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1. 发明专利

JP2005528159A Apparatus and method for rapidly aspirating and collecting body tissue from encapsulated somatic space 有权
公开(公告)号：JP2005528159A
公开(公告)日：2005-09-22
申请号：JP2004508671
申请日：2003-06-04
申请人：オフィスオブテクノロジーライセンシングスタンフォードユニバーシティOffice Of Technology Licensing Stanford University , クラフト,ダニエルKraft,Daniel , ホール,ジェイムズHole,James
发明人：クラフト，ダニエル , ホール，ジェイムズ
IPC分类号： A61B10/02 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B19/00 , A61M1/00
CPC分类号： A61M25/0082 , A61B10/025 , A61B10/0283 , A61B17/1615 , A61B17/2202 , A61B17/320068 , A61B17/3415 , A61B17/3423 , A61B17/3472 , A61B2010/0258 , A61B2017/00292 , A61B2017/00309 , A61B2017/320032 , A61B2017/3413 , A61B2090/378 , A61M3/0279 , A61M3/0283 , A61M2202/09 , A61M2202/10 , A61M2210/02
摘要：【課題】被包化された体腔から体組織を迅速に抽出するための装置および方法を提供する。
【解決手段】オプションのコア要素104を備えた中空のエントリカニューレ101は骨髄など体組織へのエントリを提供する。吸引カニューレ105は、エントリカニューレ101を通って体組織に挿入され、方向性を持ちながら体腔内を前進できるように操作される。吸引カニューレ105に内在するオプションのスタイレット106は、吸引カニューレ105が体組織を通って前進することを補助し、吸引カニューレ105を通じた体組織の容易な抽出のために取り除かれる。吸引カニューレ105近端部にある陰圧源は制御陰圧を供給し、これにより先端チップ130近くの吸い込み開口150から組織の採取が可能となる。吸引カニューレ105は取り出されてもよく、その経路は同一エントリポイントを通って複数回の挿入を行うために調整され、より多量の組織を吸引するために組織空間を通って次の吸引を行うために他の経路を辿る。

2. 发明专利

JP4808961B2 Apparatus for rapid aspiration and collection of body tissue from the encapsulated somatic space 有权
公开(公告)号：JP4808961B2
公开(公告)日：2011-11-02
申请号：JP2004508671
申请日：2003-06-04
申请人：オフィスオブテクノロジーライセンシングスタンフォードユニバーシティOffice Of Technology Licensing Stanford University
发明人：クラフト，ダニエル , ホール，ジェイムズ
IPC分类号： A61B10/02 , A61B17/16 , A61B10/00 , A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B19/00 , A61M1/00
CPC分类号： A61M25/0082 , A61B10/025 , A61B10/0283 , A61B17/1615 , A61B17/2202 , A61B17/320068 , A61B17/3415 , A61B17/3423 , A61B17/3472 , A61B2010/0258 , A61B2017/00292 , A61B2017/00309 , A61B2017/320032 , A61B2017/3413 , A61B2090/378 , A61M3/0279 , A61M3/0283 , A61M2202/09 , A61M2202/10 , A61M2210/02
摘要： Device and method for rapid extraction of body tissue from an enclosed body cavity. Hollow entry cannula with optional core element provides entry into body tissue space such as bone marrow. Aspiration cannula is inserted through entry cannula into body tissue and is manipulated to advance directionally through body cavity. Optional stylet within aspiration cannula aids in advancing aspiration cannula through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula. Inlet openings near distal tip of aspiration cannula allow tissue aspiration, with negative pressure source at proximal end of aspiration cannula providing controlled negative pressure. Aspiration cannula may be withdrawn and its path adjusted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.

3. 发明专利

JP2011229938A Device for rapid aspiration and collection of body tissue from within enclosed body space 审中-公开
标题翻译：用于快速吸收和收集体内组织的装置
公开(公告)号：JP2011229938A
公开(公告)日：2011-11-17
申请号：JP2011152419
申请日：2011-07-11
申请人： Office Of Technology Licensing Stanford Univ , オフィスオブテクノロジーライセンシングスタンフォードユニバーシティOffice Of Technology Licensing Stanford University
发明人： KRAFT DANIEL , HOLE JAMES
IPC分类号： A61B10/02 , A61M1/00 , A61B10/00 , A61B17/00 , A61B17/16 , A61B17/22 , A61B17/32 , A61B17/34 , A61B19/00
CPC分类号： A61M25/0082 , A61B10/025 , A61B10/0283 , A61B17/1615 , A61B17/2202 , A61B17/320068 , A61B17/3415 , A61B17/3423 , A61B17/3472 , A61B2010/0258 , A61B2017/00292 , A61B2017/00309 , A61B2017/320032 , A61B2017/3413 , A61B2090/378 , A61M3/0279 , A61M3/0283 , A61M2202/09 , A61M2202/10 , A61M2210/02
摘要： PROBLEM TO BE SOLVED: To provide a device and method for rapid extraction of body tissue from an enclosed body cavity.SOLUTION: A hollow entry cannula 101 provides entry into body tissue space. An aspiration cannula 105 is inserted through an entry cannula 101 into body tissue and is manipulated to advance directionally through body cavity. An optional stylet 106 aids in advancing aspiration cannula 105 through body tissue and is removed to facilitate extraction of body tissue through the aspiration cannula 105. A negative pressure source at proximal end of the aspiration cannula 105 provides controlled negative pressure, and tissue is collected from an inlet openings near a distal tip 130. The aspiration cannula 105 may be inserted for multiple entries through the same entry point, following different paths through tissue space for subsequent aspiration of more tissue.
摘要翻译：要解决的问题：提供一种用于从封闭体腔快速提取身体组织的装置和方法。解决方案：空心入口套管101提供进入体组织空间。抽吸插管105通过入口插管101插入体内组织，并被操纵以便定向地穿过体腔。可选的探针106有助于通过身体组织推进抽吸套管105，并且被移除以便于通过抽吸套管105提取身体组织。抽吸套管105的近端处的负压源提供受控的负压，并且从在远侧末端130附近的入口开口。抽吸插管105可以插入穿过组织空间的不同路径之后的多个入口通过相同的入口点，以便随后抽吸更多的组织。版权所有（C）2012，JPO＆INPIT

4. 发明专利

TW200927102A 治療黃病毒科病毒感染之方法、治療黃病毒科病毒感染之組合物及用於鑑定供治療黃病毒科病毒感染之組合物的篩選檢測法 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION 审中-公开
简体标题：治疗黄病毒科病毒感染之方法、治疗黄病毒科病毒感染之组合物及用于鉴定供治疗黄病毒科病毒感染之组合物的筛选检测法 METHODS OF TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION, AND SCREENING ASSAYS FOR IDENTIFYING COMPOSITIONS FOR TREATING A FLAVIVIRIDAE FAMILY VIRAL INFECTION
公开(公告)号：TW200927102A
公开(公告)日：2009-07-01
申请号：TW097135844
申请日：2008-09-18
申请人：美國史丹佛大學 STANFORD UNIVERSITY
发明人：史蒂芬R 奎克 QUAKE, STEPHEN R. , 奇瑞特伊那夫 EINAV, SHIRIT , 傑佛瑞S 格林 GLENN, JEFFREY S. , 羅伯麥克道威 MCDOWELL, ROBERT , 楊文傑 YANG, WENJIN , 多倫吉伯 GERBER, DORON , 海達斯德沃瑞索伯 DVORY-SOBOL, HADAS
IPC分类号： A61K , C07D , C12Q , G01N , A61P , C12R
CPC分类号： A61K31/4184 , A61K31/67 , A61K31/7056 , A61K38/212 , A61K45/06 , C07D235/08 , C07D235/12 , C07K14/005 , C12N2770/24222 , G01N2333/186 , G01N2500/02 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395 , A61K2300/00
摘要：簡言之,本揭示案之實施例包括組合物、醫藥組合物、治療經黃病毒(Flaviviridae)科病毒之病毒感染的宿主之方法、治療宿主中HCV複製之方法、抑制宿主中NS4B多與HCV負鏈RNA之3'UTR結合之方法、治療宿主之肝臟纖維化的方法、鑑定用以治療C型肝炎病毒(HCV)感染之候選藥劑之方法,及其類似方法。
简体摘要：简言之,本揭示案之实施例包括组合物、医药组合物、治疗经黄病毒(Flaviviridae)科病毒之病毒感染的宿主之方法、治疗宿主中HCV复制之方法、抑制宿主中NS4B多与HCV负链RNA之3'UTR结合之方法、治疗宿主之肝脏纤维化的方法、鉴定用以治疗C型肝炎病毒(HCV)感染之候选药剂之方法,及其类似方法。

5. 发明专利

DE59910367D1 未知
公开(公告)号：DE59910367D1
公开(公告)日：2004-10-07
申请号：DE59910367
申请日：1999-02-02
申请人： I M E S GES FUER INNOVATIVE ME , STANFORD UNIVERSITY STANFORD
发明人： SCHUETH DR , REINHARD PROF DR
IPC分类号： B01J29/068 , B01J33/00 , B01J38/60 , B01J38/70 , C02F1/70 , A62D3/00

6. 发明专利

DE69914746D1 未知
公开(公告)号：DE69914746D1
公开(公告)日：2004-03-18
申请号：DE69914746
申请日：1999-06-01
申请人： STANFORD UNIVERSITY PALO ALTO
发明人： NEMATI FARID , PLUMMER JAMES
IPC分类号： G11C11/39 , H01L21/8244 , G11C11/41 , H01L27/06 , H01L27/11 , H01L29/417 , H01L29/423 , H01L29/74 , H01L29/87
摘要： A thyristor device can be used to implement a variety of semiconductor memory circuits, including high-density memory-cell arrays and single cell circuits. In one example embodiment, the thyristor device includes doped regions of opposite polarity, and a first word line that is used to provide read and write access to the memory cell. A second word line is located adjacent to and separated by an insulative material from one of the doped regions of the thyristor device for write operations to the memory cell, for example, by enhancing the switching of the thyristor device from a high conductance state to a low conductance state and/or from the low conductance state to the high conductance. This type of memory circuit can be implemented to significantly reduce standby power consumption and access time.

7. 发明专利

DE69914746T2 未知
公开(公告)号：DE69914746T2
公开(公告)日：2004-07-15
申请号：DE69914746
申请日：1999-06-01
申请人： STANFORD UNIVERSITY PALO ALTO
发明人： NEMATI FARID , PLUMMER JAMES
IPC分类号： G11C11/39 , H01L21/8244 , G11C11/41 , H01L27/06 , H01L27/11 , H01L29/417 , H01L29/423 , H01L29/74 , H01L29/87
摘要： A thyristor device can be used to implement a variety of semiconductor memory circuits, including high-density memory-cell arrays and single cell circuits. In one example embodiment, the thyristor device includes doped regions of opposite polarity, and a first word line that is used to provide read and write access to the memory cell. A second word line is located adjacent to and separated by an insulative material from one of the doped regions of the thyristor device for write operations to the memory cell, for example, by enhancing the switching of the thyristor device from a high conductance state to a low conductance state and/or from the low conductance state to the high conductance. This type of memory circuit can be implemented to significantly reduce standby power consumption and access time.

8. 发明公开

US20230256026A1 GENE EDITING FOR THE TREATMENT OF EPIDERMOLYSIS BULLOSA 审中-公开
公开(公告)号：US20230256026A1
公开(公告)日：2023-08-17
申请号：US17794183
申请日：2021-01-20
申请人： UNIVERSIDAD CARLOS III DE MADRID , CENTRO DE INVESTIGACIONES ENERGÉTICAS, MEDIO AMBIENTASDS Y TECNOLÓGICAS O.A., M.P. , CONSORCIO CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED , FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA FUNDACIÓN JIMÉNEZ DÍAZ , STANFORD UNIVERSITY
发明人： José BONAFONT ARAGÓ , Fernando LARCHER LAGUZZI , Rodolfo MURILLAS ANGOITI , Marcela DEL RÍO NECHAEVSKY , Ángeles MENCÍA RODRIGUEZ , Marta GARCÍA DÍEZ , María José ESCÁMEZ TOLEDANO , Matthew PORTEUS
IPC分类号： A61K35/36 , C12N15/11 , C12N9/22 , C12N15/90 , C12N15/86 , A61P17/00
CPC分类号： A61K35/36 , A61P17/00 , C12N9/22 , C12N15/11 , C12N15/86 , C12N15/907 , C12N2310/20 , C12N2750/14143 , C12N2800/80
摘要： The present invention relates to the treatment of Epidermolysis Bullosa, particularly the recessive dystrophic subtype (RDEB), using the Clustered- Regularly Interspaced Short Palindromic Repeats (CRISPR) system. This technology offers the possibility to design a single guide RNA (sgRNA) which is incorporated into a CRISPR- associated protein (Cas9) to recognize and induce DNA double-strand breaks at a specific target location. DNA double-strand breaks will be repaired by homologous recombination (HR) in the presence of a donor sequence for Epidermolysis Bullosa gene repair. In the context of Epidermolysis Bullosa, this allows to repair the mutation/s causing the disease.

9. 发明申请

US20150039289A1 Systems and Methods for Representing, Diagnosing, and Recommending Interaction Sequences 有权
标题翻译：用于表示，诊断和推荐交互序列的系统和方法
公开(公告)号：US20150039289A1
公开(公告)日：2015-02-05
申请号：US13955425
申请日：2013-07-31
申请人： Stanford University
发明人： Adegboyega Mabogunje , Neeraj Sonalkar , Larry J. Leifer , Shashikant Khandelwal
IPC分类号： G06F17/28
CPC分类号： G06Q10/10
摘要： Systems and methods for representing and diagnosing interaction sequences in accordance embodiments of the invention are disclosed. In one embodiment of the invention, a group interaction diagnosis and recommendation server system includes a processor and a memory configured to store a set of reference interaction data, where the reference interaction data includes a set of reference interaction sequences, wherein a group interaction diagnosis application configures the processor to obtain a set of group interaction data, generate an interaction model based on the group interaction data and an interaction dynamics language, determine at least one interaction sequence within the set of group interaction data based on the generated interaction model, identify at least one matching interaction sequence within the determined at least one interaction sequence, and recommend at least one improved interaction sequence based on the identified at least one matching interaction sequence and the set of reference interaction data.
摘要翻译：公开了根据本发明的实施例的用于表示和诊断交互序列的系统和方法。在本发明的一个实施例中，组交互诊断和推荐服务器系统包括处理器和被配置为存储一组参考交互数据的存储器，其中参考交互数据包括一组参考交互序列，其中组交互诊断应用配置处理器以获得一组组交互数据，基于组交互数据和交互动态语言生成交互模型，基于所生成的交互模型确定组交互数据集合中的至少一个交互序列，在在所确定的至少一个交互序列内的至少一个匹配的相互作用序列，并且基于所识别的至少一个匹配交互序列和所述一组参考交互数据来推荐至少一个改进的交互序列。

10. 发明申请

US20030199387A1 Fuel cell and method for making the same 失效
公开(公告)号：US20030199387A1
公开(公告)日：2003-10-23
申请号：US10449392
申请日：2003-06-02
申请人： Honda Giken Kogyo Kabushiki Kaisha , Stanford University
发明人： Yuji Saito , Jun Sasahara , Nariaki Kuriyama , Tadahiro Kubota , Toshifumi Suzuki , Yuji Isogai , Friedrich B. Prinz , Sang-Joon John Lee , Suk Won Cha , Yaocheng Liu , Ryan O'Hayre
IPC分类号： H01M004/88 , H01M004/94
CPC分类号： H01M8/2404 , H01M4/8605 , H01M4/8885 , H01M8/1213 , H01M8/243 , H01M8/2475 , Y02P70/56
摘要： In a fuel cell comprising a tubular casing, an electrolyte layer received in the tubular casing, and a pair of gas diffusion electrodes interposing the electrolyte layer and defining a fuel gas passage and an oxidizing gas passage, respectively, each gas diffusion electrode is formed by stacking a plurality of layers of material therefor, for instance in the axial direction of the casing. Because the gas diffusion layers are formed layer by layer, components can be formed in highly fine patterns so that a highly compact tubular fuel cell can be achieved. Similarly, the dimensions of the various elements of the fuel cell can be controlled in a highly accurate manner. Also, the geometric arrangement can be changed at will in intermediate parts of each gas passage.

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