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1. 发明申请

WO2004078216A3 USE OF A TRICYCLIC ANTIDEPRESSANT DRUG FOR PROMOTING ENDOCYTOSIS 审中-公开
标题翻译：使用三环类抗抑郁药，以促进细胞内吞作用
公开(公告)号：WO2004078216A3
公开(公告)日：2005-01-06
申请号：PCT/DE2004000321
申请日：2004-02-17
申请人： RINA NETZWERK RNA TECHNOLOGIEN , NEUKAMM BIRGIT , LANG CHRISTINE , GESSNER REINHARD
发明人： NEUKAMM BIRGIT , LANG CHRISTINE , GESSNER REINHARD
IPC分类号： A61K31/00 , A61K47/18 , A61K47/22 , A61K48/00 , C12N15/87
CPC分类号： A61K47/18 , A61K47/22
摘要： The invention relates to the use of a tricyclic compound for promoting the endocytotic uptake of macromolecular active compounds.
摘要翻译：本发明教导了使用的三环化合物的促进大分子活性化合物的内吞摄取。

2. 发明申请

WO0216935A9 SCREENING METHOD FOR DISCOVERING AUXILIARY AGENTS PROMOTING ENDOCYTOSIS 审中-公开
标题翻译：检查方法用于确定促销的内吞作用的佐剂
公开(公告)号：WO0216935A9
公开(公告)日：2003-09-04
申请号：PCT/EP0107509
申请日：2001-06-30
申请人： RINA NETZWERK RNA TECHNOLOGIEN , LANG CHRISTINE , GESSNER REINHARD , NEUKAMM BIRGIT , PRINZ BIANKA , NEVOIGT ELKE
发明人： LANG CHRISTINE , GESSNER REINHARD , NEUKAMM BIRGIT , PRINZ BIANKA , NEVOIGT ELKE
IPC分类号： C12Q1/02 , G01N33/50
CPC分类号： G01N33/502 , C12Q1/025 , G01N33/5008
摘要： The invention relates to a screening method for discovering auxiliary agents promoting the endocytosis of low molecular and/or macro-molecular compounds, especially nucleic acids, in cells. The inventive method comprises the following steps: a) a yeast strain is selected and yeast cells are cultivated therefrom; b) the yeast cells are incubated with a potential auxiliary agent promoting the endocytosis of low molecular and/or macro-molecular compounds, especially nucleic acids, in cells in addition to a nucleic acid which is replicable and/or replicable in the nucleus and/or in the cytosol of the yeast cells or a low molecular and/or macro-molecular compound, c) the transformation rates or the transport rates into the cytosol or the nucleus are determined and analysis occurs if the transformation rates or transport rates increase in comparison with the transformation rates and transport rates in a reference test in which the auxiliary substance is not used, d) the auxiliary substance is selected or rejected according to the result of the value obtained for the increase in the transformation rates or transport rates or transport rates in step c). The invention also relates to a screening method of the above-mentioned variety, wherein vertebrate cells are used, in addition to the use of auxiliary agents obtained according to said method in order to produce pharmaceutical substances.
摘要翻译：本发明教导了一种筛选方法，用于发现低和/或大分子化合物的细胞内吞作用，特别是核酸，细胞，包括以下方法步骤：a）的酵母菌株被选择和酵母细胞中培养由此，b）将酵母细胞用一个潜在的孵育低和/或大分子化合物的细胞内吞作用，特别是核酸，细胞，赋形剂和具有可复制的和/或在核心和/或酵母细胞中复制的核酸或低和/或大分子化合物c的胞质溶胶）确定转化率或运输速率进入细胞质或细胞核，和转化率或运输速率的增加，相对于转化率或在参考测试输送速率，而不使用辅助物质，检查，d）中的赋形剂是NA selektriert或丢弃 CH小于本所得到的转化率的增加或在步骤c运输速率），使用脊椎动物细胞以及与这样的用于生产药物组合物的方法获得的佐剂使用的筛选方法对应的方式的值。

3. 发明专利

DE50111327D1 未知
公开(公告)号：DE50111327D1
公开(公告)日：2006-12-07
申请号：DE50111327
申请日：2001-06-30
申请人： RINA NETZWERK RNA TECHNOLOGIEN
发明人： LANG CHRISTINE , GESSNER REINHARD , NEUKAMM BIRGIT , PRINZ BIANKA , NEVOIGT ELKE
IPC分类号： G01N33/50 , C12Q1/02

4. 发明专利

DE10310196A1 未知
公开(公告)号：DE10310196A1
公开(公告)日：2004-09-23
申请号：DE10310196
申请日：2003-03-06
申请人： RINA NETZWERK RNA TECHNOLOGIEN
发明人： NEUKAMM BIRGIT , LANG CHRISTINE , GESSNER REINHARD
IPC分类号： A61K31/00 , A61K47/18 , A61K47/22 , A61K48/00 , C12N15/87
摘要： The invention teaches the use of a tricyclic compound for promoting the endocytotic uptake of macromolecular active ingredients.

5. 发明申请

WO2008074473A2 USES AND METHODS FOR PREVENTING AND/OR TREATING CARIES CAUSED BY MUTANTS STREPTOCOCCI 审中-公开
标题翻译：用于预防和/或治疗由MUTANTS STREPTOCOCCI引起的药物的用途和方法
公开(公告)号：WO2008074473A2
公开(公告)日：2008-06-26
申请号：PCT/EP2007011127
申请日：2007-12-18
申请人： BASF SE , REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
发明人： REINDL ANDREAS , LANG CHRISTINE , BOETTNER MEWES , VEEN MARKUS
IPC分类号： A61K35/74 , A61P1/02
CPC分类号： C12N1/20 , A23G3/366 , A23G4/123 , A23L33/135 , A61K8/99 , A61K35/747 , A61Q11/00 , C12R1/225
摘要： The present invention relates to the use of a microorganism belonging to the group of lactic acid bacteria or a mutant or derivative thereof, characterized in that it is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci, wherein the specific binding is (i) resistant to heat treatment; and/or (ii) resistant to protease treatment; and/or (iii) calcium-dependent; and/or (iv) formed within a pH range between 4.5 and 8.5; and/or (v) formed in the presence of saliva, for the preparation of an anticariogenic composition for the treatment or prevention of caries caused by mutans Streptococci other than Streptococcus mutans. Preferably, the specific binding can be assayed as follows: (a) growing said microorganism to stationary phase; (b) mixing said microorganism with a bacterium belonging to the group of mutans Streptococci which has been grown to stationary phase; (c) incubating the mixture obtained in step (b) under conditions allowing the formation of aggregates of said microorganism and a bacterium of the group of mutans Streptococci; and (d) detecting aggregates by the occurrence of a pellet. Another aspect of the present invention is a method of prophylaxis or treatment of caries caused by mutans Streptococci other than Streptococcus mutans, comprising administering a microorganism belonging to the group of lactic acid bacteria characterized in that said microorganism is capable of specifically binding to a bacterium belonging to the group of mutans Streptococci or a mutant, derivative, analog or fragment of said microorganism.
摘要翻译：本发明涉及属于乳酸菌群或其突变体或衍生物的微生物的用途，其特征在于能够特异性结合属于变形链球菌链球菌属的细菌，其中特异性结合是（i）耐热处理; 和/或（ii）抗蛋白酶处理; 和/或（iii）钙依赖性; 和/或（iv）在4.5至8.5之间的pH范围内形成; 和/或（v）在唾液存在下形成，用于制备用于治疗或预防由变形链球菌变异链球菌变异链球菌引起的龋齿的抗焦虑性组合物。优选地，可以如下测定特异性结合：（a）将所述微生物生长至固定相; （b）将所述微生物与已经生长至固定相的变种链球菌属组的细菌混合; （c）在允许形成所述微生物的聚集体和变种链球菌组的细菌的条件下温育步骤（b）中获得的混合物; 和（d）通过颗粒的发生检测聚集体。本发明的另一方面是预防或治疗由变形链球菌变形链球菌以外的变形链球菌引起的龋齿的方法，包括给予属于所述乳酸菌群的微生物，其特征在于，所述微生物能够特异性结合属于变体链球菌或所述微生物的突变体，衍生物，类似物或片段。

6. 发明申请

WO2012116783A3 A YEAST CELL FOR THE PRODUCTION OF TERPENES AND USES THEREOF 审中-公开
标题翻译：一种用于生产蕨类的酵母细胞及其用途
公开(公告)号：WO2012116783A3
公开(公告)日：2012-10-26
申请号：PCT/EP2012000665
申请日：2012-02-15
申请人： ORGANOBALANCE GMBH , RAAB ANDREAS , LANG CHRISTINE
发明人： RAAB ANDREAS , LANG CHRISTINE
IPC分类号： C12N9/02 , C12N9/04 , C12N9/10 , C12P5/02
CPC分类号： C12P5/026 , C12N9/0004 , C12N9/0006 , C12N9/1025 , C12N15/81 , C12P5/02
摘要： The present invention relates to a yeast cell, wherein said cell comprises a functional gene coding for soluble hydroxymethylglutaryl-coenzyme-A (HMG-CoA) reductase; one or more gene(s) coding for steryl acyltransferase(s) in said cell are defective or deleted; and said cell is prototrophic for at least histidine, leucine or uracil. Moreover, the present invention relates to the use of said cell for the production of one or more terpene(s). Further, the present invention relates to methods of generating said cell and the production of one or more terperne(s) and a pharmaceutical or cosmetically composition, a lubricant or transformer oil comprising said terpene(s).
摘要翻译：本发明涉及酵母细胞，其中所述细胞包含编码可溶性羟甲基戊二酰辅酶A（HMG-CoA）还原酶的功能性基因; 编码所述细胞中的甾基酰基转移酶的一种或多种基因缺陷或缺失; 并且所述细胞对于至少组氨酸，亮氨酸或尿嘧啶是原养型的。此外，本发明涉及所述细胞用于生产一种或多种萜烯的用途。此外，本发明涉及产生所述细胞和产生一种或多种萜烯和药物或化妆组合物，包含所述萜烯的润滑剂或变压器油的方法。

7. 发明申请

WO2009124694A3 SYNTHESIS OF POLYUNSATURATED FATTY ACIDS IN YEAST 审中-公开
标题翻译：聚合脂肪酸在YEAST中的合成
公开(公告)号：WO2009124694A3
公开(公告)日：2010-01-14
申请号：PCT/EP2009002481
申请日：2009-04-03
申请人： ORGANOBALANCE GMBH , VAN LENGERICH BERNHARD , BOETTNER MEWES , RIECHERS SEAN-PATRICK , LANG CHRISTINE , VEEN MARKUS , SCHILLING MICHAEL
发明人： VAN LENGERICH BERNHARD , BOETTNER MEWES , RIECHERS SEAN-PATRICK , LANG CHRISTINE , VEEN MARKUS , SCHILLING MICHAEL
IPC分类号： C12P7/64 , A23K1/16 , A23L1/30 , C12N1/18
CPC分类号： C12P7/6472 , A23K20/158 , A23L33/12 , C11B1/10 , C12N1/18 , C12N9/0083 , C12N9/1029 , C12P7/6427
摘要： Described is a method of providing an organism belonging to the genus Saccharomyces, which is capable of producing polyunsaturated fatty acids (PUFAs) comprising the steps of subjecting such an organism, which does not produce PUFAs, to a mutagenesis step and selecting a Saccharomyces organism, which is capable of accumulating at least 15% of the cellular dry weight as lipids; and genetically modifying the Saccharomyces organism selected in step (a) so that it is capable of synthesizing PUFAs, in particular eicosapentaenoic acid and/or docosahexaenoic acid. Also described are organisms obtained by such a method, as well as a method for the synthesis of PUFAs, in particular eicosapentaenoic acid and/or docosahexaenoic acid comprising culturing such an organism.
摘要翻译：描述了提供属于酵母属（Saccharomyces）的生物体的方法，其能够产生多不饱和脂肪酸（PUFA），包括以下步骤：使不产生PUFA的生物体进行诱变步骤并选择酵母属生物，其能够作为脂质积聚至少15％的细胞干重; 和遗传修饰在步骤（a）中选择的酵母属生物体，使得其能够合成PUFA，特别是二十碳五烯酸和/或二十二碳六烯酸。还描述了通过这种方法获得的生物体，以及用于合成PUFA，特别是二十碳五烯酸和/或二十二碳六烯酸的方法，其包括培养这种生物体。

8. 发明申请

WO2008128522A3 MICROORGANISM FOR THE PRODUCTION OF SUCCINIC ACID 审中-公开
标题翻译：菌对琥珀酸生产
公开(公告)号：WO2008128522A3
公开(公告)日：2009-04-02
申请号：PCT/DE2008000670
申请日：2008-04-16
申请人： ORGANO BALANCE GMBH , LANG CHRISTINE , VEEN MARKUS , BOETTNER MEWES , RAAB ANDREAS
发明人： LANG CHRISTINE , VEEN MARKUS , BOETTNER MEWES , RAAB ANDREAS
IPC分类号： C12P7/46 , C12N1/19 , C12N9/04 , C12N9/88
CPC分类号： C12P7/46 , C12N1/18 , C12N9/0006 , C12N9/88
摘要： The invention relates to an isolated genetically modified microorganism in which the gene IDH1 and at least one of the genes SDH2 and DIC1 are under the control of a first promoter that is repressed to a growth culture medium by means of a cultivation additive and is active in the absence of the cultivation additive. The genes that are part of the group comprising "PYC1, ACS1, CIT1, ACO1, ICL1, MSL1, and CIT2, optionally also MDH3" are constitutively active. The invention further relates to uses of such a microorganism, especially for producing succinic acid.
摘要翻译：本发明涉及一种分离的遗传修饰的微生物，其中所述基因IDH1和基因SDH2中的至少一个，并且是第一启动子DIC1，其由培养添加剂压抑到培养生长介质，并且是活性在没有培养添加剂的控制下，对其中的基因基“PYC1，ACS1，CIT1，ACO1，ICL1，MSL1和CIT2任选MDH3”是这样的微生物的组成性活性，以及用途，特别是用于生产琥珀酸。

9. 发明专利

NL194507B 未知
公开(公告)号：NL194507B
公开(公告)日：2002-02-01
申请号：NL9301021
申请日：1993-06-11
申请人： LANG CHRISTINE , WEIMANN MAIKE JANSEN
发明人： JANSEN-WEIMANN MAIKE , LANG CHRISTINE
IPC分类号： C07K5/02 , C12P21/02 , C12N1/16 , C12N1/18 , C12N15/01
摘要： Use of zinc-resistant Saccharomyces for fermentative prodn. of glutathione (I) is new. The zinc-resistant strain S. cerevisiae DSM 7092 is new (and is the pref. organism for (I) prodn.). USE/ADVANTAGE - Zn-resistant strains provide higher yields of (I) (8-10 times higher for DSM 7092) and product purity is also improved. These advantages are achieved without addn. of sulphur sources or amino acid mixts. The required mutants are quickly and easily selected. (I) is well known as a cytoprotectant against oxidative injury caused by toxic chemicals, reactive oxygen derivs. or radiation. It is used to treat liver damage; to prevent kidney toxicity by drugs and as a food additive (e.g. for baked goods).

10. 发明专利

NL194507C 未知
公开(公告)号：NL194507C
公开(公告)日：2002-06-04
申请号：NL9301021
申请日：1993-06-11
申请人： LANG CHRISTINE , JANSEN-WEIMANN MAIKE
发明人： JANSEN-WEIMANN MAIKE , LANG CHRISTINE
IPC分类号： C07K5/02 , C12P21/02 , C12N1/16 , C12N1/18 , C12N15/01
摘要： Use of zinc-resistant Saccharomyces for fermentative prodn. of glutathione (I) is new. The zinc-resistant strain S. cerevisiae DSM 7092 is new (and is the pref. organism for (I) prodn.). USE/ADVANTAGE - Zn-resistant strains provide higher yields of (I) (8-10 times higher for DSM 7092) and product purity is also improved. These advantages are achieved without addn. of sulphur sources or amino acid mixts. The required mutants are quickly and easily selected. (I) is well known as a cytoprotectant against oxidative injury caused by toxic chemicals, reactive oxygen derivs. or radiation. It is used to treat liver damage; to prevent kidney toxicity by drugs and as a food additive (e.g. for baked goods).

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