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1. 发明申请

US20060161142A1 Multiple wavelength laser workstation 有权
公开(公告)号：US20060161142A1
公开(公告)日：2006-07-20
申请号：US11035680
申请日：2005-01-14
申请人： Rafael Sierra , Eric Koschmann , Joseph Day , Evan Sherr , James Boll
发明人： Rafael Sierra , Eric Koschmann , Joseph Day , Evan Sherr , James Boll
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B2018/00452 , A61B2018/207 , A61N5/0616 , H01S3/061 , H01S3/08086 , H01S3/082 , H01S3/092 , H01S3/1611 , H01S3/1643 , H01S3/2383
摘要： Lasers capable of lasing at at least two wavelengths are provided having a lasing medium which is capable of lasing at a first wavelength and at a second wavelength. An output coupler is positioned along a longitudinal axis at a first end of the lasing medium and a first mirror, movable beam block shutter and second mirror are positioned sequentially along the longitudinal axis of the lasing medium at a second end of the lasing medium. The first mirror is highly reflective at a first wavelength, and the second mirror is highly reflective at a second wavelength while being transparent at the first wavelength. The beam block shutter is movable between a first position along the longitudinal axis of the lasing medium and between the first and second mirrors and a second position away from the longitudinal axis of the lasing medium. Also provided are laser workstations having two lasers driven by a single electronics drive system in which a single energy storage network is connected to a first laser pump chamber operative to excite a first laser medium and connected to a second laser pump chamber operative to excite a second laser medium. In certain embodiments, a switch connects the single energy storage network to a secondary winding of a high voltage trigger transformer, which is itself connected to the laser pump chambers. These high voltage trigger transformer serve to selectively ionize the excitation source in one of the laser pump chambers such that when the switch is closed, energy from the energy storage network will flow through the pump chamber whose excitation source(s) has been previously ionized. In other embodiments, the single energy storage network is connected to the excitation sources via active semiconductor switches that permit the release of portions of energy stored in the single energy storage network to one of the lasers, leaving additional energy to be immediately or rapidly released to the excitation source of the first or another laser. Also provided are methods of treating skin having a skin problem using multiple wavelengths of laser energy.

2. 发明授权

US06506594B1 Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays 有权
公开(公告)号：US06506594B1
公开(公告)日：2003-01-14
申请号：US09526992
申请日：2000-03-16
申请人： Francis Barany , Norman P. Gerry , Nancy E. Witowski , Joseph Day , Robert P. Hammer , George Barany
发明人： Francis Barany , Norman P. Gerry , Nancy E. Witowski , Joseph Day , Robert P. Hammer , George Barany
IPC分类号： C12M134
CPC分类号： C12Q1/6837 , B01J2219/00313 , B01J2219/00326 , B01J2219/00416 , B01J2219/00527 , B01J2219/00585 , B01J2219/0059 , B01J2219/00599 , B01J2219/00605 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00722 , B01J2219/00729 , C12Q1/6827 , C12Q1/6858 , C40B40/06 , C40B50/08 , C40B60/14 , C12Q2565/514 , C12Q2565/125 , C12Q2561/125
摘要： The present invention describes a method for identifying one or more of a plurality of sequences differing by one or more single base changes, insertions, deletions, or translocations in a plurality of target nucleotide sequences. The ligation phase utilizes a ligation detection reaction between one oligonucleotide probe, which has a target sequence-specific portion and an addressable array-specific portion, and a second oligonucleotide probe, having a target sequence-specific portion and a detectable label. After the ligation phase, the capture phase is carried out by hybridizing the ligated oligonucleotide probes to a solid support with an array of immobilized capture oligonucleotides at least some of which are complementary to the addressable array-specific portion. Following completion of the capture phase, a detection phase is carried out to detect the labels of ligated oligonucleotide probes hybridized to the solid support. The ligation phase can be preceded by an amplification process. The present invention also relates to a kit for practicing this method, a method of forming arrays on solid supports, and the supports themselves.

3. 发明申请

US20060014189A1 Controls for determining reaction performance in polynucleotide sequence detection assays 审中-公开
标题翻译：用于确定多核苷酸序列检测测定中反应性能的对照
公开(公告)号：US20060014189A1
公开(公告)日：2006-01-19
申请号：US11171107
申请日：2005-06-29
申请人： H. Wenz , Joseph Day
发明人： H. Wenz , Joseph Day
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6813 , C12Q1/68 , C12Q2561/125 , C12Q2545/101 , C12Q2531/113 , C12Q2525/173 , C12Q2525/161 , C12Q2521/501
摘要： The present teachings relate to methods, compositions, and kits for detecting one or more target polynucleotide sequences in a sample. In some embodiments of the present teachings, probes are hybridized to complementary target polynucleotides and are ligated together to form a ligation product. Some embodiments of the present teachings comprise positive assay control probes that provide information regarding the occurrence of specific ligation in a complex ligation assay mixture. Some embodiments of the present teachings provide for negative assay control probes that provide information regarding the occurrence of non-specific ligation in a complex ligation assay mixture. Some embodiments of the present teachings provide for the generation of two distinct signals from a monomorphic target polynucleotide sequence.
摘要翻译：本教导涉及用于检测样品中一种或多种靶多核苷酸序列的方法，组合物和试剂盒。在本教导的一些实施方案中，探针与互补靶多核苷酸杂交并连接在一起以形成连接产物。本教导的一些实施方案包括提供关于复合连接测定混合物中特异性连接的发生的信息的阳性测定对照探针。本发明的一些实施方案提供了阴性测定对照探针，其提供关于复合连接测定混合物中非特异性连接的发生的信息。本教导的一些实施方案提供从单形靶多核苷酸序列产生两个不同信号。

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