，将导线连接到起搏源，并通过电刺激源将电刺激施加到患者心脏的特定腔室植入铅。引线包括一个灵活的尖端和过渡环，增强引导引导通过冠状静脉的能力。

4. 发明授权

US06671560B2 Modified guidewire for left ventricular access lead 失效
标题翻译：修改左心室导线导丝
公开(公告)号：US06671560B2
公开(公告)日：2003-12-30
申请号：US10081436
申请日：2002-02-20
申请人： Randy W. Westlund , Bruce A. Tockman , Randall M. Peterfeso , John S. Greenland , Mary N. Hinders
发明人： Randy W. Westlund , Bruce A. Tockman , Randall M. Peterfeso , John S. Greenland , Mary N. Hinders
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61B2017/22035 , A61M25/09 , A61M2025/09175 , A61N2001/0578
摘要： An improved guidewire for assisting in implantation of a cardiac lead includes three sections. The most distal zone is sufficiently floppy to prevent trauma to the vessel walls through which the guidewire and lead are inserted. An intermediate zone is generally stiffer and has a cross-section less than or equal to the cross-section of the distal zone. The third zone is stiffer yet and is joined to the intermediate zone by a shoulder. The shoulder cooperates with protrusions on the lead to transfer forces between the guidewire and lead. A removal wire having temporary locking device to lock the removal wire to the lead is employed to remove the guide catheter without moving the lead from its desired location. Lubricious coatings are also provided to reduce friction between the lead and guidewire.
摘要翻译：用于辅助植入心脏引线的改进的导线包括三个部分。最远端的区域是足够的软盘，以防止对引导线和引线插入的血管壁的创伤。中间区通常较硬，横截面小于或等于远端区的横截面。第三区域较硬，并通过肩部连接到中间区域。肩部与导线上的突起配合，以在导丝和导线之间传递力。使用具有临时锁定装置以将去除线锁定到引线的去除线去除引导导管而不将引线从其期望位置移动。还提供润滑涂层以减少引线和导丝之间的摩擦。

5. 发明授权

US06356791B1 Modified guidewire for left ventricular access lead 有权
标题翻译：修改左心室导线导丝
公开(公告)号：US06356791B1
公开(公告)日：2002-03-12
申请号：US09466266
申请日：1999-12-17
申请人： Randy W. Westlund , Randall M. Peterfeso , Mary N. Hinders , Bruce A. Tockman , John S. Greenland
发明人： Randy W. Westlund , Randall M. Peterfeso , Mary N. Hinders , Bruce A. Tockman , John S. Greenland
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61B2017/22035 , A61M25/09 , A61M2025/09175 , A61N2001/0578
摘要： An improved guidewire for assisting in implantation of a cardiac lead includes three sections. The most distal zone is sufficiently floppy to prevent trauma to the vessel walls through which the guidewire and lead are inserted. An intermediate zone is generally stiffer and has a cross-section less than or equal to the cross-section of the distal zone. The third zone is stiffer yet and is joined to the intermediate zone by a shoulder. The shoulder cooperates with protrusions on the lead to transfer forces between the guidewire and lead. A removal wire having temporary locking means to lock the removal wire to the lead is employed to remove the guide catheter without moving the lead from its desired location. Lubricious coatings are also provided to reduce friction between the lead and guidewire.
摘要翻译：用于辅助植入心脏引线的改进的导线包括三个部分。最远端的区域是足够的软盘，以防止对引导线和引线插入的血管壁的创伤。中间区通常较硬，横截面小于或等于远端区的横截面。第三区域较硬，并通过肩部连接到中间区域。肩部与导线上的突起配合，以在导丝和导线之间传递力。采用具有将去除线锁定到引线上的临时锁定装置的移除线去除引导导管，而不将引线从其期望的位置移动。还提供润滑涂层以减少引线和导丝之间的摩擦。

6. 发明授权

US06178356B1 Coronary venous lead having fixation mechanism 有权
标题翻译：冠状静脉导管具有固定机制
公开(公告)号：US06178356B1
公开(公告)日：2001-01-23
申请号：US09280128
申请日：1999-03-26
申请人： Stuart A. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
发明人： Stuart A. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
IPC分类号： A61N105
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A body implantable lead for placement in a selected coronary vein includes a resilient retention structure for inhibiting displacement of the lead because of heart beat action, breathing or other body movement. The retention structure includes a plurality of resilient projections that are attached to the lead body and which are adapted to project at a predetermined acute angle to the axis of the lead body when unconstrained. Prior to being routed through the vascular system, the projections can be bonded to the lead body to provide a low profile with a biodegradable adhesive. Following exposure to body fluids, the adhesive dissolves, releasing the projections so that they can engage the walls of the vein in which the lead is disposed.
摘要翻译：用于放置在所选择的冠状静脉中的身体可植入引线包括弹性保持结构，用于抑制由于心跳动作，呼吸或其他身体运动引起的位移。保持结构包括多个弹性突起，其附接到引线主体并且适于在不受约束时以与引线主体的轴线成预定的锐角突出。在被引导通过血管系统之前，突起可以结合到引线主体以通过可生物降解的粘合剂提供低轮廓。在暴露于体液后，粘合剂溶解，释放突起使得它们可以与引导物置于其中的静脉的壁接合。

7. 发明授权

US5931864A Coronary venous lead having fixation mechanism 失效
标题翻译：冠状静脉导管具有固定机制
公开(公告)号：US5931864A
公开(公告)日：1999-08-03
申请号：US27288
申请日：1998-02-20
申请人： Stuart R. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
发明人： Stuart R. Chastain , Bruce A. Tockman , Randy W. Westlund , Lili Liu
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N2001/0585
摘要： A body implantable lead for placement in a selected coronary vein includes a resilient retention structure for inhibiting displacement of the lead because of heart beat action, breathing or other body movement. The retention structure includes a plurality of resilient projections that are attached to the lead body and which are adapted to project at a predetermined acute angle to the axis of the lead body when unconstrained. Prior to being routed through the vascular system, the projections can be bonded to the lead body to provide a low profile with a biodegradable adhesive. Following exposure to body fluids, the adhesive dissolves, releasing the projections so that they can engage the walls of the vein in which the lead is disposed.
摘要翻译：用于放置在所选择的冠状静脉中的身体可植入引线包括弹性保持结构，用于抑制由于心跳动作，呼吸或其他身体运动引起的位移。保持结构包括多个弹性突起，其附接到引线主体并且适于在不受约束时以与引线主体的轴线成预定的锐角突出。在被引导通过血管系统之前，突起可以结合到引线主体以通过可生物降解的粘合剂提供低轮廓。在暴露于体液后，粘合剂溶解，释放突起使得它们可以与引导物置于其中的静脉的壁接合。

8. 发明授权

US5803928A Side access "over the wire" pacing lead 失效
标题翻译：侧面通过电线“起搏线
公开(公告)号：US5803928A
公开(公告)日：1998-09-08
申请号：US788647
申请日：1997-01-24
申请人： Bruce A. Tockman , Bruce H. Kenknight , Stuart R. Chastain , Randy W. Westlund
发明人： Bruce A. Tockman , Bruce H. Kenknight , Stuart R. Chastain , Randy W. Westlund
IPC分类号： A61N1/05
CPC分类号： A61N1/056 , A61N2001/058 , A61N2001/0585
摘要： Intravenous cardiac leads having at least one electrode intended to be implanted within the coronary artery are disclosed. Also disclosed are structures and techniques for advancing such leads through the atrium and coronary sinus into the coronary veins overlaying the left ventricle.
摘要翻译：公开了具有至少一个待植入冠状动脉的电极的静脉内心脏引线。还公开了用于将这种引线通过心房和冠状窦推进到覆盖左心室的冠状静脉的结构和技术。

9. 发明授权

US07089065B2 Modified guidewire for left ventricular access lead 失效
公开(公告)号：US07089065B2
公开(公告)日：2006-08-08
申请号：US10730269
申请日：2003-12-09
申请人： Randy W. Westlund , Bruce A. Tockman , Randall M. Peterfeso , John S. Greenland , Mary N. Hinders
发明人： Randy W. Westlund , Bruce A. Tockman , Randall M. Peterfeso , John S. Greenland , Mary N. Hinders
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61B2017/22035 , A61M25/09 , A61M2025/09175 , A61N2001/0578
摘要： An improved guidewire for assisting in implantation of a cardiac lead includes three sections. The most distal zone is sufficiently floppy to prevent trauma to the vessel walls through which the guidewire and lead are inserted. An intermediate zone is generally stiffer and has a cross-section less than or equal to the cross-section of the distal zone. The third zone is stiffer yet and is joined to the intermediate zone by a shoulder. The shoulder cooperates with protrusions on the lead to transfer forces between the guidewire and lead. A finishing wire having temporary locking means to lock the finishing wire to the lead is employed to remove the guide catheter without moving the lead from its desired location. Lubricious coatings are also provided to reduce friction between the lead and guidewire.

10. 发明授权

US06129750A Fixation mechanism for a coronary venous pacing lead 有权
标题翻译：冠状动脉静脉起搏导联的固定机制
公开(公告)号：US06129750A
公开(公告)日：2000-10-10
申请号：US274620
申请日：1999-03-23
申请人： Bruce A. Tockman , Randy W. Westlund , Stuart R. Chastain , Brian D. Soltis , Dwight A. Skinner
发明人： Bruce A. Tockman , Randy W. Westlund , Stuart R. Chastain , Brian D. Soltis , Dwight A. Skinner
IPC分类号： A61N1/05
CPC分类号： A61N1/057 , A61N2001/0585
摘要： An apparatus for fixing a cardiac lead in place within the vasculature of the heart includes a coil having a normal helical shape and a stylet for holding the coil straight during insertion of the coil through a lumen of the lead. Upon retraction of the stylet, the coil returns to its helical shape along with the lead, forcing portions of the lead into contact with the vessel wall.
摘要翻译：用于将心脏引线固定在心脏脉管内的设备包括具有正常螺旋形状的线圈和用于在线圈插入线圈的内腔期间将线圈保持直线的探针。当探针回缩时，线圈与引线一起返回其螺旋形状，迫使引线的部分与血管壁接触。

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