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1. 发明申请

WO2008131920A8 INSTRUMENT AND SYSTEM FOR PRODUCING A SAMPLE OF A BODY LIQUID AND FOR ANALYSIS THEREOF 审中-公开
标题翻译：用于生产体液样品及其分析的仪器和系统
公开(公告)号：WO2008131920A8
公开(公告)日：2009-11-05
申请号：PCT/EP2008003355
申请日：2008-04-25
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , KRAEMER UWE , ZIMMER VOLKER , ROEDEL WOLFGANG , LIST HANS , FREY STEPHAN-MICHAEL , HOERAUF CHRISTIAN , PATEL PAUL
发明人： KRAEMER UWE , ZIMMER VOLKER , ROEDEL WOLFGANG , LIST HANS , FREY STEPHAN-MICHAEL , HOERAUF CHRISTIAN , PATEL PAUL
IPC分类号： A61B5/155 , A61B5/00
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150183 , A61B5/150358 , A61B5/150389 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/157
摘要： Instrument for producing a sample of body liquid for analysis by piercing the skin with a lancing element (12) having a skin piercing tip. The instrument (11) has a housing (13) and a lancing drive (14) for driving a lancing element (12) connected thereto in a puncturing movement. A pressure ring (1) surrounds a skin contact opening (4) and is adapted for pressing against the skin such that the skin (3) bulges into the opening (4) for promoting expression of body fluid. The skin contact opening (4) has an opening area corresponding to a circle with a diameter of at least 3 mm and at most 8 mm, and the instrument comprises a pressing force control device (37) for controlling the pressing force between the pressure ring (1) and the skin (3) at the time of triggering the puncturing movement, to be at least 3 N and at most 8 N.
摘要翻译：用于通过用具有皮肤刺穿尖端的穿刺元件（12）刺穿皮肤来生产用于分析的体液样品的仪器。仪器（11）具有壳体（13）和用于在穿刺运动中驱动与其连接的穿刺元件（12）的穿刺驱动器（14）。压力环（1）围绕皮肤接触开口（4）并且适于压靠皮肤，使得皮肤（3）凸起到开口（4）中以促进体液的表达。皮肤接触开口（4）具有对应于直径为至少3mm且至多为8mm的圆的开口面积，并且该仪器包括用于控制压力环之间的按压力的按压力控制装置（37）（1）和皮肤（3）在触发穿刺运动时为至少3N且至多8N。

2. 发明申请

WO2008131920A3 INSTRUMENT AND SYSTEM FOR PRODUCING A SAMPLE OF A BODY LIQUID AND FOR ANALYSIS THEREOF 审中-公开
标题翻译：用于生产体液样品及其分析的仪器和系统
公开(公告)号：WO2008131920A3
公开(公告)日：2009-03-19
申请号：PCT/EP2008003355
申请日：2008-04-25
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , ZIMMER VOLKER , KRAEMER UWE , ROEDEL WOLFGANG , LIST HANS , FREY STEPHAN-MICHAEL , HOERAUF CHRISTIAN , PATEL PAUL
发明人： KRAEMER UWE , ROEDEL WOLFGANG , LIST HANS , FREY STEPHAN-MICHAEL , HOERAUF CHRISTIAN , PATEL PAUL
IPC分类号： A61B5/155 , A61B5/00
CPC分类号： A61B5/15194 , A61B5/14532 , A61B5/1455 , A61B5/150022 , A61B5/150183 , A61B5/150358 , A61B5/150389 , A61B5/150503 , A61B5/15113 , A61B5/15117 , A61B5/15128 , A61B5/1519 , A61B5/157
摘要： Instrument for producing a sample of body liquid for analysis by piercing the skin with a lancing element (12) having a skin piercing tip. The instrument (11 ) has a housing (13) and a lancing drive (14) for driving a lancing element (12) connected thereto in a puncturing movement. A pressure ring (1 ) surrounds a skin contact opening (4) and is adapted for pressing against the skin such that the skin (3) bulges into the opening (4) for promoting expression of body fluid. The skin contact opening (4) has an opening area corresponding to a circle with a diameter of at least 3 mm and at most 8 mm, and the instrument comprises a pressing force control device (37) for controlling the pressing force between the pressure ring (1 ) and the skin (3) at the time of triggering the puncturing movement, to be at least 3 N and at most 8 N.
摘要翻译：用于通过用具有皮肤刺穿尖端的穿刺元件（12）刺穿皮肤来生产用于分析的体液样品的仪器。仪器（11）具有壳体（13）和用于在穿刺运动中驱动与其连接的穿刺元件（12）的穿刺驱动器（14）。压力环（1）围绕皮肤接触开口（4）并且适于压靠皮肤，使得皮肤（3）凸起到开口（4）中以促进体液的表达。皮肤接触开口（4）具有对应于直径为至少3mm且至多为8mm的圆的开口面积，并且该仪器包括用于控制压力环之间的按压力的按压力控制装置（37）（1）和皮肤（3）在触发穿刺运动时为至少3N且至多8N。

3. 发明申请

WO2007042137A3 PIERCING SYSTEM 审中-公开
标题翻译： HOLLY系统
公开(公告)号：WO2007042137A3
公开(公告)日：2007-07-12
申请号：PCT/EP2006009257
申请日：2006-09-23
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , LIST HANS , HOERAUF CHRISTIAN , DECK FRANK , WEISS THOMAS , KISTNER MICHAEL , SCHMELZEISEN-REDEKER GUENTHER , FRUHSTORFER HEINRICH , HAAR HANS-PETER , KRAEMER UWE , HOENES JOACHIM , MILTNER KARL
发明人： LIST HANS , HOERAUF CHRISTIAN , DECK FRANK , WEISS THOMAS , KISTNER MICHAEL , SCHMELZEISEN-REDEKER GUENTHER , FRUHSTORFER HEINRICH , HAAR HANS-PETER , KRAEMER UWE , HOENES JOACHIM , MILTNER KARL
IPC分类号： A61B5/15
CPC分类号： A61B5/1519 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150412 , A61B5/150503 , A61B5/150824 , A61B5/150954 , A61B5/15113
摘要： The invention relates to a piercing system for producing a puncture wound which enables to pick up a body liquid sample and comprises a pressure part (4) applicable to a body part (32) in which the puncture wound is producible, a triggering element (8) whose operation enables a user to trigger a puncture movement of a puncture element (3) after pressing the pressure part (4) and a checking device (5,15,20) for determining at least one parameter dependent on the sampling probability. According to said invention, a security device (9) is used for locking the triggering element (8) in the locking state in such a way that no puncture movement is triggered and for releasing said triggering element (8) in the triggering state in such a way that the puncture movement is triggered, wherein the security device (9) is transferred from the locking state to the releasing state by the action of the checking device (5,15,20) when the checking parameter determined thereby satisfies the minimum predetermined requirements, the puncture system also comprises a signalling device (12) for signalling the transition of the security device (9) to the triggering state and/or for signalling that said device is in the triggering state. A method for preparing the puncture system for producing a puncture wound is also disclosed.
摘要翻译：本发明涉及一种刺血系统对于用于获得体液样品，其包括用于压在主体部分（32），其中一个单一的穿刺伤口是压力部分（4）产生的穿刺伤口中产生，一个触发装置（8），通过其致动穿刺元件的穿刺运动（3），用户可以经过所述按压按（4）的触发，以及用于从从属获得样品概率来确定至少一个检查参数判断装置（5,15,20）的。根据本发明，它提供了一个安全装置（9），该锁在锁定状态下，（8），使得没有穿刺运动可以被触发的触发装置，并释放释放装置（8）处于跳闸状态，所以通过穿刺运动的致动触发可，其中，从所述测试设备（5,15,20）的固定装置（9）被从锁定状态到释放状态时，判断装置（5,15,20）来确定测试参数满足最低要求设置，并且一个信号装置移位（12 ）用于信令的固定装置（9）在释放状态的转换和/或用于用信号表明所述固定装置处于跳闸状态。本发明还涉及到用于制备穿刺系统用于创建穿刺伤口的方法。

4. 发明申请

WO2007147494A3 PACKAGING SYSTEM 审中-公开
标题翻译：包装系统
公开(公告)号：WO2007147494A3
公开(公告)日：2008-04-17
申请号：PCT/EP2007005112
申请日：2007-06-09
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , LIST HANS , KRAEMER UWE , ZIMMER VOLKER , ROE STEVEN N
发明人： LIST HANS , KRAEMER UWE , ZIMMER VOLKER , ROE STEVEN N
IPC分类号： B65D83/04 , A61B17/06 , A61B17/32 , A61B19/02
CPC分类号： B65D83/0472 , A61B5/150022 , A61B5/150358 , A61B5/150419 , A61B5/150702 , A61B5/15128 , A61B5/15151 , A61B5/15167 , A61B5/15169 , A61B5/15173 , A61B5/15176 , A61B5/15184 , A61B50/3001
摘要： The invention refers to a system comprising disposable medical devices and a packaging strip (1) comprising a plurality of chambers (2) containing the disposable medical devices, the strip being folded along breadthwise running fold lines to form a series of loops, each loop comprising opposing sections (3, 4), the opposing sections of at least some of these loops being sealed to each other thus forming chambers (2) between said sections. The invention also refers to a cartridge (10) containing such a packaging strip.
摘要翻译：本发明涉及一种包括一次性医疗装置和包含多个包含一次性医疗装置的腔室（2）的包装条（1）的系统，该条带沿着宽度方向的折叠线折叠以形成一系列环，每个环包括相对的部分（3,4），这些环中的至少一些的相对部分彼此密封，从而在所述部分之间形成室（2）。本发明还涉及一种包含这种包装带的盒（10）。

5. 发明申请

WO2005084546A3 BODY FLUID SAMPLING DEVICE 审中-公开
标题翻译：身体液体取样装置
公开(公告)号：WO2005084546A3
公开(公告)日：2006-03-02
申请号：PCT/EP2005002357
申请日：2005-03-07
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , CALASSO IRIO , GRISS PATRICK , SAROFIM EMAD , JAEGGI RAINER , KRAEMER UWE , HASKER DAVE , ZIMMER VOLKER , SCHMID WILFRIED , FUERST OTTO , LIST HANS , HAAR HANS-PETER , ARNITZ THEO , ROE STEVEN N
发明人： CALASSO IRIO , GRISS PATRICK , SAROFIM EMAD , JAEGGI RAINER , KRAEMER UWE , HASKER DAVE , ZIMMER VOLKER , SCHMID WILFRIED , FUERST OTTO , LIST HANS , HAAR HANS-PETER , ARNITZ THEO , ROE STEVEN N
IPC分类号： A61B5/00 , A61B5/15
CPC分类号： A61B5/14532 , A61B5/1411 , A61B5/1486 , A61B5/150022 , A61B5/150251 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150435 , A61B5/150503 , A61B5/15107 , A61B5/15117
摘要： Body fluid sampling device comprising a skin-piercing element (1) having a collection zone (9) for receiving body fluid, and the device further comprising a fluid receiving means (10) remote spaced apart from said collection zone so that body fluid in said collection zone will not contact the fluid receiving means initially. Said collection zone takes up a very small volume of body fluid of about 10 to 500 nl in a very short time period of less than 0,5 s. Said fluid receiving means may have a test zone for performing an analytical reaction. Fluid sample from said collection zone is automatically or manually transported to said fluid receiving means to contact said fluid with said test zone.
摘要翻译：体液取样装置包括具有用于接收体液的收集区（9）的皮肤刺穿元件（1），并且该装置还包括与所述收集区间隔开的流体接收装置（10），使得所述收集区域最初不会接触流体接收装置。所述收集区在小于0.5s的非常短的时间段内占据非常小体积的体液约10至500nl。所述流体接收装置可以具有用于进行分析反应的测试区域。来自所述收集区的流体样品被自动或手动地运送到所述流体接收装置，以与所述测试区接触所述流体。

6. 发明申请

WO2010094427A3 COMPACT STORAGE OF AUXILIARY ANALYTICAL DEVICES IN A CARTRIDGE 审中-公开
标题翻译：节省空间的Magazining分析工具
公开(公告)号：WO2010094427A3
公开(公告)日：2011-01-13
申请号：PCT/EP2010000865
申请日：2010-02-12
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , KUHR HANS-JUERGEN , LIST HANS , LEICHNER WILHELM , KRAEMER UWE
发明人： KUHR HANS-JUERGEN , LIST HANS , LEICHNER WILHELM , KRAEMER UWE
IPC分类号： A61B5/151 , G01N33/487
CPC分类号： A61B5/157 , A61B5/1411 , A61B5/1451 , A61B5/14532 , A61B5/1455 , A61B5/1468 , A61B5/150022 , A61B5/150297 , A61B5/150358 , A61B5/150419 , A61B5/150503 , A61B5/15107 , A61B5/15115 , A61B5/15151 , A61B5/15161 , A61B5/15176 , A61B10/0045 , A61B10/007 , G01N33/4875
摘要： Disclosed is an analytical cartridge (110) comprising a plurality of auxiliary analytical devices (128) that are accommodated in chambers (126). The analytical cartridge (110) is designed to be accommodated in an analytical system (114) in at least two directions and to supply a plurality of auxiliary analytical devices (128) to the analytical system (114) in each direction. The auxiliary analytical devices (128) allow at least one sample-taking movement to be made. The analytical cartridge (110) is designed so that the auxiliary analytical devices (128) can be stored in the cartridge again.
摘要翻译：建议的分析盒（110）包括在腔室（126）分析设备（128）截取的多个的。分析盒（110）被适配在至少两个取向被接收在分析系统（114）。分析盒（110）还适于在每个多个分析系统（114）上分析辅助（128）的的取向，以提供。由分析设备（128）的装置是至少一个采样运动是可行的。分析盒（110）被适配成允许所述Remagazinierung分析装置（128）。

7. 发明申请

WO2005006985A3 ANALYSIS APPARATUS AND ANALYSIS METHOD FOR BODY FLUIDS 审中-公开
标题翻译：体液分析仪和分析程序
公开(公告)号：WO2005006985A3
公开(公告)日：2005-05-12
申请号：PCT/EP2004007785
申请日：2004-07-14
申请人： HOFFANN LA ROCHE AG F , ROCHE DIAGNOSTICS GMBH , HOENES JOACHIM , LIST HANS , KRAEMER UWE , MILTNER KARL , RASCH-MENGES JUERGEN , SCHMELZEISEN-REDEKER GUENTHER , ZIMMER VOLKER , HESS PETER , JANSEN PAUL
发明人： HOENES JOACHIM , LIST HANS , KRAEMER UWE , MILTNER KARL , RASCH-MENGES JUERGEN , SCHMELZEISEN-REDEKER GUENTHER , ZIMMER VOLKER , HESS PETER , JANSEN PAUL
IPC分类号： A61B5/00 , A61B5/15 , G01N33/487 , G01N35/00
CPC分类号： G01N33/48764 , A61B5/14532 , A61B5/150022 , A61B5/150068 , A61B5/150198 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15113 , A61B5/15163 , A61B5/157 , G01N35/00009 , G01N2035/00019
摘要： The invention relates to an analysis apparatus for body fluids, having the following characteristics: a) a housing (10) provided receiving element (12) for engaging a part of the body (66); b) an abutment (14) for the part of the body (66), which can be moved from a release position to an active position relative to the receiving element (12; c) a piercing unit (16) having a piercing element (18) that can pierce the part of the body (66) placed against the abutment (14) in a linear piercing stroke; d) a test strip unit (20) having a test strip (22) that is applied to the body fluids coming out of the part of the body (66) and e) a detecting unit (24) for examining the body fluid applied on one segment of the test strip (22).
摘要翻译：本发明涉及一种用于体液包括以下特征a）一种（与设置有壳体（10主体（66）的一部分的卡合的插座12））中，b）一释放位置和所述容器的操作位置之间的相对（12）可动抵接的分析装置（14），用于所述主体部分（66）中，c）一个在（针对在所述主体（66的线性穿刺行程部分施加的支座14））einstechbares穿刺体（18），其具有穿孔单元（16），d）中的测试带（22）具有用于从新兴体液测试带单元（20），以及e）用于调查检测单元（24）（在测试条22的一部分）的主体部分（66）将施加体液。

8. 发明申请

WO2006032441A3 STOICHIOMETRICALLY DEFINED DYE-LABELED SUBSTANCES FOR MEASURING GLOMERULAR FILTRATION RATE 审中-公开
标题翻译：化学计量DEFINED染料标记的物质用于测量肾小球滤过率
公开(公告)号：WO2006032441A3
公开(公告)日：2007-02-01
申请号：PCT/EP2005010093
申请日：2005-09-20
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , PILL JOHANNES , KRAEMER UWE , GRETZ NORBERT , DEUS CARSTEN , HAGENBRUCH BERND , KLOETZER HANS-MARTIN
发明人： PILL JOHANNES , KRAEMER UWE , GRETZ NORBERT , DEUS CARSTEN , HAGENBRUCH BERND , KLOETZER HANS-MARTIN
IPC分类号： A61K49/00 , A61K47/48
CPC分类号： A61K49/0052 , A61K49/0043
摘要： The invention relates to novel chemical compounds that can be used as tracers in renal diagnosis, to the production and use thereof, and to renal diagnostic reagent containing them.
摘要翻译：本发明涉及一种可以用作肾诊断含有它们的肾诊断标记物的物质，其制备和用途，和组合物的新化合物。

9. 发明申请

WO02069790A2 METHOD FOR THE DETERMINATION OF A LIGHT TRANSPORT PARAMETER IN A BIOLOGICAL MATRIX 审中-公开
标题翻译：用于确定生物基质中的光传输参数的方法
公开(公告)号：WO02069790A2
公开(公告)日：2002-09-12
申请号：PCT/EP0201944
申请日：2002-02-23
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE , KRAEMER UWE , HEIN HEINZ-MICHAEL , VOLZ DIETMAR
发明人： KRAEMER UWE , HEIN HEINZ-MICHAEL , VOLZ DIETMAR
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B2562/0242 , Y10T436/144444
摘要： Method for the selective determination of a light transport parameter, characteristic of the light scattering in a biological matrix (5), in particular for the purpose of non-invasive determination of the concentration of glucose in the biological matrix. The above includes a number of detection measurements in which light is injected into the biological sample as primary light and an intensity value for escaping secondary light measured in a detection location, which is found at various separations from the location of light injection for the number of detection measurements. The light transport parameter which is characteristic for the light scattering in the biological matrix is derived from the intensity values in an analytical step by means of an analytical algorithm. According to the invention, the scattering coefficient can be selectively determined, whereby the analytical algorithm comprises a step in which a value for change with time DELTA tI(r) describing the change with time of the intensity value is derived from at least two different intensity values from different times.
摘要翻译：用于选择性测定生物基质（5）中光散射特征的光传输参数的方法，特别是用于无创测定生物基质中葡萄糖浓度的目的。它包括多个检测测量值的，在各照射光作为一次光到生物基体和在其位于所述多个在从照射部位不同的测量距离检测测量的被检测部位的强度测量值的，易失性次级光被测量。在评估步骤中，通过评估算法从强度测量值导出生物基质中光散射的光传输参数特征。为散射系数的选择性测定建议评估算法包括其中所获得的组成测量的强度值的至少两个不同的时间的步骤中，强度测量值描述时间导数值DELTA的Ti（R）随时间的变化被计算。

10. 发明申请

WO2008043565A3 TAPE TRANSPORT LANCE SAMPLER 审中-公开
标题翻译：胶带运输部门采样器
公开(公告)号：WO2008043565A3
公开(公告)日：2008-07-03
申请号：PCT/EP2007008870
申请日：2007-10-12
申请人： ROCHE DIAGNOSTICS GMBH , HOFFMANN LA ROCHE
发明人： ROE STEVEN N , BEATY TERRY , KRAEMER UWE , ZIMMER VOLKER
IPC分类号： A61B5/151
CPC分类号： A61B5/15173 , A61B5/150022 , A61B5/150175 , A61B5/150213 , A61B5/150282 , A61B5/150358 , A61B5/15045 , A61B5/150465 , A61B5/150503 , A61B5/150564 , A61B5/150702 , A61B5/15113 , A61B5/15117 , A61B5/15123 , A61B5/15128 , A61B5/15167 , A61B5/15176 , A61B5/15178
摘要： A lancet-sampler system is configured to automatically remove a protective cover (56) from a lancet (30) and automatically unpack a test pad (64) just prior to use. This minimizes the risk of injury and reduces the chance of cross-contamination between the lancet and the test pad. The lancet defines a capillary groove (36) for drawing body fluid from the incision via capillary action and a sample transfer opening (38) for collecting the fluid from the groove. A carrier tape (62) is coupled to the lancet. The carrier tape includes a test pad for analyzing the fluid. The tape is folded around the test pad to form an airtight package (66). The test pad is located at a position to align with the sample transfer opening when the tape is unfolded. The protective cover covers a portion of the lancet, and when the tape is pulled, the protective cover is automatically pulled from the lancet.
摘要翻译：刺血针取样器系统被配置为自动地从柳叶刀（30）上移除保护罩（56）并且在使用之前自动地打开测试垫（64）。这可以最大限度地减少伤害的风险，并减少刺血针和测试垫之间交叉污染的可能性。柳叶刀定义了用于从切口经由毛细作用抽出体液的毛细管槽（36）和用于从槽收集流体的样品转移开口（38）。载体带（62）联接到刺血针。载带包括用于分析流体的测试垫。胶带围绕测试垫折叠以形成气密包装（66）。当胶带展开时，测试垫位于与样品传送开口对准的位置。保护盖覆盖柳叶刀的一部分，当拉动带子时，保护罩将从刺血针自动拉出。

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