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1. 发明申请

WO1988008427A1 NUCLEOSIDE DERIVATIVES AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：核苷衍生物及其制备方法
公开(公告)号：WO1988008427A1
公开(公告)日：1988-11-03
申请号：PCT/JP1988000393
申请日：1988-04-22
申请人： RIKAGAKU KENKYUSHO , KUZUHARA, Hiroyoshi , KAMANA, Masajiro , YAMASAKI, Noritsugu , NISHIKAWA, Masahiro
发明人： RIKAGAKU KENKYUSHO
IPC分类号： C07H19/052
CPC分类号： C07D473/00 , C07D405/04 , C07H19/06 , C07H19/16 , Y02P20/55
摘要： Dideoxynucleoside derivatives effective as antiviral agents, intermediates for their synthesis, and process for their synthesis are disclosed. The process is characterized in that a mesyl, tosyl or trifluoromethanesulfonyl group is introduced selectively into the 3'-position of a ribose unit of various nucleoside whose base and 2'- and 5'-positions of the ribose unit are protected, and the product is treated with a base and a reducing agent to give an intermediate useful for synthesizing the dinucleoside derivatives. This process enables preparation of various novel intermediates and dideoxynucleoside derivatives. Another process of synthesizing intermediates useful for synthesizing dideoxynucleoside derivatives is also disclosed, which comprises reacting a nucleoside derivative whose base and 2'- and 5'-positions of the ribose unit are protected by pivaloyl groups and 3'-position is protected by a mesyl, tosyl or trifluoromethanesulfonyl group with an alkaline compound to thereby selectively eliminate pivaloyl groups of the base.

2. 发明申请

WO1988006182A1 BOVINE LEUKEMIA VIRUS VACCINE PREPARED BY USING RECOMBINANT VACCINIA VIRUS 审中-公开
标题翻译：使用重组病毒疫苗制备的维生素VV疫苗
公开(公告)号：WO1988006182A1
公开(公告)日：1988-08-25
申请号：PCT/JP1988000136
申请日：1988-02-10
申请人： TOA NENRYO KOGYO KABUSHIKI KAISHA , RIKAGAKU KENKYUSHO , OISHI, Kazue , MARUYAMA, Tadashi , SUGOMOTO, Masanobu , SAGATA, Yoshiyuki , IKAWA, Yoji
发明人： TOA NENRYO KOGYO KABUSHIKI KAISHA , RIKAGAKU KENKYUSHO
IPC分类号： C12N07/00
CPC分类号： C12N15/86 , A61K39/00 , C07K14/005 , C12N2710/24143 , C12N2740/13022
摘要： A recombinant virus containing a gene of a surface antigen of a bovine leukemia virus incorporated in a vaccinia virus gene and capable of expressing a surface antigen of a bovine leukemia virus; a process for preparing the recombinant virus comprising the steps of (1) inserting a DNA fraction containing a hemagglutinin gene of vaccinia virus gene origin into a cloning vector to prepare a hemagglutinin gene-containing vector, (2) inserting a surface antigen gene of a bovine leukemia virus into the hemagglutinin gene in the hemagglutinin gene-containing vector and a promoter for the gene to prepare a vector containing the surface antigen gene of the bovine leukemia virus, and (3) incorporating the surface antigen gene of the bovine leukemia virus together with its promoter into the hemagglutinin gene region of the vaccinia virus gene by homologous recombination between the hemagglutinin gene region in the surface antigen gene-containing vector and the hemagglutinin gene region of the vaccinia virus gene; and a process for immunizing mammals against a bovine leukemia virus, which comprises inoculating mammals with the recombinant virus and then with a deactivated bovine leukemia virus or its part having antigenicity.
摘要翻译：一种重组病毒，其含有引入牛痘病毒基因并能够表达牛白血病病毒表面抗原的牛白血病病毒的表面抗原基因; 一种制备重组病毒的方法，包括以下步骤：（1）将含有痘苗病毒基因来源血凝素基因的DNA级分插入克隆载体中以制备含血凝素基因的载体，（2）将表达抗原基因插入到牛白血病病毒转入含血凝素基因的载体中的血凝素基因和用于该基因的启动子，以制备含有牛白血病病毒的表面抗原基因的载体，和（3）将牛白血病病毒的表面抗原基因并入其启动子通过表面抗原基因载体中的血凝素基因区域与痘苗病毒基因的血凝素基因区域之间的同源重组而进入痘苗病毒基因的血凝素基因区域; 以及用于对牛白血病病毒免疫哺乳动物的方法，其包括用重组病毒接种哺乳动物，然后用失活的牛白血病病毒或其部分具有抗原性。

3. 发明申请

WO1994007232A1 APPARATUS AND METHOD FOR PRODUCING VISUAL EFFECT 审中-公开
标题翻译：用于生产视觉效果的装置和方法
公开(公告)号：WO1994007232A1
公开(公告)日：1994-03-31
申请号：PCT/JP1993001307
申请日：1993-09-14
申请人： RIKAGAKU KENKYUSHO , IDESAWA, Masanori , NISHI, Katsuo , KATO, Hiroshi , SHIMODA, Susumu
发明人： RIKAGAKU KENKYUSHO
IPC分类号： G09F19/12
CPC分类号： G09F19/12
摘要： The apparatus comprises a first object (A) in which a plurality of windows (W) are arranged around a rotational shaft (C), and a polygonal second object (B) so arranged as to be partially observed through the windows of the first object (A). The first object (A) and second object (B) rotate relatively around the rotational shaft (C). Because of optical illusion, a visual effect that the polygonal object (B) is perceived expanding, contracting, deforming and eccentrically rotating is produced.
摘要翻译：该装置包括：第一物体（A），其中多个窗口（W）围绕旋转轴（C）布置;以及多边形第二物体（B），其被布置成通过第一物体的窗口部分地观察（一个）。第一物体（A）和第二物体（B）相对于旋转轴（C）旋转。由于视觉错觉，产生多边形物体（B）被感觉到扩张，收缩，变形和偏心旋转的视觉效果。

4. 发明申请

WO1991003308A1 METHOD OF CONCENTRATING OXYGEN 18 WITH LASER 审中-公开
标题翻译：用激光浓缩氧气18的方法
公开(公告)号：WO1991003308A1
公开(公告)日：1991-03-21
申请号：PCT/JP1990001093
申请日：1990-08-29
申请人： RIKAGAKU KENKYUSHO , MAJIMA, Tetsuro , SUGITA, Kyoko , ARAI, Shigeyoshi
发明人： RIKAGAKU KENKYUSHO
IPC分类号： B01D59/34
CPC分类号： B01D59/34
摘要： A method of concentrating oxygen 18 with laser which comprises adding optionally a hydrocarbon to a saturated acyclic ether (except dimethyl ether) or a saturated cyclic ether as a starting material containing oxygen 18 and laser beams are applied thereto for causing selective photolysis of oxygen 18, and separating a product containing oxygen 18 from the products of said photolysis. The concentrated oxygen 18 can be used as a tracer or the like.

5. 发明申请

WO1989011794A1 PLANT GROWTH INHIBITOR 审中-公开
标题翻译：植物生长抑制剂
公开(公告)号：WO1989011794A1
公开(公告)日：1989-12-14
申请号：PCT/JP1989000539
申请日：1989-05-30
申请人： RIKAGAKU KENKYUSHO , FUJISAWA PHARMACEUTICAL CO., LTD. , YOSHIOKA, Hirosuke , KO, Keido , KO, Myoka , KO, Rinkei , KO, Michi , KO, Hiroshi , SHIMIZU, Makoto , NAKAHARA, Yuko , INOUE, Ikuko , KAMURO, Yasuo , KAKIUCHI, Toshihito
发明人： RIKAGAKU KENKYUSHO , FUJISAWA PHARMACEUTICAL CO., LTD.
IPC分类号： A01N47/20
CPC分类号： A01N47/20
摘要： The invention relates to a plant growth inhibitor, which contains as an active ingredient a carbamate compound represented by general formula (I). This inhibitor shows an excellent effect as a growth retardant for axillary buds of tobacco or soybean or for preventing barley from lodging.
摘要翻译：本发明涉及植物生长抑制剂，其含有作为活性成分的由通式（I）表示的氨基甲酸酯化合物。该抑制剂作为烟草或大豆的腋芽的生长阻滞剂或用于防止大麦倒伏的效果良好。

6. 发明申请

WO1988000339A1 OXYGEN CONCENTRATION PROBE 审中-公开
标题翻译：氧气浓度探测
公开(公告)号：WO1988000339A1
公开(公告)日：1988-01-14
申请号：PCT/JP1987000463
申请日：1987-07-03
申请人： RIKAGAKU KENKYUSHO , TERUMO KABUSHIKI KAISHA , KANEKO, Masao , NAKAMURA, Hideki
发明人： RIKAGAKU KENKYUSHO , TERUMO KABUSHIKI KAISHA
IPC分类号： G01N21/77
CPC分类号： G01N21/643 , G01N21/78 , G01N31/22 , G01N31/221 , G01N31/225
摘要： An oxygen concentration probe which measures an oxygen concentration in a solution or a gas in accordance with equation (1) below by utilizing extinction of light by oxygen, said light being generated by excitation of light through immobilization of a polypyridine metal complex. Namely, the invention provides an oxygen concentration probe which can be readily miniaturized and consists of immobilized polypyridine metal complex which can be prepared from an economical material for visible rays of light as a photoconductor or optical material since the excited light and emitted light are visible rays of light and can be used stably even when it is dipped directly into a solution, or the like, without any protective film such as an oxygen-permeable film. I0/I = 1 + K[O2] (1), where I0 and I each represent the intensity of emitted light (with the proviso that I0 is the intensity of the emitted light when the oxygen concentration is substantially zero), K is a constant and [O2] is an oxygen concentration. I0 and K are constants that are independent of the oxygen concentration of a sample.

7. 发明申请

WO1992015599A1 OLIGOSIALYL-1,2-DIALKYL-Sn-GLYCEROL AND INTERMEDIATE FOR ITS SYNTHESIS 审中-公开
标题翻译：低聚物-1,2-二烷基-Sn-甘油和其合成的中间体
公开(公告)号：WO1992015599A1
公开(公告)日：1992-09-17
申请号：PCT/JP1992000249
申请日：1992-03-03
申请人： RIKAGAKU KENKYUSHO , MECT CORPORATION , OGAWA, Tomoya , NUNOMURA, Shigeki , SUGIMOTO, Mamoru
发明人： RIKAGAKU KENKYUSHO , MECT CORPORATION
IPC分类号： C07H15/04
CPC分类号： C07H15/04 , C07H3/06 , C07H15/18 , C07H15/26 , Y02P20/55
摘要： An oligosialyl-1,2-dialkyl-Sn-glycerol represented by general formula (I) and an intermediate for its synthesis, wherein R groups represent each independently hydrogen or an alkali metal; R groups represent each independently C14 to C18 alkyl; Ac represents acetyl; and n represents an integer of 0 to 20. The above glycerol can be used as immunopotentiator, antitumor agent, and diagnostic and therapeutic agent for cancer.
摘要翻译：由通式（I）表示的唾液酸-1,2-二烷基-Sn-甘油和其合成中间体，其中R 1各自独立地表示氢或碱金属; R 2基团各自独立地表示C 14至C 18烷基; Ac表示乙酰基; n表示0〜20的整数。作为上述甘油，可以使用作为免疫增强剂，抗肿瘤剂，癌症诊断和治疗剂。

8. 发明申请

WO1990002140A1 METHOD FOR PURIFYING TENEICINE 审中-公开
标题翻译：净化尼龙的方法
公开(公告)号：WO1990002140A1
公开(公告)日：1990-03-08
申请号：PCT/JP1989000839
申请日：1989-08-17
申请人： RIKAGAKU KENKYUSHO , JAPAN IMMUNORESEARCH LABORATORIES CO., LTD. , AMANO PHARMACEUTICAL CO., LTD. , NIPPON SHINYAKU CO., LTD. , SAKAKURA, Teruyo , OIKE, Yasuteru , HIRAIWA, Hideki , KAWAKATSU, Hisaaki
发明人： RIKAGAKU KENKYUSHO , JAPAN IMMUNORESEARCH LABORATORIES CO., LTD. , AMANO PHARMACEUTICAL CO., LTD. , NIPPON SHINYAKU CO., LTD.
IPC分类号： C07K15/14
CPC分类号： C07K14/47
摘要： According to the method of this invention, highly pure teneicine can be obtained in a high yield from an extract of an extracellular substance containing teneicine by flowing said extract through an affinity chromatograph containing gelatin bound thereto via covalent bonds to remove fibronectin to such an extent that its content is lowered to 1 % by weight or less of the solute and purifying the fraction thus treated by using a basic anion exchange resin.

9. 发明申请

WO1989008679A1 PROCESS FOR PRODUCING POROUS POLYMER MEMBRANE AND COMPOSITE POLYMER MEMBRANE 审中-公开
标题翻译：用于生产多孔聚合物膜和复合聚合物膜的方法
公开(公告)号：WO1989008679A1
公开(公告)日：1989-09-21
申请号：PCT/JP1989000239
申请日：1989-03-07
申请人： RIKAGAKU KENKYUSHO , KYOWA HAKKO KOGYO CO., LTD. , FURUKAWA, Takeo , INABA, Yukio
发明人： RIKAGAKU KENKYUSHO , KYOWA HAKKO KOGYO CO., LTD.
IPC分类号： C08J09/28
CPC分类号： C08J9/28 , C08J2201/05 , C08J2201/0542
摘要： Composite membranes of liquid crystal and/or dye and a polymer are expected to have various functions in addition to electro-optical effects and non-linear optical effects of the starting substances, and are promising as various industrial materials. Liquid crystal-polymer composite membranes produced by conventional processes do not have fully satisfactory electric and optical properties because the diameters of the low-molecular functional compounds and their distribution are nonuniform. A process for producing a porous polymer membrane by evaporating a solvent from a polymer solution containing water and alcohol according to this invention provides a porous polymer membrane having pores of a uniform size uniformly distributed therein. Furthermore a process for producing a composite membrane according to this invention comprises filling the pores of the porous polymer membrane with low-molecular functional compounds such as liquid crystal or dye to obtain a composite membrane wherein the low-molecular functional compoumd is uniformly distributed in a uniform size. In addition, in the case of producing the porous polymer membrane, the size of the pore of the polymer membrane can be controlled by controlling humidity of a highly humid environment or the amount of water in the polymer solution. Fixed membranes with excellent electric and optical properties can be obtained by providing electrodes in the composite membrane obtained by filling a low-molecular functional compound such as liquid crystal or dye in the pores of the obtained porous polymer membrane.
摘要翻译：预期液晶和/或染料和聚合物的复合膜除了起始物质的电光效应和非线性光学效应之外还具有各种功能，并且作为各种工业材料是有希望的。通过常规方法制备的液晶聚合物复合膜由于低分子官能化合物的直径及其分布不均匀而不具有令人满意的电和光学性质。通过根据本发明从含有水和醇的聚合物溶液中蒸发溶剂来生产多孔聚合物膜的方法提供了具有均匀分布在其中的尺寸均匀的孔的多孔聚合物膜。此外，根据本发明的复合膜的制造方法包括用液晶或染料等低分子官能化合物填充多孔聚合物膜的孔，得到复合膜，其中低分子官能化合物均匀分布在均匀尺寸。此外，在制造多孔聚合物膜的情况下，可以通过控制高湿度环境的湿度或聚合物溶液中的水量来控制聚合物膜的孔的尺寸。通过在通过在所得多孔聚合物膜的孔中填充液晶或染料等低分子官能化合物而得到的复合膜中设置电极，可以得到电气和光学特性优异的固定膜。

10. 发明申请

WO1988010302A1 NOVEL PLASMID, MICROBIAL CELLS, PROCESS FOR PREPARING POLYPEPTIDE WITH ONCOSTATIC ACTIVITY, AND SECRETED POLYPEPTIDE WITH ONCOSTATIC ACTIVITY 审中-公开
标题翻译：新型PLASMID，微生物细胞，制备具有止痛活性的多肽的方法和具有呼吸活性的分泌的多肽
公开(公告)号：WO1988010302A1
公开(公告)日：1988-12-29
申请号：PCT/JP1988000595
申请日：1988-06-17
申请人： TEIJIN LIMITED , RIKAGAKU KENKYUSHO , NAKAMURA, Satoshi , ICHIKAWA, Yataro , HORIKOSHI, Koki
发明人： TEIJIN LIMITED , RIKAGAKU KENKYUSHO
IPC分类号： C12N15/00
CPC分类号： C12N15/70 , C07K14/525 , C12N15/67
摘要： A plasmid containing: (1) a first DNA region having a DNA sequence coding a polypeptide with an oncostatic activity, a DNA sequence having the promoter function of controlling expression of the polypeptide, and a DNA sequence coding a signal peptide, and (2) a second DNA region having a DNA sequence giving host cells the action of accelerating extracellular secretion and a DNA sequence having the promoter function of controlling expression of the DNA sequence; microbial cells transformed by said plasmid; a process for producing a polypeptide with an oncostatic activity through extracellular secretion using said cells; and a polypeptide with an oncostatic activity secreted from said cells are disclosed.

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