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1. 发明申请

WO2011047020A1 MULTISITE BIOSENSOR AND ASSOCIATED METHOD 审中-公开
标题翻译：多生物传感器及相关方法
公开(公告)号：WO2011047020A1
公开(公告)日：2011-04-21
申请号：PCT/US2010/052472
申请日：2010-10-13
申请人： ROBERT BOSCH GMBH , STANFORD UNIVERSITY , LANG, Christoph , KAVUSI, Sam , ROSER, Daniel , TALASAZ, Amirali Haj, Hossein
发明人： LANG, Christoph , KAVUSI, Sam , ROSER, Daniel , TALASAZ, Amirali Haj, Hossein
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N29/32 , G01N33/53 , G01N33/543 , G01N33/54366
摘要： A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.
摘要翻译：在一个实施方案中检测生物标志物的方法包括鉴定样品中生物分子类型的数量，将样品暴露于多个测试位点，其中多个测试位点中的测试位点的数目等于或大于所鉴定的生物分子类型的数量，为每个测试点建立相应的测试环境，其中，所述多个测试位置中的每一个的测试环境与所述多个测试位置中的每一个测试位置中的每一个的测试环境不同获得与所述多个测试点中的每一个相关联的检测信号，以及基于所获得的检测信号来确定所述生物分子类型之一的浓度。

2. 发明申请

WO2011088077A1 SUCCESSIVE SAMPLING DEVICE AND ASSOCIATED METHOD 审中-公开
标题翻译：成功采样设备及相关方法
公开(公告)号：WO2011088077A1
公开(公告)日：2011-07-21
申请号：PCT/US2011/020934
申请日：2011-01-12
申请人： ROBERT BOSCH GMBH , KAVUSI, Sam , ROSER, Daniel , LANG, Christoph , TALASAZ, Amirali, Haj Hossein , STANFORD UNIVERSITY
发明人： KAVUSI, Sam , ROSER, Daniel , LANG, Christoph , TALASAZ, Amirali, Haj Hossein
IPC分类号： G01N33/53 , G01N33/543 , G01N33/558
CPC分类号： G01N33/54366 , B01L3/5027 , C12Q1/6816 , G01N33/54393 , C12Q2565/501
摘要： A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.
摘要翻译：确定溶液成分的数量的方法包括将第一数量的溶液成分引入到第一测试位置，为所引入的第一数量的溶液成分建立第一结合环境，通过将第一数量的溶液成分结合到第一残留数量的溶液成分多个溶液成分，为第一剩余数量的溶液成分建立第二结合环境，通过将第二多个溶液组分与第一剩余数量的溶液成分结合而产生第二剩余数量的溶液成分，获得与绑定的第一多个解决方案组成部分，获得与绑定的第二多个解决方案组成部分相关联的第二信号，以及基于获得的第一信号和获得的第二信号来确定感兴趣的组成部分的第二数量。

3. 发明授权

EP2488870B1 MULTISITE BIOSENSOR AND ASSOCIATED METHOD 有权
标题翻译：多功能生物传感器及相关方法
公开(公告)号：EP2488870B1
公开(公告)日：2017-05-10
申请号：EP10770679.8
申请日：2010-10-13
申请人： Robert Bosch GmbH , Stanford University
发明人： LANG, Christoph , KAVUSI, Sam , ROSER, Daniel , TALASAZ, Amirali Haj, Hossein
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N29/32 , G01N33/53 , G01N33/543 , G01N33/54366
摘要： A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.
摘要翻译：在一个实施方案中检测生物标志物的方法包括鉴定样品中生物分子类型的量，将样品暴露于多个测试位点，其中多个测试位点中的测试位点的数量等于或大于鉴定的生物分子类型的数量，为多个测试站点中的每一个建立相应的测试环境，其中针对多个测试站点中的每一个的测试环境与用于多个测试站点中的其他站点中的每一个的测试环境不同获得与多个测试部位中的每一个相关联的检测信号，并且基于获得的检测信号确定生物分子类型之一的浓度。

4. 发明授权

EP2524228B1 METHOD OF DETERMINING A NUMBER OF SOLUTION CONSTITUENTS 有权
标题翻译： METHOD FOR确定抽样组分的浓度
公开(公告)号：EP2524228B1
公开(公告)日：2017-03-15
申请号：EP11700494.5
申请日：2011-01-12
申请人： ROBERT BOSCH GMBH , STANFORD UNIVERSITY
发明人： KAVUSI, Sam , ROSER, Daniel , LANG, Christoph , TALASAZ, Amirali, Haj Hossein
IPC分类号： G01N33/53 , G01N33/543 , G01N33/558
CPC分类号： G01N33/54366 , B01L3/5027 , C12Q1/6816 , G01N33/54393 , C12Q2565/501

5. 发明公开

EP2524228A1 SUCCESSIVE SAMPLING DEVICE AND ASSOCIATED METHOD 有权
标题翻译： VERFAHREN ZUR BESTIMMUNG DER KONZENTRATION VON PROBENKOMPONENTEN
公开(公告)号：EP2524228A1
公开(公告)日：2012-11-21
申请号：EP11700494.5
申请日：2011-01-12
申请人： ROBERT BOSCH GMBH , STANFORD UNIVERSITY
发明人： KAVUSI, Sam , ROSER, Daniel , LANG, Christoph , TALASAZ, Amirali, Haj Hossein
IPC分类号： G01N33/53 , G01N33/543 , G01N33/558
CPC分类号： G01N33/54366 , B01L3/5027 , C12Q1/6816 , G01N33/54393 , C12Q2565/501
摘要： A method of determining a number of a solution constituent includes introducing a first number of solution constituents to a first test location, establishing a first binding environment for the introduced first number of solution constituents, creating a first residual number of solution constituents by binding a first plurality of solution constituents, establishing a second binding environment for the first residual number of solution constituents, creating a second residual number of solution constituents by binding a second plurality of solution constituents from the first residual number of solution constituents, obtaining a first signal associated with the bound first plurality of solution constituents, obtaining a second signal associated with the bound second plurality of solution constituents, and determining a second number of a constituent of interest based upon the obtained first signal and the obtained second signal.
摘要翻译：确定溶液成分的数量的方法包括将第一数量的溶液成分引入到第一测试位置，为所引入的第一数量的溶液成分建立第一结合环境，通过将第一个多个溶液成分，为第一剩余数量的溶液成分建立第二结合环境，通过将第二多个溶液组分与第一剩余数量的溶液组分结合而产生第二剩余数量的溶液组分，获得与约束的第一多个解决方案组成部分，获得与绑定的第二多个解决方案组成部分相关联的第二信号，以及基于获得的第一信号和获得的第二信号来确定感兴趣的成分的第二数量。

6. 发明公开

EP2488870A1 MULTISITE BIOSENSOR AND ASSOCIATED METHOD 有权
标题翻译：多位生物传感器和相关方法
公开(公告)号：EP2488870A1
公开(公告)日：2012-08-22
申请号：EP10770679.8
申请日：2010-10-13
申请人： Robert Bosch GmbH , Stanford University
发明人： LANG, Christoph , KAVUSI, Sam , ROSER, Daniel , TALASAZ, Amirali Haj, Hossein
IPC分类号： G01N33/543
CPC分类号： G01N33/54393 , G01N29/32 , G01N33/53 , G01N33/543 , G01N33/54366
摘要： A method of detecting a biomarker in one embodiment includes identifying a quantity of biomolecule types in a sample, exposing the sample to a plurality of test sites, wherein the number of test sites in the plurality of test sites is equal to or greater than the identified quantity of biomolecule types, establishing, for each of the plurality of test sites, a respective test environment, wherein the test environment for each of the plurality of test sites is different from the test environment for each of the other of the plurality of test sites, obtaining a detection signal associated with each of the plurality of test sites, and determining the concentration of one of the biomolecule types based upon the obtained detection signals.

7. 发明申请

WO2019149617A1 SEGMENTED DIGITAL TO OPTICAL PHASE-SHIFT CONVERTER 审中-公开
公开(公告)号：WO2019149617A1
公开(公告)日：2019-08-08
申请号：PCT/EP2019/051768
申请日：2019-01-24
申请人： ROBERT BOSCH GMBH
发明人： LAJEVARDI, Pedram , BEHROOZPOUR, Behnam , LANG, Christoph , WOJCIECHOWSKI, Ken
IPC分类号： G02F1/295 , G02F1/025 , G01S7/481
摘要： A phase-shifter for a light-transmitting waveguide is segmented into multiple segments that can be calibrated to the overall length of a conventional single phase-shifter. Each segment receives a control signal, which can be a single bit signal, with the phase-shift capability of the segmented phase-shifter controlled by which segment(s) receive(s) a control signal. In one implementation, a binary weighting is applied to determine segment lengths. Smaller segments can be increased in length to achieve a 2π offset of the phase shift produced by the segment while maintaining the same binary relationship among segments. In another embodiment, multiple segments of uniform lengths can be used for a single phase-shifter with each segment controlled by an n-bit signal.

8. 发明申请

WO2018166861A1 INTELLIGENT EVENT SYSTEM AND METHOD FOR A VEHICLE 审中-公开
公开(公告)号：WO2018166861A1
公开(公告)日：2018-09-20
申请号：PCT/EP2018/055570
申请日：2018-03-07
申请人： ROBERT BOSCH GMBH
发明人： JAIN, Vivek , BOCCA, Maurizio , LEE, Huang , LANG, Christoph , KESHAVARZIAN, Abtin
IPC分类号： B60R16/037 , G07C9/00
摘要： A system (90) comprising: an interface of a vehicle (12) for communicating with a vehicle user; and a controller of the vehicle in communication with the interface and configured to: connect to a thin device (14) carried by or worn by the vehicle user responsive to the vehicle user approaching the vehicle; retrieve data associated with a calendar event from the thin device, when the vehicle user is within a range of authorization for exchanging data over a data channel with the thin device, the data including a destination location and a time at which the calendar event occurs; and display the destination location and the time to the vehicle user.

9. 发明申请

WO2014210139A1 WIRELESS CHARGING SYSTEM 审中-公开
标题翻译：无线充电系统
公开(公告)号：WO2014210139A1
公开(公告)日：2014-12-31
申请号：PCT/US2014/044071
申请日：2014-06-25
申请人： ROBERT BOSCH GMBH , LANG, Christoph
发明人： LANG, Christoph
IPC分类号： H02J17/00 , H02J7/00
CPC分类号： H02J7/025 , H02J7/0068 , H02J17/00 , H02J50/12 , H02J50/40 , H02J50/60 , H02J50/90 , H02J2003/143 , Y02B70/3266 , Y04S20/242
摘要： A wireless power transmission system includes a first power transmitter configured to transmit a first electromagnetic field, a first power receiver configured to generate electrical energy using the first transmitted electromagnetic field, a first occupancy sensor configured to indicate a first presence of a first individual within a first sensed area, and a control unit configured to control the first power transmitter based upon the indicated first presence.
摘要翻译：无线电力传输系统包括被配置为发送第一电磁场的第一电力发射器，被配置为使用第一传输电磁场产生电能的第一电力接收器，第一占用传感器，被配置为指示第一电力接收器第一感测区域，以及控制单元，被配置为基于所指示的第一存在来控制第一功率发射器。

10. 发明申请

WO2014165198A1 GENERATION OF pH/TEMPERATURE/IONIC GRADIENTS IN LATERAL FLOW IMMUNOASSAYS FOR MODULATING BIOMOLECULAR INTERACTIONS AND ITS APPLICATIONS 审中-公开
标题翻译：用于调节生物分子相互作用的流动免疫测定中pH /温度/离子梯度的产生及其应用
公开(公告)号：WO2014165198A1
公开(公告)日：2014-10-09
申请号：PCT/US2014/024760
申请日：2014-03-12
申请人： ROBERT BOSCH GMBH , JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib , LANG, Christoph
发明人： JOHNSON, Christopher , KAVUSI, Sam , AHMAD, Habib , LANG, Christoph
IPC分类号： B01L3/00 , G01N33/50
CPC分类号： G01N27/3276 , B01L3/5027 , B01L2300/0636 , B01L2300/0645 , B01L2300/069 , B01L2300/089 , B01L2400/0406 , G01N33/5438 , G01N33/558
摘要： Lateral flow assay devices comprising a multisite array of test sites (8) for measuring a biomolecule analyte (3) having a solid support (5) including absorbent material for providing capillary flow, one device being divided into parallel lanes (7) in the flow direction. The devices comprising a sample portion for receiving a sample; a diagnostic portion comprising a multisite array of test sites (8) each comprising a probe for the biomolecular analyte (3), wherein at each test site of the multisite array the conditions for the interaction between the biomolecular analyte and the probe can be varied independently; an absorbent portion of absorbent material for providing capillary flow; and electrodes (10) for actuating and controlling conditions. The sample portion, diagnostic portion, and absorbent portion are in capillary flow communication resulting in a capillary flow from sample portion towards absorbent portion, whereby the sample flows across the probe at each test site in the diagnostic portion to provide contact between the sample and such probe. Methods for measuring analyte concentration in a sample using such lateral flow assay devices.
摘要翻译：包括用于测量具有固体支持物（5）的生物分子分析物（3）的测试位点（8）的多部分阵列的横向流动测定装置，所述固体支撑物包括用于提供毛细血管流动的吸收材料，一个装置被分成流动的平行通道（7）方向。所述装置包括用于接收样品的样品部分; 诊断部分包括测试部位（8）的多部分阵列，每个测试部位包括用于生物分子分析物（3）的探针，其中在多位点阵列的每个测试位置处，生物分子分析物和探针之间的相互作用条件可以独立变化 ; 用于提供毛细管流的吸收材料的吸收部分; 以及用于致动和控制条件的电极（10）。样品部分，诊断部分和吸收部分处于毛细管流动连通，导致从样品部分向吸收部分的毛细管流动，由此样品在诊断部分的每个测试部位处流过探针，以提供样品与其间的接触探测。使用这种侧流测定装置测量样品中分析物浓度的方法。

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