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1. 发明授权

US08185347B2 Outlier correction with a median method 有权
标题翻译：用中值法进行异常值校正
公开(公告)号：US08185347B2
公开(公告)日：2012-05-22
申请号：US11021591
申请日：2004-12-23
申请人： Ralph Moessner , Stefan Theis
发明人： Ralph Moessner , Stefan Theis
IPC分类号： H04B15/00 , G06F11/30 , G21C17/00
CPC分类号： G06Q10/10
摘要： A method and apparatus, including computer program products, for determining characteristic parameters on the basis of a series of m values, H_1, H_2, . . . , H_m, over time. The values are descriptive for a predetermined process, and the series has linear characteristics. Differences, denoted as Δ_i, between pairs of values of points of the historical time series, the points having a predetermined time distance to each other, denoted as p are computed. The median value, denoted as Δ_i_M, of the computed differences Δ_i is determined. On the basis of the determined median value Δ_i_M, a trend parameter, denoted as T, T being defined as T=Δ_1_M/p is computed.
摘要翻译：一种用于基于一系列m个值H_1，H_2，...确定特征参数的计算机程序产品的方法和装置。。。，H_m，随着时间的流逝。这些值对于预定的处理是描述性的，并且该系列具有线性特征。在历史时间序列的点对值对之间表示为＆Dgr; _i的差异，计算表示为p的彼此之间具有预定时间距离的点。确定计算出的差值Dgr; _i的中值，表示为＆Dgr; _i_M。基于确定的中值＆Dgr; __M，计算T =＆Dgr; _1_M / p表示为T，T的趋势参数。

2. 发明申请

US20050137830A1 Outlier correction with a median method 有权
标题翻译：用中值法进行异常值校正
公开(公告)号：US20050137830A1
公开(公告)日：2005-06-23
申请号：US11021591
申请日：2004-12-23
申请人： Ralph Moessner , Stefan Theis
发明人： Ralph Moessner , Stefan Theis
IPC分类号： G04F1/00
CPC分类号： G06Q10/10
摘要： The invention provides methods and apparatus, including computer program products, for determining characteristic parameters on the basis of a series of m values, H_1, H_2, . . . , H_m, over time, the values being descriptive for a predetermined process, the series having linear characteristics, the method comprising: computing differences, denoted as Δ_i, between pairs of values of points of the historical time series, the points having a predetermined time distance to each other, denoted as p; determining the median value, denoted as Δ_i_M, of the computed differences Δ_i; computing, on the basis of the determined median value Δ_i_M, a trend parameter, denoted as T, T being defined as T=Δ_i_M/p.
摘要翻译：本发明提供了用于基于一系列m值H_1，H_2来确定特征参数的方法和装置，包括计算机程序产品。。。 H_m，随着时间的推移，这些值对于预定的处理是描述的，该系列具有线性特征，该方法包括：在历史时间序列的点对值之间计算表示为Delta_i的差异，所述点具有预定时间彼此之间的距离，表示为p; 确定所计算的差Δiii的中值，表示为Delta_i_M; 基于确定的中值Delta_i_M计算表示为T，T的趋势参数被定义为T = Delta_i_M / p。

3. 发明申请

US20100035834A1 NOVEL 1,4-BENZOTHIEPIN-1, 1-DIOXIDE DERIVATIVES WITH IMPROVED PROPERTIES METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND THE USE THEREOF 有权
标题翻译：具有改进性质的新颖的1,4-苯并二氢吡喃-1,1-二氧化物衍生物，其制备方法，含有化合物的药物及其用途
公开(公告)号：US20100035834A1
公开(公告)日：2010-02-11
申请号：US12465883
申请日：2009-05-14
申请人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/7028 , C07H5/06 , A61P25/00 , A61P3/10 , A61P25/28 , A61P25/18
CPC分类号： C07H5/06 , C07D409/12
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译：本发明涉及具有改进性质的新型1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。

4. 发明授权

US07956085B2 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof 有权
标题翻译：被苄基取代的1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途
公开(公告)号：US07956085B2
公开(公告)日：2011-06-07
申请号：US12465911
申请日：2009-05-14
申请人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/38 , C07D409/08
CPC分类号： C07H5/06 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H7/02 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： This invention relates to Novel 1,4-benzothiepine 1,1-dioxide derivatives substituted by benzyl radicals, method for their preparation, pharmaceuticals comprising these compounds, and the use thereof.
摘要翻译：本发明涉及由苄基取代的新型1,4-苯并噻吩1,1-二氧化物衍生物，其制备方法，包含这些化合物的药物及其用途。

5. 发明授权

US08101583B2 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof 有权
标题翻译：被氟取代的1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途
公开(公告)号：US08101583B2
公开(公告)日：2012-01-24
申请号：US12465928
申请日：2009-05-14
申请人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： C07D281/10 , A61K31/55 , A61K31/70
CPC分类号： C07H7/02 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H5/06 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译：本发明涉及被氟取代的新的1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。

6. 发明授权

US07923468B2 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof 有权
标题翻译：被环己基取代的1,4-苯并噻吩-1-,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途
公开(公告)号：US07923468B2
公开(公告)日：2011-04-12
申请号：US12465920
申请日：2009-05-14
申请人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Wendelin Frick , Heiner Glombik , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/38 , C07D337/08
CPC分类号： C07D337/08
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with cyclohexyl groups, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译：本发明涉及用环己基取代的新的1,4-苯并硫苯-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。

7. 发明授权

US07615536B2 1,4-benzothiazepine 1,1-dioxide derivative, process for its preparation, medicaments comprising this compound, and use thereof as a hypolipidaemic 失效
标题翻译： 1,4-苯并硫氮杂1,1-二氧化物衍生物，其制备方法，包含该化合物的药物及其作为降血脂药的用途
公开(公告)号：US07615536B2
公开(公告)日：2009-11-10
申请号：US11970281
申请日：2008-01-07
申请人： Wendelin Frick , Heiner Glombik , Hubert Heuer , Hans-Ludwig Schaefer , Stefan Theis
发明人： Wendelin Frick , Heiner Glombik , Hubert Heuer , Hans-Ludwig Schaefer , Stefan Theis
IPC分类号： C07D281/10 , A61K31/55 , A61K31/70
CPC分类号： C07H13/12
摘要： The invention relates to the compound of the formula (A) and also to its physiologically acceptable salts. The compound is suitable as, for example, a hypolipidemic
摘要翻译：本发明涉及式（A）的化合物以及其生理上可接受的盐。该化合物适合作为例如降血脂药

8. 发明授权

US08106023B2 1,4-benzothiepin-1, 1-dioxide derivatives with improved properties method for producing the same, drugs containing said compounds and the use thereof 有权
标题翻译：具有改进性质的1,4-苯并硫氮杂_1,1-二氧化物衍生物的制备方法，含有所述化合物的药物及其用途
公开(公告)号：US08106023B2
公开(公告)日：2012-01-31
申请号：US12465883
申请日：2009-05-14
申请人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： C07D281/10 , A61K31/55 , A61K31/70
CPC分类号： C07H5/06 , C07D409/12
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives with improved properties, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译：本发明涉及具有改进性质的新型1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。

9. 发明授权

US07820804B2 Fluoroglycoside derivatives of pyrazoles, medicaments containing these compounds, and the use thereof 有权
标题翻译：吡唑类氟草甘膦衍生物，含有这些化合物的药物及其用途
公开(公告)号：US07820804B2
公开(公告)日：2010-10-26
申请号：US11567410
申请日：2006-12-06
申请人： Harm Brummerhop , Wendeline Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
发明人： Harm Brummerhop , Wendeline Frick , Heiner Glombik , Oliver Plettenburg , Martin Bickel , Hubert Heuer , Stefan Theis
IPC分类号： C07H17/02 , C07H17/00 , A61K31/7056
CPC分类号： C07H17/02
摘要： The invention relates to substituted fluoroglycoside derivatives of pyrazoles of formula (I) as further defined in the specification, to the physiologically compatible salts thereof, to a method for their production, and to their use as antidiabetics.
摘要翻译：本发明涉及在说明书中进一步定义的式（I）的吡唑的取代的氟代糖苷衍生物与其生理上相容的盐，其生产方法及其作为抗糖尿病药物的用途。

10. 发明申请

US20100062991A1 NOVEL 1,4-BENZOTHIEPIN-1,1-DIOXIDE DERIVATIVES WHICH ARE SUBSTITUTED WITH FLUORINE, METHOD FOR PRODUCING THE SAME, DRUGS CONTAINING SAID COMPOUNDS AND USE THEREOF 有权
标题翻译：与氟化物取代的新的1,4-苯并二氢吡喃-1,1-二氧化物衍生物，其制备方法，含有化合物的药物及其用途
公开(公告)号：US20100062991A1
公开(公告)日：2010-03-11
申请号：US12465928
申请日：2009-05-14
申请人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
发明人： Heiner Glombik , Wendelin Frick , Stefan Theis , Hubert Heuer , Hans-Ludwig Schaefer , Werner Kramer
IPC分类号： A61K31/7028 , C07H5/06 , A61P3/10 , A61P25/28 , A61P25/18 , A61P3/06
CPC分类号： C07H7/02 , A61K31/38 , A61K31/7028 , A61K45/06 , C07D409/12 , C07H5/04 , C07H5/06 , C07H7/027 , C07H13/12 , C07H15/26 , A61K2300/00
摘要： This invention relates to Novel 1,4-benzothiepin-1,1-dioxide derivatives which are substituted with fluorine, method for producing the same, drugs containing said compounds and use thereof.
摘要翻译：本发明涉及被氟取代的新的1,4-苯并硫代-1,1-二氧化物衍生物，其制备方法，含有所述化合物的药物及其用途。

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